Yansheng Liu (0000-0002-2626-3912)

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Biography

Dr. Liu received his Ph.D. of Biomedical Sciences at Shanghai Institute for Biological Sciences, Chinese Academy of Sciences. Dr. Liu completed a post-doctoral research fellowship (May 2011 - October 2017) in the Proteomics Laboratory of Dr. Ruedi Aebersold in the Institute of Molecular Systems Biology, ETH Zurich, Switzerland. Dr. Liu joined the Yale Cancer Biology Institute as an Assistant Professor of Pharmacology in December 2017. His research group at Yale aims to contribute to the development of Data independent acquisition (DIA) mass spectrometry and other proteomic techniques and their applications in Cancer Biology and Systems Biology studies.

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Yale School of Medicine: New Haven, CT, US

2023-07-01 to present | Associate Professor (Pharmacology)

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Yansheng Liu

https://orcid.org/0000-0002-2626-3912

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Employment (3)

Yale School of Medicine: New Haven, CT, US

Yale School of Medicine: New Haven, CT, US

ETH Zurich: Zurich, CH

Education and qualifications (1)

Shanghai Institutes for Biological Sciences: Shanghai, Shanghai, CN

Works (50 of 69)

Mass spectrometry-based mapping of plasma protein QTLs in children and adolescents

An in vivo screen identifies NAT10 as a master regulator of brain metastasis

Advancing Scientific Communication in Proteomics

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation

Role of AMPK in Atrial Metabolic Homeostasis and Substrate Preference

EGFR targeting PhosTACs as a dual inhibitory approach reveals differential downstream signaling

Chk2 sustains PLK1 activity in mitosis to ensure proper chromosome segregation

The SysteMHC Atlas v2.0, an updated resource for mass spectrometry-based immunopeptidomics

7SK methylation by METTL3 promotes transcriptional activity

Phosphoproteomic analysis of metformin signaling in colorectal cancer cells elucidates mechanism of action and potential therapeutic opportunities

Post‐translational modification and phenotype

Toward a hypothesis‐free understanding of how phosphorylation dynamically impacts protein turnover

Targeted Dephosphorylation of Tau by Phosphorylation Targeting Chimeras (PhosTACs) as a Therapeutic Modality

Reciprocal inhibition of PIN1 and APC/CCDH1 controls timely G1/S transition and creates therapeutic vulnerability

The Cul5 E3 Ligase Complex Is a Key Negative Feedback Regulator of TCR/IL2 Signaling and Anti-Tumor Activity in CD8+T Cells

7SK methylation Promotes Transcriptional Activity

7q11.23 CNV alters protein synthesis and REST-mediated neuronal intrinsic excitability

Proteotype coevolution and quantitative diversity across 11 mammalian species

Deep Phosphoproteomic Elucidation of Metformin-Signaling in Heterogenous Colorectal Cancer Cells

Proteotype Co-evolution and Diversity in Mammals

A peptidoform based proteomic strategy for studying functions of post‐translational modifications

Evolution of higher mesenchymal CD44 expression in the human lineage

Data-independent acquisition-based proteome and phosphoproteome profiling across six melanoma cell lines reveals determinants of proteotypes

Developing a Bimolecular Affinity Purification Strategy to Isolate 26S Proteasome Holocomplexes for Complex-Centric Proteomic Analysis

BoxCarmax: A High-Selectivity Data-Independent Acquisition Mass Spectrometry Method for the Analysis of Protein Turnover and Complex Samples

Cross-compartment signal propagation in the mitotic exit network

Data-independent Acquisition-based Proteome and Phosphoproteome Profiling across Six Melanoma Cell Lines Reveals Determinants of Proteotypes

BoxCarmax: a high-selectivity data-independent acquisition mass spectrometry method for the analysis of protein turnover and complex samples

Cross-compartment signal propagation in the Mitotic Exit Network

NAguideR: performing and prioritizing missing value imputations for consistent bottom-up proteomic analyses

Human vulnerability to cancer malignancy is enhanced by evolution of higher mesenchymal CD44 expression compared to other mammals

Multi-in-One: Multiple-Proteases, One-Hour-Shot Strategy for Fast and High-Coverage Phosphoproteomic Investigation

Selection of Features with Consistent Profiles Improves Relative Protein Quantification in Mass Spectrometry Experiments

Global impact of phosphorylation on protein endurance

motifeR: An Integrated Web Software for Identification and Visualization of Protein Posttranslational Modification Motifs

Assessing the Relationship Between Mass Window Width and Retention Time Scheduling on Protein Coverage for Data-Independent Acquisition

Combining Rapid Data Independent Acquisition and CRISPR Gene Deletion for Studying Potential Protein Functions: A Case of HMGN1

Similarities and Differences of Blood N-Glycoproteins in Five Solid Carcinomas at Localized Clinical Stage Analyzed by SWATH-MS

Systems pharmacology using mass spectrometry identifies critical response nodes in prostate cancer

Rapid Proteomic Screen of CRISPR Experiment Outcome by Data Independent Acquisition Mass Spectrometry: A Case Study for HMGN1

Genomic, Proteomic and Phenotypic Heterogeneity in HeLa Cells across Laboratories: Implications for Reproducibility of Research Results

A Class of Environmental and Endogenous Toxins Induces BRCA2 Haploinsufficiency and Genome Instability

Comparison of targeted proteomics approaches for detecting and quantifying proteins derived from human cancer tissues

Impact of Alternative Splicing on the Human Proteome

Shotgun and targeted plasma proteomics to predict prognosis of non-small cell lung cancer

Systematic proteome and proteostasis profiling in human Trisomy 21 fibroblast cells

Statistical control of peptide and protein error rates in large-scale targeted data-independent acquisition analyses

Protein kinase D at the Golgi controls NLRP3 inflammasome activation

Inference and quantification of peptidoforms in large sample cohorts by SWATH-MS

Multi-laboratory assessment of reproducibility, qualitative and quantitative performance of SWATH-mass spectrometry

Peer review (48 reviews for 15 publications/grants)