Personal information

Activities

Employment (2)

Baltimore VA Medical Center: Baltimore, MD, US

2017-12-01 to present | Merit Scientist (Research)
Employment
Source: Self-asserted source
France Carrier

University of Maryland Baltimore: Baltimore, MD, US

1998-07-01 to present | Professor (Radiation Oncology)
Employment
Source: Self-asserted source
France Carrier

Education and qualifications (1)

University of Montreal: Montreal, Quebec, CA

1988 to present | Ph.D. (Clinical Sciences/Biochemistry)
Education
Source: Self-asserted source
France Carrier

Professional activities (3)

American Society for Radiation Oncology: Arlington, VA, US

Associate member
Membership
Source: Self-asserted source
France Carrier

Radiation Research Society: MT, MT, US

2018-09-20 to present | Full member
Membership
Source: Self-asserted source
France Carrier

American Association for Cancer Research: Philadelphia, PA, US

1997-01-01 to present | Active member
Membership
Source: Self-asserted source
France Carrier

Funding (5)

Chemopotentiation by Low Dose Fractionated Radiation Therapy for disseminated intra-abdominal cancers

2017-07-01 to 2021-06-30 | Grant
United States Department of Veterans Affairs (Washington D.C., US)
GRANT_NUMBER: I01BX003437
Source: Self-asserted source
France Carrier via DimensionsWizard

Rational targeting of protein translation of cancer treatments

2013-07-01 to 2019-06-30 | Grant
National Cancer Institute (Rockville, US)
GRANT_NUMBER: R01CA177981
Source: Self-asserted source
France Carrier via DimensionsWizard

Biomodulation of anticancer drugs targeting DNA

2007-08-01 to 2011-05-31 | Grant
National Cancer Institute (Rockville, US)
GRANT_NUMBER: R01CA116491
Source: Self-asserted source
France Carrier via DimensionsWizard

Development of basic tools for Cancer Research

2001-09-30 to 2003-03-31 | Grant
National Cancer Institute (Rockville, US)
GRANT_NUMBER: R41CA090082
Source: Self-asserted source
France Carrier via DimensionsWizard

RADIATION INDUCED RNA BINDING PROTEINS

1999-05-01 to 2004-04-30 | Grant
National Institute of General Medical Sciences (Bethesda, US)
GRANT_NUMBER: R01GM057827
Source: Self-asserted source
France Carrier via DimensionsWizard

Works (50 of 55)

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Page 1 of 2

Small molecules inhibitors of the heterogeneous ribonuclear protein A18 (hnRNP A18): a regulator of protein translation and an immune checkpoint

Nucleic Acids Research
2021-02-22 | Journal article
Contributors: Eduardo Solano-Gonzalez; Katherine M Coburn; Wenbo Yu; Gerald M Wilson; Elmar Nurmemmedov; Santosh Kesari; Elizabeth T Chang; Alexander D MacKerell, Jr; David J Weber; France Carrier
Source: check_circle
Crossref

Crystal structure of the human heterogeneous ribonucleoprotein A18 RNA-recognition motif

Acta Crystallographica Section:F Structural Biology Communications
2017 | Journal article
EID:

2-s2.0-85016999388

Contributors: Coburn, K.; Melville, Z.; Aligholizadeh, E.; Roth, B.M.; Varney, K.M.; Carrier, F.; Pozharski, E.; Weber, D.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Heterogenous ribonucleoprotein A18 (hnRNP A18) promotes tumor growth by increasing protein translation of selected transcripts in cancer cells

Oncotarget
2016 | Journal article
EID:

2-s2.0-84961653797

Contributors: Chang, E.T.; Parekh, P.R.; Yang, Q.; Nguyen, D.M.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Contribution of dual oxidase 2 (DUOX2) to hyper-radiosensitivity in human gastric cancer cells

Radiation Research
2015 | Journal article
EID:

2-s2.0-84939242944

Contributors: Nguyen, D.M.; Parekh, P.R.; Chang, E.T.; Sharma, N.K.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Chromatin modulation by histone deacetylase inhibitors: Impact on cellular sensitivity to ionizing radiation

Molecular and Cellular Pharmacology
2013 | Journal article
EID:

2-s2.0-84880160537

Contributors: Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Introduction: New insights in the cellular and molecular response to radiation therapy

Molecular and Cellular Pharmacology
2013 | Journal article
EID:

2-s2.0-84880147673

Contributors: Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Translational phase I trial of vorinostat (suberoylanilide hydroxamic acid) combined with cytarabine and etoposide in patients with relapsed, refractory, high-risk acute myeloid leukemia

Clinical Cancer Research
2013 | Journal article
EID:

2-s2.0-84877093178

Contributors: Gojo, I.; Tan, M.; Fang, H.-B.; Sadowska, M.; Lapidus, R.; Baer, M.R.; Carrier, F.; Beumer, J.H.; Anyang, B.N.; Srivastava, R.K. et al.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

HnRNP A18: A new pathway to regulate protein translation in cancer cells

Molecular and Cellular Pharmacology
2012 | Journal article
EID:

2-s2.0-84857890794

Contributors: Pamboukian, R.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Nucleolin inhibits G4 oligonucleotide unwinding by werner helicase

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84861907147

Contributors: Indig, F.E.; Rybanska, I.; Karmakar, P.; Devulapalli, C.; Fu, H.; Carrier, F.; Bohr, V.A.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Cancer cells' epigenetic composition and predisposition to histone deacetylase inhibitor sensitization

Epigenomics
2011 | Journal article
EID:

2-s2.0-79955148265

Contributors: Nalabothula, N.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Enhanced translation by Nucleolin via G-rich elements in coding and non-coding regions of target mRNAs

Nucleic Acids Research
2011 | Journal article
EID:

2-s2.0-80455168361

Contributors: Abdelmohsen, K.; Tominaga, K.; Lee, E.K.; Srikantan, S.; Kang, M.-J.; Kim, M.M.; Selimyan, R.; Martindale, J.L.; Yang, X.; Carrier, F. et al.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Functional significance for a heterogenous ribonucleoprotein A18 signature RNA Motif in the 3′-untranslated region of ataxia telangiectasia mutated and rad3-related (ATR) Transcript

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-77950561704

Contributors: Yang, R.; Zhan, M.; Rao Nalabothula, N.; Yang, Q.; Indig, F.E.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Over expression of nucleophosmin and nucleolin contributes to the suboptimal activation of a G2/M checkpoint in Ataxia Telangiectasia fibroblasts

Molecular and Cellular Pharmacology
2010 | Journal article
EID:

2-s2.0-78651472975

Contributors: Nalabothula, N.; Chakravarty, D.; Pierce, A.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

The calcium-binding protein S100B down-regulates p53 and apoptosis in malignant melanoma

Journal of Biological Chemistry
2010 | Journal article
EID:

2-s2.0-77956252897

Contributors: Lin, J.; Yang, Q.; Wilder, P.T.; Carrier, F.; Weber, D.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

The nucleolus takes control of protein trafficking under cellular stress

Molecular and Cellular Pharmacology
2010 | Journal article
EID:

2-s2.0-78651476942

Contributors: Nalabothula, N.; Indig, F.E.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Nucleolin binds to the proliferating cell nuclear antigen and inhibits nucleotide excision repair

Molecular and Cellular Pharmacology
2009 | Journal article
EID:

2-s2.0-77953462682

Contributors: Yang, C.; Kim, M.S.; Chakravarty, D.; Indig, F.E.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Post-transcriptional regulation of thioredoxin by the stress inducible heterogenous ribonucleoprotein A18

Nucleic Acids Research
2006 | Journal article
EID:

2-s2.0-33644932167

Contributors: Yang, R.; Weber, D.J.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Recognition of the tumor suppressor protein p53 and other protein targets by the calcium-binding protein S100B

Biochimica et Biophysica Acta - Molecular Cell Research
2006 | Journal article
EID:

2-s2.0-33751171262

Contributors: Wilder, P.T.; Lin, J.; Bair, C.L.; Charpentier, T.H.; Yang, D.; Liriano, M.; Varney, K.M.; Lee, A.; Oppenheim, A.B.; Adhya, S. et al.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Design of inhibitors for S100B

Current Topics in Medicinal Chemistry
2005 | Journal article
EID:

2-s2.0-27844542227

Contributors: Markowitz, J.; MacKerell Jr., A.D.; Carrier, F.; Charpentier, T.H.; Weber, D.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Sensitization to UV-induced apoptosis by the histone deacetylase inhibitor trichostatin A (TSA)

Experimental Cell Research
2005 | Journal article
EID:

2-s2.0-18844415633

Contributors: Kim, M.S.; Baek, J.H.; Chakravarty, D.; Sidransky, D.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction

Journal of Medicinal Chemistry
2004 | Journal article
EID:

2-s2.0-4744357517

Contributors: Markowitz, J.; Chen, I.; Gitti, R.; Baldisseri, D.M.; Pan, Y.; Udan, R.; Carrier, F.; MacKerell Jr., A.D.; Weber, D.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Inhibiting S100B restores p53 levels in primary malignant melanoma cancer cells

Journal of Biological Chemistry
2004 | Journal article
EID:

2-s2.0-4043105578

Contributors: Lin, J.; Yang, Q.; Yan, Z.; Markowitz, J.; Wilder, P.T.; Carrier, F.; Weber, D.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Nucleophosmin Sets a Threshold for p53 Response to UV Radiation

Molecular and Cellular Biology
2004 | Journal article
EID:

2-s2.0-1942518437

Contributors: Maiguel, D.A.; Jones, L.; Chakravarty, D.; Yang, C.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Phosphorylation regulates nucleophosmin targeting to the centrosome during mitosis as detected by cross-reactive phosphorylation-specific MKK1/MKK2 antibodies

Biochemical Journal
2004 | Journal article
EID:

2-s2.0-1642464045

Contributors: Cha, H.; Hancock, C.; Dangi, S.; Maiguel, D.; Carrier, F.; Shapiro, P.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Inhibition of Histone Deacetylase Increases Cytotoxicity to Anticancer Drugs Targeting DNA

Cancer Research
2003 | Journal article
EID:

2-s2.0-0242610850

Contributors: Kim, M.S.; Blake, M.; Baek, J.H.; Kohlhagen, G.; Pommier, Y.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Identification of nucleolin and nucleophosmin as genotoxic stress-responsive RNA-binding proteins

Nucleic Acids Research
2002 | Journal article
EID:

2-s2.0-0037052950

Contributors: Yang, C.; Maiguel, D.A.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Inhibition of p53 Transcriptional Activity by the S100B Calcium-binding Protein

Journal of Biological Chemistry
2001 | Journal article
EID:

2-s2.0-0035860784

Contributors: Lin, J.; Blake, M.; Tang, C.; Zimmer, D.; Rustandi, R.R.; Weber, D.J.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

The UV-inducible RNA-binding Protein A18 (A18 hnRNP) Plays a Protective Role in the Genotoxic Stress Response

Journal of Biological Chemistry
2001 | Journal article
EID:

2-s2.0-0035861655

Contributors: Yang, C.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Association with Cdc2 and inhibition of Cdc2/Cyclin B1 kinase activity by the p53-regulated protein Gadd45

Oncogene
1999 | Journal article
EID:

2-s2.0-0033529121

Contributors: Zhan, Q.; Antinore, M.J.; Wang, X.W.; Carrier, F.; Smith, M.L.; Harris, C.C.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Gadd45, a p53-responsive stress protein, modifies DNA accessibility on damaged chromatin

Molecular and Cellular Biology
1999 | Journal article
EID:

2-s2.0-0033023893

Contributors: Carrier, F.; Georgel, P.T.; Pourquier, P.; Blake, M.; Kontny, H.U.; Antinore, M.J.; Gariboldi, M.; Myers, T.G.; Weinstein, J.N.; Pommier, Y. et al.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Evidence for distinct kinase-mediated pathways in gadd gene responses

Biochemical Pharmacology
1998 | Journal article
EID:

2-s2.0-0032520755

Contributors: Carrier, F.; Zhan, Q.; Alamo, I.; Hanaoka, F.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Identification of an additional p53-responsive site in the human epidermal growth factor receptor gene promotor

Oncogene
1997 | Journal article
EID:

2-s2.0-0001080345

Contributors: Sheikh, M.S.; Carrier, F.; Johnson, A.C.; Ogdon, S.E.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Identification of several human homologs of hamster DNA damage-inducible transcripts. Cloning and characterization of a novel UV-inducible cDNA that codes for a putative RNA-binding protein

Journal of Biological Chemistry
1997 | Journal article
EID:

2-s2.0-0030726447

Contributors: Sheikh, M.S.; Carrier, F.; Papathanasiou, M.A.; Hollander, M.C.; Zhan, Q.; Yu, K.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Characterization of the GADD45 response to ionizing radiation in WI-L2-NS cells, a p53 mutant cell line

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis
1996 | Journal article
EID:

2-s2.0-0029939552

Contributors: Carrier, F.; Bae, I.; Smith, M.L.; Ayers, D.M.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

The production and characterization of murine monoclonal antibodies to human Gadd45 raised against a recombinant protein

Hybridoma
1995 | Journal article
EID:

2-s2.0-0029122183

Contributors: Kilpatrick, K.E.; Carrier, F.; Smith, M.L.; Chen, C.-Y.; Lee, A.J.; Rusnak, D.W.; Kastan, M.B.; Fornace Jr., A.J.; Champion, B.R.; Gilmer, T.M. et al.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Activation of HIV Type 1 Long Terminal Repeat by Ultraviolet Light Is Serum and Strain Specific

AIDS Research and Human Retroviruses
1994 | Journal article
EID:

2-s2.0-0028168508

Contributors: Carrier, F.; Mccary, J.M.; Bae, I.; Yarosh, D.B.; Fornace, A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Characterization of human Gadd45, a p53-regulated protein

Journal of Biological Chemistry
1994 | Journal article
EID:

2-s2.0-0028575445

Contributors: Carrier, F.; Smith, M.L.; Bae, I.; Kilpatrick, K.E.; Lansing, T.J.; Chen -, C.Y.; Engelstein, M.; Friend, S.H.; Henner, W.D.; Gilmer, T.M. et al.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Induction of RNA-binding proteins in mammalian cells by DNA-damaging agents

Proceedings of the National Academy of Sciences of the United States of America
1994 | Journal article
EID:

2-s2.0-0028058185

Contributors: Carrier, F.; Gatignol, A.; Hollander, M.C.; Jeang, K.-T.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Interaction of the regulatory domains of the murine Cyp1a1 gene with two DNA-binding proteins in addition to the Ah receptor and the Ah receptor nuclear translocator (ARNT)

Biochemical Pharmacology
1994 | Journal article
EID:

2-s2.0-0027943255

Contributors: Carrier, F.; Chang, C.-Y.; Duh, J.-L.; Nebert, D.W.; Puga, A.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

The gadd and MyD genes define a novel set of mammalian genes encoding acidic proteins that synergistically suppress cell growth

Molecular and Cellular Biology
1994 | Journal article
EID:

2-s2.0-0028351565

Contributors: Zhan, Q.; Lord, K.A.; Alamo Jr., I.; Hollander, M.C.; Carrier, F.; Ron, D.; Kohn, K.W.; Hoffman, B.; Liebermann, D.A.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Cyclobutane pyrimidine dimers in UV-DNA induce release of soluble mediators that activate the human immunodeficiency virus promoter

Journal of Investigative Dermatology
1993 | Journal article
EID:

2-s2.0-0027197097

Contributors: Yarosh, D.B.; Alas, L.; Kibitel, J.; O'Connor, A.; Carrier, F.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Erratum: Induction of cellular p53 activity by DNA-damaging agents and growth arrest (Molecular and Cellular Biology 13:7 (4249))

Molecular and Cellular Biology
1993 | Journal article
EID:

2-s2.0-0027166281

Contributors: Zhan, Q.; Carrier, F.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Induction of cellular p53 activity by DNA-damaging agents and growth arrest

Molecular and Cellular Biology
1993 | Journal article
EID:

2-s2.0-0027298576

Contributors: Zhan, Q.; Carrier, F.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Cell
1992 | Journal article
EID:

2-s2.0-0026496885

Contributors: Kastan, M.B.; Zhan, Q.; El-Deiry, W.S.; Carrier, F.; Jacks, T.; Walsh, W.V.; Plunkett, B.S.; Vogelstein, B.; Fornace Jr., A.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Dioxin Induces Expression of c-fos and c-jun Proto-Oncogenes and a Large Increase in Transcription Factor AP-1

DNA and Cell Biology
1992 | Journal article
EID:

2-s2.0-0026648792

Contributors: Puga, A.; Nebert, D.W.; Carrier, F.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Dioxin-dependent activation of murine Cyp1a-1 gene transcription requires protein kinase C-dependent phosphorylation

Molecular and Cellular Biology
1992 | Journal article
EID:

2-s2.0-0026559509

Contributors: Carrier, F.; Owens, R.A.; Nebert, D.W.; Puga, A.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Inhibition of protein phosphatases-1 and -2A with acanthifolicin. Comparison with diarrhetic shellfish toxins and identification of a region on okadaic acid important for phosphatase inhibition

FEBS Letters
1990 | Journal article
EID:

2-s2.0-0025002918

Contributors: Holmes1, C.F.B.; Luu1, H.A.; Carrier1, F.; Schmitz, F.J.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Structural homology between the rat calreticulin gene product and the Onchocerca volvulus antigen Ral-1

Nucleic Acids Research
1990 | Journal article
EID:

2-s2.0-0025714428

Contributors: Murthy, K.K.; Banville, D.; Srikant, C.B.; Carrier, F.; Holmes, C.; Bell, A.; Patel, Y.C.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Identification and characterization of atrial natriuretic factor receptors in the rat retina

Life Sciences
1989 | Journal article
EID:

2-s2.0-0024357020

Contributors: Fernandez-Durango, R.; Sanchez, D.; Gutkowska, J.; Carrier, F.; Fernandez-Cruz, A.
Source: Self-asserted source
France Carrier via Scopus - Elsevier

Glomerular ANF receptor regulation during changes in sodium and water metabolism

American Journal of Physiology - Renal Fluid and Electrolyte Physiology
1988 | Journal article
EID:

2-s2.0-0023873845

Contributors: Gauquelin, G.; Garcia, R.; Carrier, F.; Cantin, M.; Gutkowska, J.; Thibault, G.; Schiffrin, E.L.
Source: Self-asserted source
France Carrier via Scopus - Elsevier
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