Personal information

Diabetes, Inflammation, Transcription, Epigenetics
France

Activities

Employment (3)

INSERM: Paris, Île-de-France, FR

2010-01-01 to present
Employment
Source: Self-asserted source
Venteclef N

Karolinska Institutet: Stockholm, SE

2008-01-01 to 2009-12-31
Employment
Source: Self-asserted source
Venteclef N

GlaxoSmithKline Plc: Brentford, London, GB

2003-01-02 to 2007-12-21
Employment
Source: Self-asserted source
Venteclef N

Education and qualifications (2)

Pierre and Marie Curie University: Paris, FR

2015-03-03 to present | HDR
Education
Source: Self-asserted source
Venteclef N

Pierre and Marie Curie University: Paris, FR

2004-10-01 to 2007-10-05 | PhD in Physiology and Physiopathology
Education
Source: Self-asserted source
Venteclef N

Funding (5)

EpiFAT

2017-06 to 2023 | Grant
ERC (Brussels, BE)
GRANT_NUMBER:

725790

Source: Self-asserted source
Venteclef N

Understanding the PROtectiVe Inflammation in DiabEtes

2016-01-01 to 2018-12-31 | Grant
Swiss National Science Foundation (Berne, CH)
GRANT_NUMBER: 164240
Source: Self-asserted source
Venteclef N via DimensionsWizard

Understanding the PROtectiVe Inflammation in DiabEtes

Source: Self-asserted source
Venteclef N via DimensionsWizard

SMRT-GPS2 co-repressor complex: molecular sensor of adipose tissue inflammation in human obesity

Source: Self-asserted source
Venteclef N via DimensionsWizard

Metabolic Function of the nuclear receptor corepressor GPS2

Source: Self-asserted source
Venteclef N via DimensionsWizard

Works (35)

Transcriptional repression in macrophages-basic mechanisms and alterations in metabolic inflammatory diseases.

FEBS letters
2017-09 | Journal article
Source: Self-asserted source
Venteclef N via Europe PubMed Central

Loss of the co-repressor GPS2 sensitizes macrophage activation upon metabolic stress induced by obesity and type 2 diabetes

Nature Medicine
2016 | Journal article
EID:

2-s2.0-84976323804

Contributors: Fan, R.; Toubal, A.; Goñi, S.; Drareni, K.; Huang, Z.; Alzaid, F.; Ballaire, R.; Ancel, P.; Liang, N.; Damdimopoulos, A. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans.

JCI insight
2016-12 | Journal article
Source: Self-asserted source
Venteclef N via Europe PubMed Central

Adipocyte ATP-binding cassette G1 promotes triglyceride storage, fat mass growth, and human obesity

Diabetes
2015 | Journal article
EID:

2-s2.0-84928208608

Contributors: Frisdal, E.; Le Lay, S.; Hooton, H.; Poupel, L.; Olivier, M.; Alili, R.; Plengpanich, W.; Villard, E.F.; Gilibert, S.; Lhomme, M. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Adipocyte mineralocorticoid receptor activation leads to metabolic syndrome and induction of prostaglandin D2 synthase

Hypertension
2015 | Journal article
EID:

2-s2.0-84940048286

Contributors: Urbanet, R.; Cat, A.N.D.; Feraco, A.; Venteclef, N.; El Mogrhabi, S.; Sierra-Ramos, C.; De La Rosa, D.A.; Adler, G.K.; Quilliot, D.; Rossignol, P. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Human epicardial adipose tissue has a specific transcriptomic signature depending on its anatomical peri-atrial, peri-ventricular, or peri-coronary location

Cardiovascular Research
2015 | Journal article
EID:

2-s2.0-84943416994

Contributors: Gaborit, B.; Venteclef, N.; Ancel, P.; Pelloux, V.; Gariboldi, V.; Leprince, P.; Amour, J.; Hatem, S.N.; Jouve, E.; Dutour, A. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Human epicardial adipose tissue induces fibrosis of the atrial myocardium through the secretion of adipo-fibrokines

European Heart Journal
2015 | Journal article
EID:

2-s2.0-84926683179

Contributors: Venteclef, N.; Guglielmi, V.; Balse, E.; Gaborit, B.; Cotillard, A.; Atassi, F.; Amour, J.; Leprince, P.; Dutour, A.; Clément, K. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Irf5 deficiency in macrophages promotes beneficial adipose tissue expansion and insulin sensitivity during obesity

Nature Medicine
2015 | Journal article
EID:

2-s2.0-84930571997

Contributors: Dalmas, E.; Toubal, A.; Alzaid, F.; Blazek, K.; Eames, H.L.; Lebozec, K.; Pini, M.; Hainault, I.; Montastier, E.; Denis, R.G.P. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Les macrophages Nouveaux modulateurs de la répartition de la masse grasse au cours de l'obésité

Medecine/Sciences
2015 | Journal article
EID:

2-s2.0-85006483486

Contributors: Dalmas, E.; Venteclef, N.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Mucosal-associated invariant T cell alterations in obese and type 2 diabetic patients

Journal of Clinical Investigation
2015 | Journal article
EID:

2-s2.0-84926318323

Contributors: Magalhaes, I.; Pingris, K.; Poitou, C.; Bessoles, S.; Venteclef, N.; Kiaf, B.; Beaudoin, L.; Da Silva, J.; Allatif, O.; Rossjohn, J. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Adaptive expression of microRNA-125a in adipose tissue in response to obesity in mice and men

PLoS ONE
2014 | Journal article
EID:

2-s2.0-84899839946

Contributors: Diawara, M.R.; Hue, C.; Wilder, S.P.; Venteclef, N.; Aron-Wisnewsky, J.; Scott, J.; Clément, K.; Gauguier, D.; Calderari, S.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

An « inflamed » relationship between GPS2 and the adipose tissue in human obesity | Une relation « inflammée » entre le complexe GPS2 et le tissu adipeux dans l'obésité

Medecine/Sciences
2014 | Journal article
EID:

2-s2.0-84893351334

Contributors: Toubal, A.; Treuter, E.; Venteclef, N.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Cathepsin S inhibition lowers blood glucose levels in mice

Diabetologia
2014 | Journal article
EID:

2-s2.0-84904726605

Contributors: Lafarge, J.-C.; Pini, M.; Pelloux, V.; Orasanu, G.; Hartmann, G.; Venteclef, N.; Sulpice, T.; Shi, G.-P.; Clément, K.; Guerre-Millo, M.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Liver X receptor: From metabolism to cancer

Biochemical Journal
2014 | Journal article
EID:

2-s2.0-84897509433

Contributors: Venteclef, N.; Ferré, P.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

T cell+derived IL-22 amplifies IL-1β+driven inflammation in human adipose tissue: Relevance to obesity and type 2 diabetes

Diabetes
2014 | Journal article
EID:

2-s2.0-84901367595

Contributors: Dalmas, E.; Venteclef, N.; Caer, C.; Poitou, C.; Cremer, I.; Aron-Wisnewsky, J.; Lacroix-Desmazes, S.; Bayry, J.; Kaveri, S.V.; Clément, K. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

The oxysterol receptor LXRβ protects against DSS- and TNBS-induced colitis in mice

Mucosal Immunology
2014 | Journal article
EID:

2-s2.0-84908153894

Contributors: Jakobsson, T.; Vedin, L.-L.; Hassan, T.; Venteclef, N.; Greco, D.; D'Amato, M.; Treuter, E.; Gustafsson, J.-A.; Steffensen, K.R.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Fetal PGC-1α overexpression programs adult pancreatic β-cell dysfunction

Diabetes
2013 | Journal article
EID:

2-s2.0-84875444428

Contributors: Valtat, B.; Riveline, J.-P.; Zhang, P.; Singh-Estivalet, A.; Armanet, M.; Venteclef, N.; Besseiche, A.; Kelly, D.P.; Tronche, F.; Ferré, P. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Genomic and epigenomic regulation of adipose tissue inflammation in obesity

Trends in Endocrinology and Metabolism
2013 | Journal article
EID:

2-s2.0-84888128603

Contributors: Toubal, A.; Treuter, E.; Clément, K.; Venteclef, N.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

SMRT-GPS2 corepressor pathway dysregulation coincides with obesity-linked adipocyte inflammation

Journal of Clinical Investigation
2013 | Journal article
EID:

2-s2.0-84873846887

Contributors: Toubal, A.; Clément, K.; Fan, R.; Ancel, P.; Pelloux, V.; Rouault, C.; Veyrie, N.; Hartemann, A.; Treuter, E.; Venteclef, N.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Fasting-induced FGF21 is repressed by LXR activation via recruitment of an HDAC3 corepressor complex in mice

Molecular Endocrinology
2012 | Journal article
EID:

2-s2.0-84870312300

Contributors: Archer, A.; Venteclef, N.; Mode, A.; Pedrelli, M.; Gabbi, C.; Clément, K.; Parini, P.; Gustafsson, J.-A.; Korach-André, M.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Response to letter regarding article, "increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation"

Circulation
2012 | Journal article
EID:

2-s2.0-84856820231

Contributors: Goossens, G.H.; Essers, Y.; Konings, E.; Jocken, J.W.E.; Blaak, E.E.; Bizzarri, A.; Čajlaković, M.; Ribitsch, V.; Clément, K.; Venteclef, N. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Valsartan improves adipose tissue function in humans with impaired glucose metabolism: A randomized placebo-controlled double-blind trial

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84863113881

Contributors: Goossens, G.H.; Moors, C.C.M.; van der Zijl, N.J.; Venteclef, N.; Alili, R.; Jocken, J.W.E.; Essers, Y.; Cleutjens, J.P.; Clément, K.; Diamant, M. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Increased adipose tissue oxygen tension in obese compared with lean men is accompanied by insulin resistance, impaired adipose tissue capillarization, and inflammation

Circulation
2011 | Journal article
EID:

2-s2.0-79960359853

Contributors: Goossens, G.H.; Bizzarri, A.; Venteclef, N.; Essers, Y.; Cleutjens, J.P.; Konings, E.; Jocken, J.W.E.; Čajlaković, M.; Ribitsch, V.; Clément, K. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Krüppel-like factor 4 regulates macrophage polarization

Journal of Clinical Investigation
2011 | Journal article
EID:

2-s2.0-79960021457

Contributors: Liao, X.; Sharma, N.; Kapadia, F.; Zhou, G.; Lu, Y.; Hong, H.; Paruchuri, K.; Mahabeleshwar, G.H.; Dalmas, E.; Venteclef, N. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Liver X Receptor (LXR) regulates human adipocyte lipolysis

Journal of Biological Chemistry
2011 | Journal article
EID:

2-s2.0-78650950535

Contributors: Stenson, B.M.; Rydén, M.; Venteclef, N.; Dahlman, I.; Pettersson, A.M.L.; Mairal, A.; Åström, G.; Blomqvist, L.; Wang, V.; Jocken, J.W.E. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Metabolic nuclear receptor signaling and the inflammatory acute phase response

Trends in Endocrinology and Metabolism
2011 | Journal article
EID:

2-s2.0-79960918745

Contributors: Venteclef, N.; Jakobsson, T.; Steffensen, K.R.; Treuter, E.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Transcriptional control of metabolic and inflammatory pathways by nuclear receptor SUMOylation

Biochimica et Biophysica Acta - Molecular Basis of Disease
2011 | Journal article
EID:

2-s2.0-79958244237

Contributors: Treuter, E.; Venteclef, N.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

GPS2-dependent corepressor/SUMO pathways govern anti-inflammatory actions of LRH-1 and LXRβ in the hepatic acute phase response

Genes and Development
2010 | Journal article
EID:

2-s2.0-76749125430

Contributors: Venteclef, N.; Jakobsson, T.; Ehrlund, A.; Damdimopoulos, A.; Mikkonen, L.; Ellis, E.; Nilsson, L.-M.; Parini, P.; Jänne, O.A.; Gustafsson, J.-Å. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

The human ADFP gene is a direct liver-X-receptor (LXR) target gene and differentially regulated by synthetic LXR ligands

Molecular Pharmacology
2010 | Journal article
EID:

2-s2.0-73549110874

Contributors: Kotokorpi, P.; Venteclef, N.; Ellis, E.; Gustafsson, J.-Å.; Mode, A.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

E3 Ubiquitin Ligase RNF31 Cooperates with DAX-1 in Transcriptional Repression of Steroidogenesis

Molecular and Cellular Biology
2009 | Journal article
EID:

2-s2.0-64649091704

Contributors: Ehrlund, A.; Anthonisen, E.H.; Gustafsson, N.; Venteclef, N.; Remen, K.R.; Damdimopoulos, A.E.; Galeeva, A.; Pelto-Huikko, M.; Lalli, E.; Steffensen, K.R. et al.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

GPS2 Is Required for Cholesterol Efflux by Triggering Histone Demethylation, LXR Recruitment, and Coregulator Assembly at the ABCG1 Locus

Molecular Cell
2009 | Journal article
EID:

2-s2.0-65649129652

Contributors: Jakobsson, T.; Venteclef, N.; Toresson, G.; Damdimopoulos, A.E.; Ehrlund, A.; Lou, X.; Sanyal, S.; Steffensen, K.R.; Gustafsson, J.-A.; Treuter, E.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Regulation of anti-atherogenic apolipoprotein M gene expression by the orphan nuclear receptor LRH-1

Journal of Biological Chemistry
2008 | Journal article
EID:

2-s2.0-39649102432

Contributors: Venteclef, N.; Haroniti, A.; Tousaint, J.-J.; Talianidis, I.; Delerive, P.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Interleukin-1 receptor antagonist induction as an additional mechanism for liver receptor homolog-1 to negatively regulate the hepatic acute phase response

Journal of Biological Chemistry
2007 | Journal article
EID:

2-s2.0-33947538319

Contributors: Venteclef, N.; Delerive, P.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Liver receptor homolog 1 is a negative regulator of the hepatic acute-phase response

Molecular and Cellular Biology
2006 | Journal article
EID:

2-s2.0-33748669670

Contributors: Venteclef, N.; Smith, J.C.; Goodwin, B.; Delerive, P.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

The imidazoline-like drug S23515 affects lipid metabolism in hepatocyte by inhibiting the oxidosqualene:lanosterol cyclase activity

Biochemical Pharmacology
2005 | Journal article
EID:

2-s2.0-14844312884

Contributors: Venteclef, N.; Guillard, R.; Issandou, M.
Source: Self-asserted source
Venteclef N via Scopus - Elsevier

Peer review (2 reviews for 2 publications/grants)

Review activity for Acta diabetologica. (1)
Review activity for Nature communications (1)