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Employment (2)

Genentech Inc: South San Francisco, CA, US

Postdoctoral Fellow (Neuroscience)
Employment
Source: Self-asserted source
Shih-Ching Lo

Biogen Inc: Cambridge, MA, US

2015 to present | Scientist
Employment
Source: Self-asserted source
Shih-Ching Lo

Education and qualifications (2)

University of Missouri: Columbia, MO, US

PhD (Biochemistry)
Education
Source: Self-asserted source
Shih-Ching Lo

National Tsing Hua University: Hsinchu, TW

BS (Life Sciences)
Education
Source: Self-asserted source
Shih-Ching Lo

Works (15)

Use of CRISPR/Cas9-mediated disruption of CNS cell type genes to profile transduction of AAV by neonatal intracerebroventricular delivery in mice.

Gene therapy
2021-02-22 | Journal article
DOI: 10.1038/s41434-021-00223-3
PMID: 33612827
Source: Self-asserted source
Shih-Ching Lo
grade
Preferred source (of 2)‎

Highly efficient neuronal gene knockout in vivo by CRISPR-Cas9 via neonatal intracerebroventricular injection of AAV in mice.

Gene therapy
2021-02-08 | Journal article
DOI: 10.1038/s41434-021-00224-2
PMID: 33558692
Source: Self-asserted source
Shih-Ching Lo

Characterization of social behaviors in caspase-3 deficient mice.

Scientific reports
2016-01-19 | Journal article
DOI: 10.1038/srep18335
PMID: 26783106
PMC: PMC4726076
Source: Self-asserted source
Shih-Ching Lo

Caspase-3 deficiency results in disrupted synaptic homeostasis and impaired attention control.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2015-02-01 | Journal article
DOI: 10.1523/jneurosci.3280-14.2015
PMID: 25653368
PMC: PMC6705356
Source: Self-asserted source
Shih-Ching Lo

Histone deacetylase 2 cell autonomously suppresses excitatory and enhances inhibitory synaptic function in CA1 pyramidal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2013-04-01 | Journal article
DOI: 10.1523/jneurosci.3162-12.2013
PMID: 23554474
PMC: PMC6618922
Source: Self-asserted source
Shih-Ching Lo

Aβ(1-42) inhibition of LTP is mediated by a signaling pathway involving caspase-3, Akt1 and GSK-3β.

Nature neuroscience
2011-03-27 | Journal article
DOI: 10.1038/nn.2785
PMID: 21441921
Source: Self-asserted source
Shih-Ching Lo

Caspase-3 activation via mitochondria is required for long-term depression and AMPA receptor internalization.

Cell
2010-05-01 | Journal article
DOI: 10.1016/j.cell.2010.03.053
PMID: 20510932
PMC: PMC2909748
Source: Self-asserted source
Shih-Ching Lo

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria.

Experimental cell research
2008-03-05 | Journal article
DOI: 10.1016/j.yexcr.2008.02.014
PMID: 18387606
PMC: PMC2409987
Source: Self-asserted source
Shih-Ching Lo

ERRbeta: a potent inhibitor of Nrf2 transcriptional activity.

Molecular and cellular endocrinology
2007-08-31 | Journal article
DOI: 10.1016/j.mce.2007.08.011
PMID: 17920186
Source: Self-asserted source
Shih-Ching Lo

PGAM5, a Bcl-XL-interacting protein, is a novel substrate for the redox-regulated Keap1-dependent ubiquitin ligase complex.

The Journal of biological chemistry
2006-10-17 | Journal article
DOI: 10.1074/jbc.m606539200
PMID: 17046835
Source: Self-asserted source
Shih-Ching Lo

Structure of the Keap1:Nrf2 interface provides mechanistic insight into Nrf2 signaling.

The EMBO journal
2006-08-03 | Journal article
DOI: 10.1038/sj.emboj.7601243
PMID: 16888629
PMC: PMC1538563
Source: Self-asserted source
Shih-Ching Lo

CAND1-mediated substrate adaptor recycling is required for efficient repression of Nrf2 by Keap1.

Molecular and cellular biology
2006-02-01 | Journal article
DOI: 10.1128/mcb.26.4.1235-1244.2006
PMID: 16449638
PMC: PMC1367193
Source: Self-asserted source
Shih-Ching Lo

Distinct signaling pathways for induction of type II NOS by IFNgamma and LPS in BV-2 microglial cells.

Neurochemistry international
2005-09-01 | Journal article
DOI: 10.1016/j.neuint.2005.03.007
PMID: 15955597
Source: Self-asserted source
Shih-Ching Lo

Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway.

The Journal of biological chemistry
2005-06-27 | Journal article
DOI: 10.1074/jbc.m501279200
PMID: 15983046
Source: Self-asserted source
Shih-Ching Lo

Keap1 is a redox-regulated substrate adaptor protein for a Cul3-dependent ubiquitin ligase complex.

Molecular and cellular biology
2004-12-01 | Journal article
DOI: 10.1128/mcb.24.24.10941-10953.2004
PMID: 15572695
PMC: PMC533977
Source: Self-asserted source
Shih-Ching Lo
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