Personal information

Activities

Collapse all

Works (8)

SAR Matrices Enable Discovery of Mixed Efficacy μ-Opioid Receptor Agonist Peptidomimetics with Simplified Structures through an Aromatic-Amine Pharmacophore

ACS Chemical Neuroscience
2021-01-06 | Journal article
DOI: 10.1021/acschemneuro.0c00693
Contributors: Sean Henry; Jessica P. Anand; Ashley C. Brinkel; Douglas M. McMillan; Jack. J. Twarozynski; Christian E. Loo; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Incorporation of Agouti-Related Protein (AgRP) Human Single Nucleotide Polymorphisms (SNPs) in the AgRP-Derived Macrocyclic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Decreases Melanocortin-4 Receptor Antagonist Potency and Results in the Discovery of Melanocortin-5 Receptor Antagonists

Journal of Medicinal Chemistry
2020-03-12 | Journal article
DOI: 10.1021/acs.jmedchem.9b00860
Contributors: Zoe M. Koerperich; Mark D. Ericson; Katie T. Freeman; Robert C. Speth; Irina D. Pogozheva; Henry I. Mosberg; Carrie Haskell-Luevano
Source: check_circle
Crossref

Aromatic–Amine Pendants Produce Highly Potent and Efficacious Mixed Efficacy μ-Opioid Receptor (MOR)/δ-Opioid Receptor (DOR) Peptidomimetics with Enhanced Metabolic Stability

Journal of Medicinal Chemistry
2020-02-27 | Journal article
DOI: 10.1021/acs.jmedchem.9b01818
Contributors: Sean Henry; Jessica P. Anand; Jack J. Twarozynski; Ashley C. Brinkel; Irina D. Pogozheva; Bryan F. Sears; Emily M. Jutkiewicz; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Novel Dimethyltyrosine–Tetrahydroisoquinoline Peptidomimetics with Aromatic Tetrahydroisoquinoline Substitutions Show in Vitro Kappa and Mu Opioid Receptor Agonism

ACS Chemical Neuroscience
2019-08-21 | Journal article
DOI: 10.1021/acschemneuro.9b00250
Contributors: Deanna Montgomery; Jessica P. Anand; Nicholas W. Griggs; Thomas J. Fernandez; Joshua G. Hartman; Ashley A. Sánchez-Santiago; Irina D. Pogozheva; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Dual Pharmacophores Explored via Structure–Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design

Journal of Medicinal Chemistry
2019-04-25 | Journal article
DOI: 10.1021/acs.jmedchem.9b00378
Contributors: Anthony F. Nastase; Jessica P. Anand; Aaron M. Bender; Deanna Montgomery; Nicholas W. Griggs; Thomas J. Fernandez; Emily M. Jutkiewicz; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Structural Simplification of a Tetrahydroquinoline-Core Peptidomimetic μ-Opioid Receptor (MOR) Agonist/δ-Opioid Receptor (DOR) Antagonist Produces Improved Metabolic Stability

Journal of Medicinal Chemistry
2019-04-25 | Journal article
DOI: 10.1021/acs.jmedchem.9b00219
Contributors: Sean P. Henry; Thomas J. Fernandez; Jessica P. Anand; Nicholas W. Griggs; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Synthesis and Pharmacological Evaluation of Novel C-8 Substituted Tetrahydroquinolines as Balanced-Affinity Mu/Delta Opioid Ligands for the Treatment of Pain

ACS Chemical Neuroscience
2018-07-18 | Journal article
DOI: 10.1021/acschemneuro.8b00139
Contributors: Anthony F. Nastase; Nicholas W. Griggs; Jessica P. Anand; Thomas J. Fernandez; Aubrie A. Harland; Tyler J. Trask; Emily M. Jutkiewicz; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Placement of Hydroxy Moiety on Pendant of Peptidomimetic Scaffold Modulates Mu and Kappa Opioid Receptor Efficacy

ACS Chemical Neuroscience
2017-11-15 | Journal article
DOI: 10.1021/acschemneuro.7b00284
Contributors: Aubrie A. Harland; Irina D. Pogozheva; Nicholas W. Griggs; Tyler J. Trask; John R. Traynor; Henry I. Mosberg
Source: check_circle
Crossref

Peer review (21 reviews for 4 publications/grants)

Review activity for ACS chemical neuroscience. (5)
Review activity for ACS medicinal chemistry letters. (2)
Review activity for ChemMedChem. (1)
Review activity for Journal of medicinal chemistry. (13)
How many people are using ORCID?