Personal information

Websites & social links

Education Against Tobacco
German Center for Lung Research (DZL)

Activities

Collapse all

Employment (4)

Heidelberg University Hospital: Heidelberg, DE

2017-12-01 to present | Clinician Scientist / Head of App Development (National Center for Tumor Diseases (NCT) and Department of Dermatology)
Employment
Source: Self-asserted source
Titus Josef Brinker

German Cancer Research Center: Heidelberg, DE

2017-12-01 to present
Employment
Source: Self-asserted source
Titus Josef Brinker

Wolfgang Goethe University: Frankfurt am Main, Hessen, DE

2012 to present (Institute for Occupational, Environmental and Social Medicine)
Employment
Source: Self-asserted source
Titus Josef Brinker

Universities of Giessen and Marburg Lung Center; Member of the German Center for Lung Research (DZL); Justus-Liebig-University of Giessen: Giessen, Hessen, DE

2012 to present (Internal Medicine)
Employment
Source: Self-asserted source
Titus Josef Brinker

Works (50 of 133)

Items per page:
Page 1 of 3

AI-generated cancer prevention influencers can target risk groups on social media at low cost

European Journal of Cancer
2025-02 | Journal article
DOI: 10.1016/j.ejca.2025.115251
Contributors: Jana T. Winterstein; Julia Abels; Arlene Kuehn; Nicolas Carl; Christoph Wies; Titus J. Brinker
Source: check_circle
Crossref

End-to-end prediction of clinical outcomes in head and neck squamous cell carcinoma with foundation model-based multiple instance learning

2025-01-25 | Preprint
DOI: 10.1101/2025.01.22.25320517
Contributors: Asier Rabasco Meneghetti; Marta Ligero Hernández; Jens-Peter Kuehn; Steffen Löck; Zunamys Itzel Carrero; Raquel Perez-Lopez; Keno Bressem; Titus K. Brinker; Alexander T. Pearson; Daniel Truhn et al.
Source: check_circle
Crossref

Human-centered AI as a framework guiding the development of image-based diagnostic tools in oncology: a systematic review

ESMO Real World Data and Digital Oncology
2024-12 | Journal article
DOI: 10.1016/j.esmorw.2024.100077
Contributors: K. Allen; A.K. Yawson; S. Haggenmüller; J.N. Kather; T.J. Brinker
Source: check_circle
Crossref

Superhuman performance on urology board questions using an explainable language model enhanced with European Association of Urology guidelines

ESMO Real World Data and Digital Oncology
2024-12 | Journal article
DOI: 10.1016/j.esmorw.2024.100078
Contributors: M.J. Hetz; N. Carl; S. Haggenmüller; C. Wies; J.N. Kather; M.S. Michel; F. Wessels; T.J. Brinker
Source: check_circle
Crossref

Noninvasive Technologies for the Diagnosis of Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis

JID Innovations
2024-11 | Journal article
DOI: 10.1016/j.xjidi.2024.100303
Contributors: Carina Nogueira Garcia; Christoph Wies; Katja Hauser; Titus J. Brinker
Source: check_circle
Crossref

Large language model use in clinical oncology

npj Precision Oncology
2024-10-23 | Journal article
DOI: 10.1038/s41698-024-00733-4
Contributors: Nicolas Carl; Franziska Schramm; Sarah Haggenmüller; Jakob Nikolas Kather; Martin J. Hetz; Christoph Wies; Maurice Stephan Michel; Frederik Wessels; Titus J. Brinker
Source: check_circle
Crossref

Reply to: False conflict and false confirmation errors are crucial components of AI accuracy in medical decision making

Nature Communications
2024-08-13 | Journal article
DOI: 10.1038/s41467-024-50954-1
Contributors: Christoph Wies; Katja Hauser; Titus J. Brinker
Source: check_circle
Crossref

3-Dimensional Reconstruction From Histopathological Sections: A Systematic Review

Laboratory Investigation
2024-06 | Journal article
DOI: 10.1016/j.labinv.2024.102049
Contributors: Alexander Kurz; Heimo Müller; Jakob N. Kather; Lucas Schneider; Tabea C. Bucher; Titus J. Brinker
Source: check_circle
Crossref

Multi-domain stain normalization for digital pathology: A cycle-consistent adversarial network for whole slide images

Medical Image Analysis
2024-05 | Journal article
DOI: 10.1016/j.media.2024.103149
Contributors: Martin J. Hetz; Tabea-Clara Bucher; Titus J. Brinker
Source: check_circle
Crossref

Deep learning for dual detection of microsatellite instability and POLE mutations in colorectal cancer histopathology

npj Precision Oncology
2024-05-23 | Journal article
DOI: 10.1038/s41698-024-00592-z
Contributors: Marco Gustav; Nic Gabriel Reitsam; Zunamys I. Carrero; Chiara M. L. Loeffler; Marko van Treeck; Tanwei Yuan; Nicholas P. West; Philip Quirke; Titus J. Brinker; Hermann Brenner et al.
Source: check_circle
Crossref

Deep learning-based proteomics enables accurate classification of bulk and single-cell samples

2024-02-07 | Preprint
DOI: 10.1101/2024.02.03.578734
Contributors: Karl K. Krull; Arlene Kühn; Julia Höhn; Titus J. Brinker; Jeroen Krijgsveld
Source: check_circle
Crossref

Evaluating deep learning-based melanoma classification using immunohistochemistry and routine histology: A three center study

PLOS ONE
2024-01-19 | Journal article
DOI: 10.1371/journal.pone.0297146
Contributors: Christoph Wies; Vincenzo L’Imperio; Lucas Schneider; Sarah Haggenmüller; Tabea-Clara Bucher; Sarah Hobelsberger; Markus V. Heppt; Gerardo Ferrara; Eva I. Krieghoff-Henning; Titus J. Brinker
Source: check_circle
Crossref

Pitfalls of Conformal Predictions for Medical Image Classification

2023 | Book chapter
DOI: 10.1007/978-3-031-44336-7_20
Contributors: Hendrik Mehrtens; Tabea Bucher; Titus J. Brinker
Source: check_circle
Crossref

Benchmarking common uncertainty estimation methods with histopathological images under domain shift and label noise

Medical Image Analysis
2023-10 | Journal article
DOI: 10.1016/j.media.2023.102914
Contributors: Hendrik A. Mehrtens; Alexander Kurz; Tabea-Clara Bucher; Titus J. Brinker
Source: check_circle
Crossref

Multimodal integration of image, epigenetic and clinical data to predict BRAF mutation status in melanoma

European Journal of Cancer
2023-04 | Journal article
DOI: 10.1016/j.ejca.2023.01.021
Contributors: Lucas Schneider; Christoph Wies; Eva I. Krieghoff-Henning; Tabea-Clara Bucher; Jochen S. Utikal; Dirk Schadendorf; Titus J. Brinker
Source: check_circle
Crossref

[The Rise of Artificial Intelligence - High Prediction Accuracy in Early Detection of Pigmented Melanoma].

Laryngo- rhino- otologie
2022-12-29 | Journal article
DOI: 10.1055/a-1949-3639
PMID: 36580975
Contributors: Jutzi T; Krieghoff-Henning EI; Brinker TJ
Source: Self-asserted source
Titus Josef Brinker

Erratum to 'Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology' Medical Image Analysis, Volume 79, July 2022, 102474.

Medical image analysis
2022-09-18 | Journal article
DOI: 10.1016/j.media.2022.102622
PMID: 36130464
Contributors: Ghaffari Laleh N; Muti HS; Loeffler CML; Echle A; Saldanha OL; Mahmood F; Lu MY; Trautwein C; Langer R; Dislich B et al.
Source: Self-asserted source
Titus Josef Brinker

Deep learning can predict survival directly from histology in clear cell renal cell carcinoma.

PloS one
2022-08-17 | Journal article | Author
DOI: 10.1371/journal.pone.0272656
PMID: 35976907
PMC: PMC9385058
Contributors: Frederik Wessels; Schmitt M; Krieghoff-Henning E; Kather JN; Nientiedt M; Kriegmair MC; Worst TS; Neuberger M; Steeg M; Popovic ZV et al.
Source: Self-asserted source
Titus Josef Brinker

Model soups improve performance of dermoscopic skin cancer classifiers.

European journal of cancer (Oxford, England : 1990)
2022-08-13 | Journal article
DOI: 10.1016/j.ejca.2022.07.002
PMID: 35973360
Contributors: Maron RC; Hekler A; Haggenmüller S; von Kalle C; Utikal JS; Müller V; Gaiser M; Friedegund Meier; Sarah Hobelsberger; Gellrich FF et al.
Source: Self-asserted source
Titus Josef Brinker

Uncertainty Estimation in Medical Image Classification: Systematic Review.

JMIR medical informatics
2022-08-02 | Journal article | Author
DOI: 10.2196/36427
PMID: 35916701
PMC: PMC9382553
Contributors: Alexander Kurz; Katja Hauser; Hendrik Alexander Mehrtens; Eva Krieghoff-Henning; Achim Hekler; Jakob Nikolas Kather, MD, MSc; Stefan Fröhling; Christof von Kalle; Titus Josef Brinker
Source: Self-asserted source
Titus Josef Brinker
grade
Preferred source (of 2)‎

Response to letter entitled: Re: Integration of deep learning-based image analysis and genomic data in cancer pathology: A systematic review.

European journal of cancer (Oxford, England : 1990)
2022-06-30 | Journal article | Author
DOI: 10.1016/j.ejca.2022.06.001
PMID: 35781181
Contributors: Schneider L; Eva Krieghoff-Henning; Laiouar-Pedari S; Kuntz S; Hekler A; Kather JN; Gaiser T; Fröhling S; Titus Josef Brinker
Source: Self-asserted source
Titus Josef Brinker
grade
Preferred source (of 2)‎

Benchmarking weakly-supervised deep learning pipelines for whole slide classification in computational pathology.

Medical image analysis
2022-05-04 | Journal article
DOI: 10.1016/j.media.2022.102474
PMID: 35588568
Contributors: Ghaffari Laleh N; Muti HS; Loeffler CML; Amelie Echle; Saldanha OL; Mahmood F; Lu MY; Trautwein C; Langer R; Dislich B et al.
Source: Self-asserted source
Titus Josef Brinker

Swarm learning for decentralized artificial intelligence in cancer histopathology.

Nature medicine
2022-04-25 | Journal article
DOI: 10.1038/s41591-022-01768-5
PMID: 35469069
PMC: PMC9205774
Contributors: Saldanha OL; Philip Quirke; Nicholas West; Jackie James; Loughrey MB; Heike Grabsch; Salto-Tellez M; Alwers E; Didem Cifci; Ghaffari Laleh N et al.
Source: Self-asserted source
Titus Josef Brinker

Explainable artificial intelligence in skin cancer recognition: A systematic review.

European journal of cancer (Oxford, England : 1990)
2022-04-05 | Journal article
DOI: 10.1016/j.ejca.2022.02.025
PMID: 35390650
Contributors: Katja Hauser; Kurz A; Haggenmüller S; Maron RC; Christof von Kalle; Utikal JS; Friedegund Meier; Sarah Hobelsberger; Frank Friedrich Gellrich; Mildred Sergon et al.
Source: Self-asserted source
Titus Josef Brinker
grade
Preferred source (of 2)‎

Künstliche Intelligenz auf dem Vormarsch – Hohe Vorhersage-Genauigkeit bei der Früherkennung pigmentierter Melanome

Aktuelle Dermatologie
2022-03 | Journal article
DOI: 10.1055/a-1514-2013
Contributors: Tanja B. Jutzi; Eva I. Krieghoff-Henning; Titus J. Brinker
Source: check_circle
Crossref

Artificial intelligence to predict oncological outcome directly from hematoxylin and eosin-stained slides in urology.

Minerva urology and nephrology
2022-03-11 | Journal article
DOI: 10.23736/s2724-6051.22.04758-9
PMID: 35274903
Contributors: Wessels F; Kuntz S; Krieghoff-Henning E; Schmitt M; Braun V; Worst TS; Neuberger M; Steeg M; Gaiser T; Fröhling S et al.
Source: Self-asserted source
Titus Josef Brinker

Artificial intelligence for detection of microsatellite instability in colorectal cancer-a multicentric analysis of a pre-screening tool for clinical application.

ESMO open
2022-03-02 | Journal article
DOI: 10.1016/j.esmoop.2022.100400
PMID: 35247870
PMC: PMC9058894
Contributors: Echle A; Ghaffari Laleh N; Philip Quirke; Grabsch HI; Muti HS; Saldanha OL; Brockmoeller SF; van den Brandt PA; Hutchins GGA; Susan Richman et al.
Source: Self-asserted source
Titus Josef Brinker

Deep learning identifies inflamed fat as a risk factor for lymph node metastasis in early colorectal cancer.

The Journal of pathology
2021-12-28 | Journal article
DOI: 10.1002/path.5831
PMID: 34738636
Contributors: Scarlet Fiona Brockmoeller; Echle A; Ghaffari Laleh N; Eiholm S; Malmstrøm ML; Plato Kuhlmann T; Levic K; Grabsch HI; Nicholas West; Saldanha OL et al.
Source: Self-asserted source
Titus Josef Brinker

Swarm learning for decentralized artificial intelligence in cancer histopathology

2021-11 | Preprint
DOI: 10.1101/2021.11.19.469139
PPR: PPR423063
Contributors: Saldanha OL; Quirke P; West NP; James JA; Loughrey MB; Grabsch HI; Salto-Tellez M; Alwers E; Cifci D; Laleh NG et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Integration of deep learning-based image analysis and genomic data in cancer pathology: A systematic review.

European journal of cancer (Oxford, England : 1990)
2021-11-19 | Journal article | Author
DOI: 10.1016/j.ejca.2021.10.007
PMID: 34810047
Contributors: Schneider L; Laiouar-Pedari S; Kuntz S; Krieghoff-Henning E; Hekler A; Jakob Nikolas Kather, MD, MSc; Gaiser T; Fröhling S; Titus Josef Brinker
Source: Self-asserted source
Titus Josef Brinker
grade
Preferred source (of 2)‎

Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology.

The Journal of pathology
2021-10 | Journal article
DOI: 10.1002/path.5800
PMID: 34561876
Contributors: Schrammen PL; Ghaffari Laleh N; Echle A; Truhn D; Schulz V; Brinker TJ; Brenner H; Chang-Claude J; Alwers E; Brobeil A et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Deep learning can predict lymph node status directly from histology in colorectal cancer.

European journal of cancer (Oxford, England : 1990)
2021-10-11 | Journal article
DOI: 10.1016/j.ejca.2021.08.039
PMID: 34649117
Contributors: Kiehl L; Kuntz S; Höhn J; Tanja Jutzi; Krieghoff-Henning E; Kather JN; Holland-Letz T; Annette Kopp-Schneider; Chang-Claude J; Brobeil A et al.
Source: Self-asserted source
Titus Josef Brinker

Deep learning approach to predict sentinel lymph node status directly from routine histology of primary melanoma tumours

European Journal of Cancer
2021-09 | Journal article
DOI: 10.1016/j.ejca.2021.05.026
Contributors: Titus J. Brinker; Lennard Kiehl; Max Schmitt; Tanja B. Jutzi; Eva I. Krieghoff-Henning; Dieter Krahl; Heinz Kutzner; Patrick Gholam; Sebastian Haferkamp; Joachim Klode et al.
Source: check_circle
Crossref

Evaluation of Long-term Clearance Rates of Interventions for Actinic Keratosis: A Systematic Review and Network Meta-analysis.

JAMA dermatology
2021-09 | Journal article
DOI: 10.1001/jamadermatol.2021.2779
PMID: 34347015
PMC: PMC8340012
Contributors: Steeb T; Wessely A; Petzold A; Brinker TJ; Schmitz L; Leiter U; Garbe C; Schöffski O; Berking C; Heppt MV
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Skin cancer classification via convolutional neural networks: systematic review of studies involving human experts.

European journal of cancer (Oxford, England : 1990)
2021-09 | Journal article
DOI: 10.1016/j.ejca.2021.06.049
PMID: 34509059
Contributors: Haggenmüller S; Maron RC; Hekler A; Utikal JS; Barata C; Barnhill RL; Beltraminelli H; Berking C; Betz-Stablein B; Blum A et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Logistics Workers Are a Key Factor for SARS-CoV-2 Spread in Brazilian Small Towns: Case-Control Study

JMIR Public Health and Surveillance
2021-09-01 | Journal article
DOI: 10.2196/30406
Contributors: Breno Bernardes-Souza; Saulo Ricardo Costa Júnior; Carolina Ali Santos; Raimundo Marques Do Nascimento Neto; Fernando De Carvalho Bottega; Daiana Carolina Godoy; Bruno Lourençoni Freitas; Daniela Leite Garcia Silva; Titus Josef Brinker; Raiza Aranha Nascimento et al.
Source: check_circle
Crossref

A benchmark for neural network robustness in skin cancer classification.

European journal of cancer (Oxford, England : 1990)
2021-08 | Journal article
DOI: 10.1016/j.ejca.2021.06.047
PMID: 34388516
Contributors: Maron RC; Schlager JG; Haggenmüller S; von Kalle C; Utikal JS; Meier F; Gellrich FF; Hobelsberger S; Hauschild A; French L et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Benchmarking artificial intelligence methods for end-to-end computational pathology

2021-08 | Preprint
DOI: 10.1101/2021.08.09.455633
PPR: PPR380946
Contributors: Laleh NG; Muti HS; Lavinia Loeffler CM; Echle A; Saldanha OL; Mahmood F; Lu MY; Trautwein C; Langer R; Dislich B et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Gastrointestinal cancer classification and prognostication from histology using deep learning: Systematic review.

European journal of cancer (Oxford, England : 1990)
2021-08 | Journal article
DOI: 10.1016/j.ejca.2021.07.012
PMID: 34391053
Contributors: Kuntz S; Krieghoff-Henning E; Kather JN; Jutzi T; Höhn J; Kiehl L; Hekler A; Alwers E; von Kalle C; Fröhling S et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Digital Natives’ Preferences on Mobile Artificial Intelligence Apps for Skin Cancer Diagnostics: Survey Study

JMIR mHealth and uHealth
2021-08-27 | Journal article
DOI: 10.2196/22909
Contributors: Sarah Haggenmüller; Eva Krieghoff-Henning; Tanja Jutzi; Nicole Trapp; Lennard Kiehl; Jochen Sven Utikal; Sascha Fabian; Titus Josef Brinker
Source: check_circle
Crossref

Integrating Patient Data Into Skin Cancer Classification Using Convolutional Neural Networks: Systematic Review.

Journal of medical Internet research
2021-07 | Journal article
DOI: 10.2196/20708
PMID: 34255646
PMC: PMC8285747
Contributors: Höhn J; Hekler A; Krieghoff-Henning E; Kather JN; Utikal JS; Meier F; Gellrich FF; Hauschild A; French L; Schlager JG et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Deep learning approach to predict lymph node metastasis directly from primary tumour histology in prostate cancer.

BJU international
2021-05 | Journal article
DOI: 10.1111/bju.15386
PMID: 33706408
Contributors: Wessels F; Schmitt M; Krieghoff-Henning E; Jutzi T; Worst TS; Waldbillig F; Neuberger M; Maron RC; Steeg M; Gaiser T et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Logistics Workers Are a Key Factor for SARS-CoV-2 Spread in Brazilian Small Towns: Case-Control Study (Preprint)

2021-05-13 | Other
DOI: 10.2196/preprints.30406
Contributors: Breno Bernardes-Souza; Saulo Ricardo Costa Júnior; Carolina Ali Santos; Raimundo Marques Do Nascimento Neto; Fernando De Carvalho Bottega; Daiana Carolina Godoy; Bruno Lourençoni Freitas; Daniela Leite Garcia Silva; Titus Josef Brinker; Raiza Aranha Nascimento et al.
Source: check_circle
Crossref

Artificial Intelligence-based Detection of FGFR3 Mutational Status Directly from Routine Histology in Bladder Cancer: A Possible Preselection for Molecular Testing?

European urology focus
2021-04 | Journal article
DOI: 10.1016/j.euf.2021.04.007
PMID: 33895087
Contributors: Loeffler CML; Ortiz Bruechle N; Jung M; Seillier L; Rose M; Laleh NG; Knuechel R; Brinker TJ; Trautwein C; Gaisa NT et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Combining CNN-based histologic whole slide image analysis and patient data to improve skin cancer classification.

European journal of cancer (Oxford, England : 1990)
2021-04 | Journal article
DOI: 10.1016/j.ejca.2021.02.032
PMID: 33838393
Contributors: Höhn J; Krieghoff-Henning E; Jutzi TB; von Kalle C; Utikal JS; Meier F; Gellrich FF; Hobelsberger S; Hauschild A; Schlager JG et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Long-term recurrence rates of actinic keratosis: A systematic review and pooled analysis of randomized controlled trials.

Journal of the American Academy of Dermatology
2021-04 | Journal article
DOI: 10.1016/j.jaad.2021.04.017
PMID: 33872716
Contributors: Steeb T; Wessely A; Petzold A; Brinker TJ; Schmitz L; Schöffski O; Berking C; Heppt MV
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Deep learning detects genetic alterations in cancer histology generated by adversarial networks.

The Journal of pathology
2021-03 | Journal article
DOI: 10.1002/path.5638
PMID: 33565124
Contributors: Krause J; Grabsch HI; Kloor M; Jendrusch M; Echle A; Buelow RD; Boor P; Luedde T; Brinker TJ; Trautwein C et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Reducing the Impact of Confounding Factors on Skin Cancer Classification via Image Segmentation: Technical Model Study

Journal of Medical Internet Research
2021-03-25 | Journal article
DOI: 10.2196/21695
Contributors: Roman C Maron; Achim Hekler; Eva Krieghoff-Henning; Max Schmitt; Justin G Schlager; Jochen S Utikal; Titus J Brinker
Source: check_circle
Crossref

Diagnostic performance of artificial intelligence for histologic melanoma recognition compared to 18 international expert pathologists.

Journal of the American Academy of Dermatology
2021-02 | Journal article
DOI: 10.1016/j.jaad.2021.02.009
PMID: 33581189
Contributors: Brinker TJ; Schmitt M; Krieghoff-Henning EI; Barnhill R; Beltraminelli H; Braun SA; Carr R; Fernandez-Figueras MT; Ferrara G; Fraitag S et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central

Hidden Variables in Deep Learning Digital Pathology and Their Potential to Cause Batch Effects: Prediction Model Study.

Journal of medical Internet research
2021-02 | Journal article
DOI: 10.2196/23436
PMID: 33528370
PMC: PMC7886613
Contributors: Schmitt M; Maron RC; Hekler A; Stenzinger A; Hauschild A; Weichenthal M; Tiemann M; Krahl D; Kutzner H; Utikal JS et al.
Source: Self-asserted source
Titus Josef Brinker via Europe PubMed Central
Items per page:
Page 1 of 3

Peer review (9 reviews for 5 publications/grants)

Review activity for EJC skin cancer. (1)
Review activity for European journal of cancer. (2)
Review activity for Nature communications (1)
Review activity for Nature medicine. (3)
Review activity for npj precision oncology. (2)
How many people are using ORCID?