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melanoma, stem cells, cancer stem cells, myeloid derived suppressor cells, tumor dormancy,sEvs, prostate cancer, breast cancer, hypoxia neutrophils
United States

Activities

Employment (4)

The Wistar Institute: Philadelphia, Pennsylvania, US

2020-07-01 to present | Research Assistant Professor (Immunology, Microenvironment & Metastasis Program)
Employment
Source: Self-asserted source
michela perego

Wistar Institute: Philadelphia, PA, US

2015-10-01 to 2020-07-01 | Associate Staff Scientist-Staff Scientist (Translational Tumor Immunology program)
Employment
Source: Self-asserted source
michela perego

Wistar Institute: Philadelphia, PA, US

2012-07-31 to 2015-09-30 | post- doctoral fellow (melanoma reseach center)
Employment
Source: Self-asserted source
michela perego

Fondazione IRCCS Istituto Nazionale dei Tumori: Milano, Lombardia, IT

2005-09-01 to 2012-07-21 | fellow/PhD student (immunotherpay of human tumors)
Employment
Source: Self-asserted source
michela perego

Works (36)

Parkin activates innate immunity and promotes antitumor immune responses

Journal of Clinical Investigation
2025-01-16 | Journal article
Contributors: Michela Perego; Minjeong Yeon; Ekta Agarwal; Andrew T. Milcarek; Irene Bertolini; Chiara Camisaschi; Jagadish C. Ghosh; Hsin-Yao Tang; Nathalie Grandvaux; Marcus Ruscetti et al.
Source: check_circle
Crossref

Parkin activates innate immunity and promotes antitumor immune responses

Journal of Clinical Investigation
2024-11-15 | Journal article
Contributors: Michela Perego; Minjeong Yeon; Ekta Agarwal; Andrew T. Milcarek; Irene Bertolini; Chiara Camisaschi; Jagadish C. Ghosh; Hsin-Yao Tang; Nathalie Grandvaux; Marcus Ruscetti et al.
Source: check_circle
Crossref

Correction: NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment

Oncogene
2023-06-30 | Journal article
Contributors: Irene Bertolini; Michela Perego; Jagadish C. Ghosh; Andrew V. Kossenkov; Dario C. Altieri
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Crossref

Intercellular hif1α reprograms mammary progenitors and myeloid immune evasion to drive high-risk breast lesions

Journal of Clinical Investigation
2023-04-17 | Journal article
Contributors: Irene Bertolini; Michela Perego; Yulia Nefedova; Cindy Lin; Andrew Milcarek; Peter Vogel; Jagadish C. Ghosh; Andrew V. Kossenkov; Dario C. Altieri
Source: check_circle
Crossref

Data from Syntaphilin Regulates Neutrophil Migration in Cancer

2023-04-04 | Preprint
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
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Crossref

Data from Syntaphilin Regulates Neutrophil Migration in Cancer

2023-04-04 | Preprint
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
Source: check_circle
Crossref

Supplemental Figures and Tables from Syntaphilin Regulates Neutrophil Migration in Cancer

2023-04-04 | Preprint
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
Source: check_circle
Crossref

Supplemental Figures and Tables from Syntaphilin Regulates Neutrophil Migration in Cancer

2023-04-04 | Preprint
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
Source: check_circle
Crossref

Supplemental Video from Syntaphilin Regulates Neutrophil Migration in Cancer

2023-04-04 | Preprint
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
Source: check_circle
Crossref

Supplemental Video from Syntaphilin Regulates Neutrophil Migration in Cancer

2023-04-04 | Preprint
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
Source: check_circle
Crossref

Syntaphilin Regulates Neutrophil Migration in Cancer

Cancer Immunology Research
2023-03-01 | Journal article
Contributors: Shuyu Fu; Hui Deng; Irene Bertolini; Michela Perego; Eric S. Chen; Emilio Sanseviero; Ali Mostafa; Kevin Alicea-Torres; Laura Garcia-Gerique; Erica L. Stone et al.
Source: check_circle
Crossref

Correction: NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment

Oncogene
2023-02-24 | Journal article
Contributors: Irene Bertolini; Michela Perego; Jagadish C. Ghosh; Andrew V. Kossenkov; Dario C. Altieri
Source: check_circle
Crossref

Mitochondrial fitness and cancer risk

PLOS ONE
2022-10-12 | Journal article
Contributors: Andrew V. Kossenkov; Pankaj K. Singh; Andrew Milcarek; Faiyaz Notta; Gun-Ho Jang; Julie M. Wilson; Steven Gallinger; Daniel Cui Zhou; Li Ding; Jagadish C. Ghosh et al.
Source: check_circle
Crossref

NFκB activation by hypoxic small extracellular vesicles drives oncogenic reprogramming in a breast cancer microenvironment

Oncogene
2022-04-22 | Journal article
Contributors: Irene Bertolini; Michela Perego; Jagadish C. Ghosh; Andrew V. Kossenkov; Dario C. Altieri
Source: check_circle
Crossref

Ghost mitochondria drive metastasis through adaptive GCN2/Akt therapeutic vulnerability

Proceedings of the National Academy of Sciences
2022-02-22 | Journal article
Contributors: Jagadish C. Ghosh; Michela Perego; Ekta Agarwal; Irene Bertolini; Yuan Wang; Aaron R. Goldman; Hsin-Yao Tang; Andrew V. Kossenkov; Catherine J. Landis; Lucia R. Languino et al.
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Crossref

Distinct Populations of Immune-Suppressive Macrophages Differentiate from Monocytic Myeloid-Derived Suppressor Cells in Cancer

Cell Reports
2020-12 | Journal article
Contributors: Taekyoung Kwak; Fang Wang; Hui Deng; Thomas Condamine; Vinit Kumar; Michela Perego; Andrew Kossenkov; Luis J. Montaner; Xiaowei Xu; Wei Xu et al.
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Crossref

Reactivation of dormant tumor cells by modified lipids derived from stress-activated neutrophils

Science Translational Medicine
2020-12-02 | Journal article
Contributors: Michela Perego; Vladimir A. Tyurin; Yulia Y. Tyurina; Jonathan Yellets; Timothy Nacarelli; Cindy Lin; Yulia Nefedova; Andrew Kossenkov; Qin Liu; Sreesha Sreedhar et al.
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Crossref

Cancer Stem Cell Challenges in Melanoma Characterization and Treatment

Cancer Stem Cell Resistance to Targeted Therapy
2019 | Book chapter
Source: Self-asserted source
michela perego

Lactoferrin-induced myeloid-derived suppressor cell therapy attenuates pathologic inflammatory conditions in newborn mice

Journal of Clinical Investigation
2019-09-04 | Journal article
Contributors: Yufeng Liu; Michela Perego; Qiang Xiao; Yumei He; Shuyu Fu; Juan He; Wangkai Liu; Xing Li; Yanlai Tang; Xiaoyu Li et al.
Source: check_circle
Crossref

Myeloid-derived suppressor cells coming of age

Nature Immunology
2018-02-18 | Journal article
Contributors: Filippo Veglia; Michela Perego; Dmitry Gabrilovich
Source: check_circle
Crossref

Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation

Nature Medicine
2018-02-15 | Journal article
Contributors: Yu-Mei He; Xing Li; Michela Perego; Yulia Nefedova; Andrew V Kossenkov; Erik A Jensen; Valerian Kagan; Yu-Feng Liu; Shu-Yu Fu; Qing-Jian Ye et al.
Source: check_circle
Crossref

Tumor-associated B-cells induce tumor heterogeneity and therapy resistance

nature communication
2017-09-19 | Journal article
Source: Self-asserted source
michela perego

A slow-cycling subpopulation of melanoma cells with highly invasive properties

oncogene
2017-09-18 | Journal article
Source: Self-asserted source
michela perego

Melanoma Stem Cell Sphere Formation Assay

BioProtocol
2017-04-20 | Journal article
Source: Self-asserted source
michela perego

Abstract PR02: Humanized mouse melanoma model using patient-derived xenografts

clinical cancer research
2016-08 | Conference abstract
Source: Self-asserted source
michela perego

PIM kinases as therapeutic targets against advanced melanoma

Oncotarget
2016-08-23 | Journal article
Source: Self-asserted source
michela perego

Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells

stem cells
2016-06-28 | Journal article
Source: Self-asserted source
michela perego

Enhancing the evaluation of PI3K inhibitors through 3D melanoma models

pigment cell melanoma research
2016-03-21 | Journal article
Source: Self-asserted source
michela perego

Heterogeneity in Melanoma

Melanoma
2015-11-25 | Book chapter
Source: Self-asserted source
michela perego

Wnt5A-expressing melanoma cells show classical markers of senescence following radiation and therapeutic stress, but retain the ability to metastasize and proliferate at distant sites

cancer research
2015-07 | Conference abstract
Source: Self-asserted source
michela perego

Wnt5A promotes an adaptive, senescent-like stress response, while continuing to drive invasion in melanoma cells

pigment cell melanoma research
2014-12-29 | Journal article
Source: Self-asserted source
michela perego

Comparative secretome analysis of epithelial and mesenchymal subpopulations of head and neck squamous cell carcinoma identifies S100A4 as a potential therapeutic target

Molecular cell protemics
2013-09-13 | Journal article
Source: Self-asserted source
michela perego

Eighth annual meeting of the Italian network for tumor biotherapy (NIBIT), Siena, October 7-9, 2010.

cancer immunology, immunotherapy
2011-03-24 | Report
Source: Self-asserted source
michela perego

Spheres of influence of cancer stem cell biology

journal of investigative dermatology
2010-10-21 | Journal article
Source: Self-asserted source
michela perego

LAG-3 expression defines a subset of CD4(+)CD25(high)Foxp3(+) regulatory T cells that are expanded at tumor sites

journal of immunology
2010-04-26 | Journal article
Source: Self-asserted source
michela perego

Heterogeneous phenotype of human melanoma cells with in vitro and in vivo features of tumor-initiating cells.

journal of investigative dermatology
2010-04-08 | Journal article
Source: Self-asserted source
michela perego

Peer review (2 reviews for 2 publications/grants)

Review activity for Cancer immunology and immunotherapy. (1)
Review activity for Nature communications (1)