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Employment (1)

Beckman Research Institute, City of Hope: Duarte, CA, US

2019-06-24 to present | Assistant Research Professor
Employment
Source: Self-asserted source
0000-0002-5982-9660

Works (22)

Long-term cell fate and functional maintenance of human hepatocyte through stepwise culture configuration.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
2023-02-01 | Journal article
Contributors: Sugahara G; Ishida Y; Lee JJ; Li M; Tanaka Y; Eoh H; Higuchi Y; Takeshi Saito
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 2)‎

Discovering protein–protein interaction stabilisers by native mass spectrometry

Chemical Science
2021 | Journal article
Part of ISSN: 2041-6520
Part of ISSN: 2041-6539
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 3)‎

Differential Kat3 Usage Orchestrates the Integration of Cellular Metabolism with Differentiation

Cancers
2021-11 | Journal article | Author
Contributors: Xiaohui Hu; Masaya Ono; Nyam-Osor Chimge; Keisuke Chosa; Cu Nguyen; Elizabeth Melendez; Chih-Hong Lou; Punnajit Lim; John Termini; Keane K. Y. Lai et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

p300 Serine 89: A Critical Signaling Integrator and Its Effects on Intestinal Homeostasis and Repair

Cancers
2021-03-14 | Journal article
Part of ISSN: 2072-6694
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 2)‎

Selectivity via Cooperativity: Preferential Stabilization of the p65/14-3-3 Interaction with Semisynthetic Natural Products

Journal of the American Chemical Society
2020-07-08 | Journal article
Part of ISSN: 0002-7863
Part of ISSN: 1520-5126
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 3)‎

Polypharmacological Perturbation of the 14-3-3 Adaptor Protein Interactome Stimulates Neurite Outgrowth

Cell Chemical Biology
2020-06 | Journal article
Part of ISSN: 2451-9456
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 2)‎

Cooperativity basis for small-molecule stabilization of protein–protein interactions

Chemical Science
2019 | Journal article
Part of ISSN: 2041-6520
Part of ISSN: 2041-6539
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 3)‎

Native CRISPR-Cas-Mediated Genome Editing Enables Dissecting and Sensitizing Clinical Multidrug-Resistant P. aeruginosa

Cell Reports
2019-11 | Journal article
Part of ISSN: 2211-1247
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 2)‎

Semisynthesis and biological evaluation of a cotylenin A mimic derived from fusicoccin A

Bioorganic & Medicinal Chemistry Letters
2018 | Journal article
WOSUID:

WOS:000425882800019

Contributors: Inoue, Takatsugu; Higuchi, Yusuke; Yoneyama, Toru; Lin, Bangzhong; Nunomura, Kazuto; Honma, Yoshio; Kato, Nobuo
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity

Chemistry - A European Journal
2018-10-26 | Journal article
Part of ISSN: 0947-6539
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 2)‎

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14-3-3 Protein-Protein Interactions

Angewandte Chemie International Edition
2018-10-08 | Journal article
Part of ISSN: 1433-7851
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 3)‎

Rationally Designed Semisynthetic Natural Product Analogues for Stabilization of 14‐3‐3 Protein–Protein Interactions

Angewandte Chemie
2018-10-08 | Journal article
Contributors: Sebastian A. Andrei; Pim de Vink; Eline Sijbesma; Ling Han; Luc Brunsveld; Nobuo Kato; Christian Ottmann; Yusuke Higuchi
Source: check_circle
Crossref

Total Biosynthesis of Brassicicenes: Identification of a Key Enzyme for Skeletal Diversification

Organic Letters
2018-10-05 | Journal article
Part of ISSN: 1523-7060
Part of ISSN: 1523-7052
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 2)‎

Small molecule p300/catenin antagonist enhances hematopoietic recovery after radiation

Plos One
2017 | Journal article
WOSUID:

WOS:000401314000063

Contributors: Zhao, Yi; Wu, Kaijin; Nguyen, Cu; Smbatyan, Goar; Melendez, Elisabeth; Higuchi, Yusuke; Chen, Yibu; Kahn, Michael
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Specific Direct Small Molecule p300/β-Catenin Antagonists Maintain Stem Cell Potency

Current Molecular Pharmacology
2016-09-05 | Journal article
Part of ISSN: 1874-4672
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 3)‎

Combined treatment with cotylenin A and phenethyl isothiocyanate induces strong antitumor activity mainly through the induction of ferroptotic cell death in human pancreatic cancer cells

Oncology Reports
2016-08 | Journal article
Part of ISSN: 1021-335X
Part of ISSN: 1791-2431
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 3)‎

Small-Molecule Stabilization of the 14-3-3/Gab2 Protein-Protein Interaction (PPI) Interface

ChemMedChem
2016-04-19 | Journal article
Part of ISSN: 1860-7179
Source: Self-asserted source
0000-0002-5982-9660
grade
Preferred source (of 4)‎

A Semisynthetic Fusicoccane Stabilizes a Protein-Protein Interaction and Enhances the Expression of K+ Channels at the Cell Surface

Chemistry & Biology
2013 | Journal article
WOSUID:

WOS:000318201700017

Contributors: Anders, Carolin; Higuchi, Yusuke; Koschinsky, Kristin; Bartel, Maria; Schumacher, Benjamin; Thiel, Philipp; Nitta, Hajime; Preisig-Mueller, Regina; Schlichthoerl, Guenter; Renigunta, Vijay et al.
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Molecular Breeding of a Fungus Producing a Precursor Diterpene Suitable for Semi-Synthesis by Dissection of the Biosynthetic Machinery

Plos One
2012 | Journal article
WOSUID:

WOS:000307212800058

Contributors: Noike, Motoyoshi; Ono, Yusuke; Araki, Yuji; Tanio, Ryo; Higuchi, Yusuke; Nitta, Hajime; Hamano, Yoshimitsu; Toyomasu, Tomonobu; Sassa, Takeshi; Kato, Nobuo et al.
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Dioxygenases, Key Enzymes to Determine the Aglycon Structures of Fusicoccin and Brassicicene, Diterpene Compounds Produced by Fungi

Journal of the American Chemical Society
2011 | Journal article
WOSUID:

WOS:000288291300039

Contributors: Ono, Yusuke; Minami, Atsushi; Noike, Motoyoshi; Higuchi, Yusuke; Toyomasu, Tomonobu; Sassa, Takeshi; Kato, Nobuo; Dairi, Tohru
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Functional analyses of cytochrome P450 genes responsible for the early steps of brassicicene C biosynthesis

Bioorganic & Medicinal Chemistry Letters
2009 | Journal article
WOSUID:

WOS:000270106700026

Contributors: Hashimoto, Makoto; Higuchi, Yusuke; Takahashi, Shunji; Osada, Hiroyuki; Sakaki, Toshiyuki; Toyomasu, Tomonobu; Sassa, Takeshi; Kato, Nobuo; Dairi, Tohru
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Identification and functional analysis of brassicicene C biosynthetic gene cluster in Alternaria brassicicola

Bioorganic & Medicinal Chemistry Letters
2009 | Journal article
WOSUID:

WOS:000262707000069

Contributors: Minami, Atsushi; Tajima, Naoto; Higuchi, Yusuke; Toyomasu, Tomonobu; Sassa, Takeshi; Kato, Nobuo; Dairi, Tohru
Source: Self-asserted source
0000-0002-5982-9660 via ResearcherID
grade
Preferred source (of 2)‎

Peer review (24 reviews for 12 publications/grants)

Review activity for ACS omega. (3)
Review activity for Biochemistry. (1)
Review activity for Cells. (2)
Review activity for Chemical communications. (5)
Review activity for International journal of molecular sciences. (2)
Review activity for Journal of cellular physiology. (2)
Review activity for Journal of medicinal chemistry. (2)
Review activity for Life. (1)
Review activity for Molecular biology reports. (1)
Review activity for Molecules. (2)
Review activity for Physical chemistry chemical physics. (1)
Review activity for RSC medicinal chemistry. (2)