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Scopus Author ID: 6507710781

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Employment (1)

University of Montpellier and INSERM U1194: Montpellier, Occitanie, FR

2008-09-01 to present | assistant professor (Cellular physiology laboratory of Montpellier and Protease Microenvironment and Cancer of IRCM)
Employment
Source: Self-asserted source
LAURENT-MATHA Valérie

Education and qualifications (1)

Faculty of pharmacy: Montpellier, Occitanie, FR

2008-09-01 to present | assistant professor (Cellular physiology laboratory of Montpellier and Protease Microenvironment and Cancer of IRCM)
Qualification
Source: Self-asserted source
LAURENT-MATHA Valérie

Funding (2)

Ciblage du microenvironnement des cancers du sein triple négatif avec des ADCs "Antibody-Drug Conjugated" anti cathepsine D de 4ième génération hautement hydrophille de DAR 8 homogéne (Drug-to-Antibody-Ratio)

2021-02 to 2022-06 | Contract
Ligue Contre le Cancer (Montpellier, 34, FR)
Source: Self-asserted source
LAURENT-MATHA Valérie

Ciblage de la cathepsine D hyper sécrétée dans le microenvironnement tumoral des cancers du sein avec des anticorps humains anti-cathepsine D couplés à des drogues cytotoxiques ADC "Antibody Drug Conjugate"

2019-02 to 2020-06 | Grant
Ligue Contre le Cancer (Montpellier, 34, FR)
Source: Self-asserted source
LAURENT-MATHA Valérie

Works (15)

Cathepsins: Novel opportunities for antibody therapeutics in cancer

British Journal of Pharmacology
2025-04 | Journal article
DOI: 10.1111/bph.17437
Contributors: Timothée David; Pénélope Desroys du Roure; Aude Mallavialle; Valérie Laurent‐Matha; Pascal Roger; Séverine Guiu; Thierry Chardès; Emmanuelle Liaudet‐Coopman
Source: check_circle
Crossref

SPARC in cancer‐associated fibroblasts is an independent poor prognostic factor in non‐metastatic triple‐negative breast cancer and exhibits pro‐tumor activity

International Journal of Cancer
2023-03-15 | Journal article
DOI: 10.1002/ijc.34345
Contributors: Lindsay B. Alcaraz; Aude Mallavialle; Caroline Mollevi; Florence Boissière‐Michot; Hanane Mansouri; Joelle Simony‐Lafontaine; Valérie Laurent‐Matha; Thierry Chardès; William Jacot; Andrei Turtoi et al.
Source: check_circle
Crossref

Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies

Journal for ImmunoTherapy of Cancer
2019 | Journal article
DOI: 10.1186/s40425-019-0498-z
EID:

2-s2.0-85061056272
Contributors: Ashraf, Y.; Mansouri, H.; Laurent-Matha, V.; Alcaraz, L.B.; Roger, P.; Guiu, S.; Derocq, D.; Robin, G.; Michaud, H.-A.; Delpech, H. et al.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment

International Journal of Oncology
2013 | Journal article
DOI: 10.3892/ijo.2013.2095
EID:

2-s2.0-84885074514
Contributors: Maynadier, M.; Farnoud, R.; Lamy, P.-J.; Laurent-Matha, V.; Garcia, M.; Rochefort, H.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis

Oncogene
2012 | Journal article
DOI: 10.1038/onc.2011.501
EID:

2-s2.0-84863227600
Contributors: Derocq, D.; Prébois, C.; Beaujouin, M.; Laurent-Matha, V.; Pattingre, S.; Smith, G.K.; Liaudet-Coopman, E.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment

FASEB Journal
2012 | Journal article
DOI: 10.1096/fj.12-205229
EID:

2-s2.0-84870332620
Contributors: Laurent-Matha, V.; Huesgen, P.F.; Masson, O.; Derocq, D.; Prébois, C.; Gary-Bobo, M.; Lecaille, F.; Rebière, B.; Meurice, G.; Oréar, C. et al.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Pathophysiological functions of cathepsin D: Targeting its catalytic activity versus its protein binding activity?

Biochimie
2010 | Journal article
DOI: 10.1016/j.biochi.2010.05.009
EID:

2-s2.0-77958546273
Contributors: Masson, O.; Bach, A.-S.; Derocq, D.; Prébois, C.; Laurent-Matha, V.; Pattingre, S.; Liaudet-Coopman, E.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Pro-cathepsin D interacts with the extracellular domain of the β chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

Journal of Cell Science
2010 | Journal article
DOI: 10.1242/jcs.070938
EID:

2-s2.0-77956892285
Contributors: Beaujouin, M.; Prébois, C.; Derocq, D.; Laurent-Matha, V.; Masson, O.; Pattingre, S.; Coopman, P.; Bettache, N.; Grossfield, J.; Hollingsworth, R.E. et al.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

NKCC1 phosphorylation stimulates neurite growth of injured adult sensory neurons

Journal of Neuroscience
2007 | Journal article
DOI: 10.1523/JNEUROSCI.1337-07.2007
EID:

2-s2.0-34250818029
Contributors: Pieraut, S.; Laurent-Matha, V.; Sar, C.; Hubert, T.; Méchaly, I.; Hilaire, C.; Mersel, M.; Delpire, E.; Valmier, J.; Scamps, F.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis

Cancer Letters
2006 | Journal article
DOI: 10.1016/j.canlet.2005.06.007
EID:

2-s2.0-33646854205
Contributors: Liaudet-Coopman, E.; Beaujouin, M.; Derocq, D.; Garcia, M.; Glondu-Lassis, M.; Laurent-Matha, V.; Prébois, C.; Rochefort, H.; Vignon, F.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Processing of human cathepsin D is independent of its catalytic function and auto-activation: Involvement of cathepsins L and B

Journal of Biochemistry
2006 | Journal article
DOI: 10.1093/jb/mvj037
EID:

2-s2.0-33646367913
Contributors: Laurent-Matha, V.; Derocq, D.; Prébois, C.; Katunuma, N.; Liaudet-Coopman, E.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Catalytically inactive human cathepsin D triggers fibroblast invasive growth

Journal of Cell Biology
2005 | Journal article
DOI: 10.1083/jcb.200403078
EID:

2-s2.0-13444266042
Contributors: Laurent-Matha, V.; Maruani-Herrmann, S.; Prébois, C.; Beaujouin, M.; Glondu, M.; Noël, A.; Alvarez-Gonzalez, M.L.; Blacher, S.; Coopman, P.; Baghdiguian, S. et al.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Procathepsin D interacts with prosaposin in cancer cells but its internalization is not mediated by LDL receptor-related protein

Experimental Cell Research
2002 | Journal article
DOI: 10.1006/excr.2002.5556
EID:

2-s2.0-0036311034
Contributors: Laurent-Matha, V.; Lucas, A.; Huttler, S.; Sandhoff, K.; Garcia, M.; Rochefort, H.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells

Oncogene
2001 | Journal article
DOI: 10.1038/sj.onc.1204843
EID:

2-s2.0-0035909530
Contributors: Glondu, M.; Coopman, P.; Laurent-Matha, V.; Garcia, M.; Rochefort, H.; Liaudet-Coopman, E.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier

Endocytosis of pro-cathepsin D into breast cancer cells is mostly independent of mannose-6-phosphate receptors

Journal of Cell Science
1998 | Journal article
EID:

2-s2.0-0031709904
Contributors: Laurent-Matha, V.; Farnoud, M.R.; Lucas, A.; Rougeot, C.; Garcia, M.; Rochefort, H.
Source: Self-asserted source
LAURENT-MATHA Valérie via Scopus - Elsevier
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