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SciProfiles: 1721932

Keywords

biopharmaceutics and pharmacokinetics, clinical pharmacology, PBPK modeling

Countries

China

Activities

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Employment (1)

Second Hospital of Anhui Medical University: Hefei, CN

2021-06-23 to present | Senior Pharmacist (Drug Clinical Trial Research Center/Department of Clinical Pharmacology)
Employment
Source: Self-asserted source
Liang Zheng

Education and qualifications (2)

Sichuan University: Chengdu, Sichuan, CN

2017-09 to 2021-06 | Ph.D. (Department of Clinical Pharmacy and Pharmacy Administration, West China School of Pharmacy)
Education
Source: Self-asserted source
Liang Zheng

Southern Medical University: Guangzhou, Guangdong, CN

2013-07 to 2016-06 | Master of Science (Department of Pharmaceutics, School of Pharmaceutical Sciences)
Education
Source: Self-asserted source
Liang Zheng

Professional activities (2)

Chinese Pharmacological Society: Xicheng, Beijing, CN

2023-01-01 to present | Youth Commissioner (Division of Clinical Pharmacology)
Membership
Source: Self-asserted source
Liang Zheng

World Federation of Chinese Medicine Societies (WFCMS): Beijing, CN

2014 to present | Member
Membership
Source: Self-asserted source
Liang Zheng

Funding (2)

PBPK modeling of antipsychotics during pregnancy

2023-01 to 2025-12 | Grant
National Natural Science Foundation of China (Beijing, CN)
Source: Self-asserted source
Liang Zheng

PBPK modeling of CYP-mediated drug interactions for innovative TKIs

2023-01 to 2025-01 | Grant
Anhui Institute of Translational Medicine (Hefei, CN)
Source: Self-asserted source
Liang Zheng

Works (23)

Evaluating Drug Interactions between Ritonavir and Opioid Analgesics: Implications from Physiologically Based Pharmacokinetic Simulation

Pharmaceuticals
2024-05-15 | Journal article
DOI: 10.3390/ph17050640
Contributors: Liang Ni; Zhihai Cao; Jiakang Jiang; Wei Zhang; Wei Hu; Qian Zhang; Chaozhuang Shen; Xijing Chen; Liang Zheng
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Physiologically based pharmacokinetic modeling to predict the pharmacokinetics of codeine in different CYP2D6 phenotypes

Frontiers in Pharmacology
2024-05-02 | Journal article
DOI: 10.3389/fphar.2024.1342515
Part of ISSN: 1663-9812
Contributors: Yujie Yang; Xiqian Zhang; Yirong Wang; Heng Xi; Min Xu; Liang Zheng
Source: Self-asserted source
Liang Zheng

Physiologically Based Pharmacokinetic Modeling of Ritonavir-Oxycodone Drug Interactions and Its Implication for Dosing Strategy

European Journal of Pharmaceutical Sciences
2024-01 | Journal article
DOI: 10.1016/j.ejps.2024.106697
Part of ISSN: 0928-0987
Contributors: Liang Zheng; Wei Zhang; Klaus T. Olkkola; André Dallmann; Liang Ni; Yingjie Zhao; Ling Wang; Qian Zhang; Wei Hu
Source: Self-asserted source
Liang Zheng

Physiologically Based Pharmacokinetic Modeling in Neonates: Current Status and Future Perspectives

Pharmaceutics
2023-12-12 | Journal article
DOI: 10.3390/pharmaceutics15122765
Contributors: Wei Zhang; Qian Zhang; Zhihai Cao; Liang Zheng; Wei Hu
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Enhancing Paclitaxel Efficacy with Piperine-Paclitaxel Albumin Nanoparticles in Multidrug-Resistant Triple-Negative Breast Cancer by Inhibiting P-Glycoprotein

Pharmaceutics
2023-11-30 | Journal article
DOI: 10.3390/pharmaceutics15122703
Contributors: Wenwen Xu; Yumeng Xiao; Liang Zheng; Mingyu Xu; Xuehua Jiang; Ling Wang
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Physiologically Based Pharmacokinetic Modeling to Simulate CYP3A4-Mediated Drug-Drug Interactions for Pyrotinib

Advances in Therapy
2023-10 | Journal article
DOI: 10.1007/s12325-023-02602-1
Contributors: Liang Ni; Liang Zheng; Yueyue Liu; Wenwen Xu; Yingjie Zhao; Ling Wang; Qian Zhang; Wei Hu; Xijing Chen
Source: check_circle
Crossref

Pharmacokinetics, Safety, and Bioequivalence of 2 Lopinavir/Ritonavir (200/50 mg) Tablets in Healthy Chinese Volunteers: Effect of Food on Absorption

Clinical Pharmacology in Drug Development
2023-02-15 | Journal article
DOI: 10.1002/cpdd.1229
Part of ISSN: 2160-763X
Part of ISSN: 2160-7648
Contributors: Wei Zhang; Lili Lin; Wanjin Fu; Dandan Bao; Qian Zhang; Yueyue Liu; Liang Zheng; Wei Hu
Source: Self-asserted source
Liang Zheng

An Open‐Label, Randomized Pharmacokinetic Study of 2 Formulations of Eldecalcitol Capsules Following Single Oral Administration in Healthy Chinese Volunteers Under Fasting and Fed Conditions

Clinical Pharmacology in Drug Development
2022-11 | Journal article
DOI: 10.1002/cpdd.1144
Part of ISSN: 2160-763X
Part of ISSN: 2160-7648
Contributors: Juan Wu; Yuru Fan; Liang Zheng; Zhiqiang Wang; Yueyue Liu; Chenlin Shen; Wei Hu
Source: Self-asserted source
Liang Zheng

LC–MS/MS determination of HY072808, a novel candidate for treating atopic dermatitis, and its active metabolite: Application to a first‐in‐human pharmacokinetic study

Biomedical Chromatography
2022-11-13 | Journal article
DOI: 10.1002/bmc.5542
Part of ISSN: 0269-3879
Part of ISSN: 1099-0801
Contributors: Liang Zheng; Jingying Wu; Liang Zheng; Qian Zhang; Qin Zhang; Huiling Qin; Renpeng Zhou; Zhaoxing Chu; Guangwei He; Ling Wang et al.
Source: Self-asserted source
Liang Zheng

Physiologically based pharmacokinetic modeling of brivaracetam and its interactions with rifampin based on CYP2C19 phenotypes

European Journal of Pharmaceutical Sciences
2022-10 | Journal article
DOI: 10.1016/j.ejps.2022.106258
Part of ISSN: 0928-0987
Contributors: Hongyi Yang; Leting Yang; Xiaofang Zhong; Xuehua Jiang; Liang Zheng; Ling Wang
Source: Self-asserted source
Liang Zheng

Antidepressants and Antipsychotics in Human Pregnancy: Transfer Across the Placenta and Opportunities for Modeling Studies

The Journal of Clinical Pharmacology
2022-09 | Journal article
DOI: 10.1002/jcph.2108
Part of ISSN: 0091-2700
Part of ISSN: 1552-4604
Contributors: Liang Zheng; Hongyi Yang; André Dallmann
Source: Self-asserted source
Liang Zheng

Physiologically Based Pharmacokinetic Modeling in Pregnant Women Suggests Minor Decrease in Maternal Exposure to Olanzapine

Frontiers in Pharmacology
2022-01-19 | Journal article
DOI: 10.3389/fphar.2021.793346
Part of ISSN: 1663-9812
Contributors: Liang Zheng; Hongyi Yang; André Dallmann; Xuehua Jiang; Ling Wang; Wei Hu
Source: Self-asserted source
Liang Zheng

Pharmacokinetics, safety and bioequivalence of two formulations of progesterone soft capsule in healthy Chinese postmenopausal females: Impacts of a high‐fat meal

Basic & Clinical Pharmacology & Toxicology
2021-12-02 | Journal article
DOI: 10.1111/bcpt.13687
Part of ISSN: 1742-7835
Part of ISSN: 1742-7843
Source: Self-asserted source
Liang Zheng

Physiologically based pharmacokinetic modeling of tramadol to inform dose adjustment and drug‐drug interactions according to CYP2D6 phenotypes

Pharmacotherapy: The Journal of Human Pharmacology and Drug Therapy
2021-03 | Journal article
DOI: 10.1002/phar.2494
Part of ISSN: 0277-0008
Part of ISSN: 1875-9114
Contributors: Miao Xu; Liang Zheng; Jin Zeng; Wenwen Xu; Xuehua Jiang; Ling Wang
Source: Self-asserted source
Liang Zheng

Dose Adjustment of Quetiapine and Aripiprazole for Pregnant Women Using Physiologically Based Pharmacokinetic Modeling and Simulation.

Clinical pharmacokinetics
2020-11-30 | Journal article | Author
DOI: 10.1007/s40262-020-00962-3
PMID: 33251573
Contributors: Liang Zheng; Tang S; Tang R; Xu M; Jiang X; Ling Wang
Source: Self-asserted source
Liang Zheng

Jian-Pi-Bu-Xue-Formula Alleviates Cyclophosphamide-Induced Myelosuppression via Up-Regulating NRF2/HO1/NQO1 Signaling

Frontiers in Pharmacology
2020-08-26 | Journal article
DOI: 10.3389/fphar.2020.01302
Part of ISSN: 1663-9812
Contributors: Qiuju Huang; Lizhi Feng; Hang Li; Liang Zheng; Xiaoxiao Qi; Ying Wang; Qian Feng; Zhongqiu Liu; Xiaohong Liu; Linlin Lu
Source: Self-asserted source
Liang Zheng

Physiologically Based Pharmacokinetic Modeling of Oxycodone in Children to Support Pediatric Dosing Optimization

Pharmaceutical Research
2019-12 | Journal article
DOI: 10.1007/s11095-019-2708-2
Part of ISSN: 0724-8741
Part of ISSN: 1573-904X
Contributors: Liang Zheng; Miao Xu; Shi-wei Tang; Hao-xin Song; Xue-hua Jiang; Ling Wang
Source: Self-asserted source
Liang Zheng

Impacts of Cytochrome P450 2D6*10 Allele and a High-Fat Meal on the Pharmacokinetics of Dapoxetine in Healthy Chinese Men: A Single-Dose, Two-Treatment Study

Advances in Therapy
2019-08 | Journal article
DOI: 10.1007/s12325-019-00982-x
Part of ISSN: 0741-238X
Part of ISSN: 1865-8652
Source: Self-asserted source
Liang Zheng

In-vitro and in situ assessment of the efflux of five antidepressants by breast cancer resistance protein

Journal of Pharmacy and Pharmacology
2019-06-07 | Journal article
DOI: 10.1111/jphp.13100
Part of ISSN: 2042-7158
Part of ISSN: 0022-3573
Contributors: Suqin Feng; Liang Zheng; Shiwei Tang; Juan Gu; Xuehua Jiang; Ling Wang
Source: Self-asserted source
Liang Zheng

In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters

The AAPS Journal
2016-09 | Journal article
DOI: 10.1208/s12248-016-9951-9
Part of ISSN: 1550-7416
Contributors: Liang Zheng; Lijun Zhu; Min Zhao; Jian Shi; Yuhuan Li; Jia Yu; Huangyu Jiang; Jinjun Wu; Yunli Tong; Yuting Liu et al.
Source: Self-asserted source
Liang Zheng

Artemisinin and its derivatives can significantly inhibit lung tumorigenesis and tumor metastasis through Wnt/β-catenin signaling

Oncotarget
2016-05-24 | Journal article
DOI: 10.18632/oncotarget.8920
Part of ISSN: 1949-2553
Source: Self-asserted source
Liang Zheng

Toxic Markers of Matrine Determined Using 1H-NMR-Based Metabolomics in Cultured Cells In Vitro and Rats In Vivo

Evidence-Based Complementary and Alternative Medicine
2015 | Journal article
DOI: 10.1155/2015/598412
Part of ISSN: 1741-427X
Part of ISSN: 1741-4288
Contributors: Zhonghuang Li; Liang Zheng; Jian Shi; Guiyu Zhang; Linlin Lu; Lijun Zhu; Jiajie Zhang; Zhongqiu Liu
Source: Self-asserted source
Liang Zheng

Study of pharmacokinetic profiles and characteristics of active components and their metabolites in rat plasma following oral administration of the water extract of Astragali radix using UPLC–MS/MS

Journal of Ethnopharmacology
2015-07 | Journal article
DOI: 10.1016/j.jep.2015.04.019
Part of ISSN: 0378-8741
Contributors: Jian Shi; Liang Zheng; Zhufen Lin; Chuqi Hou; Wenqin Liu; Tongmeng Yan; Lijun Zhu; Ying Wang; Linlin Lu; Zhongqiu Liu
Source: Self-asserted source
Liang Zheng

Peer review (2 reviews for 2 publications/grants)

Review activity for Archives of pharmacal research. (1)
Review activity for Biomedicine & pharmacotherapy. (1)
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