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Works (23)

A conserved chaperone protein is required for the formation of a noncanonical type VI secretion system spike tip complex

Journal of Biological Chemistry
2025-03 | Journal article
DOI: 10.1016/j.jbc.2025.108242
Contributors: Kartik Sachar; Katarzyna Kanarek; Jake Colautti; Youngchang Kim; Eran Bosis; Gerd Prehna; Dor Salomon; John C. Whitney
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Specialized killing across the domains of life by the type VI secretion systems of Pseudomonas aeruginosa

Biochemical Journal
2025-01-08 | Journal article
DOI: 10.1042/BCJ20230240
Contributors: Jake Colautti; Steven D. Kelly; John C. Whitney
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The antibacterial activity of a prophage-encoded fitness factor is neutralized by two cognate immunity proteins

Journal of Biological Chemistry
2024-12 | Journal article
DOI: 10.1016/j.jbc.2024.108007
Contributors: Andrea G. Alexei; Nathan P. Bullen; Stephen R. Garrett; David Sychantha; John C. Whitney
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A widespread accessory protein family diversifies the effector repertoire of the type VI secretion system spike

Nature Communications
2024-11-21 | Journal article
DOI: 10.1038/s41467-024-54509-2
Contributors: Jake Colautti; Huagang Tan; Nathan P. Bullen; Stephanie S. Thang; Dirk Hackenberger; Andrew C. Doxey; John C. Whitney
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An enterococcal phage protein inhibits type IV restriction enzymes involved in antiphage defense

Nature Communications
2024-08-13 | Journal article
DOI: 10.1038/s41467-024-51346-1
Contributors: Nathan P. Bullen; Cydney N. Johnson; Shelby E. Andersen; Garima Arya; Sonia R. Marotta; Yan-Jiun Lee; Peter R. Weigele; John C. Whitney; Breck A. Duerkop
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Structure of a tripartite protein complex that targets toxins to the type VII secretion system

Proceedings of the National Academy of Sciences
2024-01-16 | Journal article
DOI: 10.1073/pnas.2312455121
Contributors: Timothy A. Klein; Prakhar Y. Shah; Polyniki Gkragkopoulou; Dirk W. Grebenc; Youngchang Kim; John C. Whitney
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An enterococcal phage protein broadly inhibits type IV restriction enzymes involved in antiphage defense

2023-11-16 | Preprint
DOI: 10.1101/2023.11.16.567456
Contributors: Nathan P. Bullen; Cydney N. Johnson; Shelby E. Andersen; Garima Arya; Sonia R. Marotta; Yan-Jiun Lee; Peter R. Weigele; John C. Whitney; Breck A. Duerkop
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Structure of a tripartite protein complex that targets toxins to the type VII secretion system

2023-07-21 | Preprint
DOI: 10.1101/2023.07.21.550046
Contributors: Timothy A. Klein; Prakhar Y. Shah; Polyniki Gkragkopoulou; Dirk W. Grebenc; Youngchang Kim; John C. Whitney
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Identification of a broadly conserved family of enzymes that hydrolyze (p)ppApp

Proceedings of the National Academy of Sciences
2023-04-04 | Journal article
DOI: 10.1073/pnas.2213771120
Contributors: Shehryar Ahmad; Isis J. Gordon; Kara K. Tsang; Andrea G. Alexei; David Sychantha; Jake Colautti; Sarah L. Trilesky; Youngchang Kim; Boyuan Wang; John C. Whitney
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Lack of evidence that Pseudomonas aeruginosaAmpDh3‐PA0808 constitute a type VI secretion system effector–immunity pair

Molecular Microbiology
2023-02 | Journal article
DOI: 10.1111/mmi.15021
Contributors: Jake Colautti; Nathan P. Bullen; John C. Whitney
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Dual Targeting Factors Are Required for LXG Toxin Export by the Bacterial Type VIIb Secretion System

mBio
2022-10-26 | Journal article
DOI: 10.1128/mbio.02137-22
Contributors: Timothy A. Klein; Dirk W. Grebenc; Prakhar Y. Shah; Owen D. McArthur; Brandon H. Dickson; Michael G. Surette; Youngchang Kim; John C. Whitney; Caroline S. Harwood
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An ADP-ribosyltransferase toxin kills bacterial cells by modifying structured non-coding RNAs

Molecular Cell
2022-09 | Journal article
DOI: 10.1016/j.molcel.2022.08.015
Contributors: Nathan P. Bullen; David Sychantha; Stephanie S. Thang; Peter H. Culviner; Marta Rudzite; Shehryar Ahmad; Vraj S. Shah; Alain Filloux; Gerd Prehna; John C. Whitney
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Structure of a bacterial Rhs effector exported by the type VI secretion system

PLOS Pathogens
2022-01-05 | Journal article
DOI: 10.1371/journal.ppat.1010182
Contributors: Patrick Günther; Karla J.F. Satchell; Dennis Quentin; Shehryar Ahmad; Kartik Sachar; Christos Gatsogiannis; John C. Whitney; Stefan Raunser
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Structure of a bacterial Rhs effector exported by the type VI secretion system

2021-09-14 | Preprint
DOI: 10.1101/2021.09.14.460138
Contributors: Patrick Günther; Dennis Quentin; Shehryar Ahmad; Kartik Sachar; Christos Gatsogiannis; John C. Whitney; Stefan Raunser
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Dual role of a (p)ppGpp‐ and (p)ppApp‐degrading enzyme in biofilm formation and interbacterial antagonism

Molecular Microbiology
2021-06 | Journal article
DOI: 10.1111/mmi.14684
Contributors: Wieland Steinchen; Shehryar Ahmad; Martina Valentini; Kira Eilers; Mohamad Majkini; Florian Altegoer; Marcus Lechner; Alain Filloux; John C. Whitney; Gert Bange
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Emerging and divergent roles of pyrophosphorylated nucleotides in bacterial physiology and pathogenesis

PLOS Pathogens
2021-05-13 | Journal article
DOI: 10.1371/journal.ppat.1009532
Contributors: N. Y Elizabeth Chau; James B. Bliska; Shehryar Ahmad; John C. Whitney; Brian K. Coombes
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Bacterial type VII secretion: An important player in host‐microbe and microbe‐microbe interactions

Molecular Microbiology
2021-03 | Journal article
DOI: 10.1111/mmi.14680
Contributors: Hiu‐Ki R. Tran; Dirk W. Grebenc; Timothy A. Klein; John C. Whitney
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Structural basis for effector transmembrane domain recognition by type VI secretion system chaperones

eLife
2020-12-15 | Journal article
DOI: 10.7554/eLife.62816
Contributors: Shehryar Ahmad; Kara K Tsang; Kartik Sachar; Dennis Quentin; Tahmid M Tashin; Nathan P Bullen; Stefan Raunser; Andrew G McArthur; Gerd Prehna; John C Whitney
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Crossref

Structure of the extracellular region of the bacterial type VIIb secretion system subunit EsaA

2020-08-17 | Preprint
DOI: 10.1101/2020.08.17.254201
Contributors: Timothy A. Klein; Dirk W. Grebenc; Shil Y. Gandhi; Vraj S. Shah; Youngchang Kim; John C. Whitney
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Contact-Dependent Interbacterial Antagonism Mediated by Protein Secretion Machines

Trends in Microbiology
2020-05 | Journal article
DOI: 10.1016/j.tim.2020.01.003
Contributors: Timothy A. Klein; Shehryar Ahmad; John C. Whitney
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Molecular Basis for Immunity Protein Recognition of a Type VII Secretion System Exported Antibacterial Toxin

Journal of Molecular Biology
2018-10 | Journal article
DOI: 10.1016/j.jmb.2018.08.027
Contributors: Timothy A. Klein; Manuel Pazos; Michael G. Surette; Waldemar Vollmer; John C. Whitney
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Mechanism of loading and translocation of type VI secretion system effector Tse6

Nature Microbiology
2018-09-03 | Journal article
DOI: 10.1038/s41564-018-0238-z
Contributors: Dennis Quentin; Shehryar Ahmad; Premy Shanthamoorthy; Joseph D. Mougous; John C. Whitney; Stefan Raunser
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Crossref

A broadly distributed toxin family mediates contact-dependent antagonism between gram-positive bacteria

eLife
2017-07-11 | Journal article
DOI: 10.7554/eLife.26938
Contributors: John C Whitney; S Brook Peterson; Jungyun Kim; Manuel Pazos; Adrian J Verster; Matthew C Radey; Hemantha D Kulasekara; Mary Q Ching; Nathan P Bullen; Diane Bryant et al.
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Peer review (2 reviews for 2 publications/grants)

Review activity for Nature chemical biology. (1)
Review activity for Nature communications (1)
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