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Neuroinflammation, Signaling and Neuroregeneration Group at iMed.ULisboM

Other IDs

ResearcherID: M-8293-2013
Scopus Author ID: 7004026610
Ciência ID: 921C-9B98-2867
SciProfiles: 97109
Loop profile: 6970

Keywords

Extracellular vesicles, Ahlzeimer's disease, Microglia subtypes, Bilirubin neurotoxicity, Ageing-related neurodegeneration, Astrocytes and heterogeneity, Inflammatory-associated miRNAs, Intrahepatic Cholestasis, Neuron-glia communication, Amyotrophic lateral sclerosis

Activities

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Employment (1)

Universidade de Lisboa Faculdade de Farmacia: Lisboa, PT

2005 to present | Senior Researcher and Invited Full Professor (Department of Biochemistry and Human Biology)
Employment
Source: Self-asserted source
D Brites

Education and qualifications (3)

Universidade de Lisboa Faculdade de Farmacia: Lisboa, PT

2004 | Habilitation in Biological Sciences (Department of Human Biology)
Education
Source: Self-asserted source
D Brites

Universidade de Lisboa Faculdade de Farmacia: Lisboa, PT

1988 | PhD (Department of Biochemistry)
Education
Source: Self-asserted source
D Brites

Universidade de Lisboa Faculdade de Farmacia: Lisboa, PT

1972-09-01 to 1977-07-31 | PharmD (Department of Biochemistry)
Education
Source: Self-asserted source
D Brites

Funding (29)

How the brains immune cells develop: the role of Deleted in Autism-1 Related (DIA1R) in microglia ontogeny

2023-01-01 to 2024-06-30 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2022.02611.PTDC

GRANT_NUMBER: 10.54499/2022.02611.PTDC
Source: check_circle
CIÊNCIAVITAE

Targeting TDP-43 with protein kinase inhibitors: an effective and measurable therapy for ALS

2021-10 to 2023-09 | Grant
“la Caixa” Foundation (Madrid, ES)
URL: https://fundacionlacaixa.org/en/caixaresearch-health-call-2021-project-als-therapies
GRANT_NUMBER:

HR21-00931
Source: Self-asserted source
D Brites
grade
Preferred source (of 2)‎

Dissecting the role of exosome-miRNAs in Alzheimer's disease pathology using advanced human neuron-microglia models

2021-01-01 to present | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

9877
Source: check_circle
CIÊNCIAVITAE

Analyzing neuroimmune dysregulation in Alzheimer´s disease toward a therapy with miRNA-loaded exosomes

2021-01 to 2024-12 | Grant
Fundação para a Ciência e a Tecnologia (Lisbon, Portugal, PT)
GRANT_NUMBER:

PTDC/MED-NEU/2382/2021
Source: Self-asserted source
D Brites
grade
Preferred source (of 2)‎

Dementia associated with HIV infection - study of the mechanisms infectious and inflammatory mediated by extracellular vesicles

2019 to present | Grant
Gilead Sciences Lda (Lisboa, PT)
GRANT_NUMBER:

PGG/035/2019

Source: check_circle
CIÊNCIAVITAE

Engineering hybrid exosomes as microRNAs nanocarriers to microglia in Amyotrophic Lateral Sclerosis

2019 to present | Grant
N/A (N/A, PT)
GRANT_NUMBER:

UID/DTP/04138/2019
Source: check_circle
CIÊNCIAVITAE

NPSTEENSBRAIN. New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain Exposure

2018-10 to 2021-09 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-TOX/32515/2017
Source: check_circle
CIÊNCIAVITAE

Inibição da Tiorredoxina para Reduzir o Glioblastoma: Etilmercúrio e Timerosal na Terapia do Cancro

2018-09-10 to 2022-12-09 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/MED-FAR/31136/2017
Source: check_circle
CIÊNCIAVITAE

New Psychoactive Substances - A Platform for Risk Assessment of Teens Brain

2018-09 to 2021-08 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER: 32515/02/SAICT/2017
Source: check_circle
CIÊNCIAVITAE

Development of an autologous exosome-based therapy by engineering microRNAs in microglia and motor-neurons using mice and human models of amyotrophic lateral sclerosis (ALS)

2018-08 to present | Grant
Fundação para a Ciência e Tecnologia (Lisbon, PT)
GRANT_NUMBER:

PTDC/MED-NEU/31395/2017
Source: check_circle
CIÊNCIAVITAE

Thioredoxin Arrest to Reduce Glioblastoma: Ethylmercury and Thimerosal to target Cancer

2018-07 to 2021-06 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER: 31136/02/SAICT/2017
Source: check_circle
CIÊNCIAVITAE

Role of ectosomes in the spread of HIV infection into the CNS and in HIV-associated dementia pathogenesis

2017 to present | Grant
Gilead Sciences Lda (Lisboa, PT)
GRANT_NUMBER: PGG/035/2019
Source: check_circle
CIÊNCIAVITAE

Exploring the impact of astrocyte-derived microvesicles for motor neuron degeneration and as vehicles to delivery neuroroprotective cargoes in Amyotrophic Lateral Sclerosis (ALS)

2016-01 to 2020-01 | Grant
Santa Casa da Misericórdia de Lisboa (Lisboa, Lisboa, PT)
GRANT_NUMBER:

Programa de Investigação Científica em Esclerose Lateral Amiotrófica
Source: Self-asserted source
D Brites
grade
Preferred source (of 2)‎

Generation of Improved Cellular and Animal Models for Identification of Disease Phenotype and New Therapeutic Targets of Alzheimer’s Disease

2016-01 to 2018-12 | Grant
JPco-fuND (European Union, FCT, PT)
GRANT_NUMBER:

JPCOFUND/0003/2015
Source: Self-asserted source
D Brites

Role of ectosomes in the spread of HIV infection into the CNS and in HIV-associated dementia pathogenesis

2016 to 2019 | Grant
Gilead Sciences Lda (Lisboa, PT)
GRANT_NUMBER:

PGG/018/2016
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Projecto Estratégico - UI 4013 - 2011-2012

2011-01-01 to 2013-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PEst-OE/SAU/UI4013/2011

GRANT_NUMBER:

PEst-OE/EQB/LA0004/2011
Source: check_circle
CIÊNCIAVITAE

- Are microglia a new potential pharmacological target in amyotrophic lateral sclerosis (ALS)?

2010 to 2014 | Contract
Ministério da Educação e Ciência (Fundação para a Ciência e a tecnologia, PT)
GRANT_NUMBER:

PTDC/SAU-FAR/118787/2010

Source: Self-asserted source
D Brites

Are microglia a new potential pharmacological target in amyotrophic lateral sclerosis (ALS)?

2010 to 2014 | Grant
Ministério da Ciência Tecnologia e Ensino Superior (Lisboa, PT)
GRANT_NUMBER: PTDC/SAU-FAR/118787/2010
Source: check_circle
CIÊNCIAVITAE

Importância do perfil dos ácidos biliares séricos na avaliação da disfunção hepática

2008 to 2010 | Grant
Governo da República Portuguesa Ministério da Saúde (Lisboa, PT)
GRANT_NUMBER:

Ref. ACS/PAF/49/158
Source: check_circle
CIÊNCIAVITAE

Acções troficas dos factores neurotróficos: dependência da co-activação de receptores A2A da adenosina

2007-07-01 to 2010-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-NEU/64126/2006
Source: check_circle
CIÊNCIAVITAE

Trophic actions of neurotrophic factors: dependency of adenosine A2A receptors co-activation

2007-07 to 2010 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER: info:eu-repo/grantAgreement/FCT/3599-PPCDT/64126/PT
Source: check_circle
CIÊNCIAVITAE

Uncovering the potential neurodevelopmental deficits in common neonatal conditions such as hyperbilirubinemia and inflammation

2007 to 2010 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/SAU-NEU/64385/2006
Source: check_circle
CIÊNCIAVITAE

Acute and long-term injury of bilirubin to nerve cells - Looking for sensors, susceptibilities and modulators

2005-01 to 2008 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER: info:eu-repo/grantAgreement/FCT/3599-PPCDT/82303/PT
Source: check_circle
CIÊNCIAVITAE

Inflammatory response and signaling between neurons and astrocytes during cell injury by sepsis, hypoxia-ischemia and hyperbilirubinemia

2002 to 2005 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

POCTI/FCB/39906/2001

Source: check_circle
CIÊNCIAVITAE

Inflammatory response and signaling between neurons and astrocytes during cell injury by sepsis, hypoxia-ischemia and hyperbilirubinemia

2002 to 2005 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER: POCTI/FCB/39906/2001
Source: check_circle
CIÊNCIAVITAE

Mechanisms of cell injury by glycochenodeoxycholic acid, bilirubin and amyloid beta-peptide

1999 to 2001 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PRAXIS/PSAU/C/14311/1998
Source: check_circle
CIÊNCIAVITAE

Role of bilirubin species in the molecular mechanisms of cell membrane damage

1997 to 2000 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PRAXIS/PSAU/C/SAU/127/96

Source: check_circle
CIÊNCIAVITAE

Role of bilirubin species in the molecular mechanisms of cell membrane damage

1997 to 2000 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER: PRAXIS/PSAU/C/SAU/127/96
Source: check_circle
CIÊNCIAVITAE

Decoding the regulation of microglia phenotype by microRNAs in Alzheimer's Disease

Contract
Ministério da Educação e Ciência (Fundação para a Ciência e a Tecnologia, PT)
GRANT_NUMBER:

EXPL/NEU-NMC/1003/2013

Source: Self-asserted source
D Brites

Peer review (4 reviews for 4 publications/grants)

Review activity for Cells. (1)
Review activity for Journal of molecular neuroscience (1)
Review activity for Molecular neurobiology. (1)
Review activity for Nature communications (1)
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