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Works (27)

Polo-like kinase inhibitors increase AAV production by halting cell cycle progression

Molecular Therapy Methods & Clinical Development
2025-03 | Journal article
DOI: 10.1016/j.omtm.2025.101412
Contributors: Kaylin Fisher; Francis Grafton; Francesca Ispaso; Joshua Tworig; Rupert Derler; Florian Sonntag; Markus Hörer; Andreas Schulze; Christopher A. Reid; Mohammad A. Mandegar
Source: check_circle
Crossref

Transcriptomics-informed pharmacology identifies epigenetic and cell cycle regulators that enhance AAV production

Molecular Therapy - Methods & Clinical Development
2024-12 | Journal article
DOI: 10.1016/j.omtm.2024.101384
Contributors: Joshua Tworig; Francis Grafton; Kaylin Fisher; Markus Hörer; Christopher A. Reid; Mohammad A. Mandegar
Source: check_circle
Crossref

Transcriptomics-informed pharmacology identifies epigenetic and cell cycle regulators as enhancers of AAV production

2024-06-15 | Preprint
DOI: 10.1101/2024.06.14.599118
Contributors: Joshua Tworig; Francis Grafton; Markus Hörer; Christopher A. Reid; Mohammad A. Mandegar
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Crossref

Quantifying drug-induced structural toxicity in hepatocytes and cardiomyocytes derived from hiPSCs using a deep learning method.

Journal of pharmacological and toxicological methods
2020-07 | Journal article
DOI: 10.1016/j.vascn.2020.106895
PMID: 32629158
Contributors: Maddah M; Mandegar MA; Dame K; Grafton F; Loewke K; Ribeiro AJS
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Advancing physiological maturation in human induced pluripotent stem cell-derived cardiac muscle by gene editing an inducible adult troponin isoform switch.

Stem cells (Dayton, Ohio)
2020-06 | Journal article
DOI: 10.1002/stem.3235
PMID: 32497296
PMC: PMC7529900
Contributors: Wheelwright M; Mikkila J; Bedada FB; Mandegar MA; Thompson BR; Metzger JM
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Deep profiling reveals substantial heterogeneity of integration outcomes in CRISPR knock-in experiments

2019-11 | Preprint
DOI: 10.1101/841098
OTHER-ID:

PPR102019
Contributors: Canaj H; Hussmann JA; Li H; Beckman KA; Goodrich L; Cho NH; Li YJ; Santos DA; McGeever A; Stewart EM et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

MESP1 knock-down in human iPSC attenuates early vascular progenitor cell differentiation after completed primitive streak specification.

Developmental biology
2018-10 | Journal article
DOI: 10.1016/j.ydbio.2018.10.020
PMID: 30389344
Contributors: Eskildsen TV; Ayoubi S; Thomassen M; Burton M; Mandegar MA; Conklin BR; Jensen CH; Andersen DC; Sheikh SP
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Spatiotemporal mosaic self-patterning of pluripotent stem cells using CRISPR interference.

eLife
2018-10 | Journal article
DOI: 10.7554/elife.36045
PMID: 30298816
PMC: PMC6177255
Contributors: Libby AR; Joy DA; So PL; Mandegar MA; Muncie JM; Mendoza-Camacho FN; Weaver VM; Conklin BR; McDevitt TC
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Contractile deficits in engineered cardiac microtissues as a result of MYBPC3 deficiency and mechanical overload.

Nature biomedical engineering
2018-09 | Journal article
DOI: 10.1038/s41551-018-0280-4
PMID: 31015724
PMC: PMC6482859
Contributors: Ma Z; Huebsch N; Koo S; Mandegar MA; Siemons B; Boggess S; Conklin BR; Grigoropoulos CP; Healy KE
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Esophageal Organoids from Human Pluripotent Stem Cells Delineate Sox2 Functions during Esophageal Specification.

Cell stem cell
2018-09 | Journal article
DOI: 10.1016/j.stem.2018.08.008
PMID: 30244869
PMC: PMC6225525
Contributors: Trisno SL; Philo KED; McCracken KW; Catá EM; Ruiz-Torres S; Rankin SA; Han L; Nasr T; Chaturvedi P; Rothenberg ME et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Spatiotemporal mosaic patterning of pluripotent stem cells using CRISPR interference

2018-01 | Preprint
DOI: 10.1101/252189
OTHER-ID:

PPR19557
Contributors: Libby AR; Joy DA; So P; Mandegar MA; Muncie JM; Weaver VM; Conklin BR; McDevitt TC
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

A BAG3 chaperone complex maintains cardiomyocyte function during proteotoxic stress.

JCI insight
2017-07 | Journal article
DOI: 10.1172/jci.insight.94623
PMID: 28724793
PMC: PMC5518554
Contributors: Judge LM; Perez-Bermejo JA; Truong A; Ribeiro AJ; Yoo JC; Jensen CL; Mandegar MA; Huebsch N; Kaake RM; So PL et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Multi-Imaging Method to Assay the Contractile Mechanical Output of Micropatterned Human iPSC-Derived Cardiac Myocytes.

Circulation research
2017-04 | Journal article
DOI: 10.1161/circresaha.116.310363
PMID: 28400398
PMC: PMC5491345
Contributors: Ribeiro AJS; Schwab O; Mandegar MA; Ang YS; Conklin BR; Srivastava D; Pruitt BL
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

CRISPRi-based genome-scale identification of functional long noncoding RNA loci in human cells.

Science (New York, N.Y.)
2016-12 | Journal article
DOI: 10.1126/science.aah7111
PMID: 27980086
PMC: PMC5394926
Contributors: Liu SJ; Horlbeck MA; Cho SW; Birk HS; Malatesta M; He D; Attenello FJ; Villalta JE; Cho MY; Chen Y et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Engineered human pluripotent-stem-cell-derived intestinal tissues with a functional enteric nervous system.

Nature medicine
2016-11 | Journal article
DOI: 10.1038/nm.4233
PMID: 27869805
PMC: PMC5562951
Contributors: Workman MJ; Mahe MM; Trisno S; Poling HM; Watson CL; Sundaram N; Chang CF; Schiesser J; Aubert P; Stanley EG et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses.

Scientific reports
2016-04 | Journal article
DOI: 10.1038/srep24726
PMID: 27095412
PMC: PMC4837370
Contributors: Huebsch N; Loskill P; Deveshwar N; Spencer CI; Judge LM; Mandegar MA; Fox CB; Mohamed TM; Ma Z; Mathur A et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

CRISPR Interference Efficiently Induces Specific and Reversible Gene Silencing in Human iPSCs.

Cell stem cell
2016-03 | Journal article
DOI: 10.1016/j.stem.2016.01.022
PMID: 26971820
PMC: PMC4830697
Contributors: Mandegar MA; Huebsch N; Frolov EB; Shin E; Truong A; Olvera MP; Chan AH; Miyaoka Y; Holmes K; Spencer CI et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Efficient CRISPR/Cas9-Based Genome Engineering in Human Pluripotent Stem Cells.

Current protocols in human genetics
2016-01 | Journal article
DOI: 10.1002/0471142905.hg2104s88
PMID: 26724721
PMC: PMC4726454
Contributors: Kime C; Mandegar MA; Srivastava D; Yamanaka S; Conklin BR; Rand TA
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing.

Stem cell reports
2015-03 | Journal article
DOI: 10.1016/j.stemcr.2015.02.007
PMID: 25801505
PMC: PMC4400609
Contributors: Maddah M; Heidmann JD; Mandegar MA; Walker CD; Bolouki S; Conklin BR; Loewke KE
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Human iPSC-based cardiac microphysiological system for drug screening applications.

Scientific reports
2015-03 | Journal article
DOI: 10.1038/srep08883
PMID: 25748532
PMC: PMC4352848
Contributors: Mathur A; Loskill P; Shao K; Huebsch N; Hong S; Marcus SG; Marks N; Mandegar M; Conklin BR; Lee LP et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Automated Video-Based Analysis of Contractility and Calcium Flux in Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Cultured over Different Spatial Scales.

Tissue engineering. Part C, Methods
2015-01 | Journal article
DOI: 10.1089/ten.tec.2014.0283
PMID: 25333967
PMC: PMC4410286
Contributors: Huebsch N; Loskill P; Mandegar MA; Marks NC; Sheehan AS; Ma Z; Mathur A; Nguyen TN; Yoo JC; Judge LM et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

An improved technique for chromosomal analysis of human ES and iPS cells.

Stem cell reviews and reports
2011-06 | Journal article
DOI: 10.1007/s12015-010-9224-4
PMID: 21188651
PMC: PMC3073051
Contributors: Moralli D; Yusuf M; Mandegar MA; Khoja S; Monaco ZL; Volpi EV
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells.

Human molecular genetics
2011-05 | Journal article
DOI: 10.1093/hmg/ddr144
PMID: 21593218
PMC: PMC3131039
Contributors: Mandegar MA; Moralli D; Khoja S; Cowley S; Chan DY; Yusuf M; Mukherjee S; Blundell MP; Volpi EV; Thrasher AJ et al.
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Haploids adapt faster than diploids across a range of environments.

Journal of evolutionary biology
2010-12 | Journal article
DOI: 10.1111/j.1420-9101.2010.02188.x
PMID: 21159002
Contributors: Gerstein AC; Cleathero LA; Mandegar MA; Otto SP
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.

Human molecular genetics
2009-08 | Journal article
DOI: 10.1093/hmg/ddp379
PMID: 19684026
PMC: PMC3817080
Contributors: Lefebvre L; Mar L; Bogutz A; Oh-McGinnis R; Mandegar MA; Paderova J; Gertsenstein M; Squire JA; Nagy A
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

Mitotic recombination counteracts the benefits of genetic segregation.

Proceedings. Biological sciences
2007-05 | Journal article
DOI: 10.1098/rspb.2007.0056
PMID: 17360283
PMC: PMC2176173
Contributors: Mandegar MA; Otto SP
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central

A model of the evolution of dichogamy incorporating sex-ratio selection, anther-stigma interference, and inbreeding depression.

Evolution; international journal of organic evolution
2006-05 | Journal article
DOI: 10.1111/j.0014-3820.2006.tb01172.x
PMID: 16817534
Contributors: Sargent RD; Mandegar MA; Otto SP
Source: Self-asserted source
Mohammad A. Mandegar via Europe PubMed Central
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