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ResearcherID: C-1161-2015
Scopus Author ID: 6507909835

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Employment (3)

Robarts Research Institute: London, ON, CA

2019-01-01 to present | Associate Scientist
Employment
Source: Self-asserted source
Steven M Kerfoot

Western University: London, ON, CA

2017-07-01 to present | Associate Professor (Microbiology & Immunology)
Employment
Source: Self-asserted source
Steven M Kerfoot

Western University: London, ON, CA

2011-09-01 to 2017-06-31 | Assistant Professor (Microbiology and Immunology)
Employment
Source: Self-asserted source
Steven M Kerfoot

Education and qualifications (4)

Yale University School of Medicine: New Haven, CT, US

2007-07-01 to 2011-08-01 | Post-Doctoral Fellow (Laboratory Medicine)
Education
Source: Self-asserted source
Steven M Kerfoot

Yale University School of Medicine: New Haven, CT, US

2005-07-01 to 2007-06-31 | Post-Doctoral Fellow (Internal Medicine)
Education
Source: Self-asserted source
Steven M Kerfoot

University of Calgary: Calgary, AB, CA

2005-01-01 | PhD (Immunology)
Education
Source: Self-asserted source
Steven M Kerfoot

University of Calgary: Calgary, AB, CA

1996-05-01 | BSc (Hon) (Zoology)
Education
Source: Self-asserted source
Steven M Kerfoot

Professional activities (2)

Canadian Society for Immunology: Winnipeg, CA

2011-01-01 to present | Full Member
Membership
Source: Self-asserted source
Steven M Kerfoot

American Association of Immunologists: Bethesda, Maryland, US

2011-01-01 to present | Full Member
Membership
Source: Self-asserted source
Steven M Kerfoot

Funding (15)

Interactions between T cells and B cells as a potential mechanism for obexelimab to modify antigen-driven immune responses.

2023-02 to 2025-02 | Contract
Zenas BioPharma (Boston, US)
Source: Self-asserted source
Steven M Kerfoot

Defining novel, non-classical roles for tissue-infiltrating B cells in chronic CNS autoimmunity

2021-04-01 to 2026-03-31 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9649997
GRANT_NUMBER:

6716a417c430f95597072dbe5c98128c
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Identifying mechanisms and determinants of T cell control over B cell fate choice in the germinal centre response.

2021-04-01 to 2022-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.13005274
GRANT_NUMBER: 737830
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Multimodal Microplate Reader for Research in Microbiology and Immunology

2021-04-01 to 2022-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.12992199
GRANT_NUMBER: 743051
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Defining the role of unconventionally activated meningeal B cells in CNS autoimmune inflammation

2020-07 to 2023-06 | Grant
Multiple Sclerosis Society of Canada (Toronto, Ontario, CA)
Source: Self-asserted source
Steven M Kerfoot

Identifying mechanisms and determinants of T cell control over B cell fate choice in the germinal centre response.

2020-04-01 to 2021-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9871625
GRANT_NUMBER: 714905
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Canadian Sepsis Research Network: Improving Care Before, During and After Sepsis.

2019-12-01 to 2024-11-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.13279770
GRANT_NUMBER:

a73451d316abd562524865b48831e8d7
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Canadian Sepsis Research Network: Improving CareBefore, During and After Sepsis

2019-05-01 to 2020-04-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.8482856
GRANT_NUMBER:

67ab02efd30ebc2d70d391f5fd21b11d
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Identifying mechanisms and determinants of T cell control over B cell fate choice in the germinal centre response.

2019-04-01 to 2020-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9441078
GRANT_NUMBER: 684296
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Upgrades to an advanced multiphoton microscope with unique equipment to improve tissue access for intravital imaging and improved image stability

2019-04-01 to 2020-03-31 | Grant
Natural Sciences and Engineering Research Council (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.9442377
GRANT_NUMBER: 692904
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Developing behavioral testing and MR imaging to evaluate cognitive impairment in a mouse model of CNS autoimmunity.

2019-04 to 2023-12 | Grant
Western BrainsCAN (London, CA)
Source: Self-asserted source
Steven M Kerfoot

Initiating and maintaining central nervous system autoimmunity through interactions between myelin-reactive T and B cells.

2015-07-01 to 2020-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.6805303
GRANT_NUMBER:

2d95c2df9288875439c144f54aef0490
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Characterization of the pathogenic mechanisms and potential as therapeutic targets of antigen experienced B cells in chronic central nervous system autoimmunity.

2012-07 to 2015-06 | Grant
Multiple Sclerosis Society of Canada (Toronto, Ontario, CA)
Source: Self-asserted source
Steven M Kerfoot

Identification of Cellular Interactions Through Which B Cells Drive Central Nervous System Autoimmune Disease In Vivo.

2011-09 to 2014-08 | Salary award
Multiple Sclerosis Society of Canada (Toronto, Ontario, CA)
Source: Self-asserted source
Steven M Kerfoot

The role of T cells in Germinal Center development.

2005-07-01 to 2008-06-30 | Grant
Canadian Institutes of Health Research (Ottawa, CA)
URL: https://app.dimensions.ai/details/grant/grant.7641294
GRANT_NUMBER:

63e9a5259b051566ce12b0dfd592ce85
Source: Self-asserted source
Steven M Kerfoot via DimensionsWizard

Works (42)

B cell subsets have different capacities for phagocytosis and subsequent presentation of antigen to cognate T cells

2025-02-01 | Preprint
DOI: 10.1101/2025.01.28.635276
Contributors: Daniel M Morelli; Morgan Langille; Richard Zhang; Heather C Craig; Parisa Shooshtari; Bryan Heit; Steven M Kerfoot
Source: check_circle
Crossref

Integrative Data Analysis to Uncover Transcription Factors Involved in Gene Dysregulation of Nine Autoimmune and Inflammatory Diseases

2024-04-28 | Preprint
DOI: 10.1101/2024.04.24.591013
Contributors: Nader Hosseini Naghavi; Steven M. Kerfoot; Parisa Shooshtari
Source: check_circle
Crossref

Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity

Journal of Neuroimmunology
2024-02 | Journal article
DOI: 10.1016/j.jneuroim.2023.578267
Part of ISSN: 0165-5728
Contributors: Yodit Tesfagiorgis; Eden A. Kemal; Heather C. Craig; Kate A. Parham; Steven M. Kerfoot
Source: Self-asserted source
Steven M Kerfoot

Global Pannexin 1-deletion increases tumor-infiltrating lymphocytes in the BRAF/Pten mouse melanoma model

2023-07-29 | Preprint
DOI: 10.1101/2023.07.28.551021
Contributors: Rafael E. Sanchez-Pupo; Garth A. Finch; Danielle E. Johnston; Heather Craig; Rober Abdo; Kevin Barr; Steven Kerfoot; Lina Dagnino; Silvia Penuela
Source: check_circle
Crossref

Pre–Germinal Center Interactions with T Cells Are Natural Checkpoints to Limit Autoimmune B Cell Responses

The Journal of Immunology
2022-11-01 | Journal article | Author
DOI: 10.4049/jimmunol.2200534
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Contributors: Kate A Parham; Xiu Xia Sherry Tan; Daniel Mario Morelli; Lika Chowdhury; Heather Craig; Steven M Kerfoot
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 4)‎

Fecal microbiota transplantation is safe and tolerable in patients with multiple sclerosis: A pilot randomized controlled trial

Multiple Sclerosis Journal - Experimental, Translational and Clinical
2022-04 | Journal article
DOI: 10.1177/20552173221086662
Part of ISSN: 2055-2173
Part of ISSN: 2055-2173
Contributors: Kait F. Al; Laura J Craven; Shaeley Gibbons; Seema Nair Parvathy; Ana Christina Wing; Chantelle Graf; Kate A Parham; Steven M Kerfoot; Hannah Wilcox; Jeremy P Burton et al.
Source: Self-asserted source
Steven M Kerfoot

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma production

Proceedings of the National Academy of Sciences
2022-02-22 | Journal article
DOI: 10.1073/pnas.2115987119
Contributors: Stephen W. Tuffs; Mariya I. Goncheva; Stacey X. Xu; Heather C. Craig; Katherine J. Kasper; Joshua Choi; Ronald S. Flannagan; Steven M. Kerfoot; David E. Heinrichs; John K. McCormick
Source: check_circle
Crossref

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function

2021-08-17 | Other
DOI: 10.1101/2021.08.17.456537
Contributors: Stephen W. Tuffs; Mariya I. Goncheva; Stacey X. Xu; Heather C. Craig; Katherine J. Kasper; Joshua Choi; Ronald S. Flannagan; Steven M. Kerfoot; David E. Heinrichs; John K. McCormick
Source: check_circle
Crossref

Dendritic Cells Require TMEM176A/B Ion Channels for Optimal MHC Class II Antigen Presentation to Naive CD4+ T Cells

The Journal of Immunology
2021-07-15 | Journal article | Author
DOI: 10.4049/jimmunol.2000498
Part of ISSN: 0022-1767
Part of ISSN: 1550-6606
Contributors: Mélanie Lancien; Geraldine Bienvenu; Sonia Salle; Lucile Gueno; Magalie Feyeux; Emmanuel Merieau; Severine Remy; Amandine EVEN; Aurelie Moreau; Alice Mollé et al.
Source: Self-asserted source
Steven M Kerfoot

Systemic administration of anti-CD20 indirectly reduces B cells in the inflamed meninges in a chronic model of central nervous system autoimmunity

2021-01-22 | Preprint
DOI: 10.1101/2021.01.22.427667
Contributors: Yodit Tesfagiorgis; Heather C Craig; Kate A Parham; Steven M Kerfoot
Source: check_circle
Crossref

Opposing Roles for the Related ETS-Family Transcription Factors Spi-B and Spi-C in Regulating B Cell Differentiation and Function

Frontiers in Immunology
2020-05-08 | Journal article
DOI: 10.3389/fimmu.2020.00841
Part of ISSN: 1664-3224
Contributors: Anne-Sophie Laramée; Hannah Raczkowski; Peng Shao; Carolina Batista; Devanshi Shukla; Li Xu; S. M. Mansour Haeryfar; Yodit Tesfagiorgis; Steven Kerfoot; Rodney DeKoter
Source: Self-asserted source
Steven M Kerfoot

Germinal center B cell initiation, GC maturation, and the coevolution of its stromal cell niches.

Immunological reviews
2019-03-01 | Journal article
DOI: 10.1111/imr.12731
PMID: 30874342
Source: Self-asserted source
Steven M Kerfoot

Nonredundant Roles of IL-21 and IL-4 in the Phased Initiation of Germinal Center B Cells and Subsequent Self-Renewal Transitions

The Journal of Immunology
2018-12-15 | Journal article
DOI: 10.4049/jimmunol.1500497
Contributors: David G Gonzalez; Christine M Cote; Jaymin R Patel; Colin B Smith; Yuqi Zhang; Kevin M Nickerson; Tingting Zhang; Steven M Kerfoot; Ann M Haberman
Source: check_circle
Crossref

Autoreactive, Low-Affinity T Cells Preferentially Drive Differentiation of Short-Lived Memory B Cells at the Expense of Germinal Center Maintenance.

Cell reports
2018-12-01 | Journal article
DOI: 10.1016/j.celrep.2018.11.070
PMID: 30566861
Source: Self-asserted source
Steven M Kerfoot

Novel regulatory Th17 cells and regulatory B cells in modulating autoimmune diseases.

Cellular immunology
2018-09-17 | Journal article
DOI: 10.1016/j.cellimm.2018.09.002
PMID: 30249342
Source: Self-asserted source
Steven M Kerfoot

Editorial: Lymphocytes in MS and EAE: More Than Just a Cd4(+) World

Frontiers in Immunology
2017 | Journal article
DOI: 10.3389/fimmu.2017.00133
WOSUID:

WOS:000393827400002
Contributors: Rangachari, Manu; Kerfoot, Steven M.; Arbour, Nathalie; Alvarez, Jorge Ivan
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

Germinal center B cell development has distinctly regulated stages completed by disengagement from T cell help.

eLife
2017 | Journal article
DOI: 10.7554/eLife.19552
WOSUID:

MEDLINE:28498098
Contributors: Zhang, Ting-Ting; Gonzalez, David G; Cote, Christine M; Kerfoot, Steven M; Deng, Shaoli; Cheng, Yuqing; Magari, Masaki; Haberman, Ann M
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

ICAM1+ neutrophils promote chronic inflammation via ASPRV1 in B cell-dependent autoimmune encephalomyelitis.

JCI insight
2017-12-07 | Journal article
DOI: 10.1172/jci.insight.96882
PMID: 29212956
PMC: PMC5752297
Source: Self-asserted source
Steven M Kerfoot

Activated B Cells Participating in the Anti-Myelin Response Are Excluded from the Inflamed Central Nervous System in a Model of Autoimmunity that Allows for B Cell Recognition of Autoantigen

The Journal of Immunology
2017-07-15 | Journal article
DOI: 10.4049/jimmunol.1602042
Contributors: Yodit Tesfagiorgis; Sarah L. Zhu; Rajiv Jain; Steven M. Kerfoot
Source: check_circle
Crossref

Simple and Efficient Production and Purification of Mouse Myelin Oligodendrocyte Glycoprotein for Experimental Autoimmune Encephalomyelitis Studies.

2016-10 | Journal article
DOI: 10.3791/54727
PMID: 27842340
Contributors: Jain RW; Dang AK; Kerfoot SM
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

B cell recognition of myelin oligodendrocyte glycoprotein autoantigen depends on immunization with protein rather than short peptide, while B cell invasion of the CNS in autoimmunity does not.

Journal of neuroimmunology
2015 | Journal article
DOI: 10.1016/j.jneuroim.2014.12.008
WOSUID:

MEDLINE:25595255
Contributors: Dang, Amy K; Jain, Rajiv W; Craig, Heather C; Kerfoot, Steven M
Source: Self-asserted source
Steven M Kerfoot via ResearcherID
grade
Preferred source (of 2)‎

Meningeal Infiltration of the Spinal Cord by Non-Classically Activated B Cells is Associated with Chronic Disease Course in a Spontaneous B Cell-Dependent Model of CNS Autoimmune Disease.

2015 | Journal article
DOI: 10.3389/fimmu.2015.00470
PMID: 26441975
PMC: PMC4584934
Contributors: Dang AK; Tesfagiorgis Y; Jain RW; Craig HC; Kerfoot SM
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

A subset of AID-dependent B-1a cells initiates hypersensitivity and pneumococcal pneumonia resistance.

2015-12 | Journal article
DOI: 10.1111/nyas.12975
PMID: 26662721
Contributors: Askenase PW; Bryniarski K; Paliwal V; Redegeld F; Groot Kormelink T; Kerfoot S; Hutchinson AT; van Loveren H; Campos R; Itakura A et al.
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Expression of activation-induced cytidine deaminase enhances the clearance of pneumococcal pneumonia: evidence of a subpopulation of protective anti-pneumococcal B1a cells.

2015-10 | Journal article
PMID: 26456931
Contributors: Yamamoto N; Kerfoot SM; Hutchinson AT; Dela Cruz CS; Nakazawa N; Szczepanik M; Majewska-Szczepanik M; Nazimek K; Ohana N; Bryniarski K et al.
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Participation of Inkt Cells in the Early and Late Components of Tc1-Mediated DNFB Contact Sensitivity: Cooperative Role of gamma delta-T Cells

Scandinavian Journal of Immunology
2011 | Journal article
DOI: 10.1111/j.1365-3083.2011.02522.x
WOSUID:

WOS:000288799200009
Contributors: Askenase, P. W.; Majewska-Szczepanik, M.; Kerfoot, S.; Szczepanik, M.
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

A novel mechanism of erythrocyte capture from circulation in humans

2008 | Journal article
DOI: 10.1016/j.exphem.2007.08.029
Contributors: Steven M Kerfoot
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 2)‎

c-Jun NH2-terminal kinase 2 inhibits gamma interferon production during Anaplasma phagocytophilum infection

Infection and Immunity
2008 | Journal article
DOI: 10.1128/IAI.00599-07
WOSUID:

WOS:000252126000033
Contributors: Pedra, Joao H. F.; Mattner, Jochen; Tao, Jian; Kerfoot, Steven M.; Davis, Roger J.; Flavell, Richard A.; Askenase, Philip W.; Yin, Zhinan; Fikrig, Erol
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

Exogenous stromal cell-derived factor-1 induces modest leukocyte recruitment in vivo

American Journal of Physiology-Heart and Circulatory Physiology
2008 | Journal article
DOI: 10.1152/ajpheart.00984.2007
WOSUID:

WOS:000256497300014
Contributors: Kerfoot, Steven M.; Andonegui, Graciela; Bonder, Claudine S.; Liu, Lixin
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

Identification of initiator B cells, a novel subset of activation-induced deaminase-dependent B-1-like cells that mediate initiation of contact sensitivity.

2008-08 | Journal article
DOI: 10.4049/jimmunol.181.3.1717
PMID: 18641308
Contributors: Kerfoot SM; Szczepanik M; Tung JW; Askenase PW
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Reevaluation of P-selectin and alpha 4 integrin as targets for the treatment of experimental autoimmune encephalomyelitis.

2006-05 | Journal article
DOI: 10.4049/jimmunol.176.10.6225
PMID: 16670333
Contributors: Kerfoot SM; Norman MU; Lapointe BM; Bonder CS; Zbytnuik L; Kubes P
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Local coordination verses systemic disregulation: complexities in leukocyte recruitment revealed by local and systemic activation of TLR4 in vivo

Journal of Leukocyte Biology
2005 | Journal article
DOI: 10.1189/jlb.1004607
WOSUID:

WOS:000229489200004
Contributors: Kerfoot, SM; Kubes, P
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

Platelets express functional Toll-like receptor-4

Blood
2005 | Journal article
DOI: 10.1182/blood-2005-03-0916
WOSUID:

WOS:000232134700037
Contributors: Andonegui, G; Kerfoot, SM; McNagny, K; Ebbert, KVJ; Patel, KD; Kubes, P
Source: Self-asserted source
Steven M Kerfoot via ResearcherID

Role of CD44 and hyaluronan in neutrophil recruitment.

2004-12 | Journal article
DOI: 10.4049/jimmunol.173.12.7594
PMID: 15585887
Contributors: Khan AI; Kerfoot SM; Heit B; Liu L; Andonegui G; Ruffell B; Johnson P; Kubes P
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

TLR4 contributes to disease-inducing mechanisms resulting in central nervous system autoimmune disease.

2004-12 | Journal article
DOI: 10.4049/jimmunol.173.11.7070
PMID: 15557205
Contributors: Kerfoot SM; Long EM; Hickey MJ; Andonegui G; Lapointe BM; Zanardo RC; Bonder C; James WG; Robbins SM; Kubes P
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Overlapping roles of P-selectin and alpha 4 integrin to recruit leukocytes to the central nervous system in experimental autoimmune encephalomyelitis.

2002-07 | Journal article
DOI: 10.4049/jimmunol.169.2.1000
PMID: 12097407
Contributors: Kerfoot SM; Kubes P
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Leukocyte recruitment in the microcirculation: the rolling paradigm revisited.

2001-04 | Journal article
PMID: 11390953
Contributors: Kubes P; Kerfoot SM
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Autoantibodies from patients with idiopathic ataxia bind to M-phase phosphoprotein-1 (MPP1).

2000-01 | Journal article
PMID: 10695267
Contributors: Fritzler MJ; Kerfoot SM; Feasby TE; Zochodne DW; Westendorf JM; Dalmau JO; Chan EK
Source: Self-asserted source
Steven M Kerfoot via Europe PubMed Central

Cellular choreography in the germinal center: new visions from in vivo imaging

Journal article
DOI: 10.1007/s00281-010-0214-z
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 2)‎

Exclusive Neutrophil Recruitment with Oncostatin M in a Human System

Journal article
DOI: 10.1016/S0002-9440(10)62538-2
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 2)‎

Germinal Center B Cell and T Follicular Helper Cell Development Initiates in the Interfollicular Zone

Journal article
DOI: 10.1016/j.immuni.2011.03.024
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 2)‎

Human fractalkine mediates leukocyte adhesion but not capture under physiological shear conditions; a mechanism for selective monocyte recruitment

Journal article
DOI: 10.1002/eji.200323502
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 2)‎

TNF-α-secreting monocytes are recruited into the brain of cholestatic mice

Journal article
DOI: 10.1002/hep.21003
Source: Self-asserted source
Steven M Kerfoot
grade
Preferred source (of 2)‎

Peer review (1 review for 1 publication/grant)

Review activity for Molecular neurodegeneration (1)
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