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Employment (8)

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2016-11-21 to present | Genetics Health Senior Technician and Researcher (Unidade de Investigação em Patobiologia Molecular (UIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2016-09 to 2016-11 | Research fellowship (Unidade de Investigação em Patobiologia Molecular (UIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2015-03 to 2016-09 | Voluntary Internship (Unidade de Investigação em Patobiologia Molecular (UIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2010-03 to 2014-06 | PhD fellowship (Unidade de Investigação em Patobiologia Molecular (UIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2007-03 to 2009-06 | Research fellowship (Centro de Investigação de Patobiologia Molecular (CIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Instituto de Medicina Molecular: Lisboa, Lisboa, PT

2005-02 to 2007-01 | Research fellowship
Employment
Source: Self-asserted source
Patrícia Silva

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2003-09 to 2005-01 | Curricular Internship (Centro de Investigação de Patobiologia Molecular (CIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2002-09 to 2003-01 | Voluntary internship (Centro de Investigação de Patobiologia Molecular (CIPM))
Employment
Source: Self-asserted source
Patrícia Silva

Education and qualifications (1)

Universidade de Lisboa Faculdade de Ciências: Lisboa, Lisboa, PT

1998-09 to 2004-10 | BSc in Biochemistry (Departamento de Química e Bioquímica (DQB))
Education
Source: Self-asserted source
Patrícia Silva

Funding (23)

Integrated approach to target early colorectal cancer: Validation of candidate biomarkers of metastatic early onset colorectal cancer for longitudinal disease monitoring

2023 to 2025 | Grant
Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisbon, PT)
GRANT_NUMBER:

UIC1169-B-IPO
Source: Self-asserted source
Patrícia Silva

Voomics - Omics approachesto investigate the anticancer properties of colonic metabolites derived from Virgin Olive Oil

2021 to 2025 | Grant
Fundação para a Ciência e Tecnologia (Lisbon, PT)
GRANT_NUMBER:

PTDC/BAA-AGR/4732/2021
Source: Self-asserted source
Patrícia Silva

Integrated approach to target early onset colorectal cancer: from familial risk evaluation to precision therapy

2018 to 2025 | Grant
Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisbon, PT)
GRANT_NUMBER:

UIC1169-FAI2017
Source: Self-asserted source
Patrícia Silva

New genetic variants causing increased cancer risk with impact in diagnosis and treatment (Programme 2), Colorectal Cancer subdivision

2018 to 2023 | Grant
iNOVA4Health (Lisbon, PT)
GRANT_NUMBER:

UIDB/04462/2020
Source: Self-asserted source
Patrícia Silva

Integrated approach to target early onset colorectal cancer: from familial risk evaluation to precision therapy

2018 to 2022 | Grant
Sociedade Portuguesa de Gastrenterologia (Lisbon, PT)
GRANT_NUMBER:

UIC1169_SPG2018
Source: Self-asserted source
Patrícia Silva

Voomics-Omics approaches to investigate the anticancer properties of colonic metabolites derived from Virgin Olive Oil

2018 to 2021 | Grant
Instituto de Tecnologia Química e Biológica, Universidade Nova de Lisboa (Lisbon, PT)
GRANT_NUMBER:

UIC-IBETX
Source: Self-asserted source
Patrícia Silva

DeLIVERy2CTC - Delivery to LIVER metastases and Circulating TUmor Cells (CTCs) for treatment of Wnt driven metastatic colorectal cancer

2018 to 2019 | Grant
Liga Portuguesa contra o Cancro (Lisbon, PT)
GRANT_NUMBER:

LPCC/PT_2018
Source: Self-asserted source
Patrícia Silva

Potencial quimio-terapêutico de extractos naturais de brócolos e agrião-de-água enriquecidos em isotiocianatos na erradicação de células estaminais de cancro do cólon e recto.

2017-06 to 2017-06 | Award
Semana Digestiva 2017 (Lisboa, PT)
GRANT_NUMBER:

PRÉMIO PARA MELHOR COMUNICAÇÃO ORAL DE CIÊNCIA BÁSICA
Source: Self-asserted source
Patrícia Silva

Targeting metastases in colorectal cancer: identification of early biomarkers and development of novel drug delivery therapies

2017 to 2021 | Grant
Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisbon, PT)
GRANT_NUMBER:

UIC1133
Source: Self-asserted source
Patrícia Silva

Molecular profiling and development of novel therapies to target mutated genes in aggressive thyroid and colorectal cancers

2016 to 2021 | Grant
Instituto PortuguÊs de Oncologia de Lisboa Francisco Gentil (Lisbon, PT)
GRANT_NUMBER:

UIC1022
Source: Self-asserted source
Patrícia Silva

COlorectal Carcinogenesis Pathways-Establishing a link between carcinogenesis & therapeutic response

2016 to 2018 | Grant
iNOVA4Health (Lisbon, PT)
GRANT_NUMBER:

iNOVA4Health_2016_IR_CB
Source: Self-asserted source
Patrícia Silva

Molecular profiling and development of novel therapies to target mutated genes in aggressive thyroid and colorectal cancers

2016 to 2018 | Grant
iNOVA4Health - Fundação para a Ciência e Tecnologia (FCT) (Lisbon, PT)
GRANT_NUMBER:

UIC1022-FAI2015
Source: Self-asserted source
Patrícia Silva

OrangeCTherapy - Citrus bioactive compounds for targeting human colorectal cancer stem cells

2016 to 2018 | Grant
iNOVA4Health - Fundação para a Ciência e Tecnologia (FCT) (Lisbon, PT)
GRANT_NUMBER:

iNOVA4Health_ 2015_TS.CA
Source: Self-asserted source
Patrícia Silva

T2C - Development of a novel delivery system (T2C) to Target metastatic colorectal cancer (mCRC)

2016 to 2018 | Grant
iNOVA4Health - Fundação para a Ciência e Tecnologia (FCT) (Lisbon, PT)
GRANT_NUMBER:

iNOVA4Health_2015_CD_CA
Source: Self-asserted source
Patrícia Silva

Familial and individual cancer risk - Identification of novel genes

2013 to 2018 | Grant
Instituto Português de Oncologia de Lisboa Francisco Gentil (Lisbon, PT)
GRANT_NUMBER:

UIC829
Source: Self-asserted source
Patrícia Silva

Identification of biomarkers of metastasis, predictive factors of response to therapy and new therapeutic targets in colon and rectal cancer: study of Wnt/beta-catenin/TCF7L2 alterations

2013 to 2018 | Grant
Fundação para a Ciência e Tecnologia (Lisbon, PT)
GRANT_NUMBER:

IPO_2013_CA
Source: Self-asserted source
Patrícia Silva

Associação de alterações genéticas no gene TCF7L2 no cancro colorectal à progressão tumoral e à metastização.

2012-06 to 2012-06 | Award
Semana Digestiva 2012 - XXXII Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia (Lisbon, PT)
GRANT_NUMBER:

MENÇÃO HONROSA PARA MELHOR COMUNICAÇÃO ORAL DE CIÊNCIA BÁSICA
Source: Self-asserted source
Patrícia Silva

Study of the colonic distribution of APC monoallelic mutations in sporadic colorectal cancer patients

2012 to 2015 | Grant
Merck (Germany) (Darmstadt, DE)
GRANT_NUMBER:

MERCK_2012
Source: Self-asserted source
Patrícia Silva

Resistência à terapêutica no cancro do cólon e recto: contribuição da morte celular e da via de sinalização APC/beta-catenina

2010 to 2015 | Grant
Liga Portuguesa Contra o Cancro (Lisbon, PT)
GRANT_NUMBER:

NRS/LPCC_2010
Source: Self-asserted source
Patrícia Silva

Caracterização molecular da via de tumorigénese hiperplásica/serreada: implicações no diagnóstico genético da polipose hiperplásica e no prognóstico da doença

2007 to 2013 | Grant
Liga Portuguesa Contra o Cancro (Lisbon, PT)
GRANT_NUMBER:

NRS/LPCC_2007
Source: Self-asserted source
Patrícia Silva

Molecular markers of bone metastases

2005 to 2007 | Grant
Novartis (Lisbon, PT)
GRANT_NUMBER:

NOV 2005
Source: Self-asserted source
Patrícia Silva

Apoptose e responta inflamtória na carcinogénese colorectal: interacção entre as vias do p53, APC/beta-catenina e TGF-beta no prognóstico e resistência à terapêutica

2004 to 2009 | Grant
Calouste Gulbenkian Foundation (Lisbon, PT)
GRANT_NUMBER:

FCG_2004
Source: Self-asserted source
Patrícia Silva

In mismatch repair deficiency colorectal cancer are BRAF and KRAS new prognostic and therapeutic tools?

2004 to 2008 | Grant
Fundação para a Ciência e Tecnologia (FCT) (Lisbon, PT)
GRANT_NUMBER:

POCI/SAU-OBS/56921/2004
Source: Self-asserted source
Patrícia Silva

Works (47)

Germline Variants in DNA Interstrand-Cross Link Repair Genes May Contribute to Increased Susceptibility for Serrated Polyposis Syndrome

International Journal of Molecular Sciences
2024-11 | Journal article | Author
DOI: 10.3390/ijms252111848
Contributors: Patrícia Silva; Inês Francisco; Bruno Filipe; PEDRO LAGE; Isadora Rosa; Sofia Fernandes; RICARDO FONSECA; Paula Campos Rodrigues Rodrigues; Joana Parreira; Isabel Claro et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Methylation patterns in dysplasia in inflammatory bowel disease patients

Scandinavian Journal of Gastroenterology
2020-06-02 | Journal article
DOI: 10.1080/00365521.2020.1766552
Part of ISSN: 0036-5521
Part of ISSN: 1502-7708
Contributors: Isadora Rosa; Patrícia Silva; Sara da Mata; Fernando Magro; Fátima Carneiro; Armando Peixoto; Marco Silva; Helena T. Sousa; Joana Roseira; José Parra et al.
Source: Self-asserted source
Patrícia Silva
grade
Preferred source (of 2)‎

Methylation patterns in dysplasia in Inflammatory Bowel Disease patients

15th Congress of ECCO-Inflammatory Bowel Diseases 2020
2020-02-12 | Conference poster
Contributors: Patrícia Silva
Source: Self-asserted source
Patrícia Silva

Mo1868 – Methylation Patterns in Dysplasia in Inflammatory Bowel Disease Patients

Gastroenterology
2019-05 | Conference abstract
DOI: 10.1016/s0016-5085(19)39135-8
Part of ISSN: 0016-5085
Contributors: Isadora Rosa; Patrícia Silva; Sara Mata; Fernando Magro; Fatima Carneiro; Armando Peixoto; Marco Silva; Helena T. Sousa; José Parra; Rita Barosa et al.
Source: Self-asserted source
Patrícia Silva
grade
Preferred source (of 2)‎

Methylation Patterns in Dysplasia in Inflammatory Bowel Disease Patients

Digestive Disease Week
2019-05-18 | Conference poster
Contributors: Patrícia Silva
Source: Self-asserted source
Patrícia Silva

Polymethoxylated Flavones Target Cancer Stemness and Improve the Antiproliferative Effect of 5-Fluorouracil in a 3D Cell Model of Colorectal Cancer.

Nutrients
2019-02 | Journal article
DOI: 10.3390/nu11020326
PMID: 30717428
PMC: PMC6412836
Contributors: Pereira CV; Duarte M; Silva P; Bento da Silva A; Duarte CMM; Cifuentes A; García-Cañas V; Bronze MR; Albuquerque C; Serra AT
Source: Self-asserted source
Patrícia Silva via Europe PubMed Central
grade
Preferred source (of 2)‎

Padrões de metilação na displasia em Doença Inflamatória Intestinal

Reunião Anual GEDII 2019
2019-01-16 | Lecture
Contributors: Patrícia Silva
Source: Self-asserted source
Patrícia Silva

Padrões de hipermetilação na displasia no contexto de doença inflamatória intestinal

Semana Digestiva 2018
2018-06-20 | Lecture
Source: Self-asserted source
Patrícia Silva

Germline Mutations in DNA repair genes may contribute to the susceptibility to multiple adenomas in colon and rectum

3rd ASPIC International Congress
2018-05-10 | Conference poster
Contributors: Patrícia Silva
Source: Self-asserted source
Patrícia Silva

Precision therapy to distinct colorectal cancer subtypes to circunvent resistance to therapy and cancer stemness

3rd ASPIC International Congress
2018-05-10 | Conference poster
Contributors: Patrícia Silva
Source: Self-asserted source
Patrícia Silva

Targeting colorectal cancer proliferation and stemness using phytochemicals from broccoli and watercress in 3D cell models

3rd ASPIC International Congress
2018-05-10 | Conference poster
Contributors: Patrícia Silva
Source: Self-asserted source
Patrícia Silva

Germline variants in DNA interstrand-cross link repair genes may contribute to increased susceptibility for serrated polyposis

InSIGHT 7th Biennial Meeting
2017-07 | Lecture
Source: Self-asserted source
Patrícia Silva

Microsatellite instability-low and loss of heterozigozity in 2p may underlie increased susceptibility for familial rectal cancer

InSIGHT 7th Biennial Meeting
2017-07 | Conference poster
Source: Self-asserted source
Patrícia Silva

Efeito quimioterapêutico de compostos bioactivos derivados dos citrinos – acção sobre células estaminais de cancro colorectal

Semana Digestiva 2017
2017-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Mutações germinais em genes de reparação do DNA podem contribuir para a susceptibilidade para adenomas múltiplos no cólon e recto

Semana Digestiva 2017
2017-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Potencial quimio-terapêutico de extractos naturais de brócolos e agrião-de-água enriquecidos em isotiocianatos na erradicação de células estaminais de cancro do cólon e recto

Semana Digestiva 2017
2017-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Targeting Colorectal Cancer Proliferation, Stemness and Metastatic Potential Using Brassicaceae Extracts Enriched in Isothiocyanates: A 3D Cell Model-Based Study.

Nutrients
2017-04 | Journal article
DOI: 10.3390/nu9040368
PMID: 28394276
PMC: PMC5409707
Contributors: Pereira LP; Silva P; Duarte M; Rodrigues L; Duarte CM; Albuquerque C; Serra AT
Source: Self-asserted source
Patrícia Silva via Europe PubMed Central
grade
Preferred source (of 2)‎

Unveiling chemotherapeutic potential of orange peels and brassica SCF extracts in human colorectal cancer cell spheroids

16th European Meeting on Supercritical Fluids (EMSF)
2017-04 | Conference poster
Source: Self-asserted source
Patrícia Silva

Germline variants in DNA interstrand-cross link repair genes may contribute to increased susceptibility for serrated polyposis

Translating Colorectal Cancer Research Workshop
2017-02 | Conference poster
Source: Self-asserted source
Patrícia Silva

Microsatellite Instability-Low and Loss of Heterozigozity in 2P may associate to increased susceptibility for familial rectal cancer

Translating Colorectal Cancer Research Workshop
2017-02 | Conference poster
Source: Self-asserted source
Patrícia Silva

Effect of citrus polymethoxylated flavones on human colorectal cancer stem cells

1st International Conference on Food Bioactives & Health
2016-09 | Conference poster
Source: Self-asserted source
Patrícia Silva

Exploring the anti-tumoral effect of natural extracts derived from Brassicas using 2D and 3D cell models of colorectal cancer

1st International Conference on Food Bioactives & Health
2016-09 | Conference poster
Source: Self-asserted source
Patrícia Silva

Serrated polyposis associated with a family history of colorectal cancer and/or polyps: The preferential location of polyps in the colon and rectum defines two molecular entities.

International journal of molecular medicine
2016-09 | Journal article
DOI: 10.3892/ijmm.2016.2666
PMID: 27430658
PMC: PMC4990292
Contributors: Silva P; Albuquerque C; Lage P; Fontes V; Fonseca R; Vitoriano I; Filipe B; Rodrigues P; Moita S; Ferreira S et al.
Source: Self-asserted source
Patrícia Silva via Europe PubMed Central
grade
Preferred source (of 2)‎

Instabilidade de microssatélites de baixo grau e perda de heterozigotia em 2p associam-se a susceptibilidade para cancro do recto familiar

Semana Digestiva 2016
2016-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Mutações germinais em genes de reparação de ligações cruzadas no DNA contribuem para a susceptibilidade para polipose serreada

Semana Digestiva 2016
2016-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Germline variants in DNA interstrand-cross link repair genes may contribute to increased susceptibility for Serrated Polyposis

ESO, CNIO and NRCO Conference on Familial Cancer
2016-05 | Lecture
Source: Self-asserted source
Patrícia Silva

Germline variants in DNA interstrand-cross link repair genes may contribute to increased susceptibility for Serrated Polyposis

ESO, CNIO and NRCO Conference on Familial Cancer
2016-05 | Conference poster
Source: Self-asserted source
Patrícia Silva

Microsatellite instability-low and loss of heterozigozity in 2p may underlie increased susceptibility for familial rectal cancer

ESO, CNIO and NRCO Conference on Familial Cancer
2016-05 | Conference poster
Source: Self-asserted source
Patrícia Silva

Germline variants in DNA interstrand-cross link repair genes may contribute to increased susceptibility for Serrated Polyposis

2nd ASPIC International Congress
2016-04 | Conference poster
Source: Self-asserted source
Patrícia Silva

Microsatellite instability-low and loss of heterozigozity in 2p may underlie increased susceptibility for familial rectal cancer

2nd ASPIC International Congress
2016-04 | Conference poster
Source: Self-asserted source
Patrícia Silva

Specific alterations in the TCF7L2 gene correlate with colorectal cancer metastases and poor prognosis

1st ASPIC International Congress
2014-11 | Conference poster
Source: Self-asserted source
Patrícia Silva

Alterations in MMR, MGMT and APC genes suggest the involvement of oxidative stress/alkylating agents errors in the susceptibility to serrated polyposis

6th Familial Cancer Conference
2014-06 | Conference poster
Source: Self-asserted source
Patrícia Silva

Alterações nos genes MMR, MGMT e APC sugerem envolvimento de erros por stress oxidativo na susceptibilidade para a polipose serreada

Semana Digestiva 2014
2014-06 | Conference poster
Source: Self-asserted source
Patrícia Silva

Germline EPCAM-MSH2 large deletion in Lynch syndrome patients: somatic inactivation associated with an aggressive phenotype

6th Familial Cancer Conference
2014-06 | Conference poster
Source: Self-asserted source
Patrícia Silva

Grandes delecções germinais EPCAM-MSH2 em doentes com síndroma de Lynch: inactivação somática associada a um fenótipo agressivo

Semana Digestiva 2014
2014-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Alterações genéticas no gene MGMT: papel importante na iniciação tumoral em formas familiares específicas de polipose serreada

Semana Digestiva 2013 – XXXIII Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia
2013-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Estudo dos genes AXIN2, BMPR1A e MGMT na susceptibilidade para o desenvolvimento de polipose serreada

3º Encontro de Biologia Molecular em Saúde
2013-03 | Conference poster
Source: Self-asserted source
Patrícia Silva

Serrated polyposis with family history of polyps and/or colorectal cancer: a distinct clinical and molecular entity differing between the proximal and the distal colon

16ª Reunião Anual da Sociedade Portuguesa de Genética Humana
2012-11 | Conference poster
Source: Self-asserted source
Patrícia Silva

Serrated polyposis with family history of polyps and/or colorectal cancer: a distinct clinical and molecular entity differing between the proximal and the distal colon

”. A One Day Symposium with Carlos Caldas sponsored by EACR
2012-10-29 | Conference poster
Source: Self-asserted source
Patrícia Silva

A via serreada apresenta alterações moleculares distintas no sistema de reparação do DNA dependendo do contexto clínico

Semana Digestiva 2012 – XXXII Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia
2012-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Associação de alterações genéticas no gene TCF7L2 no cancro colorectal à progressão tumoral e metastização

Semana Digestiva 2012 – XXXII Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia
2012-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Serrated polyposis with family history of colorectal cancer and/or polyps: a distinct clinical and molecular entity differing between the proximal and distal colon

5th Familial Cancer Conference
2012-06 | Conference poster
Source: Self-asserted source
Patrícia Silva

Polipose hiperplásica com história familiar de cancro do cólon e recto e/ou pólipos: uma entidade distinta que difere entre o cólon proximal e distal

Semana Digestiva 2011 – XXXI Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia
2011-06 | Lecture
Source: Self-asserted source
Patrícia Silva

Prognóstico e resposta à terapêutica no cancro do cólon e recto

1º Encontro de Biologia Molecular em Saúde
2011-03 | Conference poster
Source: Self-asserted source
Patrícia Silva

Polipose hiperplásica familiar e esporádica: duas entidades clínica e geneticamente distintas?

XXX Congresso Nacional de Gastrenterologia, Endoscopia Digestiva e Hepatologia
2010-06 | Conference poster
Source: Self-asserted source
Patrícia Silva

Abstracts of the 1st Conference of InSiGHT, the International Society for Gastrointestinal Hereditary Tumors, Newcastle upon Tyne, United Kingdom, 14-17 June 2005.

Familial cancer
2005 | Journal article
PMID: 15889224
Source: Self-asserted source
Patrícia Silva via Europe PubMed Central
grade
Preferred source (of 2)‎

Characterization of genetic alterations involved in the hyperplastic/serrated tumorigenic pathway

1st Conference of the International Society for Gastrointestinal Hereditary Tumours
2005-06 | Lecture
Source: Self-asserted source
Patrícia Silva
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