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Works (31)

Immunostimulation of Fibrous Nucleic Acid Nanoparticles Can be Modulated through Aptamer-Based Functional Moieties: Unveiling the Structure–Activity Relationship and Mechanistic Insights

ACS Applied Materials & Interfaces
2024-02-21 | Journal article
DOI: 10.1021/acsami.3c17779
Contributors: Laura P. Rebolledo; Weina Ke; Edward Cedrone; Jian Wang; Krishna Majithia; M. Brittany Johnson; Nikolay V. Dokholyan; Marina A. Dobrovolskaia; Kirill A. Afonin
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Special Issue “Nanotechnology to Overcome the World’s Most Critical Health Issues: Liposomes and Beyond—A Themed Issue Dedicated to Professor Yechezkel Barenholz”

Molecules
2023-06-15 | Journal article
DOI: 10.3390/molecules28124788
Contributors: Marina A. Dobrovolskaia; Kirill A. Afonin
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Change in Lipofectamine Carrier as a Tool to Fine-Tune Immunostimulation of Nucleic Acid Nanoparticles

Molecules
2023-06-01 | Journal article
DOI: 10.3390/molecules28114484
Contributors: Hannah S. Newton; Yasmine Radwan; Jie Xu; Jeffrey D. Clogston; Marina A. Dobrovolskaia; Kirill A. Afonin
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Evaluation of non-modified wireframe DNA origami for acute toxicity and biodistribution in mice

2023-02-27 | Preprint
DOI: 10.1101/2023.02.25.530026
Contributors: Eike-Christian Wamhoff; Grant A. Knappe; Aurora A. Burds; Rebecca R. Du; Barry W. Neun; Simone Difilippantonio; Chelsea Sanders; Elijah F. Edmondson; Jennifer L. Matta; Marina A. Dobrovolskaia et al.
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Innate Immune Stimulation Using 3D Wireframe DNA Origami

ACS Nano
2022-12-27 | Journal article
DOI: 10.1021/acsnano.2c06275
Contributors: Rebecca R. Du; Edward Cedrone; Anna Romanov; Reuven Falkovich; Marina A. Dobrovolskaia; Mark Bathe
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Cancer nanomedicine

Nature Reviews Cancer
2022-10 | Journal article
DOI: 10.1038/s41568-022-00496-9
Contributors: Sangeeta N. Bhatia; Xiaoyuan Chen; Marina A. Dobrovolskaia; Twan Lammers
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Innate Immune Stimulation using 3D Wireframe DNA Origami

2022-07-10 | Preprint
DOI: 10.1101/2022.07.08.499376
Contributors: Rebecca R. Du; Edward Cedrone; Marina A. Dobrovolskaia; Mark Bathe
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Applying lessons learned from nanomedicines to understand rare hypersensitivity reactions to mRNA-based SARS-CoV-2 vaccines

Nature Nanotechnology
2022-04 | Journal article
DOI: 10.1038/s41565-022-01071-x
Contributors: Janos Szebeni; Gert Storm; Julia Y. Ljubimova; Mariana Castells; Elizabeth J. Phillips; Keren Turjeman; Yechezkel Barenholz; Daan J. A. Crommelin; Marina A. Dobrovolskaia
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An In Vitro Assessment of Immunostimulatory Responses to Ten Model Innate Immune Response Modulating Impurities (IIRMIs) and Peptide Drug Product, Teriparatide

Molecules
2021-12-09 | Journal article
DOI: 10.3390/molecules26247461
Contributors: Claire K. Holley; Edward Cedrone; Duncan Donohue; Barry W. Neun; Daniela Verthelyi; Eric S. Pang; Marina A. Dobrovolskaia
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Innate Immunity Modulating Impurities and the Immunotoxicity of Nanobiotechnology-Based Drug Products

Molecules
2021-12-01 | Journal article
DOI: 10.3390/molecules26237308
Contributors: Claire K. Holley; Marina A. Dobrovolskaia
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The International Society of RNA Nanotechnology and Nanomedicine (ISRNN): The Present and Future of the Burgeoning Field

ACS Nano
2021-11-23 | Journal article
DOI: 10.1021/acsnano.0c10240
Contributors: Morgan Chandler; Brittany Johnson; Emil Khisamutdinov; Marina A. Dobrovolskaia; Joanna Sztuba-Solinska; Aliasger K. Salem; Koen Breyne; Roger Chammas; Nils G. Walter; Lydia M. Contreras et al.
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2021: An Immunotherapy Odyssey and The Rise of Nucleic Acid Nanotechnology

Nanomedicine
2021-08 | Journal article
DOI: 10.2217/nnm-2021-0097
Contributors: Martin Panigaj; Marina A Dobrovolskaia; Kirill A Afonin
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The Recognition of and Reactions to Nucleic Acid Nanoparticles by Human Immune Cells

Molecules
2021-07-12 | Journal article
DOI: 10.3390/molecules26144231
Contributors: Dominika Bila; Yasmine Radwan; Marina A. Dobrovolskaia; Martin Panigaj; Kirill A. Afonin
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Challenges in the development of nanoparticle‐based imaging agents: Characterization and biology

WIREs Nanomedicine and Nanobiotechnology
2021-01 | Journal article
DOI: 10.1002/wnan.1665
Contributors: Rachael M. Crist; Siva Sai Krishna Dasa; Christina H. Liu; Jeffrey D. Clogston; Marina A. Dobrovolskaia; Stephan T. Stern
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Induction of Cytokines by Nucleic Acid Nanoparticles (NANPs) Depends on the Type of Delivery Carrier

Molecules
2021-01-27 | Journal article
DOI: 10.3390/molecules26030652
Contributors: Yelixza I. Avila; Morgan Chandler; Edward Cedrone; Hannah S. Newton; Melina Richardson; Jie Xu; Jeffrey D. Clogston; Neill J. Liptrott; Kirill A. Afonin; Marina A. Dobrovolskaia
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Use of human peripheral blood mononuclear cells to define immunological properties of nucleic acid nanoparticles

Nature Protocols
2020-11-23 | Journal article
DOI: 10.1038/s41596-020-0393-6
Contributors: Marina A. Dobrovolskaia; Kirill A. Afonin
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One-year chronic toxicity evaluation of single dose intravenously administered silica nanoparticles in mice and their Ex vivo human hemocompatibility

Journal of Controlled Release
2020-08 | Journal article
DOI: 10.1016/j.jconrel.2020.05.027
Contributors: Raziye Mohammadpour; Darwin L. Cheney; Jason W. Grunberger; Mostafa Yazdimamaghani; Jolanta Jedrzkiewicz; Kyle J. Isaacson; Marina A. Dobrovolskaia; Hamidreza Ghandehari
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Opportunities, Barriers, and a Strategy for Overcoming Translational Challenges to Therapeutic Nucleic Acid Nanotechnology

ACS Nano
2020-08-25 | Journal article
DOI: 10.1021/acsnano.0c04753
Contributors: Kirill A. Afonin; Marina A. Dobrovolskaia; George Church; Mark Bathe
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Detection of Beta-Glucan Contamination in Nanotechnology-Based Formulations

Molecules
2020-07-24 | Journal article
DOI: 10.3390/molecules25153367
Contributors: Barry W. Neun; Edward Cedrone; Timothy M. Potter; Rachael M. Crist; Marina A. Dobrovolskaia
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PEGylated Liposomal Methyl Prednisolone Succinate does not Induce Infusion Reactions in Patients: A Correlation Between in Vitro Immunological and in Vivo Clinical Studies

Molecules
2020-01-28 | Journal article
DOI: 10.3390/molecules25030558
Contributors: Yaelle Bavli; Bing-Mae Chen; Steve R. Roffler; Marina A. Dobrovolskaia; Eldad Elnekave; Shifra Ash; Yechezkel Barenholz; Keren Turjeman
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Nucleic Acid Nanoparticles at a Crossroads of Vaccines and Immunotherapies

Molecules
2019-12-17 | Journal article
DOI: 10.3390/molecules24244620
Contributors: Marina A. Dobrovolskaia
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Erratum: Hong, E., et al. Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells. Molecules 2019, 24, 1094

Molecules
2019-10-25 | Journal article
DOI: 10.3390/molecules24213852
Contributors: Enping Hong; Justin R. Halman; Ankit Shah; Edward Cedrone; Nguyen Truong; Kirill A. Afonin; Marina A. Dobrovolskaia
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Toll-Like Receptor-Mediated Recognition of Nucleic Acid Nanoparticles (NANPs) in Human Primary Blood Cells

Molecules
2019-03 | Journal article | Author
DOI: 10.3390/molecules24061094
Contributors: Enping Hong; Justin R. Halman; Ankit Shah; Edward Cedrone; Nguyen Truong; Kirill Afonin; Marina Dobrovolskaia
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Multidisciplinary Digital Publishing Institute
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<p>Acute physiological changes caused by complement activators and amphotericin B-containing liposomes in mice</p>

International Journal of Nanomedicine
2019-02 | Journal article
DOI: 10.2147/IJN.S187139
Contributors: Erik Őrfi; Tamás Mészáros; Mark Hennies; Tamás Fülöp; László Dézsi; Alexander Nardocci; László Rosivall; Peter Hamar; Barry W. Neun; Marina A. Dobrovolskaia et al.
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The potential utility of iron oxide nanoparticles for the treatment of skin inflammation in a mouse model of psoriasis

Precision Nanomedicine
2019-01-14 | Journal article
DOI: 10.33218/prnano2(1).181218.1
Contributors: Ankit Shah; Edward Cedrone; Chelsea E Sanders; Donna Butcher; Alexandra M DeFrancesco; Casey L DeGrange; Simone Difilippantonio; Elijah F Edmondson; Marina Dobrovolskaia
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Plasma samples from mouse strains and humans demonstrate different susceptibilities to complement activation

Precision Nanomedicine
2018-12-16 | Journal article
DOI: 10.33218/prnano1(3).181029.2
Contributors: Marina Dobrovolskaia; Barry W Neun; Gábor Szénási; János Szebeni
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Feraheme® suppresses immune function of human T lymphocytes through mitochondrial damage and mitoROS production

Toxicology and Applied Pharmacology
2018-07 | Journal article
DOI: 10.1016/j.taap.2018.04.028
Contributors: Ankit Shah; Cassandra I. Mankus; Alison M. Vermilya; Ferri Soheilian; Jeffrey D. Clogston; Marina A. Dobrovolskaia
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Understanding the Role of Anti-PEG Antibodies in the Complement Activation by Doxil in Vitro

Molecules
2018-07 | Journal article
DOI: 10.3390/molecules23071700
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Multidisciplinary Digital Publishing Institute
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Structure and Composition Define Immunorecognition of Nucleic Acid Nanoparticles

Nano Letters
2018-07-11 | Journal article
DOI: 10.1021/acs.nanolett.8b01283
Contributors: Enping Hong; Justin R. Halman; Ankit B. Shah; Emil F. Khisamutdinov; Marina A. Dobrovolskaia; Kirill A. Afonin
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Anticoagulants Influence the Performance of In Vitro Assays Intended for Characterization of Nanotechnology-Based Formulations

Molecules
2017-12 | Journal article
DOI: 10.3390/molecules23010012
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Multidisciplinary Digital Publishing Institute
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Nanoparticle Effects on Human Platelets in Vitro: A Comparison between PAMAM and Triazine Dendrimers

Molecules
2016-03-29 | Journal article
DOI: 10.3390/molecules21040428
Contributors: Alan Enciso; Barry Neun; Jamie Rodriguez; Amalendu Ranjan; Marina Dobrovolskaia; Eric Simanek
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Peer review (46 reviews for 23 publications/grants)

Review activity for ACS applied bio materials. (1)
Review activity for ACS applied materials & interfaces. (3)
Review activity for ACS nano. (14)
Review activity for ACS omega. (2)
Review activity for Advanced drug delivery reviews. (1)
Review activity for Biochemistry. (1)
Review activity for Biomacromolecules. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for Chemical research in toxicology. (1)
Review activity for Communications biology. (1)
Review activity for Communications chemistry. (1)
Review activity for Molecular pharmaceutics. (3)
Review activity for Nano letters. (1)
Review activity for Nanomedicine (2)
Review activity for Nature communications (1)
Review activity for Nature materials. (1)
Review activity for Nature medicine. (1)
Review activity for Nature nanotechnology (4)
Review activity for Nature reviews bioengineering. (1)
Review activity for Nature reviews. (2)
Review activity for Nature reviews. (1)
Review activity for npj vaccines. (1)
Review activity for Vaccine. (1)
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