Personal information

heart; calcium
United States

Activities

Employment (6)

Tianjin Medical University: Tianjin, Tianjin, CN

2021-03 to present | Professor, Dean (School of Pharmacy)
Employment
Source: Self-asserted source
Xiongwen Chen

Temple University: PA, PA, US

2020-07 to 2021-03 | Professor (Cardiovascular Research Center)
Employment
Source: Self-asserted source
Xiongwen Chen

Temple University School of Medicine: Philadelphia, PA, US

2014-07 to 2020-06-30 | Assoicate Professor (Physiology and Cardiovascular Research Center)
Employment
Source: Self-asserted source
Xiongwen Chen

Temple University School of Medicine: Philadelphia, PA, US

2008-07 to 2014-06 | Assistant Professor (Physiology and Cardiovascular Research Center)
Employment
Source: Self-asserted source
Xiongwen Chen

Temple University: Philadelphia, PA, US

2006-07 to 2008-06 | Research Assistant Professor (Cardiovascular Research Center)
Employment
Source: Self-asserted source
Xiongwen Chen

Temple University: Philadelphia, PA, US

2003-03 to 2006-06 | Post-doctoral fellow (Cardiovascular Research Center)
Employment
Source: Self-asserted source
Xiongwen Chen

Education and qualifications (3)

Temple University: Philadelphia, PA, US

1997-09 to 2003-03 | PhD (Physiology)
Education
Source: Self-asserted source
Xiongwen Chen

China Agricultural University: Beijing, Beijing, CN

1994-09 to 1997-06 | MS (Animal Physiology and Biochemistry)
Education
Source: Self-asserted source
Xiongwen Chen

China Agricultural University: Beijing, Bejing, CN

1990-09 to 1994-06 | B.S. (Animal Physiology and Biochemistry)
Education
Source: Self-asserted source
Xiongwen Chen

Works (50 of 195)

Items per page:
Page 1 of 4

Effects of maternal hypothyroidism on postnatal cardiomyocyte proliferation and cardiac disease responses of the progeny.

American journal of physiology. Heart and circulatory physiology
2023-08-04 | Journal article | Author
Contributors: Yi-Jia Li; Johnson JP; Yijun Yang; Yu D; Hajime Kubo; Berretta RM; Wang T; Xiaoying Zhang; Foster M; Jun Yu et al.
Source: Self-asserted source
Xiongwen Chen

Combining three independent pathological stressors induces a heart failure with preserved ejection fraction phenotype.

American journal of physiology. Heart and circulatory physiology
2023-02-10 | Journal article | Author
Contributors: Yi-Jia Li; Hajime Kubo; Yu D; Yijun Yang; Johnson JP; Eaton DM; Berretta RM; Foster M; Timothy; Yu J et al.
Source: Self-asserted source
Xiongwen Chen

Renin-angiotensin system inhibition and In-hospital mortality in acute coronary syndrome patients with advanced renal dysfunction: Findings from CCC-ACS project and a nationwide electronic health record-based cohort in China.

European heart journal. Quality of care & clinical outcomes
2023-02-02 | Journal article
Contributors: Li Z; Sun H; Hao Y; Liu H; Jin Z; Li L; Zhang C; Ma M; Teng T; Chen X et al.
Source: Self-asserted source
Xiongwen Chen

Gender differences in bicuspid aortic valve Sievers types, valvulopathy, aortopathy, and outcome of aortic valve replacement.

Echocardiography (Mount Kisco, N.Y.)
2022-06-29 | Journal article
Contributors: Xiongwen Chen; Yi-Jia Li; Chen X; Qi Y; Qu Y; Kumar A; Dong S; Yang Y; Zhao Q
Source: Self-asserted source
Xiongwen Chen

Editorial: Cardiac Hypertrophy: From Compensation to Decompensation and Pharmacological Interventions.

Frontiers in pharmacology
2021-04-26 | Journal article
Contributors: Xiongwen Chen; Liu Y; Chen X; Zhang HG
Source: Self-asserted source
Xiongwen Chen

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)<sup>1</sup>.

Autophagy
2021-01-01 | Journal article
Contributors: Xiongwen Chen; Klionsky DJ; Amal Kamal Abdel-Aziz; Abdelfatah S; Abdellatif M; Abdoli A; Abel S; Abeliovich H; Abildgaard MH; Yakubu Princely Abudu et al.
Source: Self-asserted source
Xiongwen Chen

A low voltage activated Ca<sup>2+</sup> current found in a subset of human ventricular myocytes.

Channels (Austin, Tex.)
2020-12-01 | Journal article
Contributors: Xiongwen Chen; Zhang X; Li Y; Xiaoying Zhang; Piacentino V 3rd; Harris DM; Berretta R; Margulies KB; Houser SR; Chen X
Source: Self-asserted source
Xiongwen Chen

Protein Kinase Inhibitor Peptide as a Tool to Specifically Inhibit Protein Kinase A.

Frontiers in physiology
2020-11-25 | Journal article
Contributors: Xiongwen Chen; Liu C; Ke P; Zhang J; Zhang X; Chen X
Source: Self-asserted source
Xiongwen Chen

Interaction of the Joining Region in Junctophilin-2 With the L-Type Ca<sup>2+</sup> Channel Is Pivotal for Cardiac Dyad Assembly and Intracellular Ca<sup>2+</sup> Dynamics.

Circulation research
2020-10-23 | Journal article
Contributors: Xiongwen Chen; Gross P; Johnson J; Romero CM; Deborah M. Eaton; Poulet C; Sanchez-Alonso J; Lucarelli C; Ross J; Andrew Gibb et al.
Source: Self-asserted source
Xiongwen Chen

miR-301a-PTEN-AKT Signaling Induces Cardiomyocyte Proliferation and Promotes Cardiac Repair Post-MI.

Molecular therapy. Nucleic acids
2020-08-29 | Journal article
Contributors: Xiongwen Chen; Zhen L; Zhao Q; Lü J; Deng S; Xu Z; Zhang L; Zhang Y; Fan H; Chen X et al.
Source: Self-asserted source
Xiongwen Chen

Bazedoxifene Regulates Th17 Immune Response to Ameliorate Experimental Autoimmune myocarditis via Inhibition of STAT3 Activation.

Frontiers in pharmacology
2020-01-01 | Journal article
Contributors: Xiongwen Chen; Wang J; Liu T; Chen X; Qiaofeng Jin; Chen Y; Zhang L; Han Z; Chen D; Li Y et al.
Source: Self-asserted source
Xiongwen Chen

Hepatic PKA inhibition accelerates the lipid accumulation in liver.

Nutrition & metabolism
2019-10-11 | Journal article
Contributors: Xiongwen Chen; Yang J; Zhang X; Yi L; Yang L; Wang WE; Zeng C; Mi M; Chen X
Source: Self-asserted source
Xiongwen Chen

Cardiomyocyte PKA Ablation Enhances Basal Contractility While Eliminates Cardiac β-Adrenergic Response Without Adverse Effects on the Heart.

Circulation research
2019-04-15 | Journal article
Contributors: Xiongwen Chen; Zhang Y; Wang WE; Zhang X; Li Y; Chen B; Liu C; Ai X; Zhang X; Tian Y et al.
Source: Self-asserted source
Xiongwen Chen

Acetylation of SERCA2a, Another Target for Heart Failure Treatment?

Circulation research
2019-04-01 | Journal article
Contributors: Xiongwen Chen; Chen X; Zhang X; Scott Gross; Houser SR; Soboloff J
Source: Self-asserted source
Xiongwen Chen

Fatty Acid Oxidation Promotes Cardiomyocyte Proliferation Rate but Does Not Change Cardiomyocyte Number in Infant Mice.

Frontiers in cell and developmental biology
2019-03-22 | Journal article
Contributors: Xiongwen Chen; Cao T; Liccardo D; LaCanna R; Zhang X; Lu R; Brian N. Finck; Leigh T; Chen X; Konstantinos Drosatos et al.
Source: Self-asserted source
Xiongwen Chen

Preclinical cardiovascular changes in children with obesity: A real-time 3-dimensional speckle tracking imaging study.

PloS one
2018-10-11 | Journal article
Contributors: Xiongwen Chen; Zhang C; Deng Y; Liu Y; Xu Y; Liu Y; Zhang L; Chen X; Xie M; Shuping Ge
Source: Self-asserted source
Xiongwen Chen

A cellular mechanism of muscle memory facilitates mitochondrial remodelling following resistance training.

The Journal of physiology
2018-08-12 | Journal article
Contributors: Xiongwen Chen; Hojun Lee; Kim K; Kim B; junchul Shin ; Rajan S; Wu J; Chen X; Brown MD; Lee S et al.
Source: Self-asserted source
Xiongwen Chen

A novel porcupine inhibitor blocks WNT pathways and attenuates cardiac hypertrophy.

Biochimica et biophysica acta. Molecular basis of disease
2018-08-01 | Journal article
Contributors: Xiongwen Chen; Jiang J; Lan C; Li L; Yang D; Xia X; Liao Q; Fu W; Chen X; An S et al.
Source: Self-asserted source
Xiongwen Chen

Gastrin Protects Against Myocardial Ischemia/Reperfusion Injury via Activation of RISK (Reperfusion Injury Salvage Kinase) and SAFE (Survivor Activating Factor Enhancement) Pathways.

Journal of the American Heart Association
2018-07-12 | Journal article
Contributors: Xiongwen Chen; Yang X; Yue R; Zhang J; Zhang X; Liu Y; Chen C; Wang X; Luo H; Wang WE et al.
Source: Self-asserted source
Xiongwen Chen

Intestinal Autophagy and Its Pharmacological Control in Inflammatory Bowel Disease

Front Immunol
2017 | Journal article
Source: Self-asserted source
Xiongwen Chen

Metformin promotes the survival of transplanted cardiosphere-derived cells thereby enhancing their therapeutic effect against myocardial infarction.

Stem Cell Res Ther
2017 | Journal article
Source: Self-asserted source
Xiongwen Chen
grade
Preferred source (of 2)‎

Neonatal Transplantation Confers Maturation of PSC-Derived Cardiomyocytes Conducive to Modeling Cardiomyopathy.

Cell Report
2017 | Journal article
Source: Self-asserted source
Xiongwen Chen

Therapeutic effect of a novel Wnt pathway inhibitor on cardiac regeneration after myocardial infarction.

Clinical science (London, England : 1979)
2017-12-08 | Journal article
Contributors: Xiongwen Chen; Yang D; Fu W; Li L; Xia X; Liao Q; Yue R; Chen H; Chen X; An S et al.
Source: Self-asserted source
Xiongwen Chen

Activating α7 nicotinic acetylcholine receptor inhibits NLRP3 inflammasome through regulation of β-arrestin-1.

CNS neuroscience & therapeutics
2017-09-21 | Journal article
Contributors: Xiongwen Chen; ping ke; Shao BZ; Xu ZQ; Chen XW; Wei W; Liu C
Source: Self-asserted source
Xiongwen Chen

Remodeling of repolarization and arrhythmia susceptibility in a myosin-binding protein C knockout mouse model.

American journal of physiology. Heart and circulatory physiology
2017-06-23 | Journal article
Contributors: Xiongwen Chen; Toib A; Zhang C; Borghetti G; Zhang X; Markus Wallner; Yang Y; Troupes CD; Kubo H; Sharp TE et al.
Source: Self-asserted source
Xiongwen Chen

Dedifferentiation, Proliferation, and Redifferentiation of Adult Mammalian Cardiomyocytes After Ischemic Injury.

Circulation
2017-06-22 | Journal article
Contributors: Xiongwen Chen; Wang WE; Li L; Xia X; Fu W; Liao Q; Lan C; Yang D; Chen H; Yue R et al.
Source: Self-asserted source
Xiongwen Chen

Role of STIM1 (Stromal Interaction Molecule 1) in Hypertrophy-Related Contractile Dysfunction.

Circulation research
2017-06-07 | Journal article
Contributors: Xiongwen Chen; Troupes CD; Markus Wallner; Borghetti G; Zhang C; Mohsin S; Dirk von Lewinski; Berretta RM; Kubo H; Chen X et al.
Source: Self-asserted source
Xiongwen Chen

Caveolae-localized L-type Ca2+ channels do not contribute to function or hypertrophic signalling in the mouse heart.

Cardiovascular research
2017-06-01 | Journal article
Contributors: Xiongwen Chen; Correll RN; Makarewich CA; Zhang H; Zhang C; Sargent MA; York AJ; Berretta RM; Chen X; Houser SR et al.
Source: Self-asserted source
Xiongwen Chen

Autophagy Plays an Important Role in Anti-inflammatory Mechanisms Stimulated by Alpha7 Nicotinic Acetylcholine Receptor.

Frontiers in immunology
2017-05-16 | Journal article
Contributors: Xiongwen Chen; Shao BZ; Ke P; Xu ZQ; Wei W; Cheng MH; Han BZ; Chen XW; Su DF; Liu C
Source: Self-asserted source
Xiongwen Chen

Reduced Myocardial Reserve in Young X-Linked Muscular Dystrophy Mice Diagnosed by Two-Dimensional Strain Analysis Combined with Stress Echocardiography.

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography
2017-05-13 | Journal article
Contributors: Xiongwen Chen; Li Z; Li Y; Zhang L; Zhang X; Sullivan R; Ai X; Szeto C; Cai A; Liu L et al.
Source: Self-asserted source
Xiongwen Chen

The mitochondrial Na<sup>+</sup>/Ca<sup>2+</sup> exchanger is essential for Ca<sup>2+</sup> homeostasis and viability.

Nature
2017-04-26 | Journal article
Contributors: Xiongwen Chen; Timothy Luongo; Jonathan P Lambert; Gross P; Nwokedi M; Lombardi AA; Santhanam Shanmughapriya; Carpenter AC; Kolmetzky D; Gao E et al.
Source: Self-asserted source
Xiongwen Chen

Analyses of caspase-1-regulated transcriptomes in various tissues lead to identification of novel IL-1β-, IL-18- and sirtuin-1-independent pathways.

Journal of hematology & oncology
2017-02-02 | Journal article
Contributors: Xiongwen Chen; Li YF; Nanayakkara G; Sun Y; Li X; Wang L; Cueto R; Shao Y; Fu H; Johnson C et al.
Source: Self-asserted source
Xiongwen Chen

A Novel Mechanism For Regenerating Functional Mammalian Cardiomyocytes After Ischemic Injury

CIRCULATION RESEARCH
2016 | Conference paper
Source: Self-asserted source
Xiongwen Chen

A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle

Science
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

Activation of Cannabinoid Receptor 2 Ameliorates DSS-Induced Colitis through Inhibiting NLRP3 Inflammasome in Macrophages.

PLoS One
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

Cavbeta2a Overexpression in Smooth Muscle Causes Hypertension via Impairment of Acetylcholine-dependent Vascular Relaxation

2016 | Other
Source: Self-asserted source
Xiongwen Chen

Combined administration of anisodamine and neostigmine rescued acute lethal crush syndrome through $α$7nAChR-dependent JAK2-STAT3 signaling

Sci Rep.
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

Crucial Role of miR-433 in Regulating Cardiac Fibrosis

Theranostics.
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

cTnI Exacerbates Myocardial Ischemia/Reperfusion Injury by Inducing Adhesion of Monocytes to VECs via TLR4/NF-$κ$B-dependent Pathway.

Clin Sci (Lond).
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

How to Improve the Survival of Transplanted Mesenchymal Stem Cell in Ischemic Heart?

2016 | Journal article
Contributors: Li L; Chen X; Wang WE; Zeng C
Source: Self-asserted source
Xiongwen Chen via Europe PubMed Central

Increased Ca2+ Influx Through Cav1. 2 in Vascular Smooth Muscle Cells Causes Hypertension Due to Impairment of Acetylcholine-dependent Vascular Relaxation

2016 | Other
Source: Self-asserted source
Xiongwen Chen

Loss of Trpc6 Function in Cardiomyocytes Improves Survival and Attenuates Progression of Cardiac Dysfunction After Mi

2016 | Other
Source: Self-asserted source
Xiongwen Chen

Persistent increases in Ca2+ influx through Cav1. 2 shortens action potential and causes Ca2+ overload-induced afterdepolarizations and arrhythmias

Basic research in cardiology
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

Pkialpha Protects Hearts From Beta-adrenergic Overstimulation

2016 | Other
Source: Self-asserted source
Xiongwen Chen

Protease-activated receptor 4 deficiency offers cardioprotection after acute ischemia reperfusion injury.

J Mol Cell Cardiol.
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen
grade
Preferred source (of 2)‎

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors.

Mol Ther Methods Clin Dev.
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen
grade
Preferred source (of 2)‎

Targeting HO-1 by Epigallocatechin-3-Gallate Reduces Contrast-Induced Renal Injury via Anti-Oxidative Stress and Anti-Inflammation Pathways.

PLoS One
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

With or Without Langendorff: A New Method for Adult Myocyte Isolation to Be Tested With Time

Circ Res
2016 | Journal article
Source: Self-asserted source
Xiongwen Chen

Circulating "lncRNA OTTHUMT00000387022" from Monocytes as a Novel Biomarker for Coronary Artery Disease.

2016-02 | Journal article
Contributors: Cai Y; Yang Y; Chen X; Wu G; Zhang X; Liu Y; Yu J; Wang X; Fu J; Li C et al.
Source: Self-asserted source
Xiongwen Chen via Europe PubMed Central

Muscle physiology. A peptide encoded by a transcript annotated as long noncoding RNA enhances SERCA activity in muscle.

2016-01 | Journal article
Contributors: Nelson BR; Makarewich CA; Anderson DM; Winders BR; Troupes CD; Wu F; Reese AL; McAnally JR; Chen X; Kavalali ET et al.
Source: Self-asserted source
Xiongwen Chen via Europe PubMed Central
Items per page:
Page 1 of 4

Peer review (2 reviews for 2 publications/grants)

Review activity for PloS one. (1)
Review activity for Signal transduction and targeted therapy. (1)