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Employment (2)

Yale University School of Medicine: NEW HAVEN, CT, US

Visiting Professor (Pharmacology)
Employment
Source: Self-asserted source
YUAN-WEI ZHANG

Guangzhou University: Guangzhou, Guangdong, CN

Professor of Biochemistry and Neuropharmacology (Life Sciences)
Employment
Source: Self-asserted source
YUAN-WEI ZHANG

Education and qualifications (3)

Yale University School of Medine: NEW HAVEN, CT, US

Associate Research Scientist (Pharmacology)
Education
Source: Self-asserted source
YUAN-WEI ZHANG

Yale University School of Medicine: NEW HAVEN, CT, US

Postdoctoral Fellow (Pharmacology)
Education
Source: Self-asserted source
YUAN-WEI ZHANG

Tohoku University: Sendai, Miyagi, JP

Ph.D. (Biochemistry)
Education
Source: Self-asserted source
YUAN-WEI ZHANG

Funding (1)

Structure and transport mechanism of serotonin transporter

Grant
National Natural Science Foundation of China (GUANGZHOU, GUANGDONG, CN)
GRANT_NUMBER:

32071233

Source: Self-asserted source
YUAN-WEI ZHANG

Works (33)

(-)-Syringaresinol Exerts an Antidepressant-like Activity in Mice by Noncompetitive Inhibition of the Serotonin Transporter

Pharmaceuticals
2024-12-05 | Journal article
Contributors: Yingyao Wu; Jianxin Cai; Hanhe Liu; Chan Li; Qingfa Tang; Yuan-Wei Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Identification of the potassium-binding site in serotonin transporter

Proceedings of the National Academy of Sciences
2024-04-30 | Journal article
Contributors: Eva Hellsberg; Danila Boytsov; Qingyang Chen; Marco Niello; Michael Freissmuth; Gary Rudnick; Yuan-Wei Zhang; Walter Sandtner; Lucy R. Forrest
Source: check_circle
Crossref

A Conserved Intramolecular Ion-Pair Plays a Critical but Divergent Role in Regulation of Dimerization and Transport Function among the Monoamine Transporters

International Journal of Molecular Sciences
2024-04-04 | Journal article
Contributors: Sixiang Chen; Xingyu Huang; Xintong Zhang; Chan Li; Yuan-Wei Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Identification of the potassium binding site in serotonin transporter SERT

2023-12-29 | Preprint
Contributors: Eva Hellsberg; Danila Boytsov; Qingyang Chen; Marco Niello; Michael Freissmuth; Gary Rudnick; Yuan-Wei Zhang; Walter Sandtner; Lucy Rachel Forrest
Source: check_circle
Crossref

Unique Substrate Recognition and Sodium–Substrate Binding Stoichiometry in a Bacterial Serotonin Transporter, TuriSERT

International Journal of Molecular Sciences
2023-12-04 | Journal article
Contributors: Mu Li; Xintong Zhang; Sixiang Chen; Hanhe Liu; Yuan-Wei Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Cross-Linking and Functional Analyses for Dimerization of a Cysteine Mutant of Glycine Transporter 1

International Journal of Molecular Sciences
2022-12-18 | Journal article
Contributors: Jingru Wang; Hanhe Liu; Yuan-Wei Zhang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Molecular docking and biochemical validation of (-)-syringaresinol-4-O-β-D-apiofuranosyl-(1→2)-β-D-glucopyranoside binding to an allosteric site in monoamine transporters

Frontiers in Pharmacology
2022-10-28 | Journal article
Part of ISSN: 1663-9812
Contributors: YUAN-WEI ZHANG; Hanhe Liu; Yingyao Wu; Chan Li; Qingfa Tang; Yuan-Wei Zhang
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Determining Ligand and Ion-Induced Conformational Changes in Serotonin Transporter with Its Fluorescent Substrates

International Journal of Molecular Sciences
2022-09-18 | Journal article
Contributors: Mu Li; Qingyang Chen; Yuan-Wei Zhang
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Two Lignan Glycosides from <i>Albizia julibrissin</i> Durazz. Noncompetitively Inhibit Serotonin Transporter

Pharmaceuticals
2022-03 | Journal article | Author
Contributors: Bishan Huang; Hanhe Liu; Yingyao Wu; Chan Li; Qingfa Tang; YUAN-WEI ZHANG
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

Chloride-dependent conformational changes in the GlyT1 glycine transporter

Proceedings of the National Academy of Sciences
2021-03-09 | Journal article
Contributors: Yuan-Wei Zhang; Stacy Uchendu; Vanessa Leone; Richard T. Bradshaw; Ntumba Sangwa; Lucy R. Forrest; Gary Rudnick
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Chinese Herbal Medicine for the Treatment of Depression: Effects on the Neuroendocrine-Immune Network

Pharmaceuticals
2021-01-14 | Journal article
Part of ISSN: 1424-8247
Contributors: YUAN-WEI ZHANG; Chan Li; Bishan Huang; Yuan-Wei Zhang
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Traditional Chinese Medicine in Depression Treatment: From Molecules to Systems

Frontiers in Pharmacology
2020-05-07 | Journal article
Part of ISSN: 1663-9812
Contributors: YUAN-WEI ZHANG; Chan Li; Junying Huang; Yung-Chi Cheng; Yuan-Wei Zhang
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Challenge and Prospect of Traditional Chinese Medicine in Depression Treatment

Frontiers in Neuroscience
2019-03-05 | Journal article
Part of ISSN: 1662-453X
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Yung-Chi Cheng
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Structural elements required for coupling ion and substrate transport in the neurotransmitter transporter homolog LeuT

Proceedings of the National Academy of Sciences
2018-09-18 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Sotiria Tavoulari; Steffen Sinning; Antoniya A. Aleksandrova; Lucy R Forrest; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Substrate-Induced Conformational Change in LeuT

Biophysical Journal
2017 | Journal article
Contributors: Zhang, Yuan-Wei; Forrest, Lucy R.; Rudnick, Gary
Source: check_circle
Web of Science Researcher Profile Sync

Control of serotonin transporter phosphorylation by conformational state

Proceedings of the National Academy of Sciences
2016-05-17 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Benjamin E. Turk; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters

Molecular Pharmacology
2016-01 | Journal article
Part of ISSN: 0026-895X
Part of ISSN: 1521-0111
Contributors: YUAN-WEI ZHANG; Walter Sandtner; Thomas Stockner; Peter S. Hasenhuetl; John S. Partilla; Amir Seddik; Yuan-Wei Zhang; Jianjing Cao; Marion Holy; Thomas Steinkellner et al.
Source: Self-asserted source
YUAN-WEI ZHANG

Two Na+ Sites Control Conformational Change in a Neurotransmitter Transporter Homolog

Journal of Biological Chemistry
2016-01 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Sotiria Tavoulari; Eleonora Margheritis; Anu Nagarajan; David C. DeWitt; Yuan-Wei Zhang; Edwin Rosado; Silvia Ravera; Elizabeth Rhoades; Lucy R. Forrest et al.
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

The Role of Sodium Sites in LeuT Conformational Changes

Biophysical Journal
2014 | Journal article
Contributors: Rudnick, Gary; Tavoulari, Sotiria; Zhang, Yuan-Wei; DeWitt, David; Nagarajan, Anu; Rosado, Edwin; Ravera, Silvia; Kreuder, Anna-Elisabeth; Forrest, Lucy R.; Rhoades, Elizabeth
Source: check_circle
Web of Science Researcher Profile Sync

Characterization of serotonin transport mechanism through extracellular cross-linking

Abstracts of Papers of the American Chemical Society
2012 | Journal article
Contributors: Jin, Qiuyu; Zhang, Yuan-Wei; Rudnick, Gary
Source: check_circle
Web of Science Researcher Profile Sync

Cyclic GMP-dependent Stimulation of Serotonin Transport Does Not Involve Direct Transporter Phosphorylation by cGMP-dependent Protein Kinase

Journal of Biological Chemistry
2012-10 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Albert Wong; Yuan-Wei Zhang; Grace R. Jeschke; Benjamin E. Turk; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

The Mechanistic Basis for Noncompetitive Ibogaine Inhibition of Serotonin and Dopamine Transporters

Journal of Biological Chemistry
2012-05 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Simon Bulling; Klaus Schicker; Yuan-Wei Zhang; Thomas Steinkellner; Thomas Stockner; Christian W. Gruber; Stefan Boehm; Michael Freissmuth; Gary Rudnick et al.
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Myristoylation of cGMP-dependent Protein Kinase Dictates Isoform Specificity for Serotonin Transporter Regulation

Journal of Biological Chemistry
2011-01 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Ligand Effects on Cross-linking Support a Conformational Mechanism for Serotonin Transport

Journal of Biological Chemistry
2009-12 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Zhen Tao; Yuan-Wei Zhang; Alice Agyiri; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG

Mechanism for alternating access in neurotransmitter transporters

Proceedings of the National Academy of Sciences
2008-07-29 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: YUAN-WEI ZHANG; Lucy R. Forrest; Yuan-Wei Zhang; Miriam T. Jacobs; Joan Gesmonde; Li Xie; Barry H. Honig; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Ibogaine, a Noncompetitive Inhibitor of Serotonin Transport, Acts by Stabilizing the Cytoplasm-facing State of the Transporter

Journal of Biological Chemistry
2007-10 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Miriam T. Jacobs; Yuan-Wei Zhang; Scott D. Campbell; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Serotonin Transporter Phosphorylation by cGMP-Dependent Protein Kinase Is Altered by a Mutation Associated with Obsessive Compulsive Disorder

Journal of Neuroscience
2007-10-03 | Journal article
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Contributors: YUAN-WEI ZHANG; Y.-W. Zhang; J. Gesmonde; S. Ramamoorthy; G. Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Identification of a chloride ion binding site in Na <sup>+</sup> /Cl <sup>−</sup> -dependent transporters

Proceedings of the National Academy of Sciences
2007-07-31 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: YUAN-WEI ZHANG; Lucy R. Forrest; Sotiria Tavoulari; Yuan-Wei Zhang; Gary Rudnick; Barry Honig
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Direct observation of substrate-enzyme complexation by surface forces measurement

Journal of the American Chemical Society
2006 | Journal article
Contributors: Suzuki, Takehiro; Zhang, Yuan-Wei; Koyama, Tanetoshi; Sasaki, Darryl Y.; Kurihara, Kazue
Source: check_circle
Web of Science Researcher Profile Sync

The Cytoplasmic Substrate Permeation Pathway of Serotonin Transporter

Journal of Biological Chemistry
2006-11 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Serotonin transporter mutations associated with obsessive-compulsive disorder and phosphorylation alter binding affinity for inhibitors

Neuropharmacology
2005-11 | Journal article
Part of ISSN: 0028-3908
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Cysteine-scanning Mutagenesis of Serotonin Transporter Intracellular Loop 2 Suggests an α-Helical Conformation

Journal of Biological Chemistry
2005-09 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Yuan-Wei Zhang; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎

Analysis of Transmembrane Domain 2 of Rat Serotonin Transporter by Cysteine Scanning Mutagenesis

Journal of Biological Chemistry
2004-05 | Journal article
Part of ISSN: 0021-9258
Contributors: YUAN-WEI ZHANG; Yuichiro Sato; Yuan-Wei Zhang; Andreas Androutsellis-Theotokis; Gary Rudnick
Source: Self-asserted source
YUAN-WEI ZHANG
grade
Preferred source (of 2)‎