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ENTERIC NERVOUS SYSTEM, TRP CHANNEL, G PROTEIN-COUPLED RECEPTOR, OPIOID RECEPTOR, NEUROIMMUNE INTERACTION, ENTERIC NEUROPATHY
Australia

Activities

Employment (4)

Monash University: Parkville, VIC, AU

2013 to present | Associate Professor and Laboratory Head (Drug Discovery Biology)
Employment
Source: Self-asserted source
Daniel Poole

The University of Melbourne: Parkville, VIC, AU

2011 to 2012 | Research Fellow (Anatomy & Neuroscience)
Employment
Source: Self-asserted source
Daniel Poole

UCSF Medical Center: San Francisco, CA, US

2007 to 2011 | Postdoctoral Scholar (Surgery)
Employment
Source: Self-asserted source
Daniel Poole

The University of Melbourne: Parkville, VIC, AU

2005 to 2006 | Research Fellow (Anatomy & Cell Biology)
Employment
Source: Self-asserted source
Daniel Poole

Education and qualifications (1)

The University of Melbourne: Parkville, VIC, AU

2001 to 2005 | PhD (Anatomy & Cell Biology)
Education
Source: Self-asserted source
Daniel Poole

Professional activities (3)

Australasian Society for Autonomic Neuroscience: Melbourne, AU

2024-02-01 to present | Vice President
Service
Source: Self-asserted source
Daniel Poole

American Journal of Physiology: Gastrointestinal & Liver Physiology: . , US

2021-06 to present | Associate Editor
Service
Source: Self-asserted source
Daniel Poole

Australasian Neurogastroenterology and Motility Association (ANGMA): Melbourne, AU

2018 to 2021 | Secretary
Service
Source: Self-asserted source
Daniel Poole

Funding (10)

Harnessing Endogenous Opioids to Treat Gut Motility Disorders and Pain

2022-12-14 to present | Grant
National Health and Medical Research Council (Canberra, AU)
GRANT_NUMBER:

2021675

Source: Self-asserted source
Daniel Poole via DimensionsWizard

The SPRINTS Project: Stroke - Prevention of Reperfusion Injury and Neuroinflammation - a Therapeutic Strategy

2021-06-11 to 2025-05-31 | Grant
Department of Health (Canberra, AU)
GRANT_NUMBER: GA187344
Source: Self-asserted source
Daniel Poole via DimensionsWizard

Caveospheres: A versatile peptide delivery system

2020-01-01 to 2022-12-31 | Grant
Australian Research Council (Canberra, AU)
GRANT_NUMBER: DP200100475
Source: Self-asserted source
Daniel Poole via DimensionsWizard

Spatial and temporal dimensions of mu-opioid receptor signalling: implications for the development of tolerance

Source: Self-asserted source
Daniel Poole via DimensionsWizard

Is abdominal discomfort a “colonic itch”? Identification of itch specific pathways in the gut in health and disease.

2016 to 2018 | Grant
NHMRC Australia (Canberra, AU)
GRANT_NUMBER:

APP1083480

Source: Self-asserted source
Daniel Poole

Identification of the key mediators and mechanisms of intestinal inflammatory pain

Source: Self-asserted source
Daniel Poole via DimensionsWizard

Opiate-induced constipation: identifying key targets for therapy

Source: Self-asserted source
Daniel Poole via DimensionsWizard

Mechanisms of Defective Digestion and Sensation in Patients with Liver Diseases

Source: Self-asserted source
Daniel Poole via DimensionsWizard

Prevention of damage to the intestine when blood flow is compromised

Source: Self-asserted source
Daniel Poole via DimensionsWizard

Molecular Mechanisms of PAR2 induced Sensitisation of TRPV4 Channels: Role in Neurogenic Inflammation and Hyperalgesia

Works (50 of 101)

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Page 1 of 3

Highly neurogenic glia from human and mouse myenteric ganglia generate functional neurons following culture and transplantation into the gut.

Cell Reports
2024-10-28 | Journal article
Contributors: Mueller JL; Leavitt AR; Rahman AA; Han CY; Ott LC; Mahdavian NS; Carbone SE; King SK; Burns AJ; Poole DP et al.
Source: Self-asserted source
Daniel Poole

Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons.

Journal of Cell Science
2024-09-02 | Journal article | Author
Contributors: Luke Sorensen; Humenick A; Poon SSB; MN Han; Narges Mahdavian; Rowe MC; Ryan Hamnett; E. Gómez-de-Mariscal; Peter Neckel; Ayame Saito et al.
Source: Self-asserted source
Daniel Poole

Therapeutic potential of allosteric modulators for the treatment of gastrointestinal motility disorders

British Journal of Pharmacology
2024-07 | Journal article
Contributors: Ayame Saito; Sadia Alvi; Celine Valant; Arthur Christopoulos; Simona E. Carbone; Daniel P. Poole
Source: check_circle
Crossref

Stroke Alters the Function of Enteric Neurons to Impair Smooth Muscle Relaxation and Dysregulates Gut Transit

Journal of the American Heart Association
2024-01-23 | Journal article | Author
Part of ISSN: 2047-9980
Contributors: Kathryn Prame Kumar; Jenny L. Wilson; Huynh Anh Thu Nguyen; Liam D. McKay; Shu Wen Wen; Tara Sepehrizadeh; Michael de Veer; Pradeep Rajasekhar; Simona Carbone; Michael J. Hickey et al.
Source: Self-asserted source
Daniel Poole

Gut Analysis Toolbox: Automating quantitative analysis of enteric neurons

2024-01-20 | Preprint | Author
Contributors: Luke Sorensen; Adam Humenick; Sabrina S.B. Poon; MN Han; Narges Mahdavian; Ryan Hamnett; E. Gómez-de-Mariscal; Peter Neckel; Ayame Saito; Keith Mutunduwe et al.
Source: Self-asserted source
Daniel Poole

TRPV4 is expressed by enteric glia and muscularis macrophages of the colon but does not play a prominent role in colonic motility

2024-01-11 | Preprint | Author
Contributors: Pradeep Rajasekhar; Simona Carbone; Stuart Johnston; Cameron Nowell; Lukasz Wiklendt; Edmund J Crampin; Yinghan She; Jesse J DiCello; Ayame Saito; Luke Sorensen et al.
Source: Self-asserted source
Daniel Poole

Therapeutic antagonism of the neurokinin 1 receptor in endosomes provides sustained pain relief

Proceedings of the National Academy of Sciences
2023-05-30 | Journal article | Author
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Contributors: Alan Hegron; Chloe Peach; Raquel Tonello; Philipp Seemann; Shavonne Teng; Rocco Latorre; Harald Huebner; Dorothée Weikert; Jeanette Rientjes; Nicholas Andrew Veldhuis et al.
Source: Self-asserted source
Daniel Poole

Mechanistic overview of how opioid analgesics promote constipation

Treatments, Mechanisms, and Adverse Reactions of Anesthetics and Analgesics
2022 | Book chapter
Source: Self-asserted source
Daniel Poole

Sustained endosomal release of a neurokinin-1 receptor antagonist from nanostars provides long-lasting relief of chronic pain

Biomaterials
2022-06 | Journal article
Contributors: Rocco Latorre; Paulina D. Ramírez-Garcia; Alan Hegron; James L. Grace; Jeffri S. Retamal; Priyank Shenoy; Mai Tran; Luigi Aurelio; Bernard Flynn; Daniel P. Poole et al.
Source: check_circle
Crossref

Gut Analysis Toolbox: Training data and 2D models for segmenting enteric neurons, neuronal subtypes and ganglia

2022-02-15 | Software
Contributors: Luke Sorensen; ; Sabrina Poon; Myat Noe Han; Adam Humenick; Keith Mutunduwe; Christie Glennan; Narges Mahdavian; Simon JH Brookes; Rachel M McQuade et al.
Source: Self-asserted source
Daniel Poole

Contributions of bile acids to gastrointestinal physiology as receptor agonists and modifiers of ion channels

American Journal of Physiology-Gastrointestinal and Liver Physiology
2022-02-01 | Journal article
Contributors: Stephen J. Keely; Andreacarola Urso; Alexandr V. Ilyaskin; Christoph Korbmacher; Nigel W. Bunnett; Daniel P. Poole; Simona E. Carbone
Source: check_circle
Crossref

Mice expressing fluorescent PAR<sub>2</sub> reveal that endocytosis mediates colonic inflammation and pain.

Proceedings of the National Academy of Sciences of the United States of America
2022-02-01 | Journal article
Source: Self-asserted source
Daniel Poole

Mini-review: Dissecting receptor-mediated stimulation of TRPV4 in nociceptive and inflammatory pathways

Neuroscience Letters
2022-01 | Journal article
Part of ISSN: 0304-3940
Source: Self-asserted source
Daniel Poole

Diverse Roles of TRPV4 in Macrophages: A Need for Unbiased Profiling

Frontiers in Immunology
2022-01-20 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Daniel Poole

Positive allosteric modulation of endogenous delta opioid receptor signaling in the enteric nervous system is a potential treatment for gut motility disorders

American Journal of Physiology-Gastrointestinal and Liver Physiology
2021-11-10 | Journal article
Part of ISSN: 0193-1857
Part of ISSN: 1522-1547
Source: Self-asserted source
Daniel Poole

Serotonin-induced vascular permeability is mediated by transient receptor potential vanilloid 4 in the airways and upper gastrointestinal tract of mice.

Laboratory Investigation
2021-04-15 | Journal article
Source: Self-asserted source
Daniel Poole

A lipid-anchored neurokinin 1 receptor antagonist prolongs pain relief by a three-pronged mechanism of action targeting the receptor at the plasma membrane and in endosomes

Journal of Biological Chemistry
2021-01 | Journal article
Contributors: Quynh N. Mai; Priyank Shenoy; Tim Quach; Jeffri S. Retamal; Arisbel B. Gondin; Holly R. Yeatman; Luigi Aurelio; Joshua W. Conner; Daniel P. Poole; Meritxell Canals et al.
Source: check_circle
Crossref
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New Small Molecule Fluorescent Probes for G protein-coupled Receptors: Valuable Tools for Drug Discovery

Future Medicinal Chemistry
2021-01 | Journal article
Contributors: Joshua W Conner; Daniel P Poole; Manuela Jörg; Nicholas A Veldhuis
Source: check_circle
Crossref

Interactive design of GPU-accelerated Image Data Flow Graphs and cross-platform deployment using multi-lingual code generation

2020-11-20 | Preprint
Contributors: Robert Haase; Akanksha Jain; Stéphane Rigaud; Daniela Vorkel; Pradeep Rajasekhar; Theresa Suckert; Talley J. Lambert; Juan Nunez-Iglesias; Daniel P. Poole; Pavel Tomancak et al.
Source: check_circle
Crossref

Transcriptional Memory-Like Imprints and Enhanced Functional Activity in γδ T Cells Following Resolution of Malaria Infection

Frontiers in Immunology
2020-10-14 | Journal article
Part of ISSN: 1664-3224
Source: Self-asserted source
Daniel Poole

Enteric Glia Modulate Macrophage Phenotype and Visceral Sensitivity following Inflammation

Cell Reports
2020-09 | Journal article
Contributors: Vladimir Grubišić; Jonathon L. McClain; David E. Fried; Iveta Grants; Pradeep Rajasekhar; Eva Csizmadia; Olujimi A. Ajijola; Ralph E. Watson; Daniel P. Poole; Simon C. Robson et al.
Source: check_circle
Crossref

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

Proceedings of the National Academy of Sciences
2020-06-16 | Journal article
Part of ISSN: 0027-8424
Part of ISSN: 1091-6490
Source: Self-asserted source
Daniel Poole

The transient receptor potential vanilloid 4 (TRPV4) ion channel mediates protease activated receptor 1 (PAR1)-induced vascular hyperpermeability

Laboratory Investigation
2020-04-27 | Journal article
Part of ISSN: 0023-6837
Part of ISSN: 1530-0307
Source: Self-asserted source
Daniel Poole

Inflammation without pain: Immune‐derived opioids hold the key

Neurogastroenterology & Motility
2020-02 | Journal article
Part of ISSN: 1350-1925
Part of ISSN: 1365-2982
Source: Self-asserted source
Daniel Poole
grade
Preferred source (of 2)‎

Granulocyte-macrophage colony stimulating factor as an indirect mediator of nociceptor activation and pain

The Journal of Neuroscience
2020-02-04 | Journal article
Part of ISSN: 0270-6474
Part of ISSN: 1529-2401
Source: Self-asserted source
Daniel Poole

A pH-responsive nanoparticle targets the neurokinin 1 receptor in endosomes to prevent chronic pain.

Nature nanotechnology
2019-11 | Journal article
Contributors: Ramírez-García PD; Retamal JS; Shenoy P; Imlach W; Sykes M; Truong N; Constandil L; Pelissier T; Nowell CJ; Khor SY et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Mu and Delta Opioid Receptors are Co-expressed and Functionally Interact in the Enteric Nervous System of the Mouse Colon

Cellular and Molecular Gastroenterology and Hepatology
2019-11 | Journal article
Part of ISSN: 2352-345X
Source: Self-asserted source
Daniel Poole

Internalized GPCRs as Potential Therapeutic Targets for the Management of Pain

Frontiers in Molecular Neuroscience
2019-11-12 | Journal article
Part of ISSN: 1662-5099
Source: Self-asserted source
Daniel Poole

Activation of pruritogenic TGR5, MRGPRA3, and MRGPRC11 on colon-innervating afferents induces visceral hypersensitivity

JCI Insight
2019-09-19 | Journal article
Part of ISSN: 2379-3708
Source: Self-asserted source
Daniel Poole

Application of a chemical probe to detect neutrophil elastase activation during inflammatory bowel disease.

Scientific reports
2019-09-16 | Journal article
Source: Self-asserted source
Daniel Poole

Agonist-dependent development of delta opioid receptor tolerance in the colon

Cellular and Molecular Life Sciences
2019-08-23 | Journal article
Contributors: Jesse J. DiCello; Ayame Saito; Pradeep Rajasekhar; Benjamin W. Sebastian; Rachel M. McQuade; Arisbel B. Gondin; Nicholas A. Veldhuis; Meritxell Canals; Simona E. Carbone; Daniel P. Poole
Source: check_circle
Crossref

Protein kinase D and Gβγ mediate sustained nociceptive signaling by biased agonists of protease-activated receptor-2

Journal of Biological Chemistry
2019-07 | Journal article
Contributors: Peishen Zhao; Luke A. Pattison; Dane D. Jensen; Nestor N. Jimenez-Vargas; Rocco Latorre; TinaMarie Lieu; Josue O. Jaramillo; Cintya Lopez-Lopez; Daniel P. Poole; Stephen J. Vanner et al.
Source: check_circle
Crossref

Clathrin and GRK2/3 inhibitors block delta opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon.

American journal of physiology. Gastrointestinal and liver physiology
2019-05-15 | Journal article
Source: Self-asserted source
Daniel Poole
grade
Preferred source (of 2)‎

Rapid Assessment of Nanoparticle Extravasation in a Microfluidic Tumor Model

ACS Applied Nano Materials
2019-04-26 | Journal article
Contributors: Mai N. Vu; Pradeep Rajasekhar; Daniel P. Poole; Song Yang Khor; Nghia P. Truong; Cameron J. Nowell; John F. Quinn; Michael Whittaker; Nicholas A. Veldhuis; Thomas P. Davis
Source: check_circle
Crossref

G Protein-Coupled Receptor Trafficking and Signaling: New Insights into the Enteric Nervous System.

Am J Physiol Gastrointest Liver Physiol
2019-01-31 | Journal article
Source: Self-asserted source
Daniel Poole
grade
Preferred source (of 2)‎

G Protein-Coupled Receptors are Dynamic Regulators of Digestion and Targets for Digestive Diseases

Gastroenterology
2019-01-08 | Journal article
Source: Self-asserted source
Daniel Poole

Protease-activated receptor-2 in endosomes signals persistent pain of irritable bowel syndrome.

Proceedings of the National Academy of Sciences of the United States of America
2018-07 | Journal article
Contributors: Jimenez-Vargas NN; Pattison LA; Zhao P; Lieu T; Latorre R; Jensen DD; Castro J; Aurelio L; Le GT; Flynn B et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Inflammation-associated changes in DOR expression and function in the mouse colon.

American journal of physiology. Gastrointestinal and liver physiology
2018-06 | Journal article
Contributors: DiCello JJ; Saito A; Rajasekhar P; Eriksson EM; McQuade RM; Nowell CJ; Sebastian BW; Fichna J; Veldhuis NA; Canals M et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Co-expression of μ and δ opioid receptors by mouse colonic nociceptors.

British journal of pharmacology
2018-05 | Journal article
Contributors: Guerrero-Alba R; Valdez-Morales EE; Jiménez-Vargas NN; Bron R; Poole D; Reed D; Castro J; Campaniello M; Hughes PA; Brierley SM et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

INSL5 activates multiple signalling pathways and regulates GLP-1 secretion in NCI-H716 cells.

Journal of molecular endocrinology
2018-04 | Journal article
Contributors: Ang SY; Evans BA; Poole DP; Bron R; DiCello JJ; Bathgate RAD; Kocan M; Hutchinson DS; Summers RJ
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

The potentially beneficial central nervous system activity profile of ivacaftor and its metabolites.

ERJ open research
2018-01 | Journal article
Contributors: Schneider EK; McQuade RM; Carbone VC; Reyes-Ortega F; Wilson JW; Button B; Saito A; Poole DP; Hoyer D; Li J et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Role of Nonneuronal TRPV4 Signaling in Inflammatory Processes.

2017 | Journal article
Contributors: Rajasekhar P; Poole DP; Veldhuis NA
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Endosomal signaling of the receptor for calcitonin gene-related peptide mediates pain transmission.

Proceedings of the National Academy of Sciences of the United States of America
2017-10 | Journal article
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Synergistic effect of IL-12 and IL-18 induces TIM3 regulation of γδ T cell function and decreases the risk of clinical malaria in children living in Papua New Guinea.

2017-06 | Journal article
Contributors: Schofield L; Ioannidis LJ; Karl S; Robinson LJ; Tan QY; Poole DP; Betuela I; Hill DL; Siba PM; Hansen DS et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

G-CSF Receptor Blockade Ameliorates Arthritic Pain and Disease.

2017-05 | Journal article
Contributors: Lee MC; McCubbin JA; Christensen AD; Poole DP; Rajasekhar P; Lieu T; Bunnett NW; Garcia-Caraballo S; Erickson A; Brierley SM et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Neurokinin 1 receptor signaling in endosomes mediates sustained nociception and is a viable therapeutic target for prolonged pain relief.

2017-05 | Journal article
Contributors: Jensen DD; Lieu T; Halls ML; Veldhuis NA; Imlach WL; Mai QN; Poole DP; Quach T; Aurelio L; Conner J et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central
grade
Preferred source (of 2)‎

G Protein-Coupled Receptor Trafficking and Signalling in the Enteric Nervous System: The Past, Present and Future.

2016 | Journal article
Contributors: Poole DP; Bunnett NW
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Plasma membrane localization of the μ-opioid receptor controls spatiotemporal signaling.

2016 | Journal article
Contributors: Halls ML; Yeatman HR; Nowell CJ; Thompson GL; Gondin AB; Civciristov S; Bunnett NW; Lambert NA; Poole DP; Canals M
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Effects of Food Components That Activate TRPA1 Receptors on Mucosal Ion Transport in the Mouse Intestine.

2016-10 | Journal article
Contributors: Fothergill LJ; Callaghan B; Rivera LR; Lieu T; Poole DP; Cho HJ; Bravo DM; Furness JB
Source: Self-asserted source
Daniel Poole via Europe PubMed Central

Antagonism of the proinflammatory and pronociceptive actions of canonical and biased agonists of protease-activated receptor-2.

2016-09 | Journal article
Contributors: Lieu T; Savage E; Zhao P; Edgington-Mitchell L; Barlow N; Bron R; Poole DP; McLean P; Lohman RJ; Fairlie DP et al.
Source: Self-asserted source
Daniel Poole via Europe PubMed Central
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