Personal information

liver cancer, hepatoblastoma, genomics, proteomics, epogenomics, biomarker
Spain

Biography

I have more than20 years of translational research focused on adult and paediatric liver cancer. Since 2009 I am the principal investigator of Childhood Liver Oncology Group (cLOG) at IGTP.

My main research domains are:
1.- Establishment of one of the largest collection of biological samples from childhood liver cancer patients
2.- Provide a comprehensive and highly validated panel of diagnostic and prognostic biomarkers for childhood patients with liver cancer from clinically-annotated patient cohorts (2 international patents)
3.- Identification of new therapeutic targets of childhood liver cancer
4.- Establishing new experimental in vivo and in vitro human tumour models (PDX and organoid cultures)
5.- Translation of childhood liver cancer findings to adulthood cancer.

Currently, I am coordinating the biological and pathological studies associated to the first international clinical trial on paediatric patients with liver cancer (PHITT) thanks to the European ChiLTERN, iPC and BT4ChildLC projects and the Spanish Association Against Cancer (Pmed4HB). By using omics studies, advanced computational machine-learning tools and mechanistic models we aim to identify therapeutic targets and new drugs for aggressive tumours.

Activities

Employment (7)

Agència de Gestió d’Ajuts Universitaris i de Recerca: Barcelona, ES

2018 to present (Head of the Emergent Research group (SGR-490) of the Agency for Management of University and Research Grants (AGAUR))
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Centro de Investigación Biomédica en Red Enfermedades Hepáticas y Digestivas: Barcelona, ES

2016 to present (Head of the research group (CB06/04/0033) of the Biomedical Research Networking Centres for Hepatic and digestive diseases (CIBERehd))
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Germans Trias i Pujol Research Institute (IGTP): Badalona, ES

2009 to present | Principal Investigator- Childhood Liver Oncology group (Gastroenterology)
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Fundació privada institut d'investigació biomed de Girona Dr. Josep Trueta: Girona, Catalunya, ES

2008-04-18 to 2008-11-01 | Investigador senior
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Institut Pasteur: Paris, Île-de-France, FR

2006-10-01 to 2007-10-30 | Investigador contratado
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Institut Pasteur: Paris, Île-de-France, FR

2004-10-01 to 2006-09-30 | Becario post-doctoral
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Hospital Clinic de Barcelona : Barcelona, Catalunya, ES

1998-07-01 to 2004-09-01 | Becario pre-doctoral
Employment
Source: Self-asserted source
CAROLINA ARMENGOL

Education and qualifications (3)

Universitat de Barcelona: Barcelona, Catalunya, ES

2004 | Doctorado en bioquímica, biología molecular y biomedicina
Education
Source: Self-asserted source
CAROLINA ARMENGOL

Universitat Autònoma de Barcelona: Bellaterra, Catalunya, ES

1998 | Bioquímica
Education
Source: Self-asserted source
CAROLINA ARMENGOL

Universitat de Girona: Girona, Catalunya, ES

1996 | Biologia
Education
Source: Self-asserted source
CAROLINA ARMENGOL

Professional activities (11)

Spanish Society of Paediatric Haematology and Oncology (SEHOP): Madrid, ES

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

Spanish Association for the Study of the Liver (AEEH): Madrid, ES

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

Pediatric Hepatic International Tumor Trial (PHITT) Biology Committee: Birmingham, GB

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

International Society of Paediatric Oncology (SIOP): Steinhausen, CH

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

International Liver Cancer Association: Brussels , BE

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

European Association for the Study of the Liver: Geneve, GE, CH

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

Childhood Liver Tumours Strategy Group (SIOPEL): Barcelona, ES

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

Catalan Society of Digestology (SCD): Barcelona, ES

Membership
Source: Self-asserted source
CAROLINA ARMENGOL

Catalan Health Institute: Barcelona, Catalonia, ES

2021-06-28 | Best PhD scientific publication
Distinction
Source: Self-asserted source
CAROLINA ARMENGOL

European Association for the Study of the Liver: Geneve, GE, CH

2017 | Best Poster award
Distinction
Source: Self-asserted source
CAROLINA ARMENGOL

Universitat Rovira i Virgili: Tarragona, Catalunya, ES

1998 | Award to young scientists
Distinction
Source: Self-asserted source
CAROLINA ARMENGOL

Funding (13)

Individualized Pediatric Cure, iPC

2019 to 2022 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

Grant Agreement: 826121

Source: Self-asserted source
CAROLINA ARMENGOL

Translational research group in hepatic pathology and innate immunity

2018 to 2020 | Grant
Agència de Gestió d’Ajuts Universitaris i de Recerca (Barcelona, ES)
GRANT_NUMBER:

2017-SGR-490

Source: Self-asserted source
CAROLINA ARMENGOL

Development of a predictive model of the lack of response to chemotherapy in patients with hepatoblastoma

2017 to 2019 | Grant
Ministerio de Economía y Competitividad (Madrid, ES)
Part of GRANT_NUMBER:

SAF2016-75-197-R

Source: Self-asserted source
CAROLINA ARMENGOL

New in Vitro Diagnostic devices for the clinical management of tuberculosis and hepatocellular carcinoma

2017 to 2018 | Grant
Agència de Gestió d’Ajuts Universitaris i de Recerca (Barcelona, ES)
Source: Self-asserted source
CAROLINA ARMENGOL

Research group in viral hepatitis, liver damage, cancer and immunity included in the Program of Liver damage mechanisms/evolution into advanced cirrhosis and transplant

2017 to 2017 | Grant
CIBERehd (Madrid, ES)
GRANT_NUMBER:

CB06/04/0033

Source: Self-asserted source
CAROLINA ARMENGOL

Children’s Liver Tumour European Research Network, ChiLTERN

2016 to 2020 | Grant
European Commission (Brussels, BE)
Part of GRANT_NUMBER:

Grant Agreement: 668596

Source: Self-asserted source
CAROLINA ARMENGOL

Prognostic value and functional importance of Spα protein in inflammation: relevance in cirrhosis and hepatocellular cancer

2014 to 2016 | Grant
Instituto de Salud Carlos III (Madrid, ES)
Part of GRANT_NUMBER:

PI13/1906

Source: Self-asserted source
CAROLINA ARMENGOL

Role of scavenger protein Spα in the interplay between macrophages, hepatic stellate cells and hepatocytes in liver cancer

2014 to 2016 | Grant
Fundació la Marató de TV3 (Barcelona, ES)
Part of GRANT_NUMBER:

MTV3 12/U/922

Source: Self-asserted source
CAROLINA ARMENGOL

Integral molecular analysis of Hepatoblastoma: identification, validation and therapeutic application of prognostic biomarkers for its incorporation into the clinical practice

2013 to 2016 | Grant
Instituto de Salud Carlos III (Madrid, ES)
GRANT_NUMBER:

PI13/02340

Source: Self-asserted source
CAROLINA ARMENGOL

Patentability report grant. Spanish Office of Patents

2012 to 2012 | Grant
Genoma España (Madrid, ES)
GRANT_NUMBER:

HGTP00411

Source: Self-asserted source
CAROLINA ARMENGOL

Identification of diagnostic, prognostic markers and new therapeutic targets in liver cancer

2011 to 2013 | Grant
Ministerio de Economía y Competitividad (Madrid, ES)
GRANT_NUMBER:

RYC-2010-07249

Source: Self-asserted source
CAROLINA ARMENGOL

Identification of diagnostic markers and prognosis in plasma of liver cancer by proteomic analysis

2010 to 2014 | Grant
Instituto de Salud Carlos III (Madrid, ES)
Part of GRANT_NUMBER:

PI09/00781

Source: Self-asserted source
CAROLINA ARMENGOL

Comprehensive proteomic study of childhood liver cancer: identification of diagnostic and prognostic factors, key signalling pathways and new therapeutic targets

2010 to 2013 | Grant
Instituto de Salud Carlos III (Madrid, ES)
GRANT_NUMBER:

FIS10/02082

Source: Self-asserted source
CAROLINA ARMENGOL

Works (29)

Mimicking cancer therapy in an agent-based model: the case of hepatoblastoma

2025-02-10 | Preprint
Contributors: Alessandro Ravoni; Enrico Mastrostefano; Roland Kappler; Carolina Armengol; Filippo Castiglione; Christine Nardini
Source: check_circle
Crossref

Characterisation of Aberrant Metabolic Pathways in Hepatoblastoma Using Liquid Chromatography and Tandem Mass Spectrometry (LC-MS/MS)

Cancers
2023-10-28 | Journal article
Contributors: Alison Whitby; Pardeep Pabla; Bhoomi Shastri; Laudina Amugi; Álvaro Del Río-Álvarez; Dong-Hyun Kim; Laura Royo; Carolina Armengol; Madhumita Dandapani
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Targeting the Unwindosome by Mebendazole Is a Vulnerability of Chemoresistant Hepatoblastoma

Cancers
2022-08 | Journal article | Author
Contributors: Qian Li; Salih Demir; Álvaro Del Río-Álvarez; Rebecca Maxwell; Alexandra Wagner; Juan Carrillo-Reixach; CAROLINA ARMENGOL; Christian Vokuhl; Beate Häberle; Dietrich von Schweinitz et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Identification of the most vulnerable populations in the psychosocial sphere: a cross-sectional study conducted in Catalonia during the strict lockdown imposed against the COVID-19 pandemic.

BMJ open
2021-11-26 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

Psychosocial impact of the Covid-19 pandemic: Identification of most vulnerable populations

2021-03-22 | Preprint
Contributors: Judith Farrés; José Luis Ruiz; José Manuel Mas; Lilibeth Arias; Maria-Rosa Sarrias; Carolina Armengol; Pere-Joan Cardona; José A. Muñoz-Moreno; Miriam Vilaplana; Belén Arranz et al.
Source: check_circle
Crossref

CD5L is a pleiotropic player in liver fibrosis controlling damage, fibrosis and immune cell content.

EBioMedicine
2019-05-08 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

Ductular Reaction Cells Display an Inflammatory Profile and Recruit Neutrophils in Alcoholic Hepatitis.

Hepatology (Baltimore, Md.)
2019-03-12 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

X-Linked Severe Combined Immunodeficiency and Hepatoblastoma: A Case Report and Review of Literature.

Journal of pediatric hematology/oncology
2018-08-01 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

Identification of theranostic biomarkers to improve the stratification of patients with pediatric liver cancer: Opportunities and challenges.

Hepatology (Baltimore, Md.)
2018-05-15 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

CD5L Promotes M2 Macrophage Polarization through Autophagy-Mediated Upregulation of ID3.

Frontiers in immunology
2018-03-12 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

Molecular bases of the poor response of liver cancer to chemotherapy.

Clinics and research in hepatology and gastroenterology
2018-03-12 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

CD5L is upregulated in hepatocellular carcinoma and promotes liver cancer cell proliferation and antiapoptotic responses by binding to HSPA5 (GRP78).

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2018-02-20 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

Hepatocellular carcinoma: Present and future.

Medicina clinica
2017-10-31 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

HEPACONTROL. A program that reduces early readmissions, mortality at 60 days, and healthcare costs in decompensated cirrhosis.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
2017-08-13 | Journal article
Source: Self-asserted source
CAROLINA ARMENGOL

Molecular classification of hepatoblastoma and prognostic value of the HB 16-gene signature.

2017-05 | Journal article
Contributors: Buendia MA; Armengol C; Cairo S
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Spontaneous regression of hepatocellular carcinoma. A case report

Gastroenterología y Hepatología (English Edition)
2017-04 | Journal article
Contributors: Ariadna Clos; Alba Hernández; María del Carmen Sánchez; Montserrat Tenesa; Joan Francesc Julián; Carolina Armengol; Margarita Sala
Source: Self-asserted source
CAROLINA ARMENGOL via Crossref Metadata Search

Spontaneous regression of hepatocellular carcinoma. A case report.

2017-04 | Journal article
Contributors: Clos A; Hernández A; Sánchez MD; Tenesa M; Julián JF; Armengol C; Sala M
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Patient-derived mouse xenografts from pediatric liver cancer predict tumor recurrence and advise clinical management.

2016-10 | Journal article
Contributors: Nicolle D; Fabre M; Simon-Coma M; Gorse A; Kappler R; Nonell L; Mallo M; Haidar H; Déas O; Mussini C et al.
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

The human CD5L/AIM-CD36 axis: A novel autophagy inducer in macrophages that modulates inflammatory responses.

2015 | Journal article
Contributors: Sanjurjo L; Amézaga N; Aran G; Naranjo-Gómez M; Arias L; Armengol C; Borràs FE; Sarrias MR
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Human scavenger protein AIM increases foam cell formation and CD36-mediated oxLDL uptake.

2014-03 | Journal article
Contributors: Amézaga N; Sanjurjo L; Julve J; Aran G; Pérez-Cabezas B; Bastos-Amador P; Armengol C; Vilella R; Escolà-Gil JC; Blanco-Vaca F et al.
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Role of scavenger receptors in the pathophysiology of chronic liver diseases.

2013 | Journal article
Contributors: Armengol C; Bartolí R; Sanjurjo L; Serra I; Amézaga N; Sala M; Sarrias MR
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Activation of Wnt and Myc signaling in hepatoblastoma.

2012 | Journal article
Contributors: Cairo S; Armengol C; Buendia MA
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Wnt signaling and hepatocarcinogenesis: the hepatoblastoma model.

2011-02 | Journal article
Contributors: Armengol C; Cairo S; Fabre M; Buendia MA
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

The LIM-only protein FHL2 mediates ras-induced transformation through cyclin D1 and p53 pathways.

2008 | Journal article
Contributors: Labalette C; Nouët Y; Levillayer F; Armengol C; Renard CA; Soubigou G; Xia T; Buendia MA; Wei Y
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Hepatic stem-like phenotype and interplay of Wnt/beta-catenin and Myc signaling in aggressive childhood liver cancer.

2008-12 | Journal article
Contributors: Cairo S; Armengol C; De Reyniès A; Wei Y; Thomas E; Renard CA; Goga A; Balakrishnan A; Semeraro M; Gresh L et al.
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

The LIM-only protein FHL2 regulates cyclin D1 expression and cell proliferation.

2008-05 | Journal article
Contributors: Labalette C; Nouët Y; Sobczak-Thepot J; Armengol C; Levillayer F; Gendron MC; Renard CA; Regnault B; Chen J; Buendia MA et al.
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.

2007-02 | Journal article
Contributors: Renard CA; Labalette C; Armengol C; Cougot D; Wei Y; Cairo S; Pineau P; Neuveut C; de Reyniès A; Dejean A et al.
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Orthotopic implantation of human hepatocellular carcinoma in mice: analysis of tumor progression and establishment of the BCLC-9 cell line.

2004-03 | Journal article
Contributors: Armengol C; Tarafa G; Boix L; Solé M; Queralt R; Costa D; Bachs O; Bruix J; Capellá G
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

p27(Kip1) is an independent predictor of recurrence after surgical resection in patients with small hepatocellular carcinoma.

2003-05 | Journal article
Contributors: Armengol C; Boix L; Bachs O; Solé M; Fuster J; Sala M; Llovet JM; Rodés J; Bruix J
Source: Self-asserted source
CAROLINA ARMENGOL via Europe PubMed Central

Peer review (3 reviews for 2 publications/grants)

Review activity for Journal of hepatology. (2)
Review activity for Nature communications (1)