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Employment (1)

Celon Pharma: Lomianki, PL

2022-12-01 to present | Clinical Development Leader
Employment
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Małgorzata Drzewiecka

Education and qualifications (1)

University of Łódź: Lodz, PL

2018-10-01 to present | PhD (Departament of Molecular Genetics)
Education
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Małgorzata Drzewiecka

Works (43)

Data from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.c.6738488.v3
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Data from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.c.6738488
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 1 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035167.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 1 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035167
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 2 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035164
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 2 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035164.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 3 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035161
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 3 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035161.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 4 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035158
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 4 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035158.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 5 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035155.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 5 from Simultaneous targeting of DNA polymerase theta and PARP1 or RAD52 triggers dual synthetic lethality in homologous recombination-deficient leukemia cells

2024-09-16 | Preprint
DOI: 10.1158/1541-7786.27035155
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Polθ Inhibitor (ART558) Demonstrates a Synthetic Lethal Effect with PARP and RAD52 Inhibitors in Glioblastoma Cells

International Journal of Molecular Sciences
2024-08-23 | Journal article
DOI: 10.3390/ijms25179134
Contributors: Gabriela Barszczewska-Pietraszek; Piotr Czarny; Małgorzata Drzewiecka; Maciej Błaszczyk; Maciej Radek; Ewelina Synowiec; Paulina Wigner-Jeziorska; Przemysław Sitarek; Janusz Szemraj; Tomasz Skorski et al.
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Data from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.c.6738488.v2
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

Molecular Cancer Research
2023-10-02 | Journal article
DOI: 10.1158/1541-7786.MCR-22-1035
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229704.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229704
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229701.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229701
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 3 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229698
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 3 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229698.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 4 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229695.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 4 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229695
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229692
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-10-02 | Preprint
DOI: 10.1158/1541-7786.24229692.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Class I HDAC Inhibition Leads to a Downregulation of FANCD2 and RAD51, and the Eradication of Glioblastoma Cells

Journal of Personalized Medicine
2023-08-27 | Journal article
DOI: 10.3390/jpm13091315
Contributors: Małgorzata Drzewiecka; Dominika Jaśniak; Gabriela Barszczewska-Pietraszek; Piotr Czarny; Anna Kobrzycka; Marek Wieczorek; Maciej Radek; Janusz Szemraj; Tomasz Skorski; Tomasz Śliwiński
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Data from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.c.6738488.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668553.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 1 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668553
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668550
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 2 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668550.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 3 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668547.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 3 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668547
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 4 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668544.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 4 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668544
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668541
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Supplementary Figure 5 from Simultaneous Targeting of DNA Polymerase Theta and PARP1 or RAD52 Triggers Dual Synthetic Lethality in Homologous Recombination–Deficient Leukemia Cells

2023-07-12 | Preprint
DOI: 10.1158/1541-7786.23668541.v1
Contributors: Katherine Sullivan-Reed; Monika M. Toma; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Reza Nejati; Adam Karami; Mariusz A. Wasik; Tomasz Sliwinski; Tomasz Skorski
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Histone Deacetylases (HDAC) Inhibitor—Valproic Acid Sensitizes Human Melanoma Cells to Dacarbazine and PARP Inhibitor

Genes
2023-06-20 | Journal article
DOI: 10.3390/genes14061295
Contributors: Małgorzata Drzewiecka; Anna Gajos-Michniewicz; Grażyna Hoser; Dominika Jaśniak; Gabriela Barszczewska-Pietraszek; Przemysław Sitarek; Piotr Czarny; Janusz Piekarski; Maciej Radek; Małgorzata Czyż et al.
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Polθ Inhibition: An Anticancer Therapy for HR-Deficient Tumours

International Journal of Molecular Sciences
2022-12-24 | Journal article
DOI: 10.3390/ijms24010319
Contributors: Gabriela Barszczewska-Pietraszek; Małgorzata Drzewiecka; Piotr Czarny; Tomasz Skorski; Tomasz Śliwiński
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DNA Polymerase Theta Protects Leukemia Cells from Metabolic-Induced DNA Damage

Blood
2022-11-15 | Journal article
DOI: 10.1182/blood-2022-156458
Part of ISSN: 0006-4971
Part of ISSN: 1528-0020
Contributors: Umeshkumar M Vekariya; Katherine Sullivan-Reed; Monika Toma; Margaret Nieborowska-Skorska; Bac Viet Le; Marie-Christine Caron; Anna-Mariya Kukuyan; Paulina Podszywalow-Bartnicka; Kumaraswamy Chitrala; Jessica Atkins et al.
Source: Self-asserted source
Małgorzata Drzewiecka

Synthetic Lethality Targeting Polθ

Genes
2022-06-20 | Journal article
DOI: 10.3390/genes13061101
Contributors: Małgorzata Drzewiecka; Gabriela Barszczewska-Pietraszek; Piotr Czarny; Tomasz Skorski; Tomasz Śliwiński
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Eradication of LIG4-deficient glioblastoma cells by the combination of PARP inhibitor and alkylating agent

Oncotarget
2018-12-07 | Journal article
DOI: 10.18632/oncotarget.26409
Part of ISSN: 1949-2553
Contributors: Monika Toma; Monika Witusik-Perkowska; Marzena Szwed; Robert Stawski; Janusz Szemraj; Malgorzata Drzewiecka; Margaret Nieborowska-Skorska; Maciej Radek; Pawel Kolasa; Ksenia Matlawska-Wasowska et al.
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Małgorzata Drzewiecka

Ethylene glycol dimethacrylate and diethylene glycol dimethacrylate exhibits cytotoxic and genotoxic effect on human gingival fibroblasts via induction of reactive oxygen species

Toxicology in Vitro
2018-03 | Journal article
DOI: 10.1016/j.tiv.2017.10.028
Part of ISSN: 0887-2333
Contributors: Anna Bielecka-Kowalska; Piotr Czarny; Paulina Wigner; Ewelina Synowiec; Bartosz Kowalski; Marzena Szwed; Renata Krupa; Monika Toma; Malgorzata Drzewiecka; Ireneusz Majsterek et al.
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Małgorzata Drzewiecka
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