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ResearcherID: HLG-6725-2023

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Japan

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Employment (2)

Tokyo University of Pharmacy and Life Sciences: Hachiōji, JP

2020-09-01 to present (Laboratory of Oncology, School of Life Scineces)
Employment
Source: Self-asserted source
Hiroki Kobayashi

RIKEN CSRS: Wako, JP

2011-04-01 to 2020-08-31
Employment
Source: Self-asserted source
Hiroki Kobayashi

Education and qualifications (1)

Keio University: Yokohama, JP

2008-04-01 to 2011-03-31 | Ph. D.
Education
Source: Self-asserted source
Hiroki Kobayashi

Works (16)

Asymmetric Synthesis, Structure Determination, and Biologic Evaluation of Isomers of TLAM as PFK1 Inhibitors

ACS Medicinal Chemistry Letters
2025-01-09 | Journal article
DOI: 10.1021/acsmedchemlett.4c00436
Contributors: Ryo Kakehi; Hiroki Kobayashi; Haruna Mashiyama; Tatsuo Yajima; Hiroo Koyama; Takashi K. Ito; Minoru Yoshida; Yasuo Nagaoka; Takaaki Sumiyoshi
Source: check_circle
Crossref

IL36G-producing neutrophil-like monocytes promote cachexia in cancer

Nature Communications
2024-09-12 | Journal article
DOI: 10.1038/s41467-024-51873-x
Contributors: Yoshihiro Hayashi; Yasushige Kamimura-Aoyagi; Sayuri Nishikawa; Rena Noka; Rika Iwata; Asami Iwabuchi; Yushin Watanabe; Natsumi Matsunuma; Kanako Yuki; Hiroki Kobayashi et al.
Source: check_circle
Crossref

HMGA2 promotes platelet-neutrophil complex formation and pulmonary tissue damage in myelodysplastic syndromes

Blood Vessels, Thrombosis & Hemostasis
2024-06 | Journal article
DOI: 10.1016/j.bvth.2024.100014
Contributors: Natsumi Matsunuma; Yoshihiro Hayashi; Marina Fukuda; Kanako Yuki; Yasushige Kamimura-Aoyagi; Hiroki Kobayashi; Naoki Shingai; Yuka Harada; Hironori Harada
Source: check_circle
Crossref

RNAi screening reveals a synthetic chemical–genetic interaction between ATP synthase and PFK1 in cancer cells

Cancer Science
2023-04 | Journal article
DOI: 10.1111/cas.15713
Contributors: Hiroki Kobayashi; Shohei Takase; Haruna Nishimura; Ken Matsumoto; Hironori Harada; Minoru Yoshida
Source: check_circle
Crossref

Isoquercitrin from Apocynum venetum L. produces an anti-obesity effect on obese mice by targeting C-1-tetrahydrofolate synthase, carbonyl reductase, and glutathione S-transferase P and modification of the AMPK/SREBP-1c/FAS/CD36 signaling pathway in mice in vivo

Food & Function
2022 | Journal article
DOI: 10.1039/d2fo02438a
Part of ISSN: 2042-6496
Part of ISSN: 2042-650X
Contributors: Majid Manzoor; Makoto MUROI; Naoko Ogawa; Hiroki Kobayashi; Haruna Nishimura; Danni Chen; Opeyemi Fasina; Jianyu Wang; Hiroyuki Osada; Minoru Yoshida et al.
Source: Self-asserted source
Hiroki Kobayashi

Chemical reversal of abnormalities in cells carrying mitochondrial DNA mutations

Nature Chemical Biology
2021-03-09 | Journal article
DOI: 10.1038/s41589-020-00676-4
Contributors: Hiroki Kobayashi; Hideyuki Hatakeyama; Haruna Nishimura; Mutsumi Yokota; Sadafumi Suzuki; Yuri Tomabechi; Mikako Shirouzu; Hiroyuki Osada; Masakazu Mimaki; Yu-ichi Goto et al.
Source: check_circle
Crossref

Unified synthesis and assessment of tumor cell migration inhibitory activity of optically active UTKO1, originally designed moverastin analog

Bioscience, Biotechnology, and Biochemistry
2021-01-07 | Journal article
DOI: 10.1093/bbb/zbaa062
Contributors: Yusuke Ogura; Hiroki Kobayashi; Masaya Imoto; Hidenori Watanabe; Hirosato Takikawa
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

A novel GSK3 inhibitor that promotes self-renewal in mouse embryonic stem cells

Bioscience, Biotechnology, and Biochemistry
2020-10-02 | Journal article
DOI: 10.1080/09168451.2020.1789445
Contributors: Hiroki Kobayashi; Haruna Nishimura; Norio Kudo; Hiroyuki Osada; Minoru Yoshida
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Identification of the determinants of 2-deoxyglucose sensitivity in cancer cells by shRNA library screening

Biochemical and Biophysical Research Communications
2015-11 | Journal article
DOI: 10.1016/j.bbrc.2015.09.106
Part of ISSN: 0006-291X
Source: Self-asserted source
Hiroki Kobayashi

5-Lipoxygenase and cysteinyl leukotriene receptor 1 regulate epidermal growth factor-induced cell migration through Tiam1 upregulation and Rac1 activation

Cancer Science
2014-03 | Journal article
DOI: 10.1111/cas.12340
Part of ISSN: 1347-9032
Source: Self-asserted source
Hiroki Kobayashi

Comprehensive predictions of target proteins based on protein-chemical interaction using virtual screening and experimental verifications

BMC Chemical Biology
2012 | Journal article
DOI: 10.1186/1472-6769-12-2
Part of ISSN: 1472-6769
Source: Self-asserted source
Hiroki Kobayashi

Involvement of 14-3-3 Proteins in the Second Epidermal Growth Factor-induced Wave of Rac1 Activation in the Process of Cell Migration

Journal of Biological Chemistry
2011-11-11 | Journal article
DOI: 10.1074/jbc.m111.255489
Part of ISSN: 0021-9258
Part of ISSN: 1083-351X
Source: Self-asserted source
Hiroki Kobayashi

Synthesis and anti-migrative evaluation of moverastin derivatives

Bioorganic & Medicinal Chemistry Letters
2011-03 | Journal article
DOI: 10.1016/j.bmcl.2011.01.028
Part of ISSN: 0960-894X
Source: Self-asserted source
Hiroki Kobayashi

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition

Autophagy
2011-02 | Journal article
DOI: 10.4161/auto.7.2.14074
Part of ISSN: 1554-8627
Part of ISSN: 1554-8635
Source: Self-asserted source
Hiroki Kobayashi

Isolation and structure elucidation of a novel androgen antagonist, arabilin, produced by Streptomyces sp. MK756-CF1

The Journal of Antibiotics
2010-10 | Journal article
DOI: 10.1038/ja.2010.98
Part of ISSN: 0021-8820
Part of ISSN: 1881-1469
Source: Self-asserted source
Hiroki Kobayashi

Integrating Statistical Predictions and Experimental Verifications for Enhancing Protein-Chemical Interaction Predictions in Virtual Screening

PLoS Computational Biology
2009-06-05 | Journal article
DOI: 10.1371/journal.pcbi.1000397
Part of ISSN: 1553-7358
Source: Self-asserted source
Hiroki Kobayashi

Peer review (11 reviews for 4 publications/grants)

Review activity for Biochimica et biophysica acta (4)
Review activity for Cancer science. (2)
Review activity for Journal of antibiotics. (2)
Review activity for Scientific reports. (3)
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