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structural biology

Biography

BA, SUNY Stony Brook
PhD, Columbia University
Postdoc, Yale University
PI, NIH

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Works (50 of 127)

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Lesion recognition by XPC, TFIIH and XPA in DNA excision repair

Nature
2023-05-04 | Journal article
Contributors: Jinseok Kim; Chia-Lung Li; Xuemin Chen; Yanxiang Cui; Filip M. Golebiowski; Huaibin Wang; Fumio Hanaoka; Kaoru Sugasawa; Wei Yang
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Structural and biochemical basis for DNA and RNA catalysis by human Topoisomerase 3Ī²

Nature Communications
2022-08-09 | Journal article
Contributors: Xi Yang; Sourav Saha; Wei Yang; Keir C. Neuman; Yves Pommier
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Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

Molecular Cell
2022-01 | Journal article
Contributors: Lan Liu; Xuemin Chen; Jun Li; Huaibin Wang; Christopher J. Buehl; Noah J. Goff; Katheryn Meek; Wei Yang; Martin Gellert
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Flexibility of telomerase in binding the RNA template and DNA telomeric repeat

Proceedings of the National Academy of Sciences
2022-01-05 | Journal article
Contributors: Woo Suk Choi; Peter J. Weng; Wei Yang
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Structure of an activated DNA-PK and its implications for NHEJ

Molecular Cell
2021 | Journal article
Contributors: Chen, Xuemin; Xu, Xiang; Chen, Yun; Cheung, Joyce C.; Wang, Huaibin; Jiang, Jiansen; de Val, Natalia; Fox, Tara; Gellert, Martin; Yang, Wei
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Novel Escherichia coli active site dnaE alleles with altered base and sugar selectivity

Molecular Microbiology
2021-09 | Journal article
Contributors: Alexandra Vaisman; Krystian Łazowski; Martin A. M. Reijns; Erin Walsh; John P. McDonald; Kristiniana C. Moreno; Dominic R. Quiros; Marlen Schmidt; Harald Kranz; Wei Yang et al.
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Multiple deprotonation paths of the nucleophile 3ā€²-OH in the DNA synthesis reaction

Proceedings of the National Academy of Sciences
2021-06-08 | Journal article
Contributors: Mark T. Gregory; Yang Gao; Qiang Cui; Wei Yang
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Mispair-bound human MutSā€“MutL complex triggers DNA incisions and activates mismatch repair

Cell Research
2021-05 | Journal article
Contributors: Janice Ortega; Grace Sanghee Lee; Liya Gu; Wei Yang; Guo-Min Li
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Structure of human BCCIP and implications for binding and modification of partner proteins

Protein Science
2021-03 | Journal article
Contributors: Woo Suk Choi; Bochao Liu; Zhiyuan Shen; Wei Yang
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Different mechanisms for translocation by monomeric and hexameric helicases

Current Opinion in Structural Biology
2020 | Journal article
Contributors: Gao, Yang; Yang, Wei
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How a B family DNA polymerase has been evolved to copy RNA

Proceedings of the National Academy of Sciences
2020-09 | Journal article
Contributors: Woo Suk Choi; Peng He; Arti Pothukuchy; Jimmy Gollihar; Andrew D. Ellington; Wei Yang
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How mouse RAG recombinase avoids DNA transposition

Nature Structural & Molecular Biology
2020-02 | Journal article
Contributors: Xuemin Chen; Yanxiang Cui; Huaibin Wang; Z. Hong Zhou; Martin Gellert; Wei Yang
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Cutting antiparallel DNA strands in a single active site

Nature Structural & Molecular Biology
2020-02-03 | Journal article
Contributors: Xuemin Chen; Yanxiang Cui; Robert B. Best; Huaibin Wang; Z. Hong Zhou; Wei Yang; Martin Gellert
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Replisome structure suggests mechanism for continuous fork progression and post-replication repair

DNA Repair
2019 | Journal article
Contributors: Yang, Wei; Seidman, Michael M.; Rupp, W. Dean; Gao, Yang
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Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase

Molecular Cell
2019-10 | Journal article
Contributors: Jinjun Wu; Nadine L. Samara; Isao Kuraoka; Wei Yang
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Structures and operating principles of the replisome

Science
2019-02-22 | Journal article
Contributors: Yang Gao; Yanxiang Cui; Tara Fox; Shiqiang Lin; Huaibin Wang; Natalia de Val; Z. Hong Zhou; Wei Yang
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Cracking the DNA Code for V(D)J Recombination

Molecular Cell
2018 | Journal article
Contributors: Kim, Min-Sung; Chuenchor, Watchalee; Chen, Xuemin; Cui, Yanxiang; Zhang, Xing; Zhou, Z. Hong; Gellert, Martin; Yang, Wei
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Translesion and Repair DNA Polymerases: Diverse Structure and Mechanism

Annual Review of Biochemistry
2018 | Journal article
Contributors: Yang, Wei; Gao, Yang
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Bypassing a 8,5ā€²-cyclo-2ā€²-deoxyadenosine lesion by human DNA polymerase Ī· at atomic resolution

Proceedings of the National Academy of Sciences
2018-10-16 | Journal article
Contributors: Peter J. Weng; Yang Gao; Mark T. Gregory; Pengcheng Wang; Yinsheng Wang; Wei Yang
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Cation trafficking propels RNA hydrolysis

Nature Structural & Molecular Biology
2018-08-03 | Journal article
Contributors: Nadine L. Samara; Wei Yang
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Template and primer requirements for DNA Pol Īø-mediated end joining

Proceedings of the National Academy of Sciences
2018-07-24 | Journal article
Contributors: Peng He; Wei Yang
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Structure of HIV-1 reverse transcriptase cleaving RNA in an RNA/DNA hybrid

Proceedings of the National Academy of Sciences
2018-01-16 | Journal article
Contributors: Lan Tian; Min-Sung Kim; Hongzhi Li; Jimin Wang; Wei Yang
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Detection of Reaction Intermediates in Mg2+-Dependent DNA Synthesis and RNA Degradation by Time-Resolved X-Ray Crystallography

Methods in Enzymology
2017 | Journal article
Contributors: Samara, Nadine L.; Gao, Yang; Wu, Jinjun; Yang, Wei
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How DNA polymerases catalyse replication and repair with contrasting fidelity

Nature Reviews Chemistry
2017 | Journal article
Contributors: Wu, Wen-Jin; Yang, Wei; Tsai, Ming-Daw
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Erratum to: A new paradigm of DNA synthesis: three-metal-ion catalysis

Cell & Bioscience
2017-12 | Journal article
Contributors: Wei Yang; Peter J. Weng; Yang Gao
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Capture of a third Mg2+ is essential for catalyzing DNA synthesis

Science
2016 | Journal article
Contributors: Gao, Yang; Yang, Wei
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Rapid generation of novel models of RAG1 deficiency by CRISPR/Cas9-induced mutagenesis in murine zygotes

Oncotarget
2016 | Journal article
Contributors: de Bruin, Lisa Ott; Yang, Wei; Capuder, Kelly; Lee, Yu Nee; Antolini, Maddalena; Meyers, Robin; Gellert, Martin; Musunuru, Kiran; Manis, John; Notarangelo, Luigi
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A new paradigm of DNA synthesis: three-metal-ion catalysis

Cell & Bioscience
2016-12 | Journal article
Contributors: Wei Yang; Peter J. Weng; Yang Gao
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A DNA-hairpin model for repeat-addition processivity in telomere synthesis

Nature Structural Biology
2015 | Journal article
Contributors: Yang, Wei; Lee, Young-Sam
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Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end Complexes

Journal of Biological Chemistry
2015 | Journal article
Contributors: Lapkouski, Mikalai; Chuenchor, Watchalee; Kim, Min-Sung; Gellert, Martin; Yang, Wei
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Crystal structure of the V(D)J recombinase RAG1-RAG2

Nature
2015 | Journal article
Contributors: Kim, Min-Sung; Lapkouski, Mikalai; Yang, Wei; Gellert, Martin
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How a homolog of high-fidelity replicases conducts mutagenic DNA synthesis

Nature Structural Biology
2015 | Journal article
Contributors: Lee, Young-Sam; Gao, Yang; Yang, Wei
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MutsĪ² generates both expansions and contractions in a mouse model of the Fragile X-associated disorders

Human Molecular Genetics
2015 | Journal article
Contributors: Zhao, Xiao-Nan; Kumari, Daman; Gupta, Shikha; Wu, Di; Evanitsky, Maya; Yang, Wei; Usdin, Karen
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Posttranslational Regulation of Human DNA Polymerase <i>i</i>

Journal of Biological Chemistry
2015 | Journal article
Contributors: McIntyre, Justyna; McLenigan, Mary P.; Frank, Ekaterina G.; Dai, Xiaoxia; Yang, Wei; Wang, Yinsheng; Woodgate, Roger
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Tripartite DNA Lesion Recognition and Verification by XPC, TFIIH, and XPA in Nucleotide Excision Repair

Molecular Cell
2015 | Journal article
Contributors: Li, Chia-Lung; Golebiowski, Filip M.; Onishi, Yuki; Samara, Nadine L.; Sugasawa, Kaoru; Yang, Wei
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An Overview of Y-Family DNA Polymerases and a Case Study of Human DNA Polymerase eta

Biochemistry
2014 | Journal article
Contributors: Yang, Wei
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Calcium Inhibition of Ribonuclease H1 Two-Metal Ion Catalysis

Journal of the American Chemical Society
2014 | Journal article
Contributors: Rosta, Edina; Yang, Wei; Hummer, Gerhard
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Correlation of Phenotype/Genotype in a Cohort of 23 Xeroderma Pigmentosum-Variant Patients Reveals 12 New Disease-Causing POLH Mutations

Human Mutation
2014 | Journal article
Contributors: Opletalova, Kristina; Bourillon, Agnes; Yang, Wei; Pouvelle, Caroline; Armier, Jacques; Despras, Emmanuelle; Martin, Ludovic; Mateus, Christine; Robert, Caroline; Kannouche, Patricia et al.
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Human Pol Ī¶ purified with accessory subunits is active in translesion DNA synthesis and complements Pol. in cisplatin bypass

Proceedings of the National Academy of Sciences
2014 | Journal article
Contributors: Lee, Young-Sam; Gregory, Mark T.; Yang, Wei
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Structural and mechanistic studies of polymerase Ī· bypass of phenanthriplatin DNA damage

Proceedings of the National Academy of Sciences
2014 | Journal article
Contributors: Gregory, Mark T.; Park, Ga Young; Johnstone, Timothy C.; Lee, Young-Sam; Yang, Wei; Lippard, Stephen J.
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The histone-fold complex MHF is remodeled by FANCM to recognize branched DNA and protect genome stability

Cell Research
2014 | Journal article
Contributors: Fox, David, III; Yan, Zhijiang; Ling, Chen; Zhao, Ye; Lee, Duck-Yeon; Fukagawa, Tatsuo; Yang, Wei; Wang, Weidong
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The Steric Gate of DNA Polymerase iota Regulates Ribonucleotide Incorporation and Deoxyribonucleotide Fidelity

Journal of Biological Chemistry
2014 | Journal article
Contributors: Donigan, Katherine A.; McLenigan, Mary P.; Yang, Wei; Goodman, Myron F.; Woodgate, Roger
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Variants of mouse DNA polymerase. reveal a mechanism of efficient and accurate translesion synthesis past a benzo[<i>a</i>] pyrene dG adduct

Proceedings of the National Academy of Sciences
2014 | Journal article
Contributors: Liu, Yang; Yang, Yeran; Tang, Tie-Shan; Zhang, Hui; Wang, Zhifeng; Friedberg, Errol; Yang, Wei; Guo, Caixia
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Complexes of HIV-1 RT, NNRTI and RNA/DNA hybrid reveal a structure compatible with RNA degradation

Nature Structural & Molecular Biology
2013 | Journal article
Contributors: Lapkouski, Mikalai; Tian, Lan; Miller, Jennifer T.; Le Grice, Stuart F. J.; Yang, Wei
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Examining the Role of the HIV-1 Reverse Transcriptase p51 Subunit in Positioning and Hydrolysis of RNA/DNA Hybrids

Journal of Biological Chemistry
2013 | Journal article
Contributors: Chung, Suhman; Miller, Jennifer T.; Lapkouski, Mikalai; Tian, Lan; Yang, Wei; Le Grice, Stuart F. J.
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Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta

Proceedings of the National Academy of Sciences
2013 | Journal article
Contributors: Zhao, Ye; Gregory, Mark T.; Biertuempfel, Christian; Hua, Yue-Jin; Hanaoka, Fumio; Yang, Wei
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Mechanism of the nucleotidyl-transfer reaction in DNA polymerase revealed by time-resolved protein crystallography

Biophysics (Japan)
2013 | Journal article
Contributors: Nakamura, Teruya; Zhao, Ye; Yamagata, Yuriko; Hua, Yue-Jin; Yang, Wei
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MuB is an AAA plus ATPase that forms helical filaments to control target selection for DNA transposition

Proceedings of the National Academy of Sciences
2013 | Journal article
Contributors: Mizuno, Naoko; Dramicanin, Marija; Mizuuchi, Michiyo; Adam, Julia; Wang, Yi; Han, Yong-Woon; Yang, Wei; Steven, Alasdair C.; Mizuuchi, Kiyoshi; Ramon-Maiques, Santiago
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The Histone Mark H3K36me3 Regulates Human DNA Mismatch Repair through Its Interaction with MutSĪ±

Cell
2013 | Journal article
Contributors: Li, Feng; Mao, Guogen; Tong, Dan; Huang, Jian; Gu, Liya; Yang, Wei; Li, Guo-Min
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Assembly of prototype foamy virus strand transfer complexes on product DNA bypassing catalysis of integration

Protein Science
2012 | Journal article
Contributors: Yin, Zhiqi; Lapkouski, Mikalai; Yang, Wei; Craigie, Robert
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