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Scopus Author ID: 56644812000
SciProfiles: 2037299

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Italy

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Employment (1)

Università degli Studi di Camerino: Camerino, Marche, IT

2017-10-01 to present | Research Fellowship (School of Pharmacy, Medicinal Chemistry Unit, Via Madonna delle Carceri 16, Camerino, 62032)
Employment
Source: Self-asserted source
Andrea Spinaci

Education and qualifications (2)

Università degli Studi di Camerino: Camerino, Marche, IT

2014-01-01 to 2017-03-31 | PhD in Chemical and Pharmaceutical Sciences and Biotechnology (School of Advanced Study)
Education
Source: Self-asserted source
Andrea Spinaci

Università degli Studi di Camerino: Camerino, Marche, IT

2008-10-17 to 2013-03-07 | Chimica e Tecnologia Farmaceutiche (Medicinal Chemistry Unit)
Education
Source: Self-asserted source
Andrea Spinaci

Professional activities (1)

Società Chimica Italiana: Rome, Lazio, IT

Service
Source: Self-asserted source
Andrea Spinaci

Works (30)

A2A Adenosine Receptor Antagonists and Their Efficacy in Rat Models of Parkinson’s Disease

Cells
2025-02-26 | Journal article
DOI: 10.3390/cells14050338
Contributors: Andrea Spinaci; Michela Buccioni; Diego Dal Ben; Beatrice Francucci; Karl-Norbert Klotz; Gabriella Marucci; Nicola Simola; Micaela Morelli; Annalisa Pinna; Rosaria Volpini et al.
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Structural Investigations on 2-Amidobenzimidazole Derivatives as New Inhibitors of Protein Kinase CK1 Delta

Pharmaceuticals
2024-04-07 | Journal article
DOI: 10.3390/ph17040468
Contributors: Sara Calenda; Daniela Catarzi; Flavia Varano; Erica Vigiani; Rosaria Volpini; Catia Lambertucci; Andrea Spinaci; Letizia Trevisan; Ilenia Grieco; Stephanie Federico et al.
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Dual Anta-Inhibitors Targeting Protein Kinase CK1δ and A2A Adenosine Receptor Useful in Neurodegenerative Disorders

Molecules
2023-06-14 | Journal article
DOI: 10.3390/molecules28124762
Contributors: Beatrice Francucci; Simone Angeloni; Diego Dal Ben; Catia Lambertucci; Massimo Ricciutelli; Andrea Spinaci; Aleksei Smirnov; Rosaria Volpini; Michela Buccioni; Gabriella Marucci
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“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

Pharmaceuticals
2023-01-23 | Journal article
DOI: 10.3390/ph16020167
Contributors: Andrea Spinaci; Michela Buccioni; Daniela Catarzi; Chang Cui; Vittoria Colotta; Diego Dal Ben; Eleonora Cescon; Beatrice Francucci; Ilenia Grieco; Catia Lambertucci et al.
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A patent review of adenosine A<sub>2B</sub> receptor antagonists (2016-present).

Expert opinion on therapeutic patents
2022-04-07 | Journal article
DOI: 10.1080/13543776.2022.2057222
PMID: 35387537
Source: Self-asserted source
Andrea Spinaci

A2A Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

Molecules
2022-04-07 | Journal article
DOI: 10.3390/molecules27082386
Contributors: Andrea Spinaci; Catia Lambertucci; Michela Buccioni; Diego Dal Ben; Claudia Graiff; Maria Cristina Barbalace; Silvana Hrelia; Cristina Angeloni; Seyed Khosrow Tayebati; Massimo Ubaldi et al.
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Casein Kinase 1δ Inhibitors as Promising Therapeutic Agents for Neurodegenerative Disorders.

Current medicinal chemistry
2022-03-01 | Journal article
DOI: 10.2174/0929867329666220301115124
PMID: 35232339
Source: Self-asserted source
Andrea Spinaci

A2A Adenosine Receptor Antagonists and their Potential in Neurological Disorders.

Current medicinal chemistry
2022-02-18 | Journal article
DOI: 10.2174/0929867329666220218094501
PMID: 35184706
Source: Self-asserted source
Andrea Spinaci
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A<sub>3</sub> Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity

Pharmaceuticals
2022-01 | Journal article | Author
DOI: 10.3390/ph15020164
Contributors: Andrea Spinaci; Michela Buccioni; Diego Dal Ben; Federica Maggi; Gabriella Marucci; Beatrice Francucci; Giorgio Santoni; Catia Lambertucci; Volpini Rosaria
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Multidisciplinary Digital Publishing Institute
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Multipotent Stromal Cells from Subcutaneous Adipose Tissue of Normal Weight and Obese Subjects: Modulation of Their Adipogenic Differentiation by Adenosine A1 Receptor Ligands

Cells
2021-12-17 | Journal article
DOI: 10.3390/cells10123560
Part of ISSN: 2073-4409
Source: Self-asserted source
Andrea Spinaci

P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications.

Frontiers in pharmacology
2021-04-13 | Journal article
DOI: 10.3389/fphar.2021.653561
PMID: 33927627
PMC: PMC8076795
Source: Self-asserted source
Andrea Spinaci

Combined Therapy of A<sub>1</sub>AR Agonists and A<sub>2A</sub>AR Antagonists in Neuroinflammation.

Molecules (Basel, Switzerland)
2021-02 | Journal article
DOI: 10.3390/molecules26041188
PMID: 33672225
PMC: PMC7926490
Contributors: Marucci G; Ben DD; Lambertucci C; Navia AM; Spinaci A; Volpini R; Buccioni M
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

Adenosine Receptors as Neuroinflammation Modulators: Role of A<sub>1</sub> Agonists and A<sub>2A</sub> Antagonists.

Cells
2020-07 | Journal article
DOI: 10.3390/cells9071739
PMID: 32708189
PMC: PMC7409197
Contributors: Martí Navia A; Dal Ben D; Lambertucci C; Spinaci A; Volpini R; Marques-Morgado I; Coelho JE; Lopes LV; Marucci G; Buccioni M
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A<sub>3</sub> Receptor Agonist, in a Rat Model of Colitis.

Cells
2020-06 | Journal article
DOI: 10.3390/cells9061509
PMID: 32575844
PMC: PMC7348903
Contributors: Antonioli L; Lucarini E; Lambertucci C; Fornai M; Pellegrini C; Benvenuti L; Di Cesare Mannelli L; Spinaci A; Marucci G; Blandizzi C et al.
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

Approaches for designing and discovering purinergic drugs for gastrointestinal diseases.

Expert opinion on drug discovery
2020-03 | Journal article
DOI: 10.1080/17460441.2020.1743673
PMID: 32228110
Contributors: Dal Ben D; Antonioli L; Lambertucci C; Spinaci A; Fornai M; D'Antongiovanni V; Pellegrini C; Blandizzi C; Volpini R
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

GPR17 receptor modulators and their therapeutic implications: review of recent patents

Expert Opinion on Therapeutic Patents
2019 | Journal article
DOI: 10.1080/13543776.2019.1568990
EID:

2-s2.0-85060709581
Contributors: Marucci, G.; Dal Ben, D.; Lambertucci, C.; Martí Navia, A.; Spinaci, A.; Volpini, R.; Buccioni, M.
Source: Self-asserted source
Andrea Spinaci via Scopus - Elsevier

Investigation on 2′,3′- O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists

ACS Medicinal Chemistry Letters
2019 | Journal article
DOI: 10.1021/acsmedchemlett.8b00524
EID:

2-s2.0-85064259275
Contributors: Dal Ben, D.; Buccioni, M.; Lambertucci, C.; Marucci, G.; Spinaci, A.; Marchenkova, A.; Abdelrahman, A.; Nistri, A.; Müller, C.E.; Volpini, R.
Source: Self-asserted source
Andrea Spinaci via Scopus - Elsevier

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications.

Expert opinion on therapeutic patents
2019-11 | Journal article
DOI: 10.1080/13543776.2019.1693542
PMID: 31726893
Contributors: Marucci G; Dal Ben D; Buccioni M; Martí Navia A; Spinaci A; Volpini R; Lambertucci C
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

Pharmaceuticals
2019-10-08 | Journal article
DOI: 10.3390/ph12040150
Contributors: Diego Dal Ben; Catia Lambertucci; Michela Buccioni; Aleix Martí Navia; Gabriella Marucci; Andrea Spinaci; Rosaria Volpini
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New A<sub>2A</sub> adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity.

Bioorganic chemistry
2019-08 | Journal article
DOI: 10.1016/j.bioorg.2019.103183
PMID: 31446240
Contributors: Lambertucci C; Spinaci A; Buccioni M; Dal Ben D; Ngouadjeu Ngnintedem MA; Kachler S; Marucci G; Klotz KN; Volpini R
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

Modifications on the Amino-3,5-dicyanopyridine Core To Obtain Multifaceted Adenosine Receptor Ligands with Antineuropathic Activity.

Journal of medicinal chemistry
2019-07 | Journal article
DOI: 10.1021/acs.jmedchem.9b00106
PMID: 31306001
Contributors: Betti M; Catarzi D; Varano F; Falsini M; Varani K; Vincenzi F; Pasquini S; di Cesare Mannelli L; Ghelardini C; Lucarini E et al.
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

New sensible method to quantize the intestinal absorption of receptor ligands.

Bioorganic & medicinal chemistry
2019-06 | Journal article
DOI: 10.1016/j.bmc.2019.06.011
PMID: 31230970
Contributors: Buccioni M; Dal Ben D; Lambertucci C; Martí Navia A; Ricciutelli M; Spinaci A; Volpini R; Marucci G
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central

Ex-vivo absorption study of lysine R-lipoate salt, a new pharmaceutical form of R-ALA

European Journal of Pharmaceutical Sciences
2018 | Journal article
DOI: 10.1016/j.ejps.2018.03.025
EID:

2-s2.0-85044962974
Contributors: Amenta, F.; Buccioni, M.; Ben, D.D.; Lambertucci, C.; Navia, A.M.; Ngouadjeu Ngnintedem, M.A.; Ricciutelli, M.; Spinaci, A.; Volpini, R.; Marucci, G.
Source: Self-asserted source
Andrea Spinaci via Scopus - Elsevier

New potent and selective A<inf>1</inf> adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases

European Journal of Medicinal Chemistry
2018 | Journal article
DOI: 10.1016/j.ejmech.2018.03.067
EID:

2-s2.0-85044585425
Contributors: Lambertucci, C.; Marucci, G.; Dal Ben, D.; Buccioni, M.; Spinaci, A.; Kachler, S.; Klotz, K.-N.; Volpini, R.
Source: Self-asserted source
Andrea Spinaci via Scopus - Elsevier

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

Organic & Biomolecular Chemistry
2017 | Journal article
DOI: 10.1039/C6OB02796B
Contributors: Chiara Zanato; Alessia Pelagalli; Katie F. M. Marwick; Monica Piras; Sergio Dall'Angelo; Andrea Spinaci; Roger G. Pertwee; David J. A. Wyllie; Giles E. Hardingham; Matteo Zanda
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2',3'-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents.

Purinergic signalling
2017-03 | Journal article
DOI: 10.1007/s11302-016-9539-y
PMID: 27757785
PMC: PMC5334199
Contributors: Dal Ben D; Marchenkova A; Thomas A; Lambertucci C; Spinaci A; Marucci G; Nistri A; Volpini R
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central
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The G Protein-Coupled Receptor GPR17: Overview and Update.

ChemMedChem
2016-12 | Journal article
DOI: 10.1002/cmdc.201600453
PMID: 27863043
Contributors: Marucci G; Dal Ben D; Lambertucci C; Santinelli C; Spinaci A; Thomas A; Volpini R; Buccioni M
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central
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Simulation and Comparative Analysis of Different Binding Modes of Non-nucleoside Agonists at the A2A Adenosine Receptor.

Molecular informatics
2016-09 | Journal article
DOI: 10.1002/minf.201501042
PMID: 27546044
Contributors: Dal Ben D; Buccioni M; Lambertucci C; Marucci G; Santinelli C; Spinaci A; Thomas A; Volpini R
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Andrea Spinaci via Europe PubMed Central
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The Length and Flexibility of the 2-Substituent of 9-Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor.

ChemMedChem
2016-08 | Journal article
DOI: 10.1002/cmdc.201500595
PMID: 27037522
Contributors: Thomas A; Buccioni M; Dal Ben D; Lambertucci C; Marucci G; Santinelli C; Spinaci A; Kachler S; Klotz KN; Volpini R
Source: Self-asserted source
Andrea Spinaci via Europe PubMed Central
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New substituted 9-propyladenine derivatives as A2Aadenosine receptor antagonists

MedChemComm
2015 | Journal article
DOI: 10.1039/C5MD00034C
Contributors: C. Lambertucci; M. Buccioni; D. Dal Ben; S. Kachler; G. Marucci; A. Spinaci; A. Thomas; K.-N. Klotz; R. Volpini
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