Personal information

Chemical biology, Fatty acid biosynthesis, Nucleoside biosynthesis, DNA demethylation, Crystal structure
China

Activities

Employment (1)

Shanghai Jiao Tong University School of Medicine: Shanghai, CN

2020-07-01 to present | Postdoc fellow (Pharmacology and Chemical Biology )
Employment
Source: Self-asserted source
Lin Zhang

Education and qualifications (2)

Shanghai Jiao Tong University School of Medicine: Shanghai, CN

2015-09-01 to 2020-06-30 | Ph.D. (Pharmacology and Chemical Biology)
Education
Source: Self-asserted source
Lin Zhang

Southern Medical University: Guangzhou, Guangdong, CN

2010-09-01 to 2014-06-30 | Bachelor (School of Chinese Medicine)
Education
Source: Self-asserted source
Lin Zhang

Funding (2)

Substrate recognition and catalytic mechanism studies of fungus DNA demethylase CcTET

2022-01 to 2024-12 | Grant
National Natural Science Foundation of China (Beijing, CN)
GRANT_NUMBER:

22107067

Source: Self-asserted source
Lin Zhang

The catalytic and regulation mechanism studies of fatty acid dehydrogenase FabX in the fatty acid biosynthesis pathway

2020-11 to 2022-06 | Grant
China Postdoctoral Science Foundation (Beijing, CN)
GRANT_NUMBER:

2020M681342

Source: Self-asserted source
Lin Zhang

Works (13)

The Molecular Basis of Human ALKBH3 Mediated RNA N1‐methyladenosine (m1A) Demethylation

Angewandte Chemie International Edition
2024-02-12 | Journal article
Contributors: Lin Zhang; Hong‐Chao Duan; Marcin Paduch; Jingyan Hu; Chi Zhang; Yajuan Mu; Houwen Lin; Chuan He; Anthony A. Kossiakoff; Guifang Jia et al.
Source: check_circle
Crossref

The Molecular Basis of Human ALKBH3 Mediated RNA N1‐methyladenosine (m1A) Demethylation

Angewandte Chemie
2024-02-12 | Journal article
Contributors: Lin Zhang; Hong‐Chao Duan; Marcin Paduch; Jingyan Hu; Chi Zhang; Yajuan Mu; Houwen Lin; Chuan He; Anthony A. Kossiakoff; Guifang Jia et al.
Source: check_circle
Crossref

The Molecular Basis of Catalysis by SDR Family Members Ketoacyl‐ACP Reductase FabG and Enoyl‐ACP Reductase FabI in Type‐II Fatty Acid Biosynthesis

Angewandte Chemie International Edition
2023-11-13 | Journal article
Contributors: Jiashen Zhou; Lin Zhang; Yiran Wang; Wenyan Song; Yuzhou Huang; Yajuan Mu; Werner Schmitz; Shu‐Yu Zhang; Houwen Lin; Hong‐Zhuan Chen et al.
Source: check_circle
Crossref

The Molecular Basis of Catalysis by SDR Family Members Ketoacyl‐ACP Reductase FabG and Enoyl‐ACP Reductase FabI in Type‐II Fatty Acid Biosynthesis

Angewandte Chemie
2023-11-13 | Journal article
Contributors: Jiashen Zhou; Lin Zhang; Yiran Wang; Wenyan Song; Yuzhou Huang; Yajuan Mu; Werner Schmitz; Shu‐Yu Zhang; Houwen Lin; Hong‐Zhuan Chen et al.
Source: check_circle
Crossref

A fungal dioxygenase CcTet serves as a eukaryotic 6mA demethylase on duplex DNA

Nature Chemical Biology
2022-07 | Journal article
Contributors: Yajuan Mu; Lin Zhang; Jingyan Hu; Jiashen Zhou; Hou-Wen Lin; Chuan He; Hong-Zhuan Chen; Liang Zhang
Source: check_circle
Crossref

Structural basis for the substrate recognition mechanism of ATP-sulfurylase domain of human PAPS synthase 2

Biochemical and Biophysical Research Communications
2022-01 | Journal article
Contributors: Pan Zhang; Lin Zhang; Zhaoyuan Hou; Houwen Lin; Hai Gao; Liang Zhang
Source: check_circle
Crossref

Helicobacter pylori FabX contains a [4Fe-4S] cluster essential for unsaturated fatty acid synthesis

Nature Communications
2021-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Lin Zhang

Structural basis for diguanylate cyclase activation by its binding partner in Pseudomonas aeruginosa

eLife
2021-09-09 | Journal article
Part of ISSN: 2050-084X
Source: Self-asserted source
Lin Zhang

Advances on Mechanism and Drug Discovery of Type-II Fatty Acid Biosynthesis Pathway

Acta Chimica Sinica
2020 | Journal article
Part of ISSN: 0567-7351
Source: Self-asserted source
Lin Zhang

Thymine DNA glycosylase recognizes the geometry alteration of minor grooves induced by 5-formylcytosine and 5-carboxylcytosine

Chemical Science
2019 | Journal article
Contributors: Tianran Fu; Liping Liu; Qing-Lin Yang; Yuxin Wang; Pan Xu; Lin Zhang; Shien Liu; Qing Dai; Quanjiang Ji; Guo-Liang Xu et al.
Source: check_circle
Crossref

A back-door Phenylalanine coordinates the stepwise hexameric loading of acyl carrier protein by the fatty acid biosynthesis enzyme β-hydroxyacyl-acyl carrier protein dehydratase (FabZ)

International Journal of Biological Macromolecules
2019-05 | Journal article
Part of ISSN: 0141-8130
Source: Self-asserted source
Lin Zhang

Enhanced PAPSS2/VCAN sulfation axis is essential for Snail-mediated breast cancer cell migration and metastasis

Cell Death & Differentiation
2019-03 | Journal article
Part of ISSN: 1350-9047
Part of ISSN: 1476-5403
Source: Self-asserted source
Lin Zhang

Crystal structure of FabZ-ACP complex reveals a dynamic seesaw-like catalytic mechanism of dehydratase in fatty acid biosynthesis

Cell Research
2016-12 | Journal article
Part of ISSN: 1001-0602
Part of ISSN: 1748-7838
Source: Self-asserted source
Lin Zhang

Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)