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Works (30)

BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers

Cancer Discovery
2024-08-02 | Journal article
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Data from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Data from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Supplementary Figure S1-S7 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Supplementary Figure S1-S7 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Supplementary Table S1 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Supplementary Table S1 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Supplementary Table S2 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Supplementary Table S2 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
Source: check_circle
Crossref

Supplementary Table S3 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
Source: check_circle
Crossref

Supplementary Table S3 from BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in <i>BRCA1</i>-Deficient Cancers

2024-08-02 | Preprint
Contributors: Guang Lei; Chao Mao; Amber D. Horbath; Yuelong Yan; Shirong Cai; Jun Yao; Yan Jiang; Mingchuang Sun; Xiaoguang Liu; Jun Cheng et al.
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Crossref

Exploring Ferroptosis-Inducing Therapies for Cancer Treatment: Challenges and Opportunities

Cancer Research
2024-04-01 | Journal article
Contributors: Guang Lei; Boyi Gan
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Cell cycle arrest induces lipid droplet formation and confers ferroptosis resistance

Nature Communications
2024-01-02 | Journal article
Contributors: Hyemin Lee; Amber Horbath; Lavanya Kondiparthi; Jitendra Kumar Meena; Guang Lei; Shayani Dasgupta; Xiaoguang Liu; Li Zhuang; Pranavi Koppula; Mi Li et al.
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Crossref

SLC7A11 expression level dictates differential responses to oxidative stress in cancer cells

Nature Communications
2023-06-21 | Journal article
Contributors: Yuelong Yan; Hongqi Teng; Qinglei Hang; Lavanya Kondiparthi; Guang Lei; Amber Horbath; Xiaoguang Liu; Chao Mao; Shiqi Wu; Li Zhuang et al.
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Crossref

Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis

Nature Cell Biology
2023-03 | Journal article
Contributors: Xiaoguang Liu; Litong Nie; Yilei Zhang; Yuelong Yan; Chao Wang; Medina Colic; Kellen Olszewski; Amber Horbath; Xiong Chen; Guang Lei et al.
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Crossref

Targeting ferroptosis as a vulnerability in cancer

Nature Reviews Cancer
2022-07 | Journal article
Contributors: Guang Lei; Li Zhuang; Boyi Gan
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Crossref

A targetable CoQ-FSP1 axis drives ferroptosis- and radiation-resistance in KEAP1 inactive lung cancers

Nature Communications
2022-04-22 | Journal article
Contributors: Pranavi Koppula; Guang Lei; Yilei Zhang; Yuelong Yan; Chao Mao; Lavanya Kondiparthi; Jiejun Shi; Xiaoguang Liu; Amber Horbath; Molina Das et al.
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Crossref

Phospholipase iPLA2β acts as a guardian against ferroptosis

Cancer Communications
2021-11 | Journal article
Contributors: Chao Mao; Guang Lei; Li Zhuang; Boyi Gan
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Crossref

Author Correction: DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Nature
2021-08-26 | Journal article
Contributors: Chao Mao; Xiaoguang Liu; Yilei Zhang; Guang Lei; Yuelong Yan; Hyemin Lee; Pranavi Koppula; Shiqi Wu; Li Zhuang; Bingliang Fang et al.
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Crossref

KEAP1 deficiency drives glucose dependency and sensitizes lung cancer cells and tumors to GLUT inhibition

iScience
2021-06 | Journal article
Contributors: Pranavi Koppula; Kellen Olszewski; Yilei Zhang; Lavanya Kondiparthi; Xiaoguang Liu; Guang Lei; Molina Das; Bingliang Fang; Masha V. Poyurovsky; Boyi Gan
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Crossref

DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer

Nature
2021-05-27 | Journal article
Contributors: Chao Mao; Xiaoguang Liu; Yilei Zhang; Guang Lei; Yuelong Yan; Hyemin Lee; Pranavi Koppula; Shiqi Wu; Li Zhuang; Bingliang Fang et al.
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Crossref

Ferroptosis as a mechanism to mediate p53 function in tumor radiosensitivity

Oncogene
2021-05-20 | Journal article
Contributors: Guang Lei; Yilei Zhang; Ting Hong; Xudong Zhang; Xiaoguang Liu; Chao Mao; Yuelong Yan; Pranavi Koppula; Weijie Cheng; Anil K. Sood et al.
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Crossref

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Molecular & Cellular Oncology
2021-05-04 | Journal article
Contributors: Yuelong Yan; Guang Lei; Boyi Gan
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mTORC1 couples cyst(e)ine availability with GPX4 protein synthesis and ferroptosis regulation

Nature Communications
2021-03-11 | Journal article
Contributors: Yilei Zhang; Robert V. Swanda; Litong Nie; Xiaoguang Liu; Chao Wang; Hyemin Lee; Guang Lei; Chao Mao; Pranavi Koppula; Weijie Cheng et al.
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Crossref

H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death.

Cancer research
2020-04-09 | Journal article
Source: Self-asserted source
Guang Lei

Cystine transporter regulation of pentose phosphate pathway dependency and disulfide stress exposes a targetable metabolic vulnerability in cancer.

Nature cell biology
2020-03-30 | Journal article
Source: Self-asserted source
Guang Lei

Efficacy and Safety of Apatinib Plus Vinorelbine in Patients With Wild-Type Advanced Non-Small Cell Lung Cancer After Second-Line Treatment Failure: A Nonrandomized Clinical Trial.

JAMA network open
2020-03-02 | Journal article
Source: Self-asserted source
Guang Lei

The role of ferroptosis in ionizing radiation-induced cell death and tumor suppression

Cell Research
2020-01 | Journal article
Part of ISSN: 1001-0602
Contributors: Guang Lei; Yilei Zhang; Pranavi Koppula; Xiaoguang Liu; Jie Zhang; Steven H. Lin; Jaffer A. Ajani; Qin Xiao; Zhongxing Liao; Hui Wang et al.
Source: Self-asserted source
Guang Lei via Crossref Metadata Search

Elastic Staining on Paraffin-embedded Slides of pT3N0M0 Gastric Cancer Tissue

Journal of Visualized Experiments
2019-05-01 | Journal article
Part of ISSN: 1940-087X
Contributors: Guang Lei; Haiyan Yang; Ting Hong; Xiangyu Zhang; Nong Yang; Yongchang Zhang
Source: Self-asserted source
Guang Lei via Crossref Metadata Search

Elastic staining—a rejuvenated method to reassess prognosis and serosal invasion in patients with pT3N0M0 gastric cancer

Human Pathology
2017-07 | Journal article
Part of ISSN: 0046-8177
Contributors: Guang Lei; Haiyan Yang; Ting Hong; Chunhua Zhou; Jigang Li; Wenbin Liu; Jun Hu; Liang Zeng; Gong Chen; Qiong Chen et al.
Source: Self-asserted source
Guang Lei via Crossref Metadata Search

Peer review (2 reviews for 2 publications/grants)

Review activity for Cell death and disease. (1)
Review activity for Oncogene. (1)