Personal information

Italy

Activities

Employment (5)

Italian Medicines Agency: Rome, IT

2024-09-11 to present | Head of Independent Research Office (Independent Research Office)
Employment
Source: Self-asserted source
Armando Magrelli

University of Rome Tor Vergata: Rome, Lazio, IT

2018-02-01 to present | Prof. (Faculty of Pharmacy)
Employment
Source: Self-asserted source
Armando Magrelli

Istituto Superiore di Sanità: Roma, Lazio, IT

2008-07-01 to present | Reasercher (National Center for Drug Research and Evaluation)
Employment
Source: Self-asserted source
Armando Magrelli

European Medicines Agency: Amsterdam, Amsterdam, NL

2012-04-01 to 2024-06-15 | Vice Chair (Committee of Orphan Medicinal Products)
Employment
Source: Self-asserted source
Armando Magrelli

European Medicines Agency: Amsterdam, Amsterdam, NL

2013-03-01 to 2022-12-31 | Member (Scientific Advice Working Party)
Employment
Source: Self-asserted source
Armando Magrelli

Education and qualifications (4)

European Molecular Biology Laboratory: Heidelberg, Baden-Württemberg, DE

2000-11-20 to 2000-12-05 | Course on Genome Analysis by High Troughput Technique
Education
Source: Self-asserted source
Armando Magrelli

International Centre for Genetic Engineering and Biotechnology: Trieste, Friuli-Venezia Giulia, IT

1999-04-12 to 1999-04-15 | Rna Structure and Funcion Theoretical Course
Education
Source: Self-asserted source
Armando Magrelli

Max-Planck-Gesellschaft: Cologne, DE

1992-11-01 to 1995-12-31 | PhD (Plant Breeding)
Education
Source: Self-asserted source
Armando Magrelli

Sapienza University of Rome: Rome, Lazio, IT

1985-11-01 to 1992-10-20 | Degree in Biological Sciences (Faculty of Science)
Education
Source: Self-asserted source
Armando Magrelli

Works (43)

Inherited retinal dystrophies and orphan designations in the European Union

European Journal of Ophthalmology
2024 | Journal article
Contributors: Moseley, Jane; Leest, Tim; Larsson, Kristina; Magrelli, Armando; Stoyanova-Beninska, Violeta
Source: check_circle
Web of Science Researcher Profile Sync
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Preferred source (of 2)‎

Navigating the Orphan Medicinal Product Designation: Evidence Requirements for Gene Therapies in Europe

Molecular Therapy
2024-10 | Journal article
Part of ISSN: 1525-0016
Contributors: G.M. Palomo; T. Pose-Boirazian; F. Naumann-Winter; E. Costa; D.M. Duarte; M.E. Kalland; E. Malikova; D. Matusevicius; D. Vitezic; K. Larsson et al.
Source: Self-asserted source
Armando Magrelli

Revolutionizing CAR T-Cell Therapies: Innovations in Genetic Engineering and Manufacturing to Enhance Efficacy and Accessibility

International Journal of Molecular Sciences
2024-09-26 | Journal article
Contributors: Lorenzo Giorgioni; Alessandra Ambrosone; Maria Francesca Cometa; Anna Laura Salvati; Robert Nisticò; Armando Magrelli
Source: check_circle
Crossref
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Advancing rare disease treatment: EMA’s decade-long insights into engineered adoptive cell therapy for rare cancers and orphan designation

Gene Therapy
2024-03-14 | Journal article | Author
Part of ISSN: 1476-5462
Contributors: Maria Elisabeth Kalland; Tomas Pose Boirazian; Gloria Maria Palomo Carrasco; Frauke Naumann-Winter; Enrico Costa; Darius Matusevicius; Dinah Duarte; Eva Malikova; Dinko Vitezic; Kristina Larsson et al.
Source: Self-asserted source
Armando Magrelli via Crossref Metadata Search
grade
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The European landscape for gene therapies in orphan diseases: 6-year experience with the EMA Committee for Orphan Medicinal Products

Molecular Therapy
2023-10 | Journal article
Part of ISSN: 1525-0016
Contributors: Gloria M. Palomo; Tomas Pose-Boirazian; Frauke Naumann-Winter; Enrico Costa; Dinah M. Duarte; Maria E. Kalland; Eva Malikova; Darius Matusevicius; Dinko Vitezic; Kristina Larsson et al.
Source: Self-asserted source
Armando Magrelli
grade
Preferred source (of 2)‎

CAR-T State of the Art and Future Challenges, A Regulatory Perspective

International Journal of Molecular Sciences
2023-07-22 | Journal article
Contributors: Lorenzo Giorgioni; Alessandra Ambrosone; Maria Francesca Cometa; Anna Laura Salvati; Armando Magrelli
Source: check_circle
Crossref
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Licensing of Orphan Medicinal Products-Use of Real-World Data and Other External Data on Efficacy Aspects in Marketing Authorization Applications Concluded at the European Medicines Agency Between 2019 and 2021

Frontiers in Pharmacology
2022 | Journal article
Contributors: Naumann-Winter, Frauke; Wolter, Franziska; Hermes, Ulrike; Malikova, Eva; Lilienthal, Nils; Meier, Tania; Kalland, Maria Elisabeth; Magrelli, Armando
Source: check_circle
Web of Science Researcher Profile Sync
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Real-World Data and Budget Impact Analysis (BIA): Evaluation of a Targeted Next-Generation Sequencing Diagnostic Approach in Two Orthopedic Rare Diseases

Frontiers in Pharmacology
2022 | Journal article
Contributors: Pedrini, Elena; Negro, Antonella; Di Brino, Eugenio; Pecoraro, Valentina; Sculco, Camilla; Abelli, Elisabetta; Gnoli, Maria; Magrelli, Armando; Sangiorgi, Luca; Cicchetti, Americo
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Web of Science Researcher Profile Sync
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Orphan Medicinal Products for the Treatment of Pancreatic Cancer: Lessons Learned From Two Decades of Orphan Designation

Frontiers in Oncology
2021 | Journal article
Contributors: Mulder, Jorn; van Rossum, Tobias; Mariz, Segundo; Magrelli, Armando; de Boer, Anthonius; Pasmooij, Anna M. G.; Stoyanova-Beninska, Violeta
Source: check_circle
Web of Science Researcher Profile Sync
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Haemophilia, state of the art and new therapeutic opportunities, a regulatory perspective

British Journal of Clinical Pharmacology
2021-11 | Journal article
Contributors: Francesca Tomeo; Segundo Mariz; Angelo Loris Brunetta; Violeta Stoyanova‐Beninska; Karri Penttila; Armando Magrelli
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Crossref
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Defining Satisfactory Methods of Treatment in Rare Diseases When Evaluating Significant Benefit–The EU Regulator's Perspective

Frontiers in Medicine
2021-08-27 | Journal article
Part of ISSN: 2296-858X
Contributors: Maria E. Sheean; Frauke Naumann-Winter; Giuseppe Capovilla; Maria Elisabeth Kalland; Eva Malikova; Segundo Mariz; Darius Matusevicius; Robert Nistico; Brigitte Schwarzer-Daum; Stelios Tsigkos et al.
Source: Self-asserted source
Armando Magrelli
grade
Preferred source (of 2)‎

Regulatory Standards in Orphan Medicinal Product Designation in the EU.

Frontiers in medicine
2021-06-25 | Journal article
Source: Self-asserted source
Armando Magrelli
grade
Preferred source (of 2)‎

Nonclinical data supporting orphan medicinal product designations in the area of rare infectious diseases

Drug Discovery Today
2020 | Journal article
EID:

2-s2.0-85075864514

Part of ISBN:

18785832 13596446

Contributors: Sheean, M.E.; Malikova, E.; Duarte, D.; Capovilla, G.; Fregonese, L.; Hofer, M.P.; Magrelli, A.; Mariz, S.; Mendez-Hermida, F.; Nistico, R. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
Preferred source (of 3)‎

Reply to the article “Management of status epilepticus in adults. Position paper of the Italian League against Epilepsy”

Epilepsy and Behavior
2020 | Journal article
EID:

2-s2.0-85084576452

Part of ISBN:

15255069 15255050

Contributors: Capovilla, G.; Nistico, R.; Magrelli, A.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Reply to the reply of the authors of the review article entitled “Management of status epilepticus in adults. Position paper of the Italian League against Epilepsy”

Epilepsy and Behavior
2020 | Journal article
EID:

2-s2.0-85085768331

Part of ISBN:

15255069 15255050

Contributors: Capovilla, G.; Nistico, R.; Magrelli, A.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Providing high-quality care remotely to patients with rare bone diseases during COVID-19 pandemic.

Orphanet journal of rare diseases
2020-08-31 | Journal article
Source: Self-asserted source
Armando Magrelli
grade
Preferred source (of 2)‎

European regulators’ views on a wearable-derived performance measurement of ambulation for Duchenne muscular dystrophy regulatory trials

Neuromuscular Disorders
2019 | Journal article
EID:

2-s2.0-85068091701

Contributors: Haberkamp, M.; Moseley, J.; Athanasiou, D.; de Andres-Trelles, F.; Elferink, A.; Rosa, M.M.; Magrelli, A.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Using a stated preference discrete choice experiment to assess societal value from the perspective of patients with rare diseases in Italy

Orphanet journal of rare diseases
2019 | Journal article
EID:

2-s2.0-85068902411

Contributors: López-Bastida, J.; Ramos-Goñi, J.M.; Aranda-Reneo, I.; Taruscio, D.; Magrelli, A.; Kanavos, P.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Defining orphan conditions in the context of the European orphan regulation: challenges and evolution

Nature reviews. Drug discovery
2018 | Journal article
Source: Self-asserted source
Armando Magrelli
grade
Preferred source (of 2)‎

Demonstrating significant benefit of orphan medicines: analysis of 15 years of experience in Europe

Drug Discovery Today
2018 | Journal article
EID:

2-s2.0-85034961095

Contributors: Fregonese, L.; Greene, L.; Hofer, M.; Magrelli, A.; Naumann-Winter, F.; Larsson, K.; Sheean, M.; Stoyanova-Beninska, V.; Tsigkos, S.; Westermark, K. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Nonclinical data supporting orphan medicinal product designations: lessons from rare neurological conditions

Drug Discovery Today
2018 | Journal article
EID:

2-s2.0-85030862015

Contributors: Sheean, M.E.; Stoyanova-Beninska, V.; Capovilla, G.; Duarte, D.; Hofer, M.P.; Hoffmann, M.; Magrelli, A.; Mariz, S.; Tsigkos, S.; Shaili, E. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Hepatoblastoma and microRNA-483 Two Forms and One Outcome

J Genet Syndr Gene Ther
2016 | Journal article
Contributors: Marco Salvatore; Armando Magrelli; Valentini Flamini; Andrea Brunati; Eleonora Basso; Renato Romagnoli; Ezio David; Domenica Taruscio
Source: Self-asserted source
Armando Magrelli via Crossref Metadata Search

Pathways Implicated in Tadalafil Amelioration of Duchenne Muscular Dystrophy

Journal of Cellular Physiology
2016 | Journal article
EID:

2-s2.0-84942342503

Contributors: De Arcangelis, V.; Strimpakos, G.; Gabanella, F.; Corbi, N.; Luvisetto, S.; Magrelli, A.; Onori, A.; Passananti, C.; Pisani, C.; Rome, S. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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The Italian National Centre for Rare Diseases: where research and public health translate into action.

Blood Transfusion
2014-04 | Journal article
Source: Self-asserted source
Armando Magrelli via Europe PubMed Central
grade
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Predictive medicine and biomarkers: The case of rare diseases

Personalized Medicine
2012 | Journal article
EID:

2-s2.0-84858379909

Contributors: Taruscio, D.; Salvatore, M.; Magrelli, A.; Tomanin, R.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Oxidative stress activation of miR-125b is part of the molecular switch for Hailey-Hailey disease manifestation

Experimental Dermatology
2011 | Journal article
Contributors: Manca, Sonia; Magrelli, Armando; Cialfi, Samantha; Lefort, Karine; Ambra, Roberto; Alimandi, Maurizio; Biolcati, Gianfranco; Uccelletti, Daniela; Palleschi, Claudio; Screpanti, Isabella et al.
Source: Self-asserted source
Armando Magrelli via ResearcherID
grade
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The role of microRNAs in the biology of rare diseases

International Journal of Molecular Sciences
2011 | Journal article
EID:

2-s2.0-80055028582

Contributors: Salvatore, M.; Magrelli, A.; Taruscio, D.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Characterization of HuH6, Hep3B, HepG2 and HLE liver cancer cell lines by WNT/beta - catenin pathway, microRNA expression and protein expression profile.

Cellular and Molecular Biology
2010 | Journal article
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Web of Science Researcher Profile Sync

Characterization of HUH6, HEP3B, HEPG2 and HLE liver cancer cell lines by WNT/Q- catenin pathway, microrna expression and protein expression profile

Cellular and Molecular Biology
2010 | Journal article
EID:

2-s2.0-79952200841

Part of ISBN:

01455680 1165158X

Contributors: Di Masi, A.; Viganotti, M.; Antoccia, A.; Magrelli, A.; Salvatore, M.; Azzalin, G.; Tosto, F.; Lorenzetti, S.; Maranghi, F.; Mantovani, A. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier

Complex multipathways alterations and oxidative stress are associated with Hailey-Hailey disease

British Journal of Dermatology
2010 | Journal article
EID:

2-s2.0-76949101328

Contributors: Cialfi, S.; Oliviero, C.; Ceccarelli, S.; Marchese, C.; Barbieri, L.; Biolcati, G.; Uccelletti, D.; Palleschi, C.; Barboni, L.; De Bernardo, C. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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In utero exposure to di-(2-ethylhexyl) phthalate affects liver morphology and metabolism in post-natal CD-1 mice

Reproductive Toxicology
2010 | Journal article
EID:

2-s2.0-77953538803

Contributors: Maranghi, F.; Lorenzetti, S.; Tassinari, R.; Moracci, G.; Tassinari, V.; Marcoccia, D.; Di Virgilio, A.; Eusepi, A.; Romeo, A.; Magrelli, A. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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MicroRNA profiling of multiple osteochondromas: identification of disease-specific and normal cartilage signatures

Clinical Genetics
2010 | Journal article
Contributors: Zuntini, M; Salvatore, M; Pedrini, E; Parra, A; Sgariglia, F; Magrelli, A; Taruscio, D; Sangiorgi, L
Source: Self-asserted source
Armando Magrelli via ResearcherID
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The artificial gene Jazz, a transcriptional regulator of utrophin, corrects the dystrophic pathology in mdx mice

Human Molecular Genetics
2010 | Journal article
EID:

2-s2.0-77950540612

Contributors: di Certo, M.G.; Corbi, N.; Strimpakos, G.; Onori, A.; Luvisetto, S.; Severini, C.; Guglielmotti, A.; Batassa, E.M.; Pisani, C.; Floridi, A. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Altered microRNA Expression Patterns in Hepatoblastoma Patients

TRANSLATIONAL ONCOLOGY
2009 | Journal article
Contributors: MAGRELLI, A; AZZALIN, G; SALVATORE, M; VIGANOTTI, M; TOSTO, F; COLOMBO, T; DEVITO, R; DI MASI, A; ANTOCCIA, A; LORENZETTI, S et al.
Source: Self-asserted source
Armando Magrelli via ResearcherID
grade
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Combined High Resolution Genomic and Expression Profiles Microarray Analysis in Sezary Syndrome

Blood
2009 | Journal article
Contributors: Caprini, Elisabeth; Cristofoletti, Cristina; Arcelli, Diego; Fadda, Paolo; Citterich, Mauro Helmer; Sampogna, Francesca; Magrelli, Armando; Torreri, Paola; Censi, Federica; Frontani, Marina et al.
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Web of Science Researcher Profile Sync

Combined High Resolution Genomic and Expression Profiles Microarray Analysis in Sezary Syndrome

Blood
2009 | Journal article
Contributors: Caprini, E; Cristofoletti, C; Arcelli, D; Fadda, P; Citterich, MH; Sampogna, F; Magrelli, A; Torreri, P; Censi, F; Frontani, M et al.
Source: Self-asserted source
Armando Magrelli via ResearcherID

Identification of key regions and genes important in the pathogenesis of Sézary syndrome by combining genomic and expression microarrays

Cancer Research
2009 | Journal article
EID:

2-s2.0-70350542803

Contributors: Caprini, E.; Cristofoletti, C.; Arcelli, D.; Fadda, P.; Citterich, M.H.; Sampogna, F.; Magrelli, A.; Censi, F.; Torreri, P.; Frontani, M. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
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Quantitative technologies establish a novel microRNA profile of chronic lymphocytic leukemia

Blood
2007 | Journal article
EID:

2-s2.0-34249661649

Contributors: Fulci, V.; Chiaretti, S.; Goldoni, M.; Azzalin, G.; Carucci, N.; Tavolaro, S.; Castellano, L.; Magrelli, A.; Citarella, F.; Messina, M. et al.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
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Altered dopamine signaling and MPTP resistance in mice lacking the Parkinson's disease-associated GPR37/parkin-associated endothelin-like receptor

Proceedings of the National Academy of Sciences of the United States of America
2004 | Journal article
EID:

2-s2.0-3042707292

Contributors: Marazziti, D.; Golini, E.; Mandillo, S.; Magrelli, A.; Witke, W.; Matteoni, R.; Tocchini-Valentini, G.P.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
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Genomic analysis of GPR37 and related orphan G-protein coupled receptor genes highly expressed in the mammalian brain

Current Genomics
2001 | Journal article
EID:

2-s2.0-0034844593

Contributors: Marazziti, D.; Golini, E.; Magrelli, A.; Matteoni, R.; Tocchini-Valentini, G.P.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
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White collar-1, a central regulator of blue light responses in Neurospora, is a zinc finger protein

EMBO Journal
1996 | Journal article
EID:

2-s2.0-0029879678

Part of ISBN:

02614189

Contributors: Ballario, P.; Vittorioso, P.; Magrelli, A.; Talora, C.; Cabibbo, A.; Macino, G.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Splicing of the rolA transcript of Agrobacterium rhizogenes in Arabidopsis

Science
1994 | Journal article
EID:

2-s2.0-0028577627

Contributors: Magrelli, A.; Langenkemper, K.; Dehio, C.; Schell, J.; Spena, A.
Source: Self-asserted source
Armando Magrelli via Scopus - Elsevier
grade
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Revolutionizing CAR T Cell Therapies: Innovations in Genetic Engineering and Manufacturing to Enhance Efficacy and Accessibility

Source: check_circle
Multidisciplinary Digital Publishing Institute

Peer review (17 reviews for 4 publications/grants)

Review activity for Cancer cell international. (9)
Review activity for Clinical pharmacology & therapeutics. (5)
Review activity for Expert opinion on biological therapy (1)
Review activity for Journal of the neurological sciences. (2)