Personal information

Websites & social links

https://www.umr-beep.fr/en
https://annuaire.ifremer.fr/cv/16838/

Keywords

DNA polymerase, Ribonuclease H, DNA replication and reparation, Archaea

Activities

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Employment (1)

Ifremer Centre de Bretagne: Plouzane, Brest, FR

Researcher in Biochemistry (PhD) (EP/LMEE)
Employment
Source: Self-asserted source
Ghislaine Henneke

Funding (2)

An integrative biology approach to study DNA primase: the swiss-knife of Archaea – ARCHAPRIM

2021-01-20 to 2024-01-19 | Grant
Agence Nationale de la Recherche (Paris, FR)
URL: https://app.dimensions.ai/details/grant/grant.9664924
GRANT_NUMBER: ANR-20-CE11-0003
Source: Self-asserted source
Ghislaine Henneke via DimensionsWizard

DNA polymerases and damaged nucleic acids in archaea: Genome maintenance and Biotechnology – ARCHPOL

Grant
Agence Nationale de la Recherche (Paris, FR)
URL: https://app.dimensions.ai/details/grant/grant.4523388
GRANT_NUMBER: ANR-10-JCJC-1501
Source: Self-asserted source
Ghislaine Henneke via DimensionsWizard

Works (33)

Processing of matched and mismatched rNMPs in DNA by archaeal ribonucleotide excision repair

iScience
2023-12 | Journal article
DOI: 10.1016/j.isci.2023.108479
Contributors: Maurane Reveil; Lucie Chapel; Blandine Vourc’h; Audrey Bossé; Léa Vialle; Raphaël Brizard; Yann Moalic; Mohamed Jebbar; Ghislaine Henneke
Source: check_circle
Crossref

Structural basis for the increased processivity of D-family DNA polymerases in complex with PCNA.

Nature communications
2020-03 | Journal article
DOI: 10.1038/s41467-020-15392-9
PMID: 32221299
PMC: PMC7101311
Contributors: Madru C; Henneke G; Raia P; Hugonneau-Beaufet I; Pehau-Arnaudet G; England P; Lindahl E; Delarue M; Carroni M; Sauguet L
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Unlike the Escherichia coli counterpart, archaeal RNase HII cannot process ribose monophosphate abasic sites and oxidized ribonucleotides embedded in DNA

Journal of Biological Chemistry
2019-08 | Journal article
DOI: 10.1074/jbc.RA119.009493
Contributors: Matilde Clarissa Malfatti; Ghislaine Henneke; Sathya Balachander; Kyung Duk Koh; Gary Newnam; Ryo Uehara; Robert J. Crouch; Francesca Storici; Gianluca Tell
Source: check_circle
Crossref

The interplay at the replisome mitigates the impact of oxidative damage on the genetic integrity of hyperthermophilic Archaea

eLife
2019-06-11 | Journal article
DOI: 10.7554/eLife.45320
Contributors: Tom Killelea; Adeline Palud; Farida Akcha; Mélanie Lemor; Stephane L'haridon; Anne Godfroy; Ghislaine Henneke
Source: check_circle
Crossref

Structure of the DP1-DP2 PolD complex bound with DNA and its implications for the evolutionary history of DNA and RNA polymerases.

PLoS biology
2019-01 | Journal article
DOI: 10.1371/journal.pbio.3000122
PMID: 30657780
PMC: PMC6355029
Contributors: Raia P; Carroni M; Henry E; Pehau-Arnaudet G; Brûlé S; Béguin P; Henneke G; Lindahl E; Delarue M; Sauguet L
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Differential Activities of DNA Polymerases in Processing Ribonucleotides during DNA Synthesis in Archaea.

Journal of molecular biology
2018-10 | Journal article
DOI: 10.1016/j.jmb.2018.10.004
PMID: 30342933
Contributors: Lemor M; Kong Z; Henry E; Brizard R; Laurent S; Bossé A; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Development of an Effective 6-Methylpurine Counterselection Marker for Genetic Manipulation in Thermococcus barophilus.

Genes
2018-02 | Journal article
DOI: 10.3390/genes9020077
PMID: 29414865
PMC: PMC5852573
Contributors: Birien T; Thiel A; Henneke G; Flament D; Moalic Y; Jebbar M
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Calcium-driven DNA synthesis by a high-fidelity DNA polymerase.

Nucleic acids research
2017-12 | Journal article
DOI: 10.1093/nar/gkx927
PMID: 29040737
PMC: PMC5716173
Contributors: Ralec C; Henry E; Lemor M; Killelea T; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Structure of an octameric form of the minichromosome maintenance protein from the archaeon Pyrococcus abyssi.

Scientific reports
2017-02 | Journal article
DOI: 10.1038/srep42019
PMID: 28176822
PMC: PMC5296750
Contributors: Cannone G; Visentin S; Palud A; Henneke G; Spagnolo L
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Shared active site architecture between archaeal PolD and multi-subunit RNA polymerases revealed by X-ray crystallography.

Nature communications
2016-08 | Journal article
DOI: 10.1038/ncomms12227
PMID: 27548043
PMC: PMC4996933
Contributors: Sauguet L; Raia P; Henneke G; Delarue M
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Replication slippage of the thermophilic DNA polymerases B and D from the Euryarchaeota Pyrococcus abyssi.

Frontiers in microbiology
2014-08 | Journal article
DOI: 10.3389/fmicb.2014.00403
PMID: 25177316
PMC: PMC4134008
Contributors: Castillo-Lizardo M; Henneke G; Viguera E
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Anomalous electrophoretic migration of short oligodeoxynucleotides labelled with 5'-terminal Cy5 dyes.

Electrophoresis
2014-06 | Journal article
DOI: 10.1002/elps.201400018
PMID: 24659099
Contributors: Killelea T; Saint-Pierre C; Ralec C; Gasparutto D; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

PCR performance of a thermostable heterodimeric archaeal DNA polymerase.

Frontiers in microbiology
2014-05 | Journal article
DOI: 10.3389/fmicb.2014.00195
PMID: 24847315
PMC: PMC4019886
Contributors: Killelea T; Ralec C; Bossé A; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

An extended network of genomic maintenance in the archaeon Pyrococcus abyssi highlights unexpected associations between eucaryotic homologs.

PloS one
2013-11 | Journal article
DOI: 10.1371/journal.pone.0079707
PMID: 24244547
PMC: PMC3820547
Contributors: Pluchon PF; Fouqueau T; Crezé C; Laurent S; Briffotaux J; Hogrel G; Palud A; Henneke G; Godfroy A; Hausner W et al.
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Novel inhibition of archaeal family-D DNA polymerase by uracil.

Nucleic acids research
2013-02 | Journal article
DOI: 10.1093/nar/gkt083
PMID: 23408858
PMC: PMC3627576
Contributors: Richardson TT; Gilroy L; Ishino Y; Connolly BA; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

In vitro reconstitution of RNA primer removal in Archaea reveals the existence of two pathways.

The Biochemical journal
2012-10 | Journal article
DOI: 10.1042/bj20120959
PMID: 22849643
Contributors: Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Molecular recognition of canonical and deaminated bases by P. abyssi family B DNA polymerase.

Journal of molecular biology
2012-08 | Journal article
DOI: 10.1016/j.jmb.2012.07.025
PMID: 22902479
Contributors: Gouge J; Ralec C; Henneke G; Delarue M
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Structure-specific nuclease activities of Pyrococcus abyssi RNase HII.

Journal of bacteriology
2010-05 | Journal article
DOI: 10.1128/jb.00268-10
PMID: 20472790
PMC: PMC2897336
Contributors: Le Laz S; Le Goaziou A; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

The glycine-rich motif of Pyrococcus abyssi DNA polymerase D is critical for protein stability.

Journal of molecular biology
2010-01 | Journal article
DOI: 10.1016/j.jmb.2010.01.006
PMID: 20070946
Contributors: Castrec B; Laurent S; Henneke G; Flament D; Raffin JP
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Binding to PCNA in Euryarchaeal DNA Replication requires two PIP motifs for DNA polymerase D and one PIP motif for DNA polymerase B.

Journal of molecular biology
2009-09 | Journal article
DOI: 10.1016/j.jmb.2009.09.044
PMID: 19781553
Contributors: Castrec B; Rouillon C; Henneke G; Flament D; Querellou J; Raffin JP
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Intrinsic properties of the two replicative DNA polymerases of Pyrococcus abyssi in replicating abasic sites: possible role in DNA damage tolerance?

Molecular microbiology
2008-09 | Journal article
DOI: 10.1111/j.1365-2958.2008.06446.x
PMID: 18826407
Contributors: Palud A; Villani G; L'Haridon S; Querellou J; Raffin JP; Henneke G
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

The heterodimeric primase from the euryarchaeon Pyrococcus abyssi: a multifunctional enzyme for initiation and repair?

Journal of molecular biology
2007-10 | Journal article
DOI: 10.1016/j.jmb.2007.10.015
PMID: 17991487
Contributors: Le Breton M; Henneke G; Norais C; Flament D; Myllykallio H; Querellou J; Raffin JP
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

DNA polymerase switching on homotrimeric PCNA at the replication fork of the euryarchaea Pyrococcus abyssi.

Journal of molecular biology
2007-03 | Journal article
DOI: 10.1016/j.jmb.2007.03.054
PMID: 17442344
Contributors: Rouillon C; Henneke G; Flament D; Querellou J; Raffin JP
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Thermophilic lifestyle for an uncultured archaeon from hydrothermal vents: evidence from environmental genomics.

Applied and environmental microbiology
2006-03 | Journal article
DOI: 10.1128/aem.72.3.2268-2271.2006
PMID: 16517686
PMC: PMC1393191
Contributors: Moussard H; Henneke G; Moreira D; Jouffe V; López-García P; Jeanthon C
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

The hyperthermophilic euryarchaeota Pyrococcus abyssi likely requires the two DNA polymerases D and B for DNA replication.

Journal of molecular biology
2005-07 | Journal article
DOI: 10.1016/j.jmb.2005.04.042
PMID: 15922358
Contributors: Henneke G; Flament D; Hübscher U; Querellou J; Raffin JP
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Flap endonuclease 1: a novel tumour suppresser protein.

Trends in biochemical sciences
2003-07 | Journal article
DOI: 10.1016/s0968-0004(03)00138-5
PMID: 12878006
Contributors: Henneke G; Friedrich-Heineken E; Hübscher U
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Phosphorylation of human Fen1 by cyclin-dependent kinase modulates its role in replication fork regulation.

Oncogene
2003-07 | Journal article
DOI: 10.1038/sj.onc.1206606
PMID: 12853968
Contributors: Henneke G; Koundrioukoff S; Hübscher U
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

The acetylatable lysines of human Fen1 are important for endo- and exonuclease activities.

Journal of molecular biology
2003-04 | Journal article
DOI: 10.1016/s0022-2836(03)00270-5
PMID: 12683998
Contributors: Friedrich-Heineken E; Henneke G; Ferrari E; Hübscher U
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Multiple roles for kinases in DNA replication.

EMBO reports
2003-03 | Journal article
DOI: 10.1038/sj.embor.embor774
PMID: 12634841
PMC: PMC1315902
Contributors: Henneke G; Koundrioukoff S; Hübscher U
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Replication factor C from the hyperthermophilic archaeon Pyrococcus abyssi does not need ATP hydrolysis for clamp-loading and contains a functionally conserved RFC PCNA-binding domain.

Journal of molecular biology
2002-11 | Journal article
DOI: 10.1016/s0022-2836(02)01028-8
PMID: 12417194
Contributors: Henneke G; Gueguen Y; Flament D; Azam P; Querellou J; Dietrich J; Hübscher U; Raffin JP
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

The flexible loop of human FEN1 endonuclease is required for flap cleavage during DNA replication and repair.

The EMBO journal
2002-11 | Journal article
DOI: 10.1093/emboj/cdf587
PMID: 12411510
PMC: PMC131084
Contributors: Storici F; Henneke G; Ferrari E; Gordenin DA; Hübscher U; Resnick MA
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

Purification and characterization of a new DNA polymerase modulator from the hyperthermophilic archaeon Thermococcus fumicolans.

Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology
2000-11 | Journal article
DOI: 10.1016/s0305-0491(00)00263-7
PMID: 11126760
Contributors: Raffin JP; Henneke G; Dietrich J
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central

The PCNA from Thermococcus fumicolans functionally interacts with DNA polymerase delta.

Biochemical and biophysical research communications
2000-09 | Journal article
DOI: 10.1006/bbrc.2000.3481
PMID: 11027519
Contributors: Henneke G; Raffin JP; Ferrari E; Jónsson ZO; Dietrich J; Hübscher U
Source: Self-asserted source
Ghislaine Henneke via Europe PubMed Central
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