Personal information

Activities

Employment (6)

National Tsing Hua University: Hsinchu, TW

2019-08-01 to present | Professor (Institute of Molecular and Cellular Biology & Department of Life Science)
Employment
Source: Self-asserted source
Hua-Wen Fu

National Tsing Hua University: HsinChu, TW

2006-08-01 to 2019-07-31 | Associate Professor (Institute of Molecular and Cellular Biology & Department of Life Science)
Employment
Source: Self-asserted source
Hua-Wen Fu

National Tsing Hua University: HsinChu, TW

2002-08-01 to 2006-07-31 | Assistant Professor (Institute of Molecular and Cellular biology)
Employment
Source: Self-asserted source
Hua-Wen Fu

National Tsing Hua University: Hsinchu, TW

2000-08-01 to 2006-07-31 | Assistant Professor (Department of Life Science)
Employment
Source: Self-asserted source
Hua-Wen Fu

University of California San Francisco: San Francisco, CA, US

1998-08 to 2000-07-31 | Postdoc (Cardiovascular Research Institute )
Employment
Source: Self-asserted source
Hua-Wen Fu

Duke University Medical Center: Durham, NC, US

1998-05 to 1998-08 | Research Assocaite (Department of Pharmacology and Molecular Cancer Biology)
Employment
Source: Self-asserted source
Hua-Wen Fu

Education and qualifications (2)

Duke University Medical Center: Durham, NC, US

1993-08 to 1998-05 | Ph. D. (Biochemistry)
Education
Source: Self-asserted source
Hua-Wen Fu

National Taiwan Normal University: Taipei, TW

1988-10 to 1993-07 | B.S. (Chemistry)
Education
Source: Self-asserted source
Hua-Wen Fu

Works (32)

The Role of Helicobacter pylori Neutrophil-Activating Protein in the Pathogenesis of H. pylori and Beyond: From a Virulence Factor to Therapeutic Targets and Therapeutic Agents

International Journal of Molecular Sciences
2022-12-21 | Journal article
Contributors: Hua-Wen Fu; Yu-Chang Lai
Source: check_circle
Crossref
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Preferred source (of 2)‎

Helicobacter pylori Neutrophil-Activating Protein Directly Interacts with and Activates Toll-like Receptor 2 to Induce the Secretion of Interleukin-8 from Neutrophils and ATRA-Induced Differentiated HL-60 Cells

International Journal of Molecular Sciences
2021-10-26 | Journal article
Contributors: Shao-Hsuan Wen; Zhi-Wei Hong; Chung-Chu Chen; Han-Wen Chang; Hua-Wen Fu
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Crossref
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Preferred source (of 2)‎

Protease-activated receptor 2 induces migration and promotes Slug-mediated epithelial-mesenchymal transition in lung adenocarcinoma cells

Biochimica et Biophysica Acta - Molecular Cell Research
2019 | Journal article
EID:

2-s2.0-85055270950

Contributors: Tsai, C.-C.; Chou, Y.-T.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Endocytosis‐dependent lysosomal degradation of Src induced by protease‐activated receptor 1

FEBS Letters
2019-03 | Journal article
Contributors: Chung‐Che Tsai; Fang‐Ting Kuo; Sung‐Bau Lee; Yu‐Ting Chang; Hua‐Wen Fu
Source: check_circle
Crossref
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Preferred source (of 2)‎

Enhanced Mutant Screening in One-step PCR-based Multiple Site-directed Plasmid Mutagenesis by Introduction of Silent Restriction Sites for Structural and Functional Study of Proteins

Biological Procedures Online
2017-12 | Journal article
Contributors: Ting-Yu Kuo; Chung-Che Tsai; Hua-Wen Fu
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Crossref
grade
Preferred source (of 2)‎

Differential effects of DEAE negative mode chromatography and gel-filtration chromatography on the charge status of Helicobacter pylori neutrophil-activating protein

PLOS ONE
2017-03-22 | Journal article
Contributors: Zhi-Wei Hong; Paulo Lee Ho; Yu-Chi Yang; Timothy Pan; Huey-Fen Tzeng; Hua-Wen Fu
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Crossref
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Preferred source (of 2)‎

One-step negative chromatographic purification of helicobacter pylori neutrophil-activating protein overexpressed in escherichia coli in batch mode

Journal of Visualized Experiments
2016 | Journal article
EID:

2-s2.0-84977498278

Contributors: Kuo, T.-Y.; Hong, Z.-W.; Tsai, C.-C.; Yang, Y.-C.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Helicobacter pylori neutrophil-activating protein induces release of histamine and interleukin-6 through G protein-mediated MAPKs and PI3K/Akt pathways in HMC-1 cells

Virulence
2015 | Journal article
EID:

2-s2.0-84964034415

Contributors: Tsai, C.-C.; Kuo, T.-Y.; Hong, Z.-W.; Yeh, Y.-C.; Shih, K.-S.; Du, S.-Y.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

High yield purification of Helicobacter pylori neutrophil-activating protein overexpressed in Escherichia coli

BMC Biotechnology
2015 | Journal article
EID:

2-s2.0-84928995384

Contributors: Yang, Y.-C.; Kuo, T.-Y.; Hong, Z.-W.; Chang, H.-W.; Chen, C.-C.; Tsai, T.-L.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Neonatal infected subgaleal hematoma: An unusual complication of early-onset E. coli sepsis

Pediatrics and Neonatology
2015 | Journal article
EID:

2-s2.0-84926521771

Contributors: Chang, H.-Y.; Cheng, K.-S.; Liu, Y.-P.; Hung, H.-F.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Helicobacter pylori neutrophil-activating protein: From molecular pathogenesis to clinical applications

World Journal of Gastroenterology
2014 | Journal article
EID:

2-s2.0-84900442087

Contributors: Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

A Novel Cell-Penetrating Peptide Derived from Human Eosinophil Cationic Protein

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84874641140

Contributors: Fang, S.-L.; Fan, T.-C.; Fu, H.-W.; Chen, C.-J.; Hwang, C.-S.; Hung, T.-J.; Lin, L.-Y.; Chang, M.D.-T.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

One-Step Chromatographic Purification of Helicobacter pylori Neutrophil-Activating Protein Expressed in Bacillus subtilis

PLoS ONE
2013 | Journal article
EID:

2-s2.0-84876012768

Contributors: Shih, K.-S.; Lin, C.-C.; Hung, H.-F.; Yang, Y.-C.; Wang, C.-A.; Jeng, K.-C.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Longan seed extract reduces hyperuricemia via modulating urate transporters and suppressing xanthine oxidase activity

American Journal of Chinese Medicine
2012 | Journal article
EID:

2-s2.0-84865755079

Contributors: Hou, C.-W.; Lee, Y.-C.; Hung, H.-F.; Fu, H.-W.; Jeng, K.-C.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Population genomic analysis of base composition evolution in Drosophila melanogaster

Genome Biology and Evolution
2012 | Journal article
EID:

2-s2.0-84876540763

Contributors: Poh, Y.-P.; Ting, C.-T.; Fu, H.-W.; Langley, C.H.; Begun, D.J.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Reduction of germ cells in the Odysseus null mutant causes male fertility defect in Drosophila melanogaster

Genes and Genetic Systems
2012 | Journal article
EID:

2-s2.0-84871248954

Contributors: Cheng, Y.-J.; Fang, S.; Tsaur, S.-C.; Chen, Y.-L.; Fu, H.-W.; Patel, N.H.; Ting, C.-T.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Elephantopus scaber inhibits lipopolysaccharide-induced liver injury by suppression of signaling pathways in rats

American Journal of Chinese Medicine
2011 | Journal article
EID:

2-s2.0-79959997265

Contributors: Hung, H.-F.; Hou, C.-W.; Chen, Y.-L.; Lin, C.-C.; Fu, H.-W.; Wang, J.-S.; Jeng, K.-C.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Cholesterol depletion reduces Helicobacter pylori CagA translocation and CagA-induced responses in AGS cells

Infection and Immunity
2008 | Journal article
EID:

2-s2.0-46449094929

Contributors: Lai, C.-H.; Chang, Y.-C.; Du, S.-Y.; Wang, H.-J.; Kuo, C.-H.; Fang, S.-H.; Fu, H.-W.; Lin, H.-H.; Chiang, A.-S.; Wang, W.-C.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

GRP78 and Raf-1 cooperatively confer resistance to endoplasmic reticulum stress-induced apoptosis

Journal of Cellular Physiology
2008 | Journal article
EID:

2-s2.0-42949138828

Contributors: Shu, C.-W.; Sun, F.-C.; Cho, J.-H.; Lin, C.-C.; Liu, P.-F.; Chen, P.-Y.; Chang, M.D.-T.; Fu, H.-W.; Lai, Y.-K.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Helicobacter pylori neutrophil-activating protein promotes myeloperoxidase release from human neutrophils

Biochemical and Biophysical Research Communications
2008 | Journal article
EID:

2-s2.0-54449100093

Contributors: Wang, C.-A.; Liu, Y.-C.; Du, S.-Y.; Lin, C.-W.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Involvement of calcium in the differential induction of heat shock protein 70 by heat shock protein 90 inhibitors, geldanamycin and radicicol, in human non-small cell lung cancer H460 cells

Journal of Cellular Biochemistry
2006 | Journal article
EID:

2-s2.0-30044440611

Contributors: Chang, Y.-S.; Lee, L.-C.; Sun, F.-C.; Chao, C.-C.; Fu, H.-W.; Lai, Y.-K.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Negative regulation of protease-activated receptor 1-induced Src kinase activity by the association of phosphocaveolin-1 with Csk

Cellular Signalling
2006 | Journal article
EID:

2-s2.0-33749248334

Contributors: Lu, T.-L.; Kuo, F.-T.; Lu, T.-J.; Hsu, C.-Y.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Opposing effects of β-arrestin1 and β-arrestin2 on activation and degradation of Src induced by protease-activated receptor 1

Cellular Signalling
2006 | Journal article
EID:

2-s2.0-33749238356

Contributors: Kuo, F.-T.; Lu, T.-L.; Fu, H.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Kinetic studies of protein farnesyltransferase mutants establish active substrate conformation

Biochemistry
2003 | Journal article
EID:

2-s2.0-0043028384

Contributors: Pickett, J.S.; Bowers, K.E.; Hartman, H.L.; Fu, H.-W.; Embry, A.C.; Casey, P.J.; Fierke, C.A.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Protease-activated receptor-1 down-regulation. A mutant HeLa cell line suggests novel requirements for PAR1 phosphorylation and recruitment to clathrin-coated pits

Journal of Biological Chemistry
2000 | Journal article
EID:

2-s2.0-0034613356

Contributors: Trejo, J.; Altschuler, Y.; Fu, H.-W.; Mostov, K.E.; Coughlin, S.R.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Enzymology and biology of CaaX protein prenylation

Recent Progress in Hormone Research
1999 | Journal article
EID:

2-s2.0-0033392946

Contributors: Fu, H.-W.; Casey, P.J.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Kinetic analysis of zinc ligand mutants of mammalian protein farnesyltransferase

Biochemistry
1998 | Journal article
EID:

2-s2.0-0000854040

Contributors: Fu, H.-W.; Beese, L.S.; Casey, P.J.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Structure-function analysis of residues important in zinc binding and activity in protein farnes yltransferase

FASEB Journal
1997 | Journal article
EID:

2-s2.0-33750124829

Contributors: Fu, H.-W.; Casey, P.J.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Identification of a cysteine residue essential for activity of protein farnesyltransferase: Cys <sup>299</sup> is exposed only upon removal of zinc from the enzyme

Journal of Biological Chemistry
1996 | Journal article
EID:

2-s2.0-0029905595

Contributors: Fu, H.-W.; Moomaw, J.F.; Moomaw, C.R.; Casey, P.J.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Substitution of cadmium for zinc in farnesyl:protein transferase alters its substrate specificity

Biochemistry
1996 | Journal article
EID:

2-s2.0-0030039165

Contributors: Zhang, F.L.; Fu, H.-W.; Casey, P.J.; Bishop, W.R.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Characterization of prenylcysteines that interact with P-glycoprotein and inhibit drug transport in tumor cells

Journal of Biological Chemistry
1995 | Journal article
EID:

2-s2.0-0029081154

Contributors: Zhang, L.; Sachs, C.W.; Fu, H.-W.; Fine, R.L.; Casey, P.J.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Construction of Bridged and Fused Bicyclic Skeletons via Intramolecular Addition of Nucleophiles to (η<sup>4</sup>-Diene)Fe(CO)<inf>3</inf> Complexes Bearing Functionalized Side Chains

Journal of the American Chemical Society
1993 | Journal article
EID:

2-s2.0-0001174328

Contributors: Yeh, M.-C.P.; Sheu, B.-A.; Fu, H.-W.; Tau, S.-I.; Chuang, L.-W.
Source: Self-asserted source
Hua-Wen Fu via Scopus - Elsevier

Peer review (2 reviews for 2 publications/grants)

Review activity for Biological procedures online (1)
Review activity for Current microbiology. (1)