Personal information

Activities

Employment (4)

Icahn School of Medicine at Mount Sinai: New York, NY, US

2017 to present | Professor (Division of Infectious Diseases, Department of Medicine)
Employment
Source: Self-asserted source
Benjamin K Chen

Icahn School of Medicine at Mount Sinai: New York, NY, US

2009 to 2017 | Associate Professor (Division of Infectious Diseases, Department of Medicine)
Employment
Source: Self-asserted source
Benjamin K Chen

Icahn School of Medicine at Mount Sinai: New York, NY, US

2003 to 2009 | Assistant Professor (Division of Infectious Diseases)
Employment
Source: Self-asserted source
Benjamin K Chen

Whitehead Institute for Biomedical Research: Cambridge, MA, US

1999 to 2003 | Post Doctoral Fellow (Biology)
Employment
Source: Self-asserted source
Benjamin K Chen

Education and qualifications (3)

Joan and Sanford I Weill Medical College of Cornell University: New York, NY, US

1990 to 1999 | M.D. (Medicine)
Education
Source: Self-asserted source
Benjamin K Chen

Rockefeller University: New York, NY, US

1992 to 1998 | Ph.D.
Education
Source: Self-asserted source
Benjamin K Chen

Stanford University: Stanford, CA, US

1986 to 1990 | B.A.S. (Biological Sciences)
Education
Source: Self-asserted source
Benjamin K Chen

Funding (11)

Cell migration and virological synapse formation in parenteral HIV transmission

Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

High throughput screening for inhibitors of HIV virological synapses

2015-03-01 to 2017-02-28 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AI112423-02
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Lineage marking in humanized mice to reveal HIV-1 reservoirs

2014-09-20 to 2016-08-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R21AI116191-02
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Identifying human antibodies that potently neutralize cell-to-cell HIV infection

2013-09-01 to 2015-08-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R21AI104471-02
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Imaging Virological Synapses During Parenteral HIV Transmission

Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Mechanisms of efficient HIV infection through T cell virological synapses

2008-02-01 to 2018-04-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: 5R01GM113885-08
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Mechanisms of highly efficient HIV transfer at virological synapses

2008-02-01 to 2013-01-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5R01AI074420-05
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Dissemination of HIV through virological synapses

2007-07-01 to 2012-06-30 | Grant
Burroughs Wellcome Fund (Durham, US)
GRANT_NUMBER:

1006960

Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Host restriction and assembly functions of HIV-1 MA

2006-07-15 to 2008-06-30 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 1R56AI058856-01A2
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Reconstitution of HIV-1 assembly in murine cells

2003-08-01 to 2006-07-31 | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5K22AI055321-02
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

CELLULAR FACTORS INVOLVED IN THE ASSEMBLY OF HIV-1

2000-11-01 to present | Grant
National Institute of Allergy and Infectious Diseases (Bethesda, US)
GRANT_NUMBER: 5F32AI010664-03
Source: Self-asserted source
Benjamin K Chen via DimensionsWizard

Works (50 of 57)

Items per page:
Page 1 of 2

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

Journal of Virology
2023-12-21 | Journal article
Contributors: Alice K. Min; Behnam Javidfar; Roy Missall; Donald Doanman; Madel Durens; Mara Graziani; Annika Mordelt; Samuele G. Marro; Lotje de Witte; Benjamin K. Chen et al.
Source: check_circle
Crossref

Viral persistence, reactivation, and mechanisms of long COVID

eLife
2023-05-04 | Journal article
Contributors: Benjamin Chen; Boris Julg; Sindhu Mohandas; Steven B Bradfute
Source: check_circle
Crossref

HIV-1 infection of genetically engineered iPSC-derived central nervous system-engrafted microglia in a humanized mouse model

2023-04-27 | Preprint
Contributors: Schahram Akbarian; Alice K Min; Benjamin K. Chen; Talia H Swartz; Lotje de Witte; Samuele Marro; Donald Doanman; Madel Durens; Samantha St. Vil; Zahra Masih et al.
Source: check_circle
Crossref

The HIV Env Glycoprotein Conformational States on Cells and Viruses

mBio
2022-04-26 | Journal article
Contributors: Connie Zhao; Hongru Li; Talia H. Swartz; Benjamin K. Chen; Li Wu; Vinayaka R. Prasad
Source: check_circle
Crossref

A Replication-Competent HIV Clone Carrying GFP-Env Reveals Rapid Env Recycling at the HIV-1 T Cell Virological Synapse

Viruses
2021-12-25 | Journal article
Contributors: Lili Wang; Alice Sandmeyer; Wolfgang Hübner; Hongru Li; Thomas Huser; Benjamin K. Chen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Endocytic Motif on a Biotin-Tagged HIV-1 Env Modulates the Co-Transfer of Env and Gag during Cell-to-Cell Transmission

Viruses
2021-08-31 | Journal article
Contributors: María Inés Barría; Raymond A. Alvarez; Kenneth Law; Deanna L. Wolfson; Thomas Huser; Benjamin K. Chen
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Sequential trafficking of Env and Gag to HIV-1 T cell virological synapses revealed by live imaging

Retrovirology
2019-12 | Journal article
Contributors: Lili Wang; Sudeh Izadmehr; Edwin Kamau; Xiang-Peng Kong; Benjamin K. Chen
Source: check_circle
Crossref

Variable infectivity and conserved engagement in cell-to-cell viral transfer by HIV-1 Env from Clade B transmitted founder clones

Virology
2019-01 | Journal article
Contributors: Hongru Li; Benjamin K. Chen
Source: check_circle
Crossref

Visualization of HIV T Cell Virological Synapses and Virus-Containing Compartments by Three-Dimensional Correlative Light and Electron Microscopy.

2017-01 | Journal article
Contributors: Wang L; Eng ET; Law K; Gordon RE; Rice WJ; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Cell-to-Cell Spread of HIV and Viral Pathogenesis.

2016 | Journal article
Contributors: Law KM; Satija N; Esposito AM; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Measuring T Cell-to-T Cell HIV-1 Transfer, Viral Fusion, and Infection Using Flow Cytometry.

2016 | Journal article
Contributors: Durham ND; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

The HIV-1 late domain-2 S40A polymorphism in antiretroviral (or ART)-exposed individuals influences protease inhibitor susceptibility.

2016-09 | Journal article
Contributors: Watanabe SM; Simon V; Durham ND; Kemp BR; Machihara S; Kemal KS; Shi B; Foley B; Li H; Chen BK et al.
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

HIV infection-induced transcriptional program in renal tubular epithelial cells activates a CXCR2-driven CD4+ T-cell chemotactic response

AIDS
2016-07 | Journal article
Contributors: Ping Chen; Zhengzi Yi; Weijia Zhang; Mary E. Klotman; Benjamin K. Chen
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

In Vivo HIV-1 Cell-to-Cell Transmission Promotes Multicopy Micro-compartmentalized Infection.

2016-06 | Journal article
Contributors: Law KM; Komarova NL; Yewdall AW; Lee RK; Herrera OL; Wodarz D; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

A high throughput Cre-lox activated viral membrane fusion assay identifies pharmacological inhibitors of HIV entry.

2016-03 | Journal article
Contributors: Esposito AM; Cheung P; Swartz TH; Li H; Tsibane T; Durham ND; Basler CF; Felsenfeld DP; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Purinergic Receptors: Key Mediators of HIV-1 Infection and Inflammation.

2015 | Journal article
Contributors: Swartz TH; Dubyak GR; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

IFITM Proteins Restrict HIV-1 Infection by Antagonizing the Envelope Glycoprotein.

2015-10 | Journal article
Contributors: Yu J; Li M; Wilkins J; Ding S; Swartz TH; Esposito AM; Zheng YM; Freed EO; Liang C; Chen BK et al.
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

HIV-1 Cell-Free and Cell-to-Cell Infections Are Differentially Regulated by Distinct Determinants in the Env gp41 Cytoplasmic Tail.

2015-09 | Journal article
Contributors: Durham ND; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Unique features of HIV-1 spread through T cell virological synapses.

2014-12 | Journal article
Contributors: Alvarez RA; Barría MI; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

P2X-selective purinergic antagonists are strong inhibitors of HIV-1 fusion during both cell-to-cell and cell-free infection.

2014-10 | Journal article
Contributors: Swartz TH; Esposito AM; Durham ND; Hartmann BM; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Renal epithelial cells produce and spread HIV-1 via T-cell contact

AIDS
2014-10 | Journal article
Contributors: Maria Blasi; Bala Balakumaran; Ping Chen; Donatella R.M. Negri; Andrea Cara; Benjamin K. Chen; Mary E. Klotman
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

HIV-1 interacts with human endogenous retrovirus K (HML-2) envelopes derived from human primary lymphocytes.

2014-06 | Journal article
Contributors: Brinzevich D; Young GR; Sebra R; Ayllon J; Maio SM; Deikus G; Chen BK; Fernandez-Sesma A; Simon V; Mulder LC
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

HIV-1 Vpu antagonism of tetherin inhibits antibody-dependent cellular cytotoxic responses by natural killer cells.

2014-06 | Journal article
Contributors: Alvarez RA; Hamlin RE; Monroe A; Moldt B; Hotta MT; Rodriguez Caprio G; Fierer DS; Simon V; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Mechanisms of enhanced HIV spread through T-cell virological synapses

2013 | Journal article
Part of ISSN: 0105-2896
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Postintegration HIV-1 infection of cervical epithelial cells mediates contact-dependent productive infection of T cells.

2013-12 | Journal article
Contributors: Micsenyi AM; Zony C; Alvarez RA; Durham ND; Chen BK; Klotman ME
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Cannabinoid Receptor 2-Mediated Attenuation of CXCR4-Tropic HIV Infection in Primary CD4+ T Cells

2012 | Journal article
Part of ISSN: 1932-6203
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

T cell virological synapses and HIV-1 pathogenesis

2012 | Journal article
Part of ISSN: 0257-277X
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Neutralization resistance of virological synapse-mediated HIV-1 Infection is regulated by the gp41 cytoplasmic tail.

2012-07 | Journal article
Contributors: Durham ND; Yewdall AW; Chen P; Lee R; Zony C; Robinson JE; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Live 3D Imaging of HIV-1 Transfer through the Virological Synapse

2011 | Conference paper
Part of ISBN: 978-1-55752-909-1
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Tracking and quantitation of fluorescent HIV during cell-to-cell transmission

2011 | Journal article
Part of ISSN: 1046-2023
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Cell-to-cell transfer of HIV-1 via virological synapses leads to endosomal virion maturation that activates viral membrane fusion.

2011-12 | Journal article
Contributors: Dale BM; McNerney GP; Thompson DL; Hubner W; de Los Reyes K; Chuang FY; Huser T; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Multiploid inheritance of HIV-1 during cell-to-cell infection.

2011-07 | Journal article
Contributors: Del Portillo A; Tripodi J; Najfeld V; Wodarz D; Levy DN; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Virological synapses allow HIV-1 uptake and gene expression in renal tubular epithelial cells.

2011-03 | Journal article
Contributors: Chen P; Chen BK; Mosoian A; Hays T; Ross MJ; Klotman PE; Klotman ME
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Human immunodeficiency virus (HIV)-1 infects human hepatic stellate cells and promotes collagen I and monocyte chemoattractant protein-1 expression: Implications for the pathogenesis of HIV/hepatitis C virus-induced liver fibrosis

2010 | Journal article
Part of ISSN: 0270-9139
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Manipulating CD4+T cells by optical tweezers for the initiation of cell-cell transfer of HIV-1

2010 | Journal article
Part of ISSN: 1864-063X
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Visualizing Cell-to-cell Transfer of HIV using Fluorescent Clones of HIV and Live Confocal Microscopy

2010 | Journal article
Part of ISSN: 1940-087X
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Quantitative 3D video microscopy of HIV transfer across T cell virological synapses.

2009-03 | Journal article
Contributors: Hübner W; McNerney GP; Chen P; Dale BM; Gordon RE; Chuang FY; Li XD; Asmuth DM; Huser T; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Predominant mode of human immunodeficiency virus transfer between T cells is mediated by sustained Env-dependent neutralization-resistant virological synapses.

2007-11 | Journal article
Contributors: Chen P; Hübner W; Spinelli MA; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Sequence of human immunodeficiency virus type 1 (HIV-1) Gag localization and oligomerization monitored with live confocal imaging of a replication-competent, fluorescently tagged HIV-1.

2007-11 | Journal article
Contributors: Hübner W; Chen P; Del Portillo A; Liu Y; Gordon RE; Chen BK
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Lymphotoxin beta receptor signaling is required for inflammatory lymphangiogenesis in the thyroid.

2007-03 | Journal article
Contributors: Furtado GC; Marinkovic T; Martin AP; Garin A; Hoch B; Hubner W; Chen BK; Genden E; Skobe M; Lira SA
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Chimeric HIV-1 containing SIV matrix exhibit enhanced assembly in murine cells and replicate in a cell-type-dependent manner in human T cells

2006 | Journal article
Part of ISSN: 0042-6822
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Inhibition of viral assembly in murine cells by HIV-1 matrix

2006 | Journal article
Part of ISSN: 0042-6822
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Efficient assembly of an HIV-1/MLV Gag-chimeric virus in murine cells.

2001-12 | Journal article
Contributors: Chen BK; Rousso I; Shim S; Kim PS
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Palmitoylation of the HIV-1 envelope glycoprotein is critical for viral infectivity.

2000-12 | Journal article
Contributors: Rousso I; Mixon MB; Chen BK; Kim PS
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

The human thioesterase II protein binds to a site on HIV-1 Nef critical for CD4 down-regulation.

2000-07 | Journal article
Contributors: Cohen GB; Rangan VS; Chen BK; Smith S; Baltimore D
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

The Selective Downregulation of Class I Major Histocompatibility Complex Proteins by HIV-1 Protects HIV-Infected Cells from NK Cells

1999 | Journal article
Part of ISSN: 1074-7613
Source: Self-asserted source
Benjamin K Chen via Crossref Metadata Search

Host control of HIV-1 parasitism in T cells by the nuclear factor of activated T cells.

1998-11 | Journal article
PMID: 9845362
Contributors: Kinoshita S; Chen BK; Kaneshima H; Nolan GP
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

HIV-1 directly kills CD4+ T cells by a Fas-independent mechanism.

1998-04 | Journal article
PMID: 9529327
Contributors: Gandhi RT; Chen BK; Straus SE; Dale JK; Lenardo MJ; Baltimore D
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes.

1998-01 | Journal article
PMID: 9450757
Contributors: Collins KL; Chen BK; Kalams SA; Walker BD; Baltimore D
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central

Genotypic and phenotypic characterization of long terminal repeat sequences from long-term survivors of human immunodeficiency virus type 1 infection.

1997-07 | Journal article
PMID: 9188635
Contributors: Zhang L; Huang Y; Yuan H; Chen BK; Ip J; Ho DD
Source: Self-asserted source
Benjamin K Chen via Europe PubMed Central
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Page 1 of 2

Peer review (7 reviews for 3 publications/grants)

Review activity for Nature communications (1)
Review activity for PLOS pathogens : (5)
Review activity for Viruses. (1)