Personal information

Emails & domains

Verified email domains

Websites & social links

University of Manchester page
MFIG page
Twitter page
The University of Manchester profile page

Other IDs

Scopus Author ID: 53983536500

Keywords

Aspergillus fumigatus, fungal pathogenesis, host-pathogen interaction, epithelial potency

Countries

United Kingdom

Activities

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Employment (5)

The University of Manchester: Manchester, GB

Employment
Source: check_circle
University of Manchester - PURE

University of Manchester: Manchester, Greater Manchester, GB

2020-03-16 to present | Lecturer in Molecular Microbiology (Division of Infection, Immunity and Respiratory Medicine, Manchester Fungal Infection Group (MFIG))
Employment
Source: Self-asserted source
Margherita Bertuzzi

University of Manchester: Manchester, Greater Manchester, GB

2017 to 2020 | Research Fellow (Division of Infection, Immunity and Respiratory Medicine, Manchester Fungal Infection Group (MFIG))
Employment
Source: Self-asserted source
Margherita Bertuzzi

University of Manchester: Manchester, Greater Manchester, GB

2014 to 2017 | Postdoctoral Researcher (Manchester Fungal Infection Group (MFIG))
Employment
Source: Self-asserted source
Margherita Bertuzzi

Imperial College London: London, London, GB

2011 to 2014 | Postdoctoral Researcher
Employment
Source: Self-asserted source
Margherita Bertuzzi

Education and qualifications (3)

Imperial College London: London, London, GB

2007 to 2011 | PhD
Education
Source: Self-asserted source
Margherita Bertuzzi

Universita degli Studi di Padova: Padova, Veneto, IT

2005 to 2007 | MRes Human Health Biology
Education
Source: Self-asserted source
Margherita Bertuzzi

Universita degli Studi di Padova: Padova, Veneto, IT

2002 to 2005 | BSc (Hons) Molecular Biology
Education
Source: Self-asserted source
Margherita Bertuzzi

Professional activities (4)

British Society for Medical Mycology : n/a, GB

2016 to present | Junior Representative
Service
Source: Self-asserted source
Margherita Bertuzzi

British Society for Medical Mycology (BSMM): Bristol, GB

2017 | Best Oral Presentation prize at the 53rd BSMM Annual scientific meeting
Distinction
Source: Self-asserted source
Margherita Bertuzzi

Public Library of Science: Cambridge, GB

2015 | Outstanding Young Investigator award poster prize at the 6th FEBS Advanced Lecture Course on Human Fungal Pathogens (Nice)
Distinction
Source: Self-asserted source
Margherita Bertuzzi

British Society fr Medical Mycology : Aberdeen , GB

2015 | Poster commendation at the BSMM 51st Annual Scientific Meeting
Distinction
Source: Self-asserted source
Margherita Bertuzzi

Works (21)

A microscopy-based image analysis pipeline for the quantification of germination of filamentous fungi

Fungal Genetics and Biology
2025-02-01 | Journal article | Author
DOI: 10.1016/j.fgb.2024.103942
SOURCE-WORK-ID:

d40ff831-ffd5-4c7c-8426-ed1055d9e5df

EID:

2-s2.0-85212336392
Contributors: Sebastien Ortiz; Thomas Easter; Clara Valero Fernandez; Michael Bromley; Margherita Bertuzzi
Source: check_circle
University of Manchester - PURE

Mgl2+ cDC2s coordinate fungal allergic airway type 2, but not type 17, inflammation in mice

Nature Communications
2025-01-22 | Journal article | Author
DOI: 10.1038/s41467-024-55663-3
SOURCE-WORK-ID:

c3fdc925-2c47-4417-a8d2-2d7d8932f77c

PMID: 39843887
EID:

2-s2.0-85216607980
Contributors: Peter C Cook; Sheila L Brown; Emma L Houlder; Julio Furlong-Silva; Daniel P Conn; Stefano Adriano Colombo; Syed Murtuza Baker; Freya R Svedberg; Gareth Howell; Margherita Bertuzzi et al.
Source: check_circle
University of Manchester - PURE

Epithelial uptake leads to fungal killing in vivo and is aberrant in COPD-derived epithelial cells

iScience
2024-06-21 | Journal article | Author
DOI: 10.1016/j.isci.2024.109939
SOURCE-WORK-ID:

60942c92-7ebb-4a60-9f13-18784587b514

EID:

2-s2.0-85194083612
Contributors: Margherita Bertuzzi; Gareth Howell; Darren Thomson; Rachael Fortune-Grant; Anna Möslinger; Patrick Dancer; Norman van Rhijn; Natasha Motsi; Alice Codling; Elaine Bignell
Source: check_circle
University of Manchester - PURE

TIGIT can inhibit T cell activation via ligation-induced nanoclusters, independent of CD226 co-stimulation

Nature Communications
2023-08-18 | Journal article | Author
DOI: 10.1038/s41467-023-40755-3
SOURCE-WORK-ID:

3f948fc3-2f1b-439c-b182-d560dc746f68

PMID: 37596248
PMID: 37596248
EID:

2-s2.0-85168316617
Contributors: Jonathan Worboys; Katherine N Vowell; Roseanna K Hare; Ashley R Ambrose; Margherita Bertuzzi; Michael A Conner; Florence P Patel; William H Zammit; Judit Gali-Moya; Khodor Hazime et al.
Source: check_circle
University of Manchester - PURE

Aspergillus fumigatus Drives Tissue Damage via Iterative Assaults upon Mucosal Integrity and Immune Homeostasis.

Infection and immunity
2023-01-10 | Journal article
DOI: 10.1128/iai.00333-22
PMID: 36625602
PMC: PMC9933693
Contributors: Uju Joy Okaa; Bertuzzi M; Fortune-Grant R; Thomson DD; Moyes DL; Naglik JR; Elaine Bignell
Source: Self-asserted source
Margherita Bertuzzi

Mutual inhibition of airway epithelial responses supports viral and fungal co-pathogenesis during coinfection

bioRxiv
2022-04-14 | Journal article | Author
DOI: 10.1101/2022.04.13.488236
SOURCE-WORK-ID:

a04a1165-f7cb-48f3-94d6-ce0ad27181a2
Contributors: Patrick Dancer; Adam Pickard; Wiktoria Potocka; Kayleigh Earle; Rachael Fortune-Grant; Karl Kadler; Margherita Bertuzzi; Sara Gago Prieto
Source: check_circle
University of Manchester - PURE

Novel Insights into <i>Aspergillus fumigatus</i> Pathogenesis and Host Response from State-of-the-Art Imaging of Host&ndash;Pathogen Interactions during Infection

Journal of Fungi
2022-03 | Journal article | Author
DOI: 10.3390/jof8030264
Contributors: Sébastien Ortiz; Katie Pennington; Darren D. Thomson; Margherita Bertuzzi
Source: check_circle
Multidisciplinary Digital Publishing Institute

Epithelial uptake of<i>Aspergillus fumigatus</i>drives efficient fungal clearance<i>in vivo</i>and is aberrant in Chronic Obstructive Pulmonary Disease (COPD)

2022-02-01 | Preprint
DOI: 10.1101/2022.02.01.478664
Contributors: M. Bertuzzi; G.J. Howell; D.D. Thomson; R. Fortune-Grant; A. Möslinger; P. Dancer; N. Van Rhijn; N. Motsi; X. Du; A. Codling et al.
Source: Self-asserted source
Margherita Bertuzzi

Live-cell imaging of rapid calcium dynamics using fluorescent, genetically-encoded GCaMP probes with Aspergillus fumigatus

mBio
2021-06 | Journal article | Author
DOI: 10.1016/j.fgb.2020.103470
SOURCE-WORK-ID:

0f43b12c-1577-41c4-b09c-f05116299f85

EID:

2-s2.0-85101050897
Contributors: Darren Thomson; Elaine Bignell; Margherita Bertuzzi; Nick Read
Source: check_circle
University of Manchester - PURE

Automated Quantitative Analysis of Airway Epithelial Cell Detachment Upon Fungal Challenge

Methods in molecular biology (Clifton, N.J.)
2021-01-07 | Journal article | Author
DOI: 10.1007/978-1-0716-1182-1_16
SOURCE-WORK-ID:

e72e4512-d356-4a00-9898-b81f4652143a

PMID: 33405042
EID:

2-s2.0-85100125124
Contributors: Sayema Rahman; Darren D Thomson; Margherita Bertuzzi
Source: check_circle
University of Manchester - PURE

Single-Cell Analysis of Fungal Uptake in Cultured Airway Epithelial Cells Using Differential Fluorescent Staining and Imaging Flow Cytometry

Methods in molecular biology (Clifton, N.J.)
2021-01-07 | Journal article | Author
DOI: 10.1007/978-1-0716-1182-1_6
SOURCE-WORK-ID:

7e44da68-588d-4848-9faf-f054bbe84379

PMID: 33405032
EID:

2-s2.0-85100125609
Contributors: Margherita Bertuzzi; Gareth J Howell
Source: check_circle
University of Manchester - PURE

On the lineage of Aspergillus fumigatus isolates in common laboratory use.

Medical Mycology
2021-01-04 | Journal article | Author
DOI: 10.1093/mmy/myaa075
SOURCE-WORK-ID:

5d4c5e34-b918-4b57-8265-18183020df1c

PMID: 32944768
EID:

2-s2.0-85099326823
Contributors: Margherita Bertuzzi; Norman van Rhijn; Sven Krappmann; paul bowyer; Michael Bromley; Elaine Bignell
Source: check_circle
University of Manchester - PURE

Microbial uptake by the respiratory epithelium: outcomes for host and pathogen.

FEMS microbiology reviews
2019-03-01 | Journal article
DOI: 10.1093/femsre/fuy045
PMID: 30657899
PMC: PMC6435450
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎

Mechanistic Basis of pH-Dependent 5-Flucytosine Resistance in Aspergillus fumigatus.

Antimicrobial agents and chemotherapy
2018-05-25 | Journal article
DOI: 10.1128/aac.02593-17
PMID: 29610197
PMC: PMC5971587
Source: Self-asserted source
Margherita Bertuzzi

Anti-Aspergillus Activities of the Respiratory Epithelium in Health and Disease.

Journal of fungi
2018-01-08 | Journal article
DOI: 10.3390/jof4010008
PMID: 29371501
PMC: PMC5872311
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎

Mutual independence of alkaline- and calcium-mediated signalling in Aspergillus fumigatus refutes the existence of a conserved druggable signalling nexus.

Molecular microbiology
2017-11-14 | Journal article
DOI: 10.1111/mmi.13840
PMID: 28922497
PMC: PMC5725717
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎

Refining the pH response in Aspergillus nidulans: a modulatory triad involving PacX, a novel zinc binuclear cluster protein.

Molecular microbiology
2015-10-16 | Journal article
DOI: 10.1111/mmi.13173
PMID: 26303777
PMC: PMC4832277
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎

Different Stress-Induced Calcium Signatures Are Reported by Aequorin-Mediated Calcium Measurements in Living Cells of Aspergillus fumigatus.

PloS one
2015-09-24 | Journal article
DOI: 10.1371/journal.pone.0138008
PMID: 26402916
PMC: PMC4581630
Source: Self-asserted source
Margherita Bertuzzi

The pH-responsive PacC transcription factor of Aspergillus fumigatus governs epithelial entry and tissue invasion during pulmonary aspergillosis.

PLoS pathogens
2014-10-16 | Journal article
DOI: 10.1371/journal.ppat.1004413
PMID: 25329394
PMC: PMC4199764
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎

Receptor-mediated signaling in Aspergillus fumigatus.

Frontiers in microbiology
2013-02-20 | Journal article
DOI: 10.3389/fmicb.2013.00026
PMID: 23430083
PMC: PMC3576715
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎

Sensory perception in fungal pathogens: Applications of the split-ubiquitin Membrane Yeast Two-Hybrid (MYTH) technique

Fungal Biology Reviews
2011-12 | Journal article
DOI: 10.1016/j.fbr.2011.10.002
Part of ISSN: 1749-4613
Source: Self-asserted source
Margherita Bertuzzi
grade
Preferred source (of 2)‎
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