Personal information

Activities

Employment (6)

Newcastle University: Newcastle upon Tyne, GB

2021-01-01 to present | Lecturer (Biosciences)
Employment
Source: Self-asserted source
Catherine Arden

Newcastle University: Newcastle upon Tyne, Tyne and Wear, GB

2004-09-01 to present | Lecturer (Biosciences)
Employment
Source: check_circle
Newcastle University via ORCID Member Portal

Newcastle University: Newcastle upon Tyne, Newcastle upon Tyne, GB

2014-09-01 to 2021-01-01 | Newcastle University Research Fellow (Institute of Cellular Medicine)
Employment
Source: Self-asserted source
Catherine Arden

Newcastle University Faculty of Medical Sciences: Newcastle upon Tyne, Newcastle upon Tyne, GB

2008-10-01 to 2014-08-31 | RD Lawrence Research Fellow (Institute of Cellular Medicine)
Employment
Source: Self-asserted source
Catherine Arden

Newcastle University Faculty of Medical Sciences: Newcastle upon Tyne, Newcastle upon Tyne, GB

2004-09-03 to 2008-09-30 | Post-doc (Institute of Cellular Medicine)
Employment
Source: Self-asserted source
Catherine Arden

University of Michigan: Ann Arbor, MI, US

2007-09-28 to 2007-12-20 | Visiting Researcher
Employment
Source: Self-asserted source
Catherine Arden

Education and qualifications (2)

Newcastle University: Newcastle upon Tyne, Newcastle upon Tyne, GB

2001-10-01 to 2004-09-01 | PhD Biochemistry (School of Clinical Medical Sciences)
Education
Source: Self-asserted source
Catherine Arden

University of Hull: Hull, Kingston upon Hull, GB

1997-10-01 to 2001-07-01 | BSc Biomedical Sciences
Education
Source: Self-asserted source
Catherine Arden

Works (27)

Overexpression of miR-199b-5p in Colony Forming Unit-Hill’s Colonies Positively Mediates the Inflammatory Response in Subclinical Cardiovascular Disease Model: Metformin Therapy Attenuates Its Expression

International Journal of Molecular Sciences
2024-07-25 | Journal article
Contributors: Sherin Bakhashab; Rosie Barber; Josie O’Neill; Catherine Arden; Jolanta U. Weaver
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Upregulation of Anti-Angiogenic miR-106b-3p Correlates Negatively with IGF-1 and Vascular Health Parameters in a Model of Subclinical Cardiovascular Disease: Study with Metformin Therapy

Biomedicines
2024-01-12 | Journal article
Contributors: Sherin Bakhashab; Josie O’Neill; Rosie Barber; Catherine Arden; Jolanta U. Weaver
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Pseudoislet Aggregation of Pancreatic β-Cells Improves Glucose Stimulated Insulin Secretion by Altering Glucose Metabolism and Increasing ATP Production

Cells
2022-07-29 | Journal article
Contributors: Deborah Cornell; Satomi Miwa; Merilin Georgiou; Scott James Anderson; Minna Honkanen-Scott; James A. M. Shaw; Catherine Arden
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Differential routing and disposition of the long-chain saturated fatty acid palmitate in rodent vs human beta-cells

Nutrition & Diabetes
2022-04-20 | Journal article
Contributors: Patricia Thomas; Catherine Arden; Jenna Corcoran; Christian Hacker; Hannah J. Welters; Noel G. Morgan
Source: check_circle
Crossref

A role for Glucagon-Like Peptide-1 in the regulation of β-cell autophagy

Peptides
2018 | Journal article
EID:

2-s2.0-85041454141

Contributors: Arden, C.
Source: Self-asserted source
Catherine Arden via Scopus - Elsevier

Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.

Diabetes, obesity & metabolism
2017-08 | Journal article
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Glucagon-Like Peptide 1 Protects Pancreatic β-Cells From Death by Increasing Autophagic Flux and Restoring Lysosomal Function.

Diabetes
2017-05 | Journal article
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Glucagon induces translocation of glucokinase from the cytoplasm to the nucleus of hepatocytes by transfer between 6-phosphofructo 2-kinase/fructose 2,6-bisphosphatase-2 and the glucokinase regulatory protein.

Biochimica et biophysica acta
2014-06 | Journal article
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Glucose induces protein targeting to glycogen in hepatocytes by fructose 2,6-bisphosphate-mediated recruitment of MondoA to the promoter.

2013-02 | Journal article
DOI:

10.1128/MCB.01576-12

PMID:

23207906

PMC:

PMC3571345

Contributors: Petrie JL; Al-Oanzi ZH; Arden C; Tudhope SJ; Mann J; Kieswich J; Yaqoob MM; Towle HC; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Fructose 2,6-bisphosphate is essential for glucose-regulated gene transcription of glucose-6-phosphatase and other ChREBP target genes in hepatocytes.

2012-04 | Journal article
DOI:

10.1042/BJ20111280

PMID:

22214556

Contributors: Arden C; Tudhope SJ; Petrie JL; Al-Oanzi ZH; Cullen KS; Lange AJ; Towle HC; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

A novel mechanism for regulating hepatic glycogen synthesis involving serotonin and cyclin-dependent kinase-5.

2012-01 | Journal article
DOI:

10.2337/db11-0870

PMID:

22106156

PMC:

PMC3237670

Contributors: Tudhope SJ; Wang CC; Petrie JL; Potts L; Malcomson F; Kieswich J; Yaqoob MM; Arden C; Hampson LJ; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis.

2011-12 | Journal article
DOI:

10.2337/db11-0061

PMID:

22013014

PMC:

PMC3219956

Contributors: Arden C; Petrie JL; Tudhope SJ; Al-Oanzi Z; Claydon AJ; Beynon RJ; Towle HC; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Susceptibility of glucokinase-MODY mutants to inactivation by oxidative stress in pancreatic β-cells.

2011-12 | Journal article
DOI:

10.2337/db11-0423

PMID:

22028181

PMC:

PMC3219952

Contributors: Cullen KS; Matschinsky FM; Agius L; Arden C
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Pseudoislets as primary islet replacements for research: Report on a symposium at King's College London, London UK

Islets
2010 | Journal article
EID:

2-s2.0-77957096453

Contributors: Persaud, S.J.; Arden, C.; Bergsten, P.; Bone, A.J.; Brown, J.; Dunmore, S.; Harrison, M.; Hauge-Evans, A.; Kelly, C.; King, A. et al.
Source: Self-asserted source
Catherine Arden via Scopus - Elsevier

Pseudoislets as primary islet replacements for research: report on a symposium at King's College London, London UK.

2010 | Journal article
PMID:

21137597

Contributors: Persaud SJ; Arden C; Bergsten P; Bone AJ; Brown J; Dunmore S; Harrison M; Hauge-Evans A; Kelly C; King A et al.
Source: Self-asserted source
Catherine Arden via Europe PubMed Central

A role for PFK-2/FBPase-2, as distinct from fructose 2,6-bisphosphate, in regulation of insulin secretion in pancreatic beta-cells.

2008-04 | Journal article
DOI:

10.1042/BJ20070962

PMID:

18039179

Contributors: Arden C; Hampson LJ; Huang GC; Shaw JA; Aldibbiat A; Holliman G; Manas D; Khan S; Lange AJ; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Inhibition of glucokinase translocation by AMP-activated protein kinase is associated with phosphorylation of both GKRP and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase.

2008-03 | Journal article
DOI:

10.1152/ajpregu.00593.2007

PMID:

18199594

Contributors: Mukhtar MH; Payne VA; Arden C; Harbottle A; Khan S; Lange AJ; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Contributions of glucokinase and phosphofructokinase-2/fructose bisphosphatase-2 to the elevated glycolysis in hepatocytes from Zucker fa/fa rats.

2007-08 | Journal article
DOI:

10.1152/ajpregu.00061.2007

PMID:

17553851

Contributors: Payne VA; Arden C; Lange AJ; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

2007-07 | Journal article
DOI:

10.2337/db06-1151

PMID:

17389332

Contributors: Arden C; Trainer A; de la Iglesia N; Scougall KT; Gloyn AL; Lange AJ; Shaw JA; Matschinsky FM; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Bioactivity of glycogen phosphorylase inhibitors that bind to the purine nucleoside site.

2006-12 | Journal article
DOI:

10.1016/j.bmc.2006.07.060

PMID:

16908161

Contributors: Hampson LJ; Arden C; Agius L; Ganotidis M; Kosmopoulou MN; Tiraidis C; Elemes Y; Sakarellos C; Leonidas DD; Oikonomakos NG
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Increased sensitivity of glycogen synthesis to phosphorylase-a and impaired expression of the glycogen-targeting protein R6 in hepatocytes from insulin-resistant Zucker fa/fa rats.

2006-05 | Journal article
DOI:

10.1111/j.1742-4658.2006.05215.x

PMID:

16640562

Contributors: Arden C; Green AR; Hampson LJ; Aiston S; Härndahl L; Greenberg CC; Brady MJ; Freeman S; Poucher SM; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Glucokinase regulatory protein is associated with mitochondria in hepatocytes.

2006-04 | Journal article
DOI:

10.1016/j.febslet.2006.03.009

PMID:

16542652

Contributors: Arden C; Baltrusch S; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

The role of protein kinase B/Akt in insulin-induced inactivation of phosphorylase in rat hepatocytes.

Diabetologia
2006-01 | Journal article
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Dual role of phosphofructokinase-2/fructose bisphosphatase-2 in regulating the compartmentation and expression of glucokinase in hepatocytes.

2005-07 | Journal article
DOI:

10.2337/diabetes.54.7.1949

PMID:

15983194

Contributors: Payne VA; Arden C; Wu C; Lange AJ; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central
grade
Preferred source (of 2)‎

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation

Diabetes
2004 | Journal article
EID:

2-s2.0-4344707758

Contributors: Arden, C.; Harboottle, A.; Baltrusch, S.; Tiedge, M.; Agius, L.
Source: Self-asserted source
Catherine Arden via Scopus - Elsevier

Glucokinase is an integral component of the insulin granules in glucose-responsive insulin secretory cells and does not translocate during glucose stimulation.

2004-09 | Journal article
PMID:

15331544

Contributors: Arden C; Harbottle A; Baltrusch S; Tiedge M; Agius L
Source: Self-asserted source
Catherine Arden via Europe PubMed Central

Compartmentation and function of glucokinase in insulin secretory granules.

Journal article
OTHER-ID:

407841

Source: Self-asserted source
Catherine Arden via Europe PubMed Central

Peer review (9 reviews for 2 publications/grants)

Review activity for Cell death and disease. (8)
Review activity for Experimental and molecular medicine (1)