Personal information

Activities

Employment (3)

Kobe Pharmaceutical University: Kobe, JP

2016-04-01 to present | Professor (Laboratory of Bioorganic & Natural Products Chemistry)
Employment
Source: Self-asserted source
Kensuke Okuda

Gifu Yakka Daigaku: Gifu, JP

2008-04-01 to 2016-03-31 | Associate Professor (Laboratory of Pharmaceutical & Medicinal Chemistry)
Employment
Source: Self-asserted source
Kensuke Okuda

Okayama Daigaku: Okayama, JP

1998-04-01 to 2008-03-31 | Research Associate
Employment
Source: Self-asserted source
Kensuke Okuda

Education and qualifications (2)

Tokyo Daigaku: Bunkyo-ku, Tokyo, JP

1994-04-01 to 1996-03-31 | M. A. (Graduate School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Kensuke Okuda

Tokyo Daigaku: Bunkyo-ku, Tokyo, JP

1990-04-01 to 1994-03-31 | B.A. (Faculty of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Kensuke Okuda

Works (50 of 77)

Items per page:
Page 1 of 2

A turn-on fluorescent probe containing a β-ketoester moiety for the selective detection of intracellular hydrazine

RSC Advances
2025 | Journal article
Contributors: Akira Takagi; Ippei Takashima; Kensuke Okuda
Source: check_circle
Crossref

Total Synthesis of Antiausterity Agent Callistrilone O Reveals Promising Antitumor Activity in a Melanoma Homograft Mouse Model

ChemMedChem
2025-02-05 | Journal article
Contributors: Kensuke Okuda; Akira Takagi; Ryohei Shimizu; Kensuke Nishi; Narumi Hayano; Ippei Takashima; Morichika Konishi
Source: check_circle
Crossref

Development of 1,3,6-Tribenzoylated Glucose as an Antiausterity Agent Targeting Tumor Microenvironment

Chemical and Pharmaceutical Bulletin
2023-08-01 | Journal article
Part of ISSN: 0009-2363
Part of ISSN: 1347-5223
Contributors: Akira Takagi; Kazuki Usuguchi; Ippei Takashima; Kensuke Okuda
Source: Self-asserted source
Kensuke Okuda

Advances in reaction-based synthetic fluorescent probes for studying the role of zinc and copper ions in living systems

Journal of Clinical Biochemistry and Nutrition
2023-01-01 | Journal article
Part of ISSN: 0912-0009
Part of ISSN: 1880-5086
Contributors: Kensuke Okuda; Ippei Takashima; Akira Takagi
Source: Self-asserted source
Kensuke Okuda

Total Synthesis of Antiausterity Agent (±)-Uvaridacol L by Regioselective Axial Diacylation of a myo-Inositol Orthoester

Organic Letters
2021-06-04 | Journal article
Contributors: Akira Takagi; Kazuki Usuguchi; Ippei Takashima; Kensuke Okuda
Source: check_circle
Crossref

A fluorogenic probe using a catalytic reaction for the detection of trace intracellular zinc

Chemical Communications
2020 | Journal article
Contributors: Ippei Takashima; Yohei Inoue; Nobuyuki Matsumoto; Akira Takagi; Kensuke Okuda
Source: check_circle
Crossref

Hydrogen sulfide increases copper-dependent neurotoxicity via intracellular copper accumulation

Metallomics
2020 | Journal article
Part of ISSN: 1756-5901
Source: Self-asserted source
Kensuke Okuda

A universal fluorogenic switch for Fe(II) ion based on N-oxide chemistry permits the visualization of intracellular redox equilibrium shift towards labile iron in hypoxic tumor cells

Chemical Science
2017 | Journal article
EID:

2-s2.0-85021748410

Contributors: Hirayama, T.; Tsuboi, H.; Niwa, M.; Miki, A.; Kadota, S.; Ikeshita, Y.; Okuda, K.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Bismuth-rhodamine: a new red light-excitable photosensitizer

Dalton Transactions
2017 | Journal article
Contributors: Tasuku Hirayama; Akari Mukaimine; Kenta Nishigaki; Hitomi Tsuboi; Shusaku Hirosawa; Kensuke Okuda; Masahiro Ebihara; Hideko Nagasawa
Source: check_circle
Crossref

Elucidating the rapid action of 2-(2-chlorophenyl)ethylbiguanide on HT-29 cells under a serum- and glucose-deprived condition

Cell Biology and Toxicology
2017 | Journal article
EID:

2-s2.0-85028870426

Contributors: Oh-hashi, K.; Matsumoto, S.; Sakai, T.; Nomura, Y.; Okuda, K.; Nagasawa, H.; Hirata, Y.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Elucidation of a novel phenformin derivative on glucose-deprived stress responses in HT-29 cells

Molecular and Cellular Biochemistry
2016 | Journal article
EID:

2-s2.0-84978148980

Contributors: Oh-hashi, K.; Irie, N.; Sakai, T.; Okuda, K.; Nagasawa, H.; Hirata, Y.; Kiuchi, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

In vivo retinal and choroidal hypoxia imaging using a novel activatable hypoxia-selective near-infrared fluorescent probe

Graefe's Archive for Clinical and Experimental Ophthalmology
2016 | Journal article
EID:

2-s2.0-84984607942

Contributors: Fukuda, S.; Okuda, K.; Kishino, G.; Hoshi, S.; Kawano, I.; Fukuda, M.; Yamashita, T.; Beheregaray, S.; Nagano, M.; Ohneda, O. et al.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Solution-phase synthesis and biological evaluation of triostin A and its analogues

Organic and Biomolecular Chemistry
2016 | Journal article
EID:

2-s2.0-84983155100

Contributors: Hattori, K.; Koike, K.; Okuda, K.; Hirayama, T.; Ebihara, M.; Takenaka, M.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

A highly sensitive assay of IRE1 activity using the small luciferase NanoLuc: Evaluation of ALS-related genetic and pathological factors

Biochemical and Biophysical Research Communications
2015 | Journal article
EID:

2-s2.0-84936890798

Contributors: Hikiji, T.; Norisada, J.; Hirata, Y.; Okuda, K.; Nagasawa, H.; Ishigaki, S.; Sobue, G.; Kiuchi, K.; Oh-Hashi, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 81: Synthesis and evaluation of pentacyclic 1,2,4,5-tetrahydro[1]benzothieno[2′,3′:6,7]thiepino[4,5-e]imidazo[1,2-c]pyrimidine and related compounds as potential antiplatelet aggregators

Journal of Heterocyclic Chemistry
2015 | Journal article
EID:

2-s2.0-85028196284

Contributors: Okuda, K.; Itzuji, Y.; Hirota, T.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 84: Reaction of N-(pyrido[3',2':4,5]thieno[3,2-d]pyrimidin-4-yl)amidines or N-(pyrido[2',3':4,5]furo[3,2-d]pyrimidin-4-yl)amidines with hydroxylamine hydrochloride

Journal of Heterocyclic Chemistry
2015 | Journal article
EID:

2-s2.0-85027953104

Contributors: Okuda, K.; Ide, R.; Uramaru, N.; Hirota, T.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 85: Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 5,6-dihydro[1]benzazepino[5,4-d]pyrimidine and related compounds

Journal of Heterocyclic Chemistry
2015 | Journal article
EID:

2-s2.0-85027950287

Contributors: Okuda, K.; Zhang, Y.-X.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 86: Synthesis and evaluation of antiplatelet aggregation activity of 2,4-disubstituted 9-chloro-5,6-dihydropyrimido[5,4-d]benzazepine and related compounds

Journal of Heterocyclic Chemistry
2015 | Journal article
EID:

2-s2.0-85028201422

Contributors: Okuda, K.; Takarada, S.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

A new class of high-contrast Fe(ii) selective fluorescent probes based on spirocyclized scaffolds for visualization of intracellular labile iron delivered by transferrin

Organic and Biomolecular Chemistry
2014 | Journal article
EID:

2-s2.0-84905750009

Contributors: Niwa, M.; Hirayama, T.; Okuda, K.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Facile one-pot synthesis of [1,2,3]triazolo[1,5-a]pyridines from 2-acylpyridines by copper(II)-catalyzed oxidative N-N bond formation

Chemistry - A European Journal
2014 | Journal article
EID:

2-s2.0-84897914776

Contributors: Hirayama, T.; Ueda, S.; Okada, T.; Tsurue, N.; Okuda, K.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Optimization of biguanide derivatives as selective antitumor agents blocking adaptive stress responses in the tumor microenvironment

Drug Design, Development and Therapy
2014 | Journal article
EID:

2-s2.0-84902127946

Contributors: Narise, K.; Okuda, K.; Enomoto, Y.; Hirayama, T.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds 76: Synthesis and antiplatelet evaluation of 2,4-disubstituted 5,6-Dihydro[1]benzofuro[3′,2′:2,3] oxepino[4,5-d]pyrimidines

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84901585527

Contributors: Okuda, K.; Takano, J.-I.; Hirota, T.; Sasaki, K.; Nishina, Y.; Ishida, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds 83: Synthesis of 2,4-disubstituted 5,6-dihydro[1]benzofuro[3′,2′:2,3]oxepino[4,5-d]pyrimidines and 2,4,5-Trisubstituted 5,6-Dihydro[1]benzofuro[2′,3′:5,6]pyrano[4,3-d] pyrimidines from 4-Chloro-5,6-dihydro[1]benzofuro[3′,2′:2,3] oxepino[4,5-d]pyrimidines

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84901617283

Contributors: Okuda, K.; Takano, J.-I.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 75: Synthesis of 2,4-disubstituted 5,6-dihydro[1]benzoxepino[5,4-d]pyrimidines and 12-substituted 1,2,4,5-tetrahydro[1]benzoxepino[4,5-e]imidazo[1,2-c]pyrimidines as potential antiplatelet aggregators

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84905003630

Contributors: Okuda, K.; Yamamoto, Y.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 78: Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclohepten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84897466361

Contributors: Okuda, K.; Zhang, Y.-X.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 79: Synthesis of 2,4-disubstituted 6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidines as potential antiplatelet aggregators

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84915737377

Contributors: Okuda, K.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 80: Synthesis and evaluation of effects on in vitro pentosidine formation of 5,6-dihydro[1]benzothieno[3′, 2′:2,3]thiepino[4,5-d]pyrimidine and related compounds

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84904958692

Contributors: Okuda, K.; Itsuji, Y.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 82: Synthesis and evaluation of anti-platelet aggregation activity of 2,4-disubstituted 5,6-dihydro[1] benzothiepino[5,4-d]pyrimidine and related compounds

Journal of Heterocyclic Chemistry
2014 | Journal article
EID:

2-s2.0-84905012104

Contributors: Okuda, K.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

A highly selective turn-on fluorescent probe for iron(ii) to visualize labile iron in living cells

Chemical Science
2013 | Journal article
EID:

2-s2.0-84876719805

Contributors: Hirayama, T.; Okuda, K.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Erratum: FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes (Organic and Biomolecular Chemistry (2013) 11 (3030-3037) DOI: 10.1039/C3OB27445D)

Organic and Biomolecular Chemistry
2013 | Journal article
EID:

2-s2.0-84888122077

Contributors: Tsuji, M.; Ueda, S.; Hirayama, T.; Okuda, K.; Sakaguchi, Y.; Isono, A.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

FRET-based imaging of transbilayer movement of pepducin in living cells by novel intracellular bioreductively activatable fluorescent probes

Organic and Biomolecular Chemistry
2013 | Journal article
EID:

2-s2.0-84879477185

Contributors: Tsuji, M.; Ueda, S.; Hirayama, T.; Okuda, K.; Sakaguchi, Y.; Isono, A.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds 73: Synthesis and evaluation of 5-substituted 1,2-dihydrofuro[2,3-c ]isoquinolines as inducers of lipoprotein lipase mRNA expression

Journal of Heterocyclic Chemistry
2013 | Journal article
EID:

2-s2.0-84876920851

Contributors: Okuda, K.; Yoshida, M.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds, part 77: Synthesis of [1]benzothieno[3',2':2,3]oxepino[4,5-d]pyrimidines and evaluation of their antiplatelet aggregation activity

Synthetic Communications
2013 | Journal article
EID:

2-s2.0-84876212171

Contributors: Okuda, K.; Nikaido, T.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

10'-Chloro-3′,4′-dihydro-2′H-spiro[cyclopropane-1, 7'(6′H)-pyrimido[2,1-a]isoquinolin]-6′-one

Acta Crystallographica Section E: Structure Reports Online
2012 | Journal article
EID:

2-s2.0-84870894778

Contributors: Okuda, K.; Hirota, T.; Nishina, Y.; Ishida, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

2-nitroimidazole-tricarbocyanine conjugate as a near-infrared fluorescent probe for in vivo imaging of tumor hypoxia

Bioconjugate Chemistry
2012 | Journal article
EID:

2-s2.0-84858716043

Contributors: Okuda, K.; Okabe, Y.; Kadonosono, T.; Ueno, T.; Youssif, B.G.M.; Kizaka-Kondoh, S.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

3-(2-Oxo-2,3,4,5-tetrahydrofuran-3-yl)-1-benzofuran-2-carbonitrile

Acta Crystallographica Section E: Structure Reports Online
2012 | Journal article
EID:

2-s2.0-84865801396

Contributors: Okuda, K.; Hirota, T.; Nishina, Y.; Ishida, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Development of a hypoxia-selective near-infrared fluorescent probe for non-invasive tumor imaging

Chemical and Pharmaceutical Bulletin
2012 | Journal article
EID:

2-s2.0-84857831944

Contributors: Youssif, B.G.M.; Okuda, K.; Kadonosono, T.; Salem, O.I.A.R.; Hayallah, A.A.M.; Hussein, M.A.; Kizaka-Kondoh, S.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds 74: Rearrangement reaction of 5-amino-1,2-dihydrofuro[2,3-c]isoquinolines with α, ω-dibromoalkanes and evaluation of product bronchodilator activity

Synthetic Communications
2012 | Journal article
EID:

2-s2.0-84055177653

Contributors: Okuda, K.; Yoshida, M.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds, part 69: Synthesis of 5-amino-1,2-dihydro[1]benzofuro[3,2-d]furo[2,3-b]pyridines and their transformations to related compounds

Journal of Heterocyclic Chemistry
2012 | Journal article
EID:

2-s2.0-84860627556

Contributors: Okuda, K.; Takano, J.-I.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds, part 71: Synthesis and bronchodilator evaluation of 5-substituted 1,2-dihydrofuro[3,2-f][1,7]naphthyridines and related compounds

Journal of Heterocyclic Chemistry
2012 | Journal article
EID:

2-s2.0-84866242970

Contributors: Okuda, K.; Matsushita, T.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds, part 72: Reaction of N-([1]benzofuro (or benzothieno)[3,2-d]pyrimidin-4-yl)formamidine and N-(pyrido[2,3-d]pyrimidin- 4-yl)formamidine derivatives with hydroxylamine hydrochloride

Journal of Heterocyclic Chemistry
2012 | Journal article
EID:

2-s2.0-84866235132

Contributors: Okuda, K.; Tsuchie, K.; Hirota, T.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Isolation, identification, and biological evaluation of HIF-1-modulating compounds from Brazilian green propolis

Bioorganic and Medicinal Chemistry
2011 | Journal article
EID:

2-s2.0-80052601576

Contributors: Hattori, H.; Okuda, K.; Murase, T.; Shigetsura, Y.; Narise, K.; Semenza, G.L.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds, part 67: Reaction of 6,7-substituted N-(quinazolin-4-yl)amidine derivatives with hydroxylamine hydrochloride: Formation of in vitro inhibitors of pentosidine

Journal of Heterocyclic Chemistry
2011 | Journal article
EID:

2-s2.0-81855218598

Contributors: Okuda, K.; Muroyama, H.; Hirota, T.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic n-heterocyclic compounds, part 68: Reactions of 3-(2-bromoethyl)quinazolin-4(3H)-one and 3-(2-bromoethyl)-5,6,7,8- tetrahydroquinazolin-4(3H)-one with primary alkylamines via a dimroth-type rearrangement

Synthetic Communications
2011 | Journal article
EID:

2-s2.0-79952075439

Contributors: Okuda, K.; Ohtomo, H.; Tagata, T.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 66: Synthesis of N-[2-([1,2,4]oxadiazol-5-yl)cyclopenten-1-yl]formamide oximes and their evaluation as inhibitors of platelet aggregation

Journal of Heterocyclic Chemistry
2011 | Journal article
EID:

2-s2.0-79957533807

Contributors: Okuda, K.; Zhang, Y.-X.; Ohtomo, H.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 70: Synthesis of 5-amino-1,2-dihydrofuro[2,3-b]pyrido[3',2':4,5]-thieno[3,2-d]pyridines and related compounds. Evaluation of effects on lipoprotein lipase mRNA expression

Heterocycles
2011 | Journal article
EID:

2-s2.0-79957638334

Contributors: Okuda, K.; Takechi, H.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Synthesis and evaluation of cyclic RGD-boron cluster conjugates to develop tumor-selective boron carriers for boron neutron capture therapy

Bioorganic and Medicinal Chemistry
2011 | Journal article
EID:

2-s2.0-79952196352

Contributors: Kimura, S.; Masunaga, S.-I.; Harada, T.; Kawamura, Y.; Ueda, S.; Okuda, K.; Nagasawa, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

7-Chloro-1,2-dihydro-furo[2,3-c]isoquinolin-5-amine

Acta Crystallographica Section E: Structure Reports Online
2010 | Journal article
EID:

2-s2.0-78650959460

Contributors: Okuda, K.; Hirota, T.; Sasaki, K.; Ishida, H.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 61: A novel Truce-Smiles type rearrangement reaction of 4-(2-cyanovinyloxy)butanenitriles to give cycloalkeno[1,2-d]furo[2,3-b]pyridines

Tetrahedron Letters
2010 | Journal article
EID:

2-s2.0-73249146107

Contributors: Okuda, K.; Watanabe, N.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier

Polycyclic N-heterocyclic compounds. Part 621: Reaction of N-(quinazolin-4-yl)amidine derivatives with hydroxylamine hydrochloride and anti-platelet aggregation activity of the products

Chemical and Pharmaceutical Bulletin
2010 | Journal article
EID:

2-s2.0-77649265069

Contributors: Okuda, K.; Zhang, Y.-X.; Ohtomo, H.; Hirota, T.; Sasaki, K.
Source: Self-asserted source
Kensuke Okuda via Scopus - Elsevier
Items per page:
Page 1 of 2

Peer review (1 review for 1 publication/grant)

Review activity for Molecular and cellular biochemistry. (1)