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Education and qualifications (1)

University of Helsinki: Helsinki, FI

2006 | Ph.D. (Faculty of Biosciences)
Education
Source: Self-asserted source
Terhi Kärpänen

Works (39)

A T cell receptor targeting a recurrent driver mutation in FLT3 mediates elimination of primary human acute myeloid leukemia in vivo

Nature Cancer
2023-10-02 | Journal article
DOI: 10.1038/s43018-023-00642-8
Contributors: Eirini Giannakopoulou; Madeleine Lehander; Stina Virding Culleton; Weiwen Yang; Yingqian Li; Terhi Karpanen; Tetsuichi Yoshizato; Even H. Rustad; Morten Milek Nielsen; Ravi Chand Bollineni et al.
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Crossref

Efficient activation of the lymphangiogenic growth factor VEGF-C requires the C-terminal domain of VEGF-C and the N-terminal domain of CCBE1

Scientific Reports
2017-12 | Journal article
DOI: 10.1038/s41598-017-04982-1
Part of ISSN: 2045-2322
Source: Self-asserted source
Terhi Kärpänen

The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy

Frontiers in Immunology
2017-12-11 | Journal article
DOI: 10.3389/fimmu.2017.01718
Part of ISSN: 1664-3224
Source: Self-asserted source
Terhi Kärpänen

An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation

Circulation Research
2017-04-14 | Journal article
DOI: 10.1161/circresaha.116.308813
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Source: Self-asserted source
Terhi Kärpänen

T-cell receptor gene therapy - ready to go viral?

Molecular Oncology
2015-12 | Journal article
DOI: 10.1016/j.molonc.2015.10.006
Part of ISSN: 1574-7891
Source: Self-asserted source
Terhi Kärpänen

CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation

Circulation
2014-05-13 | Journal article
DOI: 10.1161/circulationaha.113.002779
Part of ISSN: 0009-7322
Part of ISSN: 1524-4539
Source: Self-asserted source
Terhi Kärpänen

Ccbe1 regulates Vegfc-mediated induction of Vegfr3 signaling during embryonic lymphangiogenesis

Development
2014-03-15 | Journal article
DOI: 10.1242/dev.100495
Part of ISSN: 1477-9129
Part of ISSN: 0950-1991
Source: Self-asserted source
Terhi Kärpänen

The zebrafish common cardinal veins develop by a novel mechanism: lumen ensheathment

Development
2013-07-01 | Journal article
DOI: 10.1242/dev.091876
Part of ISSN: 1477-9129
Part of ISSN: 0950-1991
Source: Self-asserted source
Terhi Kärpänen

Zebrafish Provides a Novel Model for Lymphatic Vascular Research

The Zebrafish: Disease Models and Chemical Screens
2011 | Book chapter
DOI: 10.1016/b978-0-12-381320-6.00009-6
Part of ISSN: 0091-679X
Source: Self-asserted source
Terhi Kärpänen

CCBE1 Is Essential for Mammalian Lymphatic Vascular Development and Enhances the Lymphangiogenic Effect of Vascular Endothelial Growth Factor-C In Vivo

Circulation Research
2011-08-19 | Journal article
DOI: 10.1161/circresaha.111.250738
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Source: Self-asserted source
Terhi Kärpänen

Notch restricts lymphatic vessel sprouting induced by vascular endothelial growth factor

Blood
2011-07-28 | Journal article
DOI: 10.1182/blood-2010-11-317800
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Terhi Kärpänen

miR-31 Functions as a Negative Regulator of Lymphatic Vascular Lineage-Specific Differentiation <i>In Vitro</i> and Vascular Development <i>In Vivo</i>

Molecular and Cellular Biology
2010-07-15 | Journal article
DOI: 10.1128/mcb.00185-10
Part of ISSN: 0270-7306
Part of ISSN: 1098-5549
Source: Self-asserted source
Terhi Kärpänen

Targeting Lymphatic Vessel Activation and CCL21 Production by Vascular Endothelial Growth Factor Receptor-3 Inhibition Has Novel Immunomodulatory and Antiarteriosclerotic Effects in Cardiac Allografts

Circulation
2010-03-30 | Journal article
DOI: 10.1161/circulationaha.109.910703
Part of ISSN: 0009-7322
Part of ISSN: 1524-4539
Source: Self-asserted source
Terhi Kärpänen

Overexpression of Vascular Endothelial Growth Factor-B in Mouse Heart Alters Cardiac Lipid Metabolism and Induces Myocardial Hypertrophy

Circulation Research
2008-10-24 | Journal article
DOI: 10.1161/circresaha.108.178459
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Source: Self-asserted source
Terhi Kärpänen

VEGF-D: a modifier of embryonic lymphangiogenesis

Blood
2008-09-01 | Journal article
DOI: 10.1182/blood-2008-06-159343
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Terhi Kärpänen

Molecular Biology and Pathology of Lymphangiogenesis

Annual Review of Pathology: Mechanisms of Disease
2008-02-01 | Journal article
DOI: 10.1146/annurev.pathmechdis.3.121806.151515
Part of ISSN: 1553-4006
Part of ISSN: 1553-4014
Source: Self-asserted source
Terhi Kärpänen

Enhanced Capillary Formation Stimulated by a Chimeric Vascular Endothelial Growth Factor/Vascular Endothelial Growth Factor-C Silk Domain Fusion Protein

Circulation Research
2007-05-25 | Journal article
DOI: 10.1161/01.res.0000269042.58594.f6
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Source: Self-asserted source
Terhi Kärpänen

Lymphangiogenic Growth Factor Responsiveness Is Modulated by Postnatal Lymphatic Vessel Maturation

The American Journal of Pathology
2006-08 | Journal article
DOI: 10.2353/ajpath.2006.051200
Part of ISSN: 0002-9440
Source: Self-asserted source
Terhi Kärpänen

Functional interaction of VEGF‐C and VEGF‐D with neuropilin receptors

The FASEB Journal
2006-07 | Journal article
DOI: 10.1096/fj.05-5646com
Part of ISSN: 0892-6638
Part of ISSN: 1530-6860
Source: Self-asserted source
Terhi Kärpänen

Vascular Endothelial Growth Factor (VEGF)/VEGF-C Mosaic Molecules Reveal Specificity Determinants and Feature Novel Receptor Binding Patterns

Journal of Biological Chemistry
2006-04 | Journal article
DOI: 10.1074/jbc.m511593200
Part of ISSN: 0021-9258
Source: Self-asserted source
Terhi Kärpänen

Regulation of lymphangiogenesis—From cell fate determination to vessel remodeling

Experimental Cell Research
2006-03-10 | Journal article
DOI: 10.1016/j.yexcr.2005.10.034
Part of ISSN: 0014-4827
Source: Self-asserted source
Terhi Kärpänen

Periadventitial angiopoietin-1 gene transfer induces angiogenesis in rabbit carotid arteries

Gene Therapy
2005-03-01 | Journal article
DOI: 10.1038/sj.gt.3302426
Part of ISSN: 0969-7128
Part of ISSN: 1476-5462
Source: Self-asserted source
Terhi Kärpänen

PDGF-D induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis

Blood
2004-11-15 | Journal article
DOI: 10.1182/blood-2004-04-1485
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Terhi Kärpänen

Defective valves and abnormal mural cell recruitment underlie lymphatic vascular failure in lymphedema distichiasis

Nature Medicine
2004-09 | Journal article
DOI: 10.1038/nm1094
Part of ISSN: 1078-8956
Part of ISSN: 1546-170X
Source: Self-asserted source
Terhi Kärpänen

Antitumor activity of a homing peptide that targets tumor lymphatics and tumor cells

Proceedings of the National Academy of Sciences
2004-06-22 | Journal article
DOI: 10.1073/pnas.0403317101
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Terhi Kärpänen

Role of lymphangiogenic factors in tumor metastasis

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer
2004-03 | Journal article
DOI: 10.1016/j.bbcan.2003.07.003
Part of ISSN: 0304-419X
Source: Self-asserted source
Terhi Kärpänen

Suppression of Tumor Lymphangiogenesis and Lymph Node Metastasis by Blocking Vascular Endothelial Growth Factor Receptor 3 Signaling

JNCI Journal of the National Cancer Institute
2002-06-05 | Journal article
DOI: 10.1093/jnci/94.11.819
Part of ISSN: 0027-8874
Part of ISSN: 1460-2105
Source: Self-asserted source
Terhi Kärpänen

Vascular Endothelial Growth Factor Ligands and Receptors That Regulate Human Cytotrophoblast Survival Are Dysregulated in Severe Preeclampsia and Hemolysis, Elevated Liver Enzymes, and Low Platelets Syndrome

The American Journal of Pathology
2002-04 | Journal article
DOI: 10.1016/s0002-9440(10)62567-9
Part of ISSN: 0002-9440
Source: Self-asserted source
Terhi Kärpänen

VEGF-C induced lymphangiogenesis is associated with lymph node metastasis in orthotopic MCF-7 tumors

International Journal of Cancer
2002-04-20 | Journal article
DOI: 10.1002/ijc.10283
Part of ISSN: 0020-7136
Source: Self-asserted source
Terhi Kärpänen

The Drosophila VEGF receptor homolog is expressed in hemocytes

Mechanisms of Development
2001-11 | Journal article
DOI: 10.1016/s0925-4773(01)00510-x
Part of ISSN: 0925-4773
Source: Self-asserted source
Terhi Kärpänen

Lymphatic Vessels as Targets of Tumor Therapy?

Journal of Experimental Medicine
2001-09-17 | Journal article
DOI: 10.1084/jem.194.6.f37
Part of ISSN: 0022-1007
Part of ISSN: 1540-9538
Source: Self-asserted source
Terhi Kärpänen

Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3

The EMBO Journal
2001-09-03 | Journal article
DOI: 10.1093/emboj/20.17.4762
Part of ISSN: 1460-2075
Source: Self-asserted source
Terhi Kärpänen

Adenoviral Expression of Vascular Endothelial Growth Factor-C Induces Lymphangiogenesis in the Skin

Circulation Research
2001-03-30 | Journal article
DOI: 10.1161/01.res.88.6.623
Part of ISSN: 0009-7330
Part of ISSN: 1524-4571
Source: Self-asserted source
Terhi Kärpänen

Signalling via vascular endothelial growth factor receptor-3 is sufficient for lymphangiogenesis in transgenic mice

The EMBO Journal
2001-03-15 | Journal article
DOI: 10.1093/emboj/20.6.1223
Part of ISSN: 0261-4189
Part of ISSN: 1460-2075
Source: Self-asserted source
Terhi Kärpänen

Vascular endothelial growth factor C promotes tumor lymphangiogenesis and intralymphatic tumor growth.

Cancer research
2001-03-01 | Journal article
PMID: 11280723
Source: Self-asserted source
Terhi Kärpänen

Inhibition of lymphangiogenesis with resulting lymphedema in transgenic mice expressing soluble VEGF receptor-3

Nature Medicine
2001-02 | Journal article
DOI: 10.1038/84651
Part of ISSN: 1078-8956
Part of ISSN: 1546-170X
Source: Self-asserted source
Terhi Kärpänen

Mechanisms of angiogenesis and their use in the inhibition of tumor growth and metastasis

Oncogene
2000-12-11 | Journal article
DOI: 10.1038/sj.onc.1203969
Part of ISSN: 0950-9232
Part of ISSN: 1476-5594
Source: Self-asserted source
Terhi Kärpänen

Biosynthesis of Vascular Endothelial Growth Factor-D Involves Proteolytic Processing Which Generates Non-covalent Homodimers

Journal of Biological Chemistry
1999-11 | Journal article
DOI: 10.1074/jbc.274.45.32127
Part of ISSN: 0021-9258
Source: Self-asserted source
Terhi Kärpänen

Differential Binding of Vascular Endothelial Growth Factor B Splice and Proteolytic Isoforms to Neuropilin-1

Journal of Biological Chemistry
1999-07 | Journal article
DOI: 10.1074/jbc.274.30.21217
Part of ISSN: 0021-9258
Source: Self-asserted source
Terhi Kärpänen
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