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Modeling allosteric mechanisms of eukaryotic type II topoisomerases

Biophysical Journal
2024-06 | Journal article
DOI: 10.1016/j.bpj.2024.05.004
Contributors: Stefania Evoli; Nilusha L. Kariyawasam; Karin C. Nitiss; John L. Nitiss; Jeff Wereszczynski
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Using energy to go downhill—a genoprotective role for ATPase activity in DNA topoisomerase II

Nucleic Acids Research
2024-02-09 | Journal article
DOI: 10.1093/nar/gkad1157
Contributors: Afif F Bandak; Tim R Blower; Karin C Nitiss; Viraj Shah; John L Nitiss; James M Berger
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RAD54L2 counters TOP2-DNA adducts to promote genome stability

Science Advances
2023-12-08 | Journal article
DOI: 10.1126/sciadv.adl2108
Contributors: Giuseppina D’Alessandro; David A. Morales-Juarez; Sean L. Richards; Karin C. Nitiss; Almudena Serrano-Benitez; Juanjuan Wang; John C. Thomas; Vipul Gupta; Andrea Voigt; Rimma Belotserkovskaya et al.
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Modeling Allosteric Mechanisms of Eukaryotic Type II Topoisomerases

2023-08-03 | Preprint
DOI: 10.1101/2023.08.02.551689
Contributors: Stefania Evoli; Nilusha L. Kariyawasam; Karin C. Nitiss; John L. Nitiss; Jeff Wereszczynski
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A conserved SUMO pathway repairs topoisomerase DNA-protein cross-links by engaging ubiquitin-mediated proteasomal degradation

Science Advances
2020-11-13 | Journal article
DOI: 10.1126/sciadv.aba6290
Contributors: Yilun Sun; Lisa M. Miller Jenkins; Yijun P. Su; Karin C. Nitiss; John L. Nitiss; Yves Pommier
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