Personal information

Emails & domains

Verified email domains

Websites & social links

https://www.anesthesiology.cumc.columbia.edu/research/basic-science-research/guang-yang-phd

Other IDs

Loop profile: 511988

Keywords

Synapses and Circuits, Neuroimmunology, Pain, Neurodegeneration

Countries

United States

Activities

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Employment (2)

Columbia University Medical Center: New York, NY, US

2018-05 to present | Associate Professor (Anesthesiology)
Employment
Source: Self-asserted source
Guang Yang

NYU School of Medicine: New York, NY, US

2010-09-01 to 2018-04-30 | Assistant Professor ( Anesthesiology, Perioperative Care and Pain Medicine)
Employment
Source: Self-asserted source
Guang Yang

Education and qualifications (1)

Tsinghua University: Beijing, Beijing, CN

2000-09-01 to 2005-07-07 | PhD
Education
Source: Self-asserted source
Guang Yang

Works (50 of 72)

Items per page:
Page 1 of 2

Age-dependent cerebral vasodilation induced by volatile anesthetics is mediated by NG2+ vascular mural cells.

Communications biology
2024-11-15 | Journal article | Author
DOI: 10.1038/s42003-024-07200-7
PMID: 39548262
PMC: PMC11568297
Contributors: Hang Zhou; Neudecker V; Perez-Zoghbi JF; Ansgar Brambrink; Guang Yang
Source: Self-asserted source
Guang Yang

Generalized modality responses in primary sensory neurons of awake mice during the development of neuropathic pain.

Frontiers in neuroscience
2024-04-16 | Journal article
DOI: 10.3389/fnins.2024.1368507
PMID: 38690372
PMC: PMC11058805
Contributors: Sun L; Chen C; Xiang X; Guo S; Yang G
Source: Self-asserted source
Guang Yang

A mesocortical glutamatergic pathway modulates neuropathic pain independent of dopamine co-release.

Nature communications
2024-01-20 | Journal article | Author
DOI: 10.1038/s41467-024-45035-2
PMID: 38245542
PMC: PMC10799877
Contributors: MIAO LI; Guang Yang
Source: Self-asserted source
Guang Yang

EF1α-associated protein complexes affect dendritic spine plasticity by regulating microglial phagocytosis in Fmr1 knock-out mice.

Molecular psychiatry
2024-01-11 | Journal article | Author
DOI: 10.1038/s41380-023-02396-2
PMID: 38212373
Contributors: Su P; Yan S; Chen K; Huang L; Wang L; Lee FHF; Zhou H; Lai TKY; Jiang A; Samsom J et al.
Source: Self-asserted source
Guang Yang

Anesthesia-induced hippocampal-cortical hyperactivity and tau hyperphosphorylation impair remote memory retrieval in Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2023-09-11 | Journal article
DOI: 10.1002/alz.13464
PMID: 37695022
Contributors: Chen K; Gupta R; Martín-Ávila A; Cui M; Xie Z; Yang G
Source: Self-asserted source
Guang Yang

Transmission of Alzheimer's disease-associated microbiota dysbiosis and its impact on cognitive function: evidence from mice and patients.

Molecular psychiatry
2023-08-21 | Journal article | Author
DOI: 10.1038/s41380-023-02216-7
PMID: 37604976
Contributors: Yiying Zhang; Shen Y; Liufu N; Liu L; Li W; Shi Z; Zheng H; Mei X; Chen CY; Jiang Z et al.
Source: Self-asserted source
Guang Yang

Sevoflurane anaesthesia induces cognitive impairment in young mice through sequential tau phosphorylation.

British journal of anaesthesia
2023-08-01 | Journal article
DOI: 10.1016/j.bja.2023.06.059
PMID: 37537117
Contributors: Liang F; Li M; Xu M; Zhang Y; Dong Y; Soriano SG; McCann ME; Yang G; Xie Z
Source: Self-asserted source
Guang Yang

Formyl peptide receptor 1 is involved in surgery-induced neuroinflammation and dysfunction of learning and memory in mice.

Behavioural brain research
2023-07-08 | Journal article
DOI: 10.1016/j.bbr.2023.114577
PMID: 37423318
Contributors: Ma G; Li J; Wang H; Lin AL; Yang G; Zuo Z
Source: Self-asserted source
Guang Yang

Blood tau-PT217 contributes to the anesthesia/surgery-induced delirium-like behavior in aged mice.

Alzheimer's & dementia : the journal of the Alzheimer's Association
2023-05-30 | Journal article
DOI: 10.1002/alz.13118
PMID: 37249148
Contributors: Jing Lu; Liang F; Bai P; Liu C; Xu M; Sun Z; Tian W; Dong Y; Zhang Y; Quan Q et al.
Source: Self-asserted source
Guang Yang

Progranulin deficiency results in sex-dependent alterations in microglia in response to demyelination.

Acta neuropathologica
2023-04-30 | Journal article
DOI: 10.1007/s00401-023-02578-w
PMID: 37120788
PMC: PMC10375542
Contributors: Zhang T; Tuancheng FENG; Wu K; Jennifer Guo; Nana AL; Yang G; Seeley WW; Fenghua Hu
Source: Self-asserted source
Guang Yang

Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain.

Nature communications
2023-02-08 | Journal article | Author
DOI: 10.1038/s41467-023-36093-z
PMID: 36755026
PMC: PMC9908980
Contributors: Chen C; Sun L; Adler A; Hang Zhou; Zhang L; Zhang L; Junhao Deng; Bai Y; Zhang J; Guang Yang et al.
Source: Self-asserted source
Guang Yang

A sleep-active basalocortical pathway crucial for generation and maintenance of chronic pain.

Nature neuroscience
2023-01-23 | Journal article | Author
DOI: 10.1038/s41593-022-01250-y
PMID: 36690899
Contributors: Hang Zhou; Li M; Zhao R; Linlin Sun; Guang Yang
Source: Self-asserted source
Guang Yang

Optical gearbox enabled versatile multiscale high-throughput multiphoton functional imaging.

Nature communications
2022-11-02 | Journal article | Author
DOI: 10.1038/s41467-022-34472-6
PMID: 36323707
Contributors: Jianian Lin; Zongyue Cheng; Guang Yang; Meng Cui
Source: Self-asserted source
Guang Yang

Synaptic pruning through glial synapse engulfment upon motor learning.

Nature neuroscience
2022-11-01 | Journal article | Author
DOI: 10.1038/s41593-022-01184-5
PMID: 36319770
Contributors: Yosuke Morizawa; Matsumoto M; Nakashima Y; Endo N; Tomomi Aida; Hiroshi Ishikane; Beppu K; Moritoh S; Inada H; Noriko Osumi et al.
Source: Self-asserted source
Guang Yang

Activation of VIP interneurons in the prefrontal cortex ameliorates neuropathic pain aversiveness.

Cell reports
2022-09-01 | Journal article
DOI: 10.1016/j.celrep.2022.111333
PMID: 36103825
PMC: PMC9520588
Contributors: Guang Yang
Source: Self-asserted source
Guang Yang

Modeling propofol-induced cardiotoxicity in the isolated-perfused newborn mouse heart.

Physiological reports
2022-08-01 | Journal article
DOI: 10.14814/phy2.15402
PMID: 35923108
PMC: PMC9350423
Contributors: Guang Yang
Source: Self-asserted source
Guang Yang

Targeted ubiquitination of sensory neuron calcium channels reduces the development of neuropathic pain.

Proceedings of the National Academy of Sciences of the United States of America
2022-05-13 | Journal article
DOI: 10.1073/pnas.2118129119
PMID: 35561213
PMC: PMC9171802
Contributors: Guang Yang
Source: Self-asserted source
Guang Yang

Role of lipocalin-2 in surgery-induced cognitive decline in mice: a signal from neuron to microglia.

Journal of neuroinflammation
2022-04-12 | Journal article
DOI: 10.1186/s12974-022-02455-5
PMID: 35413913
PMC: PMC9006597
Source: Self-asserted source
Guang Yang

Monocyte NLRP3-IL-1β Hyperactivation Mediates Neuronal and Synaptic Dysfunction in Perioperative Neurocognitive Disorder.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2022-03-28 | Journal article
DOI: 10.1002/advs.202104106
PMID: 35347900
Source: Self-asserted source
Guang Yang

Inhibition of unfolded protein response prevents post-anesthesia neuronal hyperactivity and synapse loss in aged mice.

Aging cell
2022-03-17 | Journal article
DOI: 10.1111/acel.13592
PMID: 35299279
PMC: PMC9009124
Source: Self-asserted source
Guang Yang

Sleep promotes the formation of dendritic filopodia and spines near learning-inactive existing spines.

Proceedings of the National Academy of Sciences of the United States of America
2021-12-01 | Journal article
DOI: 10.1073/pnas.2114856118
PMID: 34873044
Source: Self-asserted source
Guang Yang

Testosterone attenuates sevoflurane-induced tau phosphorylation and cognitive impairment in neonatal male mice.

British journal of anaesthesia
2021-10-20 | Journal article
DOI: 10.1016/j.bja.2021.08.028
PMID: 34686310
Source: Self-asserted source
Guang Yang

Bdnf Produced by Cerebral Microglia Promotes Cortical Plasticity and Pain Hypersensitivity After Peripheral Nerve Injury

Plos Biology
2021-07 | Journal article
DOI: 10.1371/journal.pbio.3001337
PMID:

34292944
Source: check_circle
New York University

Learning-dependent Dendritic Spine Plasticity is Impaired in Spontaneous Autoimmune Encephalomyelitis

Developmental Neurobiology
2021-05 | Journal article
DOI: 10.1002/dneu.22827
PMID:

33949123
Source: check_circle
New York University

The Anesthetic Sevoflurane Induces Tau Trafficking from Neurons to Microglia

Communications Biology
2021-05 | Journal article
DOI: 10.1038/s42003-021-02047-8
PMID:

33980987
Source: check_circle
New York University

Behavioural impairments after exposure of neonatal mice to propofol are accompanied by reductions in neuronal activity in cortical circuitry.

British journal of anaesthesia
2021-02-26 | Journal article
DOI: 10.1016/j.bja.2021.01.017
PMID: 33641936
Source: Self-asserted source
Guang Yang

Alcohol reduces the activity of somatostatin interneurons in the mouse prefrontal cortex: A neural basis for its disinhibitory effect?

Neuropharmacology
2021-02-24 | Journal article
DOI: 10.1016/j.neuropharm.2021.108501
PMID: 33636191
Source: Self-asserted source
Guang Yang

Learning-dependent Dendritic Spine Plasticity is Reduced in the Aged Mouse Cortex

Frontiers in Neural Circuits
2020-12 | Journal article
DOI: 10.3389/fncir.2020.581435
PMID:

33324172
Source: check_circle
New York University

REM sleep promotes experience-dependent dendritic spine elimination in the mouse cortex.

Nature communications
2020-09-23 | Journal article
DOI: 10.1038/s41467-020-18592-5
PMID: 32968048
PMC: PMC7511313
Source: Self-asserted source
Guang Yang

Tau Contributes to Sevoflurane-induced Neurocognitive Impairment in Neonatal Mice.

Anesthesiology
2020-09-01 | Journal article
DOI: 10.1097/aln.0000000000003452
PMID: 32701572
PMC: PMC7429299
Source: Self-asserted source
Guang Yang

Sevoflurane Induces Neuronal Activation and Behavioral Hyperactivity in Young Mice

Scientific Reports
2020-07 | Journal article
DOI: 10.1038/s41598-020-66959-x
PMID:

32641746
Source: check_circle
New York University

P2x7 Receptor Inhibition Ameliorates Dendritic Spine Pathology and Social Behavioral Deficits in Rett Syndrome Mice

Nature Communications
2020-04 | Journal article
DOI: 10.1038/s41467-020-15590-5
PMID:

32286307
Source: check_circle
New York University

Inefficient thermogenic mitochondrial respiration due to futile proton leak in a mouse model of fragile X syndrome.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2020-04-20 | Journal article
DOI: 10.1096/fj.202000283rr
PMID: 32307754
Source: Self-asserted source
Guang Yang

Experience and sleep-dependent synaptic plasticity: from structure to activity.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2020-04-06 | Journal article
DOI: 10.1098/rstb.2019.0234
PMID: 32248786
Source: Self-asserted source
Guang Yang

Imaging Neuronal Activity in the Central and Peripheral Nervous Systems Using New Thy1.2-gcamp6 Transgenic Mouse Lines

Journal of Neuroscience Methods
2020-01 | Journal article
DOI: 10.1016/j.jneumeth.2019.108535
PMID:

31972184
Source: check_circle
New York University

A novel Tmem119-tdTomato reporter mouse model for studying microglia in the central nervous system.

Brain, behavior, and immunity
2019-10-08 | Journal article
DOI: 10.1016/j.bbi.2019.10.009
PMID: 31604143
Source: Self-asserted source
Guang Yang

Long-term Imaging of Dorsal Root Ganglia in Awake Behaving Mice

Nature Communications
2019-07 | Journal article
DOI: 10.1038/s41467-019-11158-0
PMID:

31300648
Source: check_circle
New York University

Activation of Cortical Somatostatin Interneurons Rescues Synapse Loss and Motor Deficits after Acute MPTP Infusion.

iScience
2019-07-03 | Journal article
DOI: 10.1016/j.isci.2019.06.040
PMID: 31307003
PMC: PMC6629723
Source: Self-asserted source
Guang Yang

Ketamine Reduces Aversion in Rodent Pain Models by Suppressing Hyperactivity of the Anterior Cingulate Cortex

Nature Communications
2018-09 | Journal article
DOI: 10.1038/s41467-018-06295-x
PMID:

30218052
Source: check_circle
New York University

Contributions of Monocytes to Nervous System Disorders

Journal of Molecular Medicine (berlin)
2018-07 | Journal article
DOI: 10.1007/s00109-018-1672-3
PMID:

30030568
Source: check_circle
New York University

Neuropathic Pain Causes Pyramidal Neuronal Hyperactivity in the Anterior Cingulate Cortex

Frontiers in Cellular Neuroscience
2018-04 | Journal article
DOI: 10.3389/fncel.2018.00107
PMID:

29731710
Source: check_circle
New York University

Spared Nerve Injury Model of Neuropathic Pain in Mice

Bio-protocol
2018-03 | Journal article
PMID:

29682596
Source: check_circle
New York University

Anesthesia and Surgery Impair Blood-brain Barrier and Cognitive Function in Mice

Frontiers in Immunology
2017-08 | Journal article
DOI: 10.3389/fimmu.2017.00902
Source: check_circle
New York University

Hsp90 inhibitor induces nuclear translocation of HSF1 predominantly in hippocampal CA1 region.

Molecular psychiatry
2017-07-01 | Journal article
DOI: 10.1038/mp.2017.125
PMID: 28638149
Source: Self-asserted source
Guang Yang

Activation of Cortical Somatostatin Interneurons Prevents the Development of Neuropathic Pain

Nature Neuroscience
2017-06 | Journal article
DOI: 10.1038/nn.4595
PMID:

28671692
Source: check_circle
New York University

Chronic pain induces generalized enhancement of aversion

eLife
2017-05 | Journal article
DOI: 10.7554/eLife.25302
PMID: 28524819
Source: check_circle
New York University

CX3CR1+ monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-alpha

Nature medicine
2017-05 | Journal article
DOI: 10.1038/nm.4340
PMID: 28504723
Source: check_circle
New York University

Long-lasting behavioral effects in neonatal mice with multiple exposures to ketamine-xylazine anesthesia

Neurotoxicology & teratology
2017-03 | Journal article
DOI: 10.1016/j.ntt.2016.09.003
PMID: 27622724
Source: check_circle
New York University

An Acute Mouse Spinal Cord Slice Preparation for Studying Glial Activation ex vivo

Bio-protocol
2017-01 | Journal article
DOI: 10.21769/BioProtoc.2102
PMID: 28503634
Source: check_circle
New York University

REM sleep selectively prunes and maintains new synapses in development and learning

Nature neuroscience
2017-01 | Journal article
DOI: 10.1038/nn.4479
PMID: 28092659
Source: check_circle
New York University
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Peer review (23 reviews for 14 publications/grants)

Review activity for Advanced science. (3)
Review activity for Biological psychiatry. (1)
Review activity for British journal of anaesthesia. (1)
Review activity for Cell reports medicine. (1)
Review activity for Cell reports. (2)
Review activity for Cell. (1)
Review activity for EMBO reports. (1)
Review activity for ENeuro. (1)
Review activity for Nature communications (4)
Review activity for Nature immunology. (1)
Review activity for Nature neuroscience. (3)
Review activity for Neuron. (1)
Review activity for Science. (1)
Review activity for The journal of neuroscience : (2)
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