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Comparative analysis of cell morphology in patient-paired primary human osteoblasts from the jaw and the fibula

Journal of Cranio-Maxillofacial Surgery
2025-03 | Journal article
DOI: 10.1016/j.jcms.2024.11.021
Contributors: M. Selig; R. Rothweiler; C. Gross; C. Rendenbach; S. Preissner; M. Heiland; T. Fretwurst; B. Rolauffs; K. Nelson; S. Nahles et al.
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Performance of Plug-In Augmented ChatGPT and Its Ability to Quantify Uncertainty: Simulation Study on the German Medical Board Examination

JMIR Medical Education
2025-03-21 | Journal article
DOI: 10.2196/58375
Contributors: Julian Madrid; Philipp Diehl; Mischa Selig; Bernd Rolauffs; Felix Patricius Hans; Hans-Jörg Busch; Tobias Scheef; Leo Benning
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A xenogenic-free culture medium for cell micro-patterning systems as cell-instructive biomaterials for potential clinical applications

Biomedical Materials
2025-03-01 | Journal article
DOI: 10.1088/1748-605X/ada335
Contributors: Hui Che; Melanie L Hart; Jasmin C Lauer; Mischa Selig; Marita Voelker; Bodo Kurz; Bernd Rolauffs
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Multiphasic bone-ligament-bone integrated scaffold enhances ligamentization and graft-bone integration after anterior cruciate ligament reconstruction

Bioactive Materials
2024-01 | Journal article
DOI: 10.1016/j.bioactmat.2023.08.004
Contributors: Xianrui Xie; Jiangyu Cai; Dan Li; Yujie Chen; Chunhua Wang; Guige Hou; Thorsten Steinberg; Bernd Rolauffs; Mohamed EL-Newehy; Hany EL-Hamshary et al.
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Articular Cartilage—From Basic Science Structural Imaging to Non-Invasive Clinical Quantitative Molecular Functional Information for AI Classification and Prediction

International Journal of Molecular Sciences
2023-10-07 | Journal article
DOI: 10.3390/ijms241914974
Contributors: Bodo Kurz; Thomas Lange; Marita Voelker; Melanie L. Hart; Bernd Rolauffs
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Therapeutic Modulation of Cell Morphology and Phenotype of Diseased Human Cells towards a Healthier Cell State Using Lignin

Polymers
2023-07-14 | Journal article
DOI: 10.3390/polym15143041
Contributors: Mischa Selig; Kathrin Walz; Jasmin C. Lauer; Bernd Rolauffs; Melanie L. Hart
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The articular cartilage surface is impaired by a loss of thick collagen fibers and formation of type I collagen in early osteoarthritis

Acta Biomaterialia
2022-07 | Journal article
DOI: 10.1016/j.actbio.2022.04.036
Contributors: Mathaeus Tschaikowsky; Sofia Brander; Vanessa Barth; Ralf Thomann; Bernd Rolauffs; Bizan N. Balzer; Thorsten Hugel
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Micro-patterned cell populations as advanced pharmaceutical drugs with precise functional control

Advanced Drug Delivery Reviews
2022-05 | Journal article
DOI: 10.1016/j.addr.2022.114169
Contributors: Hui Che; Mischa Selig; Bernd Rolauffs
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Physosmotic Induction of Chondrogenic Maturation Is TGF-β Dependent and Enhanced by Calcineurin Inhibitor FK506

International Journal of Molecular Sciences
2022-05-04 | Journal article
DOI: 10.3390/ijms23095110
Contributors: Holger Jahr; Anna E. van der Windt; Ufuk Tan Timur; Esther B. Baart; Wei-Shiung Lian; Bernd Rolauffs; Feng-Sheng Wang; Thomas Pufe
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Characterization and In Vitro Cytotoxicity Safety Screening of Fractionated Organosolv Lignin on Diverse Primary Human Cell Types Commonly Used in Tissue Engineering

Biology
2022-04-30 | Journal article
DOI: 10.3390/biology11050696
Contributors: Jules A. Menima-Medzogo; Kathrin Walz; Jasmin C. Lauer; Gopakumar Sivasankarapillai; F. Robert Gleuwitz; Bernd Rolauffs; Marie-Pierre Laborie; Melanie L. Hart
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Regenerative Potential of Platelet Concentrate Lysate in Mechanically Injured Cartilage and Matrix-Associated Chondrocyte Implantation In Vitro

International Journal of Molecular Sciences
2021-12-07 | Journal article
DOI: 10.3390/ijms222413179
Contributors: Jan-Tobias Weitkamp; Bernd Rolauffs; Moritz Feldheim; Andreas Bayer; Sebastian Lippross; Matthias Weuster; Ralf Smeets; Hendrik Naujokat; Alan Jay Grodzinsky; Bodo Kurz et al.
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Controlled Growth Factor Delivery and Cyclic Stretch Induces a Smooth Muscle Cell-like Phenotype in Adipose-Derived Stem Cells

Cells
2021-11-11 | Journal article
DOI: 10.3390/cells10113123
Contributors: Brandan Walters; Paul A. Turner; Bernd Rolauffs; Melanie L. Hart; Jan P. Stegemann
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Anti-Inflammatory Therapeutic Approaches to Prevent or Delay Post-Traumatic Osteoarthritis (PTOA) of the Knee Joint with a Focus on Sustained Delivery Approaches

International Journal of Molecular Sciences
2021-07-27 | Journal article
DOI: 10.3390/ijms22158005
Contributors: Christine M. Khella; Judith M. Horvath; Rojiar Asgarian; Bernd Rolauffs; Melanie L. Hart
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Architecture-Promoted Biomechanical Performance-Tuning of Tissue-Engineered Constructs for Biological Intervertebral Disc Replacement

Materials
2021-05-20 | Journal article
DOI: 10.3390/ma14102692
Contributors: Gernot Lang; Katja Obri; Babak Saravi; Aldo R. Boccaccini; Anton Früh; Michael Seidenstücker; Bodo Kurz; Hagen Schmal; Bernd Rolauffs
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Development of Bioinspired Functional Chitosan/Cellulose Nanofiber 3D Hydrogel Constructs by 3D Printing for Application in the Engineering of Mechanically Demanding Tissues

Polymers
2021-05-20 | Journal article
DOI: 10.3390/polym13101663
Contributors: Arnaud Kamdem Tamo; Ingo Doench; Lukas Walter; Alexandra Montembault; Guillaume Sudre; Laurent David; Aliuska Morales-Helguera; Mischa Selig; Bernd Rolauffs; Anke Bernstein et al.
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Articular Chondrocyte Phenotype Regulation through the Cytoskeleton and the Signaling Processes That Originate from or Converge on the Cytoskeleton: Towards a Novel Understanding of the Intersection between Actin Dynamics and Chondrogenic Function

International Journal of Molecular Sciences
2021-03-23 | Journal article
DOI: 10.3390/ijms22063279
Contributors: Jasmin C. Lauer; Mischa Selig; Melanie L. Hart; Bodo Kurz; Bernd Rolauffs
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An Evidence-Based Systematic Review of Human Knee Post-Traumatic Osteoarthritis (PTOA): Timeline of Clinical Presentation and Disease Markers, Comparison of Knee Joint PTOA Models and Early Disease Implications

International Journal of Molecular Sciences
2021-02-17 | Journal article
DOI: 10.3390/ijms22041996
Contributors: Christine M. Khella; Rojiar Asgarian; Judith M. Horvath; Bernd Rolauffs; Melanie L. Hart
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Mechanotransduction and Stiffness-Sensing: Mechanisms and Opportunities to Control Multiple Molecular Aspects of Cell Phenotype as a Design Cornerstone of Cell-Instructive Biomaterials for Articular Cartilage Repair

International Journal of Molecular Sciences
2020-07-29 | Journal article
DOI: 10.3390/ijms21155399
Contributors: Mischa Selig; Jasmin C. Lauer; Melanie L. Hart; Bernd Rolauffs
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Bioresponsive Microspheres for On-demand Delivery of Anti-inflammatory Cytokines for Osteoarthritis

2019 | Other
DOI: 10.1101/636886
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Bernd Rolauffs

Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties

Advanced materials (Deerfield Beach, Fla.)
2019 | Journal article
DOI: 10.1002/adma.201806727
Source: Self-asserted source
Bernd Rolauffs

Proof-of-concept for the detection of early osteoarthritis pathology by endomicroscopy

2019 | Other
DOI: 10.1101/734368
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Bernd Rolauffs
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Chondrocyte death after mechanically overloading degenerated human intervertebral disk explants is associated with a structurally impaired pericellular matrix

Journal of tissue engineering and regenerative medicine
2018 | Journal article
DOI: 10.1002/term.2735
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Bernd Rolauffs
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Chondrogenic potential of IL-10 in mechanically injured cartilage and cellularized collagen ACI grafts

Osteoarthritis and cartilage
2018 | Journal article
DOI: 10.1016/j.joca.2017.11.007
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Bernd Rolauffs

Chondrosarcoma: A Rare Misfortune in Aging Human Cartilage? The Role of Stem and Progenitor Cells in Proliferation, Malignant Degeneration and Therapeutic Resistance

International journal of molecular sciences
2018 | Journal article
DOI: 10.3390/ijms19010311
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Bernd Rolauffs
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Human osteoarthritic chondrons outnumber patient- and joint-matched chondrocytes in hydrogel culture-Future application in autologous cell-based OA cartilage repair?

Journal of tissue engineering and regenerative medicine
2018 | Journal article
DOI: 10.1002/term.2516
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Bernd Rolauffs
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Human osteochondritis dissecans fragment-derived chondrocyte characteristics ex vivo, after monolayer expansion-induced de-differentiation, and after re-differentiation in alginate bead culture

BMC musculoskeletal disorders
2018 | Journal article
DOI: 10.1186/s12891-018-2079-6
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Bernd Rolauffs

Induced Redifferentiation of Human Chondrocytes from Articular Cartilage Lesion in Alginate Bead Culture After Monolayer Dedifferentiation: An Alternative Cell Source for Cell-Based Therapies?

Tissue engineering. Part A
2018 | Journal article
DOI: 10.1089/ten.tea.2016.0505
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Bernd Rolauffs

Onset and Progression of Human Osteoarthritis-Can Growth Factors, Inflammatory Cytokines, or Differential miRNA Expression Concomitantly Induce Proliferation, ECM Degradation, and Inflammation in Articular Cartilage?

International journal of molecular sciences
2018 | Journal article
DOI: 10.3390/ijms19082282
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Bernd Rolauffs
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The Potential for Synovium-derived Stem Cells in Cartilage Repair

Current stem cell research & therapy
2018 | Journal article
DOI: 10.2174/1574888x12666171002111026
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Bernd Rolauffs

Differences in type II collagen turnover of osteoarthritic human knee and ankle joints

International orthopaedics
2017 | Journal article
DOI: 10.1007/s00264-017-3414-5
Source: Self-asserted source
Bernd Rolauffs

Engineering the geometrical shape of mesenchymal stromal cells through defined cyclic stretch regimens

Scientific reports
2017 | Journal article
DOI: 10.1038/s41598-017-06794-9
Source: Self-asserted source
Bernd Rolauffs

The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces

Journal of tissue engineering and regenerative medicine
2017 | Journal article
DOI: 10.1002/term.2263
Source: Self-asserted source
Bernd Rolauffs

Tissue engineering-relevant characteristics of ex vivo and monolayer-expanded chondrocytes from the notch versus trochlea of human knee joints

International orthopaedics
2017 | Journal article
DOI: 10.1007/s00264-017-3615-y
Source: Self-asserted source
Bernd Rolauffs

[Early Diagnosis of Osteoarthritis: Clinical Reality and Promising Experimental Techniques]

Zeitschrift fur Orthopadie und Unfallchirurgie
2016 | Journal article
DOI: 10.1055/s-0042-100478
Source: Self-asserted source
Bernd Rolauffs

Autologous chondrocyte implantation (ACI) for cartilage defects of the knee: A guideline by the working group "Clinical Tissue Regeneration" of the German Society of Orthopaedics and Trauma (DGOU)

The Knee
2016 | Journal article
DOI: 10.1016/j.knee.2016.02.001
Source: Self-asserted source
Bernd Rolauffs

Bone marrow-derived mesenchymal stromal cells differ in their attachment to fibronectin-derived peptides from term placenta-derived mesenchymal stromal cells

Stem cell research & therapy
2016 | Journal article
DOI: 10.1186/s13287-015-0243-6
Source: Self-asserted source
Bernd Rolauffs

Choice of xenogenic-free expansion media significantly influences the myogenic differentiation potential of human bone marrow-derived mesenchymal stromal cells

Cytotherapy
2016 | Journal article
DOI: 10.1016/j.jcyt.2015.11.019
Source: Self-asserted source
Bernd Rolauffs

IL-10 reduces apoptosis and extracellular matrix degradation after injurious compression of mature articular cartilage

Osteoarthritis and cartilage
2016 | Journal article
DOI: 10.1016/j.joca.2016.06.016
Source: Self-asserted source
Bernd Rolauffs

Loss of spatial organization and destruction of the pericellular matrix in early osteoarthritis in vivo and in a novel in vitro methodology

Osteoarthritis and cartilage
2016 | Journal article
DOI: 10.1016/j.joca.2016.02.001
Source: Self-asserted source
Bernd Rolauffs

Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition

Scientific reports
2016 | Journal article
DOI: 10.1038/srep35840
Source: Self-asserted source
Bernd Rolauffs

[Treatment of proximal humeral fractures in Germany: Influence of the level of hospital care and the frequency of treatment]

Der Unfallchirurg
2015 | Journal article
DOI: 10.1007/s00113-013-2531-x
Source: Self-asserted source
Bernd Rolauffs

Human Placenta-Derived CD146-Positive Mesenchymal Stromal Cells Display a Distinct Osteogenic Differentiation Potential

Stem cells and development
2015 | Journal article
DOI: 10.1089/scd.2014.0465
Source: Self-asserted source
Bernd Rolauffs

Mesenchymal stromal cells for sphincter regeneration

Advanced drug delivery reviews
2015 | Journal article
DOI: 10.1016/j.addr.2014.10.026
Source: Self-asserted source
Bernd Rolauffs

Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation

PloS one
2015 | Journal article
DOI: 10.1371/journal.pone.0137419
Source: Self-asserted source
Bernd Rolauffs

Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells

PloS one
2015 | Journal article
DOI: 10.1371/journal.pone.0145153
Source: Self-asserted source
Bernd Rolauffs

Which parameters affect medium- to long-term results after angular stable plate fixation for proximal humeral fractures?

Journal of shoulder and elbow surgery
2015 | Journal article
DOI: 10.1016/j.jse.2014.08.009
Source: Self-asserted source
Bernd Rolauffs

Differences in injury pattern and prevalence of cartilage lesions in knee and ankle joints: a retrospective cohort study

Orthopedic reviews
2014 | Journal article
DOI: 10.4081/or.2014.5611
Source: Self-asserted source
Bernd Rolauffs

Erratum to: Trends in epidemiology and patho-anatomical pattern of proximal humeral fractures

International orthopaedics
2014 | Journal article
DOI: 10.1007/s00264-014-2418-7
Source: Self-asserted source
Bernd Rolauffs

The spatial organisation of joint surface chondrocytes: review of its potential roles in tissue functioning, disease and early, preclinical diagnosis of osteoarthritis

Annals of the rheumatic diseases
2014 | Journal article
DOI: 10.1136/annrheumdis-2013-204308
Source: Self-asserted source
Bernd Rolauffs

Trends in epidemiology and patho-anatomical pattern of proximal humeral fractures

International orthopaedics
2014 | Journal article
DOI: 10.1007/s00264-014-2362-6
Source: Self-asserted source
Bernd Rolauffs
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