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Biography

I completed my B.Sc. with majors in Biochemistry and Organic Chemistry and subsequently my M.Sc. in Clinical Biochemistry at the University of Western Australia, before later completing my Ph.D. in the Faculty of Medicine at The University of Sydney. I have worked extensively in biomedical research and have experience in the areas of neuropharmacology and behavioural pharmacology, bioanalysis and assay validation, pharmacokinetics and pharmacodynamics, drug metabolism, and drug development. I have worked extensively with laboratory rodent behavioural and experimental models, as well as with LC-MS and HPLC, and I also have experience with histology and immunostaining procedures for microscopy. Additionally, I have experience with the use of WinNonlin® software for the analysis of pharmacokinetic data, scientific writing for commercial research projects, and working in a Quality System environment.

Earlier work has included studies of the pharmacokinetics, pharmacodynamics, and biodistribution of thiopentone enantiomers, in addition to studies of the pharmacokinetics and biodistribution of ketamine enantiomers and the pharmacokinetic-pharmacodynamic interaction of alfentanil with ketamine. Other projects have included the pharmacokinetics of morphine and oxycodone and their respective primary metabolites; development of LC-MS assays for angiotensin II type 2 receptor antagonists; and evaluation and validation of 2 transgenic mouse models of Alzheimer’s disease. More recently, I have worked on a project investigating the use of novel complement pathway inhibitors for the treatment of traumatic brain injury. Currently, I work on a project investigating a novel treatment for amyotrophic lateral sclerosis (ALS), in 2 transgenic mouse models of ALS. To date I have 34 publications in international peer reviewed journals.

Activities

Employment (1)

The University of Queensland: Brisbane, Queensland, AU

(School of Biomedical Sciences)
Employment
Source: Self-asserted source
Stephen Edwards

Education and qualifications (3)

The University of Western Australia: Perth, WA, AU

B.Sc.
Education
Source: Self-asserted source
Stephen Edwards

The University of Western Australia: Perth, WA, AU

M.Sc.
Education
Source: Self-asserted source
Stephen Edwards

The University of Sydney: Sydney, New South Wales, AU

Ph.D.
Education
Source: Self-asserted source
Stephen Edwards

Works (34)

Complement Component 5 (C5) Deficiency Improves Cognitive Outcome After Traumatic Brain Injury and Enhances Treatment Effects of Complement Inhibitors C1-Inh and CR2-Crry in a Mouse Model.

Neurotrauma reports
2023-10-11 | Journal article
Contributors: Chen M; Edwards SR; Maskey D; Trent Woodruff; Tomlinson S; Reutens D
Source: Self-asserted source
Stephen Edwards

Effects of C1-INH Treatment on Neurobehavioral Sequelae and Late Seizures After Traumatic Brain Injury in a Mouse Model of Controlled Cortical Impact.

Neurotrauma reports
2023-03-09 | Journal article
Contributors: Chen M; Tieng QM; Du J; Edwards SR; Maskey D; Peshtenski E; Reutens D
Source: Self-asserted source
Stephen Edwards

Comparative studies of glial fibrillary acidic protein and brain-derived neurotrophic factor expression in two transgenic mouse models of Alzheimer's disease.

Clinical and experimental pharmacology & physiology
2020-07-17 | Journal article
Source: Self-asserted source
Stephen Edwards

Complement in the Development of Post-Traumatic Epilepsy: Prospects for Drug Repurposing.

Journal of neurotrauma
2020-03-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Topical application of a novel oxycodone gel formulation (tocopheryl phosphate mixture) in a rat model of peripheral inflammatory pain produces localized pain relief without significant systemic exposure.

Journal of pharmaceutical sciences
2015-05-20 | Journal article
Source: Self-asserted source
Stephen Edwards

Comparative studies using the Morris water maze to assess spatial memory deficits in two transgenic mouse models of Alzheimer's disease.

Clinical and experimental pharmacology & physiology
2014-10-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Small molecule angiotensin II type 2 receptor (ATâ‚‚R) antagonists as novel analgesics for neuropathic pain: comparative pharmacokinetics, radioligand binding, and efficacy in rats.

Pain medicine (Malden, Mass.)
2013-03-14 | Journal article
Source: Self-asserted source
Stephen Edwards

Comparative studies of the neuro-excitatory behavioural effects of morphine-3-glucuronide and dynorphin A(2-17) following spinal and supraspinal routes of administration.

Pharmacology, biochemistry, and behavior
2009-07-04 | Journal article
Source: Self-asserted source
Stephen Edwards

Antinociception versus serum concentration relationships following acute administration of intravenous morphine in male and female Sprague-Dawley rats: differences between the tail flick and hot plate nociceptive tests.

Clinical and experimental pharmacology & physiology
2008-07-29 | Journal article
Source: Self-asserted source
Stephen Edwards

Sex differences in the pharmacokinetics, oxidative metabolism and oral bioavailability of oxycodone in the Sprague-Dawley rat.

Clinical and experimental pharmacology & physiology
2007-10-31 | Journal article
Source: Self-asserted source
Stephen Edwards

Oxycodone's mechanism of action and potency differences after spinal and systemic routes of administration.

Anesthesiology
2007-05-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Studies with ketamine and alfentanil following Freund's complete adjuvant-induced inflammation in rats.

Clinical and experimental pharmacology & physiology
2007-05-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Oxycodone and morphine have distinctly different pharmacological profiles: radioligand binding and behavioural studies in two rat models of neuropathic pain.

Pain
2007-04-30 | Journal article
Source: Self-asserted source
Stephen Edwards

Low-level quantitation of oxycodone and its oxidative metabolites, noroxycodone, and oxymorphone, in rat plasma by high-performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2006-11-13 | Journal article
Source: Self-asserted source
Stephen Edwards

Comparison of the pharmacokinetics of oxycodone and noroxycodone in male dark agouti and Sprague--Dawley rats: influence of streptozotocin-induced diabetes.

Pharmaceutical research
2005-07-29 | Journal article
Source: Self-asserted source
Stephen Edwards

Simultaneous determination of morphine, oxycodone, morphine-3-glucuronide, and noroxycodone concentrations in rat serum by high performance liquid chromatography-electrospray ionization-tandem mass spectrometry.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
2005-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Alfentanil potentiates anaesthetic and electroencephalographic responses to ketamine in the rat.

European journal of pharmacology
2003-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Diclofenac increases the accumulation of kynurenate following tryptophan pretreatment in the rat: a possible factor contributing to its antihyperalgesic effect.

Inflammopharmacology
2003-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Concurrent ketamine and alfentanil administration: pharmacokinetic considerations.

British journal of anaesthesia
2002-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Tissue uptake of ketamine and norketamine enantiomers in the rat: indirect evidence for extrahepatic metabolic inversion.

Life sciences
2001-09-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Effects of diclofenac in the rat tail ischaemia--reperfusion injury model of acute hyperalgesia.

Pain
2001-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Electroencephalographic effects of thiopentone and its enantiomers in the rat.

Life sciences
2000-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Glutamate and kynurenate in the rat central nervous system following treatments with tail ischaemia or diclofenac.

The Journal of pharmacy and pharmacology
2000-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Microdialysis study of the blood-brain equilibration of thiopental enantiomers.

British journal of anaesthesia
2000-01-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Electroencephalographic effects of thiopentone and its enantiomers in the rat: correlation with drug tissue distribution.

British journal of pharmacology
1999-09-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Enantioselectivity of thiopental distribution into the central neural tissue of rats: an interaction with halothane.

Anesthesia and analgesia
1999-07-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Chirality in anaesthesia--ropivacaine, ketamine and thiopentone.

Current opinion in anaesthesiology
1998-08-01 | Journal article
Source: Self-asserted source
Stephen Edwards

Suppression of central noradrenergic neuronal activity inhibits hyperglycemia.

The American journal of physiology
1992-11-01 | Journal article
PMID: 1443113
Source: Self-asserted source
Stephen Edwards

A role for central postsynaptic alpha 2-adrenoceptors in glucoregulation.

Brain research
1991-10-01 | Journal article
PMID: 1663413
Source: Self-asserted source
Stephen Edwards

Dopamine D2 agonist-induced behavioural depression is reversed by dopamine D1 agonists.

Journal of neural transmission
1989-01-01 | Journal article
PMID: 2784489
Source: Self-asserted source
Stephen Edwards

The involvement of dopamine D1 and D2 receptors in the locomotor stimulation produced by (+)-amphetamine in naive and dopamine-depleted mice.

Pharmacology & toxicology
1989-01-01 | Journal article
PMID: 2526949
Source: Self-asserted source
Stephen Edwards

Enhancement by a single dose of reserpine (plus alpha methyl-p-tyrosine) of the central stimulatory effects evoked by dopamine D-1 and D-2 agonists in the mouse.

Naunyn-Schmiedeberg's archives of pharmacology
1988-05-01 | Journal article
PMID: 3261844
Source: Self-asserted source
Stephen Edwards

Neuropharmacology of delta-aminolaevulinic acid. II. Effect of chronic administration in mice.

Neuroscience letters
1984-09-01 | Journal article
PMID: 6493622
Source: Self-asserted source
Stephen Edwards

Neuropharmacology of delta-aminolaevulinic acid--I. Effect of acute administration in rodents.

Neuropharmacology
1984-04-01 | Journal article
PMID: 6728134
Source: Self-asserted source
Stephen Edwards