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Employment (3)

OMAPiX Inc., - KU Leuven: Leuven, BE

2022-10-01 to present | Project Manager
Employment
Source: Self-asserted source
ArunKumar Tharkeshwar

VIB KU Leuven Center for Brain & Disease Research: Leuven, BE

2018-07-01 to 2022-09-30 | Postdoctoral Scientist (Neuroscience)
Employment
Source: Self-asserted source
ArunKumar Tharkeshwar

Yale School of Medicine: New Haven, CT, US

2017-02-02 to 2018-06-30 | Postdoctoral Associate (Cell Biology)
Employment
Source: Self-asserted source
ArunKumar Tharkeshwar

Education and qualifications (6)

KU Leuven: Leuven, BE

2009 to 2016 | Doctor of Biomedical Sciences (PhD)
Education
Source: Self-asserted source
ArunKumar Tharkeshwar

International Centre for Genetic Engineering and Biotechnology: New Delhi, Delhi, IN

2008-09-01 to 2009-07-31 | Junior Research Fellow (Membrane Protein Biology)
Qualification
Source: Self-asserted source
ArunKumar Tharkeshwar

International Centre for Genetic Engineering and Biotechnology: New Delhi, Delhi, IN

2007-12-01 to 2008-06-30 | Project Assistant (Membrane Protein Biology)
Qualification
Source: Self-asserted source
ArunKumar Tharkeshwar

Bharathidasan University: Tiruchirappalli, Tamil Nadu, IN

2006 to 2008 | Master of Science in Animal Biotechnology
Education
Source: Self-asserted source
ArunKumar Tharkeshwar

Aravind Eye Hospital: Madurai, Tamil Nadu, IN

2007-05-01 to 2007-07-31 | Summer Research Fellow
Qualification
Source: Self-asserted source
ArunKumar Tharkeshwar

Thiagarajar College: Madurai, Tamil Nadu, IN

2003 to 2006 | Bachelor of Science in Biotechnology
Education
Source: Self-asserted source
ArunKumar Tharkeshwar

Professional activities (2)

VIB: Leuven, BE

2009 | VIB International PhD Fellowship
Distinction
Source: Self-asserted source
ArunKumar Tharkeshwar

Indian Academy of Sciences: Bangalore, Karnataka, IN

2007 | Summer Research Fellowship
Distinction
Source: Self-asserted source
ArunKumar Tharkeshwar

Funding (2)

The role of lysosomal dysfunction in frontotemporal dementia caused by progranulin mutations

2021-01 to 2022-12 | Grant
Stichting Alzheimer Onderzoek (Belgium, BE)
Source: Self-asserted source
ArunKumar Tharkeshwar

Role of exosomes in frontotemporal dementia caused by progranulin mutations

2019-06 to 2020-05 | Grant
Vlaams Instituut voor Biotechnologie (Gent, BE)
Source: Self-asserted source
ArunKumar Tharkeshwar

Works (16)

Proximal partners of the organellar N-terminal acetyltransferase NAA60: insights into Golgi structure and transmembrane protein topology

Open Biology
2025-02 | Journal article
DOI: 10.1098/rsob.240225
Contributors: Sebastian Tanco; Veronique Jonckheere; Arun Kumar Tharkeshwar; Annelies Bogaert; Kris Gevaert; Wim Annaert; Petra Van Damme
Source: check_circle
Crossref

A toxic gain-of-function mechanism in C9orf72 ALS impairs the autophagy-lysosome pathway in neurons

Acta Neuropathologica Communications
2023-09-18 | Journal article
DOI: 10.1186/s40478-023-01648-0
Contributors: Jimmy Beckers; Arun Kumar Tharkeshwar; Laura Fumagalli; Matilde Contardo; Evelien Van Schoor; Raheem Fazal; Dietmar Rudolf Thal; Siddharthan Chandran; Renzo Mancuso; Ludo Van Den Bosch et al.
Source: check_circle
Crossref

Defective Schwann cell lipid metabolism alters plasma membrane dynamics in Charcot-Marie-Tooth disease 1A

2023-04-02 | Preprint
DOI: 10.1101/2023.04.02.535224
Contributors: Robert Prior; Alessio Silva; Tim Vangansewinkel; Jakub Idkowiak; Arun Kumar Tharkeshwar; Tom P. Hellings; Iliana Michailidou; Jeroen Vreijling; Maarten Loos; Bastijn Koopmans et al.
Source: check_circle
Crossref

CRISPR/Cas9 screen in human iPSC-derived cortical neurons identifies NEK6 as a novel disease modifier of C9orf72 poly(PR) toxicity.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2022-08-22 | Journal article | Formal analysis, Writing - review & editing
DOI: 10.1002/alz.12760
PMID: 35993441
Contributors: ArunKumar Tharkeshwar
Source: Self-asserted source
ArunKumar Tharkeshwar

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

Journal of Cell Biology
2022-07-04 | Journal article
DOI: 10.1083/jcb.202106046
Contributors: William Hancock-Cerutti; Zheng Wu; Peng Xu; Narayana Yadavalli; Marianna Leonzino; Arun Kumar Tharkeshwar; Shawn M. Ferguson; Gerald S. Shadel; Pietro De Camilli
Source: check_circle
Crossref

C9orf72 ALS-FTD: recent evidence for dysregulation of the autophagy-lysosome pathway at multiple levels

Autophagy
2021-11-02 | Journal article
DOI: 10.1080/15548627.2021.1872189
Contributors: Jimmy Beckers; Arun Kumar Tharkeshwar; Philip Van Damme
Source: check_circle
Crossref

ER-lysosome lipid transfer protein VPS13C/PARK23 prevents aberrant mtDNA-dependent STING signaling

2021-06-08 | Other
DOI: 10.1101/2021.06.08.447593
Contributors: William Hancock-Cerutti; Zheng Wu; Arun Tharkeshwar; Shawn M. Ferguson; Gerald S. Shadel; Pietro De Camilli
Source: check_circle
Crossref

Superparamagnetic Nanoparticles for Lysosome Isolation to Identify Spatial Alterations in Lysosomal Protein and Lipid Composition

STAR Protocols
2020-10 | Journal article
DOI: 10.1016/j.xpro.2020.100122
Part of ISSN: 2666-1667
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation

Journal of Cell Biology
2020-01-06 | Journal article
DOI: 10.1083/jcb.201906076
Part of ISSN: 0021-9525
Part of ISSN: 1540-8140
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

WDR41 supports lysosomal response to changes in amino acid availability.

Molecular biology of the cell
2018-07-11 | Journal article
DOI: 10.1091/mbc.E17-12-0703
PMID: 29995611
PMC: PMC6249801
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

Front Cover: Organellar Omics - A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell

PROTEOMICS
2018-03-25 | Journal article
DOI: 10.1002/pmic.201870041
Part of ISSN: 1615-9853
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

Characterization of Influenza Virus Pseudotyped with Ebolavirus Glycoprotein.

Journal of virology
2018-01-30 | Journal article
DOI: 10.1128/JVI.00941-17
PMID: 29212933
PMC: PMC5790926
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

Organellar Omics-A Reviving Strategy to Untangle the Biomolecular Complexity of the Cell.

Proteomics
2017-12-14 | Journal article
DOI: 10.1002/pmic.201700113
PMID: 29125683
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

A novel approach to analyze lysosomal dysfunctions through subcellular proteomics and lipidomics: the case of NPC1 deficiency.

Scientific reports
2017-01-30 | Journal article
DOI: 10.1038/srep41408
PMID: 28134274
PMC: PMC5278418
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool.

Cell
2016-06-09 | Journal article
DOI: 10.1016/j.cell.2016.05.020
PMID: 27293189
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

A novel strategy for the comprehensive analysis of the biomolecular composition of isolated plasma membranes.

Molecular Systems Biology
2011-10-25 | Journal article
DOI: 10.1038/msb.2011.74
PMID: 22027552
PMC: PMC3261717
Source: Self-asserted source
ArunKumar Tharkeshwar
grade
Preferred source (of 2)‎

Peer review (8 reviews for 5 publications/grants)

Review activity for Cells. (1)
Review activity for International journal of molecular sciences. (4)
Review activity for Journal of clinical medicine. (1)
Review activity for Translational neurodegeneration. (1)
Review activity for Viruses. (1)
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