Markus Hafner



I joined the Laboratory of Muscle Stem Cells and Gene Regulation as an Investigator in 2014. Before my appointment at NIAMS, I was a Postdoctoral Fellow in the Laboratory of Dr. Thomas Tuschl at the Rockefeller University in New York. There I worked on mechanisms of gene silencing by small RNAs, and developed methods to characterize posttranscriptional gene regulation by RNA binding proteins. I obtained a M.Sc. in Chemistry in 2002 and a Ph.D. in Biochemistry in 2007 from the University of Bonn, Germany. My graduate work under Dr. Michael Famulok focused on the use of RNA aptamers to select small molecule inhibitors for cytohesins, a family of guanosine exchange factors, which revealed their role in the insulin signaling pathway. In my own laboratory at NIAMS, I will focus on dissecting the composition of ribonucleoproteins (RNPs) involved in cellular RNA transport and control of RNA stability. This is a prerequisite for understanding the consequences of dysregulation and/or mutation of RNA-binding proteins (RBPs), and/or their target RNA-binding sites in disease.

Record last modified Oct 30, 2018 6:29:19 PM