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Stroke, Blood-brain barrier, Ischemic stroke, Pharmacology, Hemorrhagic stroke, MCAO
Japan, United States

Activities

Employment (2)

Massachusetts General Hospital: Boston, Massachusetts, US

2020-11 to present | PhD researcher (Neurovascular Research Lab)
Employment
Source: Self-asserted source
Takahiko Imai

Gifu Pharmaceutical University: Gifu , Gifu, JP

2020-05-01 to 2021-03 | Researcher (Pharmacy)
Employment
Source: Self-asserted source
Takahiko Imai

Education and qualifications (2)

Gifu Pharmaceutical University: Gifu, Gifu, JP

2016-04 to 2020-03 | Ph.D. (Pharmacy)
Education
Source: Self-asserted source
Takahiko Imai

Gifu Pharmaceutical University: Gifu, Gifu, JP

2010-04 to 2016-03 | Registered Pharmacist (R.Ph.) (Pharmacy)
Education
Source: Self-asserted source
Takahiko Imai

Professional activities (3)

Japanese Pharmacological Society: Bunkyo-ku, Tokyo, JP

2019-03 to present | Member (Pharmacology)
Membership
Source: Self-asserted source
Takahiko Imai

Japanese Society of Cerebral Blood Flow and Metabolism: Okayama, JP

2014-10 to present | Member
Membership
Source: Self-asserted source
Takahiko Imai

American Heart Association: Dallas, US

2024-02-01 to 2025-06-30
Membership
Source: Self-asserted source
Takahiko Imai

Works (34)

Examination of Inter‐α Inhibitor Proteins in Permanent and Transient Focal Ischemia

Journal of the American Heart Association
2025-02-18 | Journal article
Contributors: Takahiko Imai; Andreia Lopes de Morais; Tao Qin; Yuichi Sasaki; Yow‐Pin Lim; Cenk Ayata
Source: check_circle
Crossref

Isoform-selective and non-selective rho-kinase inhibitors do not affect collagenase-induced intracerebral hemorrhage outcomes in mice: Influence of sex and circadian cycle

Journal of Cerebral Blood Flow & Metabolism
2025-01-07 | Journal article
Contributors: Takahiko Imai; Andreia Morais; Tao Qin; Yuichi Sasaki; Taylan Erdogan; Lisa McKerracher; Cenk Ayata
Source: check_circle
Crossref

Biological and Procedural Predictors of Outcome in the Stroke Preclinical Assessment Network (SPAN) Trial

Circulation Research
2024-08-16 | Journal article
Contributors: Andreia Morais; Takahiko Imai; Xuyan Jin; Joseph J. Locascio; Ligia Boisserand; Alison L. Herman; Anjali Chauhan; Jessica Lamb; Karisma Nagarkatti; Marcio A. Diniz et al.
Source: check_circle
Crossref

Hippocampal infarction and generalized seizures predict early mortality after endovascular middle cerebral artery occlusion in mice.

Experimental neurology
2024-07-28 | Journal article
Contributors: Jin X; Imai T; Morais A; Sasaki Y; Chung DY; Ayata C
Source: Self-asserted source
Takahiko Imai

Spreading Depolarizations Suppress Hematoma Growth in Hyperacute Intracerebral Hemorrhage in Mice

Stroke
2023-10 | Journal article
Contributors: Paul Fischer; Isra Tamim; Kazutaka Sugimoto; Andreia Morais; Takahiko Imai; Tsubasa Takizawa; Tao Qin; Frieder Schlunk; Matthias Endres; Mohammad A. Yaseen et al.
Source: check_circle
Crossref

A multi-laboratory preclinical trial in rodents to assess treatment candidates for acute ischemic stroke.

Science translational medicine
2023-09-20 | Journal article | Author
Contributors: Patrick Lyden; Márcio Augusto Diniz; Bosetti F; Jessica Lamb; Karisma Nagarkatti; Andre Rogatko; Sungjin Kim; Ryan Cabeen; James I. Koenig; Kazi Dilruba Akhter et al.
Source: Self-asserted source
Takahiko Imai

Protective effects of alpha-mangostin encapsulated in cyclodextrin-nanoparticle on cerebral ischemia

Journal of Controlled Release
2023-01 | Journal article
Part of ISSN: 0168-3659
Contributors: Takahiko Imai; Natsumi Oka; Van Thi Hong Doan; Hirofumi Matsubara; Takahiko Imai; Yukie Yoshioka; Jun Katsuki; Shota Fujii; Shinsuke Nakamura; Masamitsu Shimazawa et al.
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Embracing Heterogeneity in The Multicenter Stroke Preclinical Assessment Network (SPAN) Trial.

Stroke
2023-01-05 | Journal article | Author
Contributors: Andreia Morais; Joseph Locascio; Lauren Sansing; Jessica Lamb; Karisma Nagarkatti; Takahiko Imai; Klaus van Leyen; Aronowski J; James I. Koenig; Francesca Bosetti et al.
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

The Stroke Preclinical Assessment Network: Rationale, Design, Feasibility, and Stage 1 Results

Stroke
2022-03-31 | Journal article
Part of ISSN: 0039-2499
Part of ISSN: 1524-4628
Source: Self-asserted source
Takahiko Imai

CADASIL mutations sensitize the brain to ischemia via spreading depolarizations and abnormal extracellular potassium homeostasis

Journal of Clinical Investigation
2022-02-24 | Journal article
Part of ISSN: 1558-8238
Source: Self-asserted source
Takahiko Imai

Nafamostat protects against early brain injury after subarachnoid hemorrhage in mice

Journal of Pharmacological Sciences
2022-01 | Journal article
Part of ISSN: 1347-8613
Source: Self-asserted source
Takahiko Imai

Involvement of Cerebral Blood Flow on Neurological and Behavioral Functions after Subarachnoid Hemorrhage in Mice

Journal of Stroke and Cerebrovascular Diseases
2021-09 | Journal article
Contributors: Hirofumi Matsubara; Takahiko Imai; Shohei Tsuji; Natsumi Oka; Takuya Ohba; Tetsuya Yamada; Yusuke Egashira; Shinsuke Nakamura; Masamitsu Shimazawa; Toru Iwama et al.
Source: check_circle
Crossref

Guanabenz and Clonidine, α2-Adrenergic Receptor Agonists, Inhibit Choroidal Neovascularization

Current Neurovascular Research
2021-05-18 | Journal article
Part of ISSN: 1567-2026
Source: Self-asserted source
Takahiko Imai

Excess adiponectin in eyes with progressive ocular vascular diseases.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2021-02-01 | Journal article
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Potential therapeutic effects of Nrf2 activators on intracranial hemorrhage

Journal of Cerebral Blood Flow & Metabolism
2021-01-14 | Journal article
Part of ISSN: 0271-678X
Part of ISSN: 1559-7016
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Importance of CBF measurement to exclude concomitant cerebral infarction in the murine endovascular perforation SAH model

Journal of Stroke and Cerebrovascular Diseases
2020-11 | Journal article
Part of ISSN: 1052-3057
Source: Self-asserted source
Takahiko Imai

Therapeutic Effects of Iron Chelation in Atorvastatin-Induced Intracranial Hemorrhage of Zebrafish Larvae

Journal of Stroke and Cerebrovascular Diseases
2020-11 | Journal article
Part of ISSN: 1052-3057
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage

Neuroscience
2020-09 | Journal article
Part of ISSN: 0306-4522
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Antitumour Effects of Astaxanthin and Adonixanthin on Glioblastoma

Marine Drugs
2020-09-18 | Journal article
Part of ISSN: 1660-3397
Source: Self-asserted source
Takahiko Imai

Deferasirox, a trivalent iron chelator, ameliorates neuronal damage in hemorrhagic stroke models

Naunyn-Schmiedeberg's Archives of Pharmacology
2020-08-18 | Journal article
Part of ISSN: 0028-1298
Part of ISSN: 1432-1912
Source: Self-asserted source
Takahiko Imai

Levetiracetam, an Antiepileptic Drug has Neuroprotective Effects on Intracranial Hemorrhage Injury

Neuroscience
2020-04 | Journal article
Part of ISSN: 0306-4522
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Intracellular Fe2+ accumulation in endothelial cells and pericytes induces blood-brain barrier dysfunction in secondary brain injury after brain hemorrhage

Scientific Reports
2019-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

A novel free radical scavenger, NSP-116, ameliorated the brain injury in both ischemic and hemorrhagic stroke models

Journal of Pharmacological Sciences
2019-11 | Journal article
Part of ISSN: 1347-8613
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Post-stroke pain caused by peripheral sensory hypersensitization after transient focal cerebral ischemia in rats

Brain Research
2019-07 | Journal article
Part of ISSN: 0006-8993
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

A novel Nrf2 activator, RS9, attenuates secondary brain injury after intracerebral hemorrhage in sub-acute phase

Brain Research
2018-12 | Journal article
Part of ISSN: 0006-8993
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Protective effects of the astaxanthin derivative, adonixanthin, on brain hemorrhagic injury

Brain Research
2018-11 | Journal article
Part of ISSN: 0006-8993
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Cilostazol protects extracellular matrix of human brain microvascular against collagenase injury

Journal of Pharmacological Sciences
2017 | Journal article
Contributors: Matsukawa, Haruka; Imai, Takahiko; Takagi, Toshinori; Tsuruma, Kazuhiro; Shimazawa, Masamitsu; Hara, Hideaki
Source: check_circle
Web of Science Researcher Profile Sync

Effects of ticagrelor in a mouse model of ischemic stroke.

Scientific reports
2017-09-21 | Journal article
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

The phosphodiesterase III inhibitor cilostazol protects the brain microvasculature from collagenase injury

NeuroReport
2017-07 | Journal article
Part of ISSN: 0959-4965
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Cilostazol ameliorates collagenase-induced cerebral hemorrhage by protecting the blood–brain barrier

Journal of Cerebral Blood Flow & Metabolism
2017-01 | Journal article
Part of ISSN: 0271-678X
Part of ISSN: 1559-7016
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Protective Effect of Bendavia (SS-31) Against Oxygen/Glucose-Deprivation Stress-Induced Mitochondrial Damage in Human Brain Microvascular Endothelial Cells

Current Neurovascular Research
2017-01-02 | Journal article
Part of ISSN: 1567-2026
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

A novel nuclear factor erythroid 2-related factor 2 (Nrf2) activator RS9 attenuates brain injury after ischemia reperfusion in mice

Neuroscience
2016-10 | Journal article
Part of ISSN: 0306-4522
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Nrf2 activator ameliorates hemorrhagic transformation in focal cerebral ischemia under warfarin anticoagulation

Neurobiology of Disease
2016-05 | Journal article
Part of ISSN: 0969-9961
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Diabetes Mellitus Aggravates Hemorrhagic Transformation after Ischemic Stroke via Mitochondrial Defects Leading to Endothelial Apoptosis

PLoS ONE
2014-08-18 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
Takahiko Imai
grade
Preferred source (of 2)‎

Peer review (60 reviews for 24 publications/grants)

Review activity for Annals of translational medicine. (1)
Review activity for Brain research. (3)
Review activity for Brain research. (6)
Review activity for European journal of medical research. (1)
Review activity for European journal of pharmaceutical sciences. (1)
Review activity for Frontiers in bioscience. (1)
Review activity for Heliyon. (2)
Review activity for Histology and histopathology. (1)
Review activity for Journal of neuroinflammation (4)
Review activity for Journal of pharmacological sciences. (1)
Review activity for Journal of the American Heart Association. (2)
Review activity for Metabolic brain disease. (1)
Review activity for Molecular biology reports. (2)
Review activity for Molecular neurobiology. (1)
Review activity for Molecular neurobiology. (9)
Review activity for Neurochemical research. (1)
Review activity for Neurochemical research. (4)
Review activity for Neuroscience letters. (1)
Review activity for Neurosurgical review. (1)
Review activity for Neurotoxicity research. (2)
Review activity for Pharmaceutical biology. (1)
Review activity for Scientific reports. (8)
Review activity for Stroke. (5)
Review activity for Translational stroke research. (1)