Albert Gjedde



Albert Gjedde is a Danish-Canadian neuroscientist. He is Professor of Neurobiology and Pharmacology at the Faculty of Health and Medical Sciences, Department of Neuroscience and Pharmacology, at the University of Copenhagen. He is currently also Adjunct Professor of Neurology and Neurosurgery in the Department of Neurology, Montreal Neurological Institute, McGill University, Montreal, Quebec, Canada, and Adjunct Professor of Radiology and Radiological Science in the Division of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University, Baltimore, MD, USA. In Denmark, Albert Gjedde served on the Medical Research Council (FSS) and chaired the Research Advisory Committee of the Royal Library. He also served as deputy on the official Danish Committee on Science Misconduct. In the Nordic countries, he served on the coordinating committee of Nordic medical research councils. In Europe, he served on the standing committee of the European Medical Research Councils of the ESF and currently serves on the Program Committee of the Health theme of Social Challenges program of the Horizon2020 program of the European Commission after service on the precursor committee of the Framework Program, as well as on a panel of the European Research Council. He also serves on the Executive Committee of the European Dana Alliance for the Brain (EDAB) which is affiliated with the Dana Foundation. Albert Gjedde is Fellow of the American Association for the Advancement of Science, The Royal Society of Canada, and the American College of NeuropsychoPharmacology, and Member of the Academy of Europe and the Norwegian Academy of Science and Letters. Born in the Copenhagen suburb of Gentofte in 1946, Albert Gjedde spent time as an undergraduate student in Berkeley, California, USA (1964–65, 1968, 1970), Stellenbosch, Cape Province, South Africa (1967), and Lexington, Kentucky, USA (1969). Albert Gjedde obtained his MD and DSc degrees from Copenhagen University in 1973 and 1983, respectively. He did postdoctoral and internship work in the Neurology Department of the New York Hospital-Cornell Medical Center 1973-76, and he held assistant and associate professorships in Medical Physiology at the University of Copenhagen 1976-1994. As a junior investigator, Albert Gjedde worked as a visiting scientist at universities and research institutions in Lund, Sweden; Cologne, Leipzig and Dresden, Germany, Paris, France, Szeged, Hungary, and Baltimore, MD, USA. In 1986, he joined the McConnell Brain Imaging Center at McGill University in Montreal as Associate and Full Professor from 1986 to 1994 and as Director of the McConnell Brain Imaging Center from 1989 to 1994. In Denmark, Albert Gjedde founded and headed the PET Center at Aarhus University Hospitals in Denmark during the years from 1994 to 2008, and in Aarhus during this period he also founded the Center of Functionally Integrative Neuroscience (CFIN) of the Danish National Science Foundation in 2001 and the Danish Neuroscience Center in 2008, both at Aarhus University. Albert Gjedde joined the University of Copenhagen as Head of Department in 2008. Albert Gjedde’s research focuses on the relations between neuroplasticity and neurotransmission that can be revealed by mapping radioligand binding and the neuroplastic changes of brain functions. The investigations explore the relation between energy metabolism and neurotransmission by recording the changes of energy metabolism and consciousness under pharmacological and other manipulations. He uses PET to understand the synthesis of radioligand and tracer molecules that match the neurotransmitter molecules and the behavior of these transmitters under different functional conditions of the brain, normal as well as pathological, and the spatial and temporal relations among changes of cerebral blood flow, which is commonly used as a measure of brain work, and the cerebral oxygen consumption rate, which is the precise measure of this work. Albert Gjedde’s collaborations focus on experiments with volunteer subjects and patients that explore the lesions and degeneration of brain tissue in disorders such as epilepsy, ludomania, Parkinson's disease, stroke, depression, and somatizing disorders, as well as disorders related to addiction. The experiments test the hypotheses seeking to explain the restructuring of neuronal networks that follows when sensory activity is processed by healthy subjects or by volunteers suffering from inborn or acquired lesions. In 1977, with Clifford Patlak, Albert Gjedde described the Gjedde-Patlak plot, also known as Multitime Graphical Analysis (MTGA), (Gjedde 1981, 1982, Patlak et al. 1983). The MTGA linearizes irreversible brain uptake of tracers in a manner that enables regression estimates to be made of uptake rates. Albert Gjedde's publications number more than 650, more than 350 of those listed in PubMed, with more than 22,000 citations and a Hirsch Index of 67-77, depending on source.

Record last modified Oct 15, 2018 7:58:42 AM