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Employment (1)

Whitehead Institute for Biomedical Research: Cambridge, MA, US

2023-09-18 to present | Whitehead Fellow, Principal Investigator
Employment
Source: Self-asserted source
Aditya Raguram

Education and qualifications (2)

Harvard University: Cambridge, MA, US

2018-07-01 to 2023-06-01 | Ph.D. (Chemical Biology)
Education
Source: Self-asserted source
Aditya Raguram

Harvard College: Cambridge, MA, US

2014-09-01 to 2018-06-01 | A.B. (Chemistry & Physics)
Education
Source: Self-asserted source
Aditya Raguram

Works (22)

Directed evolution of engineered virus-like particles with improved production and transduction efficiencies

Nature Biotechnology
2024-11-13 | Journal article
DOI: 10.1038/s41587-024-02467-x
Contributors: Aditya Raguram; Meirui An; Paul Z. Chen; David R. Liu
Source: check_circle
Crossref

Engineered virus-like particles for transient delivery of prime editor ribonucleoprotein complexes in vivo

Nature Biotechnology
2024-10 | Journal article
DOI: 10.1038/s41587-023-02078-y
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Contributors: Meirui An; Aditya Raguram; Samuel Du; Samagya Banskota; Jessie R. Davis; Gregory A. Newby; Paul Z. Chen; Krzysztof Palczewski; David Liu
Source: Self-asserted source
Aditya Raguram

Phage-assisted evolution and protein engineering yield compact, efficient prime editors

Cell
2023-08 | Journal article
DOI: 10.1016/j.cell.2023.07.039
Part of ISSN: 0092-8674
Contributors: Jordan L. Doman; Smriti Pandey; Monica E. Neugebauer; Meirui An; Jessie R. Davis; Peyton B. Randolph; Amber McElroy; Xin D. Gao; Aditya Raguram; Michelle F. Richter et al.
Source: Self-asserted source
Aditya Raguram

Base editing rescue of spinal muscular atrophy in cells and in mice

Science
2023-04-21 | Journal article
DOI: 10.1126/science.adg6518
Contributors: Mandana Arbab; Zaneta Matuszek; Kaitlyn M. Kray; Ailing Du; Gregory A. Newby; Anton J. Blatnik; Aditya Raguram; Michelle F. Richter; Kevin T. Zhao; Jonathan M. Levy et al.
Source: check_circle
Crossref

Efficient in vivo genome editing prevents hypertrophic cardiomyopathy in mice

Nature Medicine
2023-02 | Journal article
DOI: 10.1038/s41591-022-02190-7
Contributors: Daniel Reichart; Gregory A. Newby; Hiroko Wakimoto; Mingyue Lun; Joshua M. Gorham; Justin J. Curran; Aditya Raguram; Daniel M. DeLaughter; David A. Conner; Júlia D. C. Marsiglia et al.
Source: check_circle
Crossref

Evolution of an adenine base editor into a small, efficient cytosine base editor with low off-target activity

Nature Biotechnology
2022-11-10 | Journal article
DOI: 10.1038/s41587-022-01533-6
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Contributors: Aditya Raguram
Source: Self-asserted source
Aditya Raguram

Precision genome editing in the eye

Proceedings of the National Academy of Sciences
2022-09-27 | Journal article
DOI: 10.1073/pnas.2210104119
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Aditya Raguram
Source: Self-asserted source
Aditya Raguram

Therapeutic in vivo delivery of gene editing agents

Cell
2022-07 | Journal article
DOI: 10.1016/j.cell.2022.03.045
Part of ISSN: 0092-8674
Source: Self-asserted source
Aditya Raguram

Efficient in vivo base editing via single adeno-associated viruses with size-optimized genomes encoding compact adenine base editors

Nature Biomedical Engineering
2022-07-28 | Journal article
DOI: 10.1038/s41551-022-00911-4
Part of ISSN: 2157-846X
Contributors: Aditya Raguram
Source: Self-asserted source
Aditya Raguram

Programmable deletion, replacement, integration and inversion of large DNA sequences with twin prime editing

Nature Biotechnology
2022-05 | Journal article
DOI: 10.1038/s41587-021-01133-w
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Source: Self-asserted source
Aditya Raguram

In vivo base editing rescues cone photoreceptors in a mouse model of early-onset inherited retinal degeneration

Nature Communications
2022-04 | Journal article
DOI: 10.1038/s41467-022-29490-3
Part of ISSN: 2041-1723
Contributors: Aditya Raguram
Source: Self-asserted source
Aditya Raguram

CRISPR-free base editors with enhanced activity and expanded targeting scope in mitochondrial and nuclear DNA

Nature Biotechnology
2022-04-04 | Journal article
DOI: 10.1038/s41587-022-01256-8
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Source: Self-asserted source
Aditya Raguram

Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins

Cell
2022-01 | Journal article
DOI: 10.1016/j.cell.2021.12.021
Part of ISSN: 0092-8674
Source: Self-asserted source
Aditya Raguram

Disulfide-compatible phage-assisted continuous evolution in the periplasmic space

Nature Communications
2021-12 | Journal article
DOI: 10.1038/s41467-021-26279-8
Part of ISSN: 2041-1723
Source: Self-asserted source
Aditya Raguram

A bacterial cytidine deaminase toxin enables CRISPR-free mitochondrial base editing

Nature
2020-07 | Journal article
DOI: 10.1038/s41586-020-2477-4
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Aditya Raguram

Prime genome editing in rice and wheat

Nature Biotechnology
2020-05 | Journal article
DOI: 10.1038/s41587-020-0455-x
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Source: Self-asserted source
Aditya Raguram

Evaluation and minimization of Cas9-independent off-target DNA editing by cytosine base editors

Nature Biotechnology
2020-02-10 | Journal article
DOI: 10.1038/s41587-020-0414-6
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Source: Self-asserted source
Aditya Raguram

Search-and-replace genome editing without double-strand breaks or donor DNA

Nature
2019-12 | Journal article
DOI: 10.1038/s41586-019-1711-4
Part of ISSN: 0028-0836
Part of ISSN: 1476-4687
Source: Self-asserted source
Aditya Raguram

Improving cytidine and adenine base editors by expression optimization and ancestral reconstruction

Nature Biotechnology
2018-10 | Journal article
DOI: 10.1038/nbt.4172
Part of ISSN: 1087-0156
Part of ISSN: 1546-1696
Source: Self-asserted source
Aditya Raguram

Rational Engineering and Characterization of an mAb that Neutralizes Zika Virus by Targeting a Mutationally Constrained Quaternary Epitope

Cell Host & Microbe
2018-05 | Journal article
DOI: 10.1016/j.chom.2018.04.004
Part of ISSN: 1931-3128
Source: Self-asserted source
Aditya Raguram

Ribozyme-catalysed RNA synthesis using triplet building blocks

eLife
2018-05-15 | Journal article
DOI: 10.7554/elife.35255
Part of ISSN: 2050-084X
Source: Self-asserted source
Aditya Raguram

A Chiral Pentagonal Polyhedral Framework for Characterizing Virus Capsid Structures

Trends in Microbiology
2017-06 | Journal article
DOI: 10.1016/j.tim.2016.12.007
Part of ISSN: 0966-842X
Source: Self-asserted source
Aditya Raguram

Peer review (6 reviews for 4 publications/grants)

Review activity for Molecular therapy. (2)
Review activity for Nature communications (2)
Review activity for Nature protocols (1)
Review activity for Trends in genetics. (1)
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