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Platelet, Thrombosis and Hemostasis, Integrin, Marine Drugs

Activities

Employment (3)

Ocean University of China: Qingdao, CN

2022-08 to present | Professor (School of Medicine and Pharmacy)
Employment
Source: Self-asserted source
Chuanbin Shen

University of Toronto: ON, ON, CA

2019-11 to 2022-08 | Postdoctoral Research Fellow (St Michael's Hospital, Keenan Research Centre for Biomedical Science)
Employment
Source: Self-asserted source
Chuanbin Shen

Chinese Academy of Sciences: Kunming, CN

2017-07 to 2019-10 | Assistant Professor (The Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences)
Employment
Source: Self-asserted source
Chuanbin Shen

Education and qualifications (1)

Kunming Institute of Zoology Chinese Academy of Sciences: Kunming, CN

2012-09 to 2017-07 | PhD (Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences)
Education
Source: Self-asserted source
Chuanbin Shen

Funding (5)

Excellent Youth Fund of Shandong Natural Science Foundation

Grant
Natural Science Foundation of Shandong Province (Qingdao, CN)
Source: Self-asserted source
Chuanbin Shen

Keenan Research Excellence Awards

Novel mechanisms and anti-platelet therapies of COVID-19-associated thrombosis

Taishan Scholars Youth Expert Program of Shandong Province

Grant
Government of Shandong Province (Qingdao, CN)
Source: Self-asserted source
Chuanbin Shen

The effect of integrin αIIbβ3/Src/14-3-3 axis mediated mechanosensing on platelet generation from megakaryocytes

Grant
National Natural Science Foundation of China (Beijing, CN)
Source: Self-asserted source
Chuanbin Shen

Works (31)

Apolipoprotein A-IV polymorphisms Q360H and T347S attenuate its endogenous inhibition of thrombosis

Biochemical and Biophysical Research Communications
2024 | Journal article
EID:

2-s2.0-85190725879

Part of ISSN: 10902104 0006291X
Contributors: MacKeigan, D.T.; Yu, S.-Y.; Chazot, N.; Zhang, D.; Khoury, C.J.; Lei, X.; Bhoria, P.; Shen, C.; Chen, P.; Zhu, G. et al.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier
grade
Preferred source (of 2)‎

Novel GPIb-independent platelet aggregation induced by botrocetin: implications for diagnosis and antithrombotic therapy

Journal of Thrombosis and Haemostasis
2024 | Journal article
EID:

2-s2.0-85203457859

Part of ISSN: 15387836 15387933
Contributors: Shen, C.; Mackeigan, D.T.; Shoara, A.A.; Bhoria, P.; Zhu, G.; Karakas, D.; Ma, W.; Chen, Z.Y.; Xu, R.; Slavkovic, S. et al.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier

NGAL deficiency elicits Hemophilia-like bleeding and clotting disorder

bioRxiv
2023 | Other
EID:

2-s2.0-85185708551

Part of ISSN: 26928205
Contributors: Xue, M.; Wang, S.; Li, C.; Wang, Y.; Liu, M.; Xiao, D.; Yin, Q.; Niu, L.; Shen, C.; Wang, J. et al.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier

Dual roles of fucoidan-GPIbα interaction in thrombosis and hemostasis: implications for drug development targeting GPIbα

Journal of Thrombosis and Haemostasis
2023-01 | Journal article
Part of ISSN: 1538-7836
Contributors: Chuanbin Shen; Daniel T. Mackeigan; Aron A. Shoara; Runjia Xu; Preeti Bhoria; Danielle Karakas; Wenjing Ma; Eric Cerenzia; ZiYan Chen; Brock Hoard et al.
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Doxorubicin-Induced Platelet Activation and Clearance Relieved by Salvianolic Acid Compound: Novel Mechanism and Potential Therapy for Chemotherapy-Associated Thrombosis and Thrombocytopenia

Pharmaceuticals
2022 | Journal article
EID:

2-s2.0-85144728703

Part of ISSN: 14248247
Contributors: Ma, W.; Rousseau, Z.; Slavkovic, S.; Shen, C.; Yousef, G.M.; Ni, H.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier
grade
Preferred source (of 3)‎

Hypoxia and low temperature upregulate transferrin to induce hypercoagulability at high altitude

Blood
2022 | Journal article
EID:

2-s2.0-85140061194

Part of ISSN: 15280020 00064971
Contributors: Li, M.; Tang, X.; Liao, Z.; Shen, C.; Cheng, R.; Fang, M.; Wang, G.; Li, Y.; Tang, S.; Xie, L. et al.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier
grade
Preferred source (of 2)‎

Novel contact–kinin inhibitor sylvestin targets thromboinflammation and ameliorates ischemic stroke

Cellular and Molecular Life Sciences
2022 | Journal article
EID:

2-s2.0-85128157536

Part of ISSN: 14209071 1420682X
Contributors: Zhang, Z.; Shen, C.; Fang, M.; Han, Y.; Long, C.; Liu, W.; Yang, M.; Liu, M.; Zhang, D.; Cao, Q. et al.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier

In vitro assessment and phase I randomized clinical trial of anfibatide a snake venom derived anti-thrombotic agent targeting human platelet GPIbα

Scientific Reports
2021-12 | Journal article
Part of ISSN: 2045-2322
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Viper venoms drive the macrophages and hepatocytes to sequester and clear platelets: novel mechanism and therapeutic strategy for venom-induced thrombocytopenia

Archives of Toxicology
2021-11 | Journal article
Part of ISSN: 0340-5761
Part of ISSN: 1432-0738
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

A Strategy for Efficient Preparation of Genus-Specific Diagnostic Antibodies for Snakebites

Frontiers in Immunology
2021-11-09 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Snake Venom Botrocetin Induces GPIb-Independent Platelet Aggregation

Blood
2021-11-05 | Journal article
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Source: Self-asserted source
Chuanbin Shen

Soy Isoflavones Inhibit Both GPIb-IX Signaling and αIIbβ3 Outside-In Signaling via 14-3-3ζ in Platelet

Molecules
2021-08-13 | Journal article
Part of ISSN: 1420-3049
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Potential Role of Platelet-Activating C-Type Lectin-Like Proteins in Viper Envenomation Induced Thrombotic Microangiopathy Symptom

Toxins
2020-11 | Journal article | Author
Contributors: Chengbo Long; Ming Liu; Huiwen Tian; Ya Li; Feilong Wu; James Mwangi; Qiumin Lu; Tarek Mohamed Abd El-Aziz; Ren Lai; Chuanbin Shen
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

The 14-3-3ζ-c-Src-integrin-β3 complex is vital for platelet activation.

Blood
2020-08-01 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 3)‎

Conformation-Specific Blockade of αIIbβ3 by a Non-RGD Peptide to Inhibit Platelet Activation without Causing Significant Bleeding and Thrombocytopenia.

Thrombosis and haemostasis
2020-07-27 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Iron-Deficiency and Estrogen Are Associated With Ischemic Stroke by Up-Regulating Transferrin to Induce Hypercoagulability.

Circulation research
2020-05-26 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Snake C-Type Lectins Potentially Contribute to the Prey Immobilization in <i>Protobothrops mucrosquamatus</i> and <i>Trimeresurus stejnegeri</i> Venoms.

Toxins
2020-02-06 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 3)‎

Updated Understanding of Platelets in Thrombosis and Hemostasis: The Roles of Integrin PSI Domains and their Potential as Therapeutic Targets.

Cardiovascular & hematological disorders drug targets
2020-01-01 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Iron-deficiency and estrogen are associated with ischemic stroke by up-regulating transferrin to induce hypercoagulability

bioRxiv
2019 | Other
EID:

2-s2.0-85095646232

Part of ISSN: 26928205
Contributors: Tang, X.; Fang, M.; Cheng, R.; Zhang, Z.; Wang, Y.; Shen, C.; Han, Y.; Lu, Q.; Du, Y.; Liu, Y. et al.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier

In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin.

Toxins
2019-06-30 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 3)‎

3'-Methoxydaidzein exerts analgesic activity by inhibiting voltage-gated sodium channels.

Chinese journal of natural medicines
2019-06-01 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Salivary factor LTRIN from Aedes aegypti facilitates the transmission of Zika virus by interfering with the lymphotoxin-β receptor.

Nature immunology
2018-03-05 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

In vivo antimalarial activity of synthetic hepcidin against Plasmodium berghei in mice.

Chinese journal of natural medicines
2017-03-01 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Phenolic acids isolated from the fungus Schizophyllum commune exert analgesic activity by inhibiting voltage-gated sodium channels

Chinese Journal of Natural Medicines
2016 | Journal article
EID:

2-s2.0-84990867078

Part of ISSN: 18755364
Contributors: YAO, H.-M.; WANG, G.; LIU, Y.-P.; RONG, M.-Q.; SHEN, C.-B.; YAN, X.-W.; LUO, X.-D.; LAI, R.
Source: Self-asserted source
Chuanbin Shen via Scopus - Elsevier

Prokineticin 2 Plays a Pivotal Role in Psoriasis.

EBioMedicine
2016-10-19 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

Mitochondrial DNA-LL-37 Complex Promotes Atherosclerosis by Escaping from Autophagic Recognition.

Immunity
2015-12-08 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

A potent anti-thrombosis peptide (vasotab TY) from horsefly salivary glands.

The international journal of biochemistry & cell biology
2014-07-12 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

A potential wound-healing-promoting peptide from salamander skin.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2014-05-27 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

A novel 26RFa peptide containing both analgesic and anti-inflammatory functions from Chinese tree shrew.

Biochimie
2014-03-12 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

A potential wound healing-promoting peptide from frog skin.

The international journal of biochemistry & cell biology
2014-01-17 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎

The first salamander defensin antimicrobial peptide.

PloS one
2013-12-30 | Journal article
Source: Self-asserted source
Chuanbin Shen
grade
Preferred source (of 2)‎