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Scopus Author ID: 57216320359
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Latvian Institute of Organic Synthesis: Riga, LV

2018 to present | Scientific Assistant (Laboratory of Pharmaceutical Pharmacology)
Employment
Source: Self-asserted source
Melita Ozola

Works (25)

Fatty acid β-oxidation in brain mitochondria: Insights from high-resolution respirometry in mouse, rat and Drosophila brain, ischemia and aging models

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
2025-01 | Journal article
DOI: 10.1016/j.bbadis.2024.167544
Contributors: Luiza H.D. Cardoso; Cristiane Cecatto; Melita Ozola; Stanislava Korzh; Liga Zvejniece; Baiba Gukalova; Carolina Doerrier; Maija Dambrova; Marina Makrecka-Kuka; Erich Gnaiger et al.
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Development of Potent Microtubule Targeting Agent by Structural Simplification of Natural Diazonamide

Journal of Medicinal Chemistry
2024-06-13 | Journal article
DOI: 10.1021/acs.jmedchem.4c00388
Contributors: Toms Kalnins; Viktorija Vitkovska; Mihail Kazak; Diana Zelencova-Gopejenko; Melita Ozola; Nauris Narvaiss; Marina Makrecka-Kuka; Ilona Domračeva; Artis Kinens; Baiba Gukalova et al.
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Design, Synthesis, and Bioactivity Evaluations of 3‐Methylenechroman‐2‐one Derivatives as Thioredoxin Reductase (TrxR) Inhibitors

ChemMedChem
2024-02 | Journal article
DOI: 10.1002/cmdc.202300504
Contributors: Anna Nikitjuka; Melita Ozola; Kristaps Krims‐Davis; Raivis Žalubovskis
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Exploration of 3,4-unsubstituted coumarins as thioredoxin reductase 1 inhibitors for cancer therapy

Organic & Biomolecular Chemistry
2023 | Journal article
DOI: 10.1039/D3OB01522J
Contributors: A. Nikitjuka; M. Ozola; L. Jackevica; R. Bobrovs; R. Žalubovskis
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Photoredox-catalyzed direct C–H monofluoromethylation of heteroarenes

New Journal of Chemistry
2023 | Journal article
DOI: 10.1039/D3NJ04313D
Contributors: Nagarajan Ramkumar; Ketrina Plantus; Melita Ozola; Anatoly Mishnev; Vizma Nikolajeva; Maris Senkovs; Maksim Ošeka; Janis Veliks
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Decreased long-chain acylcarnitine content increases mitochondrial coupling efficiency and prevents ischemia-induced brain damage in rats

Biomedicine & Pharmacotherapy
2023-12 | Journal article
DOI: 10.1016/j.biopha.2023.115803
Contributors: Liga Zvejniece; Baiba Svalbe; Edijs Vavers; Melita Ozola; Solveiga Grinberga; Baiba Gukalova; Eduards Sevostjanovs; Edgars Liepinsh; Maija Dambrova
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Regulation of Trimethylamine N-oxide in Treatment of Cardiometabolic Diseases. Doctoral Thesis

2023-11-24 | Dissertation or Thesis
DOI: 10.25143/prom-rsu_2023-16_dt
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Regulation of Trimethylamine N-oxide in Treatment of Cardiometabolic Diseases. Summary of the Doctoral Thesis

2023-11-24 | Dissertation or Thesis
DOI: 10.25143/prom-rsu_2023-16_dts
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Trimetilamīna N-oksīda regulācija kardiometabolo slimību ārstēšanā. Promocijas darba kopsavilkums

2023-11-24 | Dissertation or Thesis
DOI: 10.25143/prom-rsu_2023-16_pdk
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May 1,2-Dithiolane-4-carboxylic Acid and Its Derivatives Serve as a Specific Thioredoxin Reductase 1 Inhibitor?

Molecules
2023-09-15 | Journal article
DOI: 10.3390/molecules28186647
Contributors: Anna Nikitjuka; Kristaps Krims-Davis; Iveta Kaņepe-Lapsa; Melita Ozola; Raivis Žalubovskis
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Synthetic Access to Fluorocyclopropylidenes

Organic Letters
2023-04-07 | Journal article
DOI: 10.1021/acs.orglett.3c00579
Part of ISSN: 1523-7060
Part of ISSN: 1523-7052
Contributors: Renate Melngaile; Melita Videja; Janis Kuka; Artis Kinens; Dzintars Zacs; Janis Veliks
Source: Self-asserted source
Melita Ozola

Heart-Type Fatty Acid Binding Protein Binds Long-Chain Acylcarnitines and Protects against Lipotoxicity

International Journal of Molecular Sciences
2023-03-14 | Journal article
DOI: 10.3390/ijms24065528
Contributors: Diana Zelencova-Gopejenko; Melita Videja; Aiga Grandane; Linda Pudnika-Okinčica; Anda Sipola; Karlis Vilks; Maija Dambrova; Kristaps Jaudzems; Edgars Liepinsh
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Data on cardiac and vascular functionality in ex vivo and in vivo models following acute administration of trimethylamine N-oxide

Data in Brief
2023-02 | Journal article
DOI: 10.1016/j.dib.2023.108890
Contributors: Melita Videja; Reinis Vilskersts; Eduards Sevostjanovs; Edgars Liepinsh; Maija Dambrova
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Fasting-Mimicking Diet Reduces Trimethylamine N-Oxide Levels and Improves Serum Biochemical Parameters in Healthy Volunteers

Nutrients
2022-03-05 | Journal article
DOI: 10.3390/nu14051093
Contributors: Melita Videja; Eduards Sevostjanovs; Sabine Upmale-Engela; Edgars Liepinsh; Ilze Konrade; Maija Dambrova
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Protective Effects of Meldonium in Experimental Models of Cardiovascular Complications with a Potential Application in COVID-19

International Journal of Molecular Sciences
2021-12-21 | Journal article
DOI: 10.3390/ijms23010045
Contributors: Reinis Vilskersts; Dana Kigitovica; Stanislava Korzh; Melita Videja; Karlis Vilks; Helena Cirule; Andris Skride; Marina Makrecka-Kuka; Edgars Liepinsh; Maija Dambrova
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Long-Chain Acylcarnitines Decrease the Phosphorylation of the Insulin Receptor at Tyr1151 Through a PTP1B-Dependent Mechanism

International Journal of Molecular Sciences
2021-06 | Journal article | Author
DOI: 10.3390/ijms22126470
Contributors: Karlis Vilks; Melita Ozola; Marina Makrecka-Kuka; Martins Katkevics; Eduards Sevostjanovs; Aiga Grandane; Maija Dambrova; Edgars Liepins
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Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Chemical composition of Prunus padus L. flower extract and its anti-inflammatory activities in primary bone marrow-derived macrophages

Journal of Ethnopharmacology
2021-03 | Journal article
DOI: 10.1016/j.jep.2020.113678
Part of ISSN: 0378-8741
Source: Self-asserted source
Melita Ozola

Microbiota-Derived Metabolite Trimethylamine N-Oxide Protects Mitochondrial Energy Metabolism and Cardiac Functionality in a Rat Model of Right Ventricle Heart Failure

Frontiers in Cell and Developmental Biology
2021-01-14 | Journal article
DOI: 10.3389/fcell.2020.622741
Part of ISSN: 2296-634X
Source: Self-asserted source
Melita Ozola

Empagliflozin Protects Cardiac Mitochondrial Fatty Acid Metabolism in a Mouse Model of Diet-Induced Lipid Overload

Cardiovascular Drugs and Therapy
2020-12 | Journal article
DOI: 10.1007/s10557-020-06989-9
Part of ISSN: 0920-3206
Part of ISSN: 1573-7241
Source: Self-asserted source
Melita Ozola

Metformin decreases bacterial trimethylamine production and trimethylamine N-oxide levels in db/db mice

Scientific Reports
2020-12 | Journal article
DOI: 10.1038/s41598-020-71470-4
Part of ISSN: 2045-2322
Source: Self-asserted source
Melita Ozola

Rats with congenital hydronephrosis show increased susceptibility to renal ischemia‐reperfusion injury

Physiological Reports
2020-11 | Journal article
DOI: 10.14814/phy2.14638
Contributors: Reinis Vilskersts; Karlis Vilks; Melita Videja; Helena Cirule; Olga Zharkova‐Malkova; Eduards Sevostjanovs; Maija Dambrova; Edgars Liepinsh
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trans-Fluorine Effect in Cyclopropane: Diastereoselective Synthesis of Fluorocyclopropyl Cabozantinib Analogs

ACS Medicinal Chemistry Letters
2020-11-12 | Journal article
DOI: 10.1021/acsmedchemlett.0c00220
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Source: Self-asserted source
Melita Ozola

Inhibition of CPT2 exacerbates cardiac dysfunction and inflammation in experimental endotoxaemia

Journal of Cellular and Molecular Medicine
2020-10 | Journal article
DOI: 10.1111/jcmm.15809
Part of ISSN: 1582-1838
Part of ISSN: 1582-4934
Source: Self-asserted source
Melita Ozola

Neuroprotective and anti-inflammatory activity of DAT inhibitor R-phenylpiracetam in experimental models of inflammation in male mice

Inflammopharmacology
2020-10 | Journal article
DOI: 10.1007/s10787-020-00705-7
Part of ISSN: 0925-4692
Part of ISSN: 1568-5608
Source: Self-asserted source
Melita Ozola

Low‐intensity exercise stimulates bioenergetics and increases fat oxidation in mitochondria of blood mononuclear cells from sedentary adults

Physiological Reports
2020-06 | Journal article
DOI: 10.14814/phy2.14489
Part of ISSN: 2051-817X
Part of ISSN: 2051-817X
Source: Self-asserted source
Melita Ozola
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