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Scopus Author ID: 6602949583
Ciência ID: 9E11-7F4C-67F4

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Portugal

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Employment (8)

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2020-01 to present | Médica (assistente)| Coordenadora Laboratório Hemato-Oncologia (Hematologia)
Employment
Source: Self-asserted source
Joana Desterro

Universidade de Lisboa Faculdade de Medicina: Lisboa, Lisboa, PT

2003-09 to present | Professora auxiliar (Biologia Molecular)
Employment
Source: Self-asserted source
Joana Desterro

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, PT

2014-01 to 2019-11 | Interna de Hematologia Clínica (Hematologia)
Employment
Source: Self-asserted source
Joana Desterro

Centro Hospitalar Lisboa Norte: Lisboa, PT

2013-01 to 2013-12 | Interna do ano comum
Employment
Source: Self-asserted source
Joana Desterro

Universidade de Lisboa Faculdade de Medicina: Lisboa, Lisboa, PT

2002-09 to 2003-09 | EC Post-Doctoral Fellow (Biologia Molecular)
Employment
Source: Self-asserted source
Joana Desterro

Universidade de Lisboa Faculdade de Medicina: Lisboa, Lisboa, PT

2000-09 to 2002-09 | EMBO Post-Doctoral Fellow (Biologia Molecular)
Employment
Source: Self-asserted source
Joana Desterro

University of St Andrews: St Andrews, St Andrews, GB

1999-10 to 2000-09 | BBRSC Post-Doctoral Fellow
Employment
Source: Self-asserted source
Joana Desterro

Instituto Nacional de Saúde Dr Ricardo Jorge: Lisboa, Lisboa, PT

1995-01 to 1995-12 | Técnica de investigação (Virologia )
Employment
Source: Self-asserted source
Joana Desterro

Education and qualifications (4)

Instituto Português de Oncologia de Lisboa Francisco Gentil EPE: Lisboa, Lisboa, PT

2014-01 to 2019-11 | ConcluídoHematologia Clínica (Título de especialista) (Hematlogia)
Education
Source: Self-asserted source
Joana Desterro

Universidade de Lisboa Faculdade de Medicina: Lisboa, Lisboa, PT

2006-09 to 2012-06 | Mestrado Integrado em Medicina (Medicina)
Education
Source: Self-asserted source
Joana Desterro

University of St Andrews: St Andrews, Scotland, GB

1996-01 to 1999-10 | PhD "Role of SUMO modification in transcription activation.” (Biomedical Sciences Research Complex )
Education
Source: Self-asserted source
Joana Desterro

Instituto Superior Técnico: Lisboa, Lisboa, PT

1989-10 to 1994-12 | Engenharia Quimica - ramo biotecnologia (Quimica)
Education
Source: Self-asserted source
Joana Desterro

Funding (19)

Diffuse Large B-cell lymphoma blood based proteome signatures

2018-10 to 2021-09 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BTM-TEC/30087/2017
Source: check_circle
CIÊNCIAVITAE

Targeting Intra-Tumor Heterogeneity as a promising therapeutic strategy for cancer

2018-10 to 2021-09 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/MED-ONC/28660/2017
Source: check_circle
CIÊNCIAVITAE

Characteristics and frequency of IDH mutations and how they associate with other known mutations in myeloid cancer genes in real world AML patients in Portugal

2018-01 to 2019-12 | Contract
Celgene Portugal (Porto Salvo, PT)
GRANT_NUMBER:

PTDC/MED-FAR/4692/2020
Source: check_circle
CIÊNCIAVITAE

Novel tumorigenic mechanisms of aberrant epigenetic regulation in clear cell renal cell carcinoma

2016-07 to 2019-12 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BIM-ONC/0016/2014
Source: check_circle
CIÊNCIAVITAE

SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma

Source: Self-asserted source
Joana Desterro via DimensionsWizard

SETD2 mediates a novel tumor suppressor mechanism that is misregulated in clear cell renal carcinoma

2013-06 to 2015-11 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BIM-ONC/0384/2012
Source: check_circle
CIÊNCIAVITAE

Oncobiology: developing educational tools for a new generation of physician-scientists

Source: Self-asserted source
Joana Desterro via DimensionsWizard
grade
Preferred source (of 2)‎

Oncobiology: developing educational tools for a new generation of physician-scientists

2011-11 to 2014-04 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

HMSP-PCM/0007/2010
Source: check_circle
CIÊNCIAVITAE

Splicing-coupled mechanisms of chromatin remodeling and their global role in transcription

Source: Self-asserted source
Joana Desterro via DimensionsWizard

Splicing-coupled mechanisms of chromatin remodeling and their global role in transcription

2011-02 to 2014-01 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BIA-BCM/111451/2009
Source: check_circle
CIÊNCIAVITAE

Is microRNA-mediated translational repression involved in auto-regulation of heterodimeric splicing factor U2AF?

2008-09 to 2008-12 | Grant
European Molecular Biology Laboratory (Heidelberg, DE)
GRANT_NUMBER:

ASTF 400-2008
Source: check_circle
CIÊNCIAVITAE

Regulation of mRNA processing and transport within the nucleus

Source: Self-asserted source
Joana Desterro via DimensionsWizard
grade
Preferred source (of 2)‎

Expression and Function of Ubiquitin Conjugating Enzyme hsUbc6e

2007-01 to 2008-03 | Contract
Fundação para a Ciência e a Tecnologia, I.P. (Lisbon, PT)
GRANT_NUMBER: Provided by PTCRIS: 82328
Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Regulation of mRNA processing and transport within the nucleus

Source: Self-asserted source
Joana Desterro via DimensionsWizard

Regulation of mRNA processing and transport within the nucleus

2005-07 to 2007-06 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

POCI/SAU-MMO/57700/2004
Source: check_circle
CIÊNCIAVITAE

Expression and Function of Ubiquitin Conjugating Enzyme hsUbc6e

Source: Self-asserted source
Joana Desterro via DimensionsWizard

Expression and Function of Ubiquitin Conjugating Enzyme hsUbc6e

2005-04 to 2007-06 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

POCI/SAU-MMO/61129/2004
Source: check_circle
CIÊNCIAVITAE

Dynamics of splicing factors

2000-09 to 2002-09 | Grant
European Molecular Biology Laboratory (Heidelberg, DE)
GRANT_NUMBER:

ALTF 239-2000
Source: check_circle
CIÊNCIAVITAE

Role of SUMO modification in Transcription activation

1996 to 1999 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PRAXIS XXI/BD/ 9240 /96
Source: check_circle
CIÊNCIAVITAE

Works (33)

Alectinib-induced anemia with acanthocytosis: To proceed or discontinue treatment in Non-Small Cell Lung Cancer patients?

Revista do Grupo de Estudos do Cancro do Pulmão
2023-12-31 | Journal article
DOI: 10.32932/gecp.2023.12.048
Contributors: Filipa Simões; Telma Sequeira; Rita Rosa; Joana Desterro; Maria Almodovar
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Screening a Targeted Panel of Genes by Next-Generation Sequencing Improves Risk Stratification in Real World Patients with Acute Myeloid Leukemia

Cancers
2022-06 | Journal article | Author
DOI: 10.3390/cancers14133236
Contributors: Sónia Matos; Paulo Bernardo; Susana Esteves; Aida Botelho de Sousa; Marcos Lemos; Patrícia Ribeiro; Madalena Silva; Albertina Nunes; Joana Lobato; Maria de Jesus Frade et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Targeting mRNA processing as an anticancer strategy

Nature Reviews Drug Discovery
2020-02 | Journal article
DOI: 10.1038/s41573-019-0042-3
Contributors: Joana Desterro; Pedro Bak-Gordon; Maria Carmo-Fonseca
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

UK Single Institution Experience of Mastocytosis: Guy's and St Thomas' NHS Foundation Trust

Blood
2019-11-13 | Journal article
DOI: 10.1182/blood-2019-130477
SOURCE-WORK-ID:

cv-prod-id-1829465

ISSN: 0006-4971
ISSN: 1528-0020
Contributors: Oni, Clare; Moonim, Mufaddal; Desterro, Joana; Grattan, Clive; Curto-Garcia, Natalia; Woodley, Claire; Ciesielska, Monika; et al.
Source: check_circle
CIÊNCIAVITAE

Essential thrombocythaemia treated with recombinant interferon: ‘real world' United Kingdom referral centre experience

British Journal of Haematology
2019-05-15 | Journal article
DOI: 10.1111/bjh.15968
SOURCE-WORK-ID:

cv-prod-id-1731624

Part of ISSN: 0007-1048
Part of ISSN: 1365-2141
Contributors: Desterro, Joana; McLornan, Donal P.; Curto Garcia, Natalia; O'Sullivan, Jennifer; Alimam, Samah; Keohane, Clodagh; Woodley, Claire; et al.
Source: check_circle
CIÊNCIAVITAE

Identification of putative biomarkers for leptomeningeal invasion in B-cell non-Hodgkin lymphoma by NMR metabolomics

Metabolomics
2017-10-06 | Journal article
DOI: 10.1007/s11306-017-1269-9
SOURCE-WORK-ID:

cv-prod-id-1826499

ISSN: 1573-3882
ISSN: 1573-3890
Contributors: Graça, Gonçalo; Desterro, Joana; Sousa, Joana; Fonseca, Carlos; Silveira, Margarida; Serpa, Jacinta; Carvalho, Tânia; da Silva, Maria G.; Gonçalves, Luís G.
Source: check_circle
CIÊNCIAVITAE

Age-adjusted international prognostic index is a predictor of survival in gastric diffuse B-cell non-Hodgkin lymphoma patients.

2016 | Journal article
DOI: 10.1016/j.bjhh.2016.04.010
PMID: 27521863
PMC: PMC4997895
Contributors: Delamain MT; da Silva MG; Miranda EC; Desterro J; Luminari S; Fedina A; Merli F; Chiattone CS; Pagnano KB; Federico M et al.
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

Pervasive transcription read-through promotes aberrant expression of oncogenes and RNA chimeras in renal carcinoma.

2015 | Journal article
DOI: 10.7554/elife.09214
PMID: 26575290
PMC: PMC4744188
Contributors: Grosso AR; Leite AP; Carvalho S; Matos MR; Martins FB; Vítor AC; Desterro JM; Carmo-Fonseca M; de Almeida SF
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

SETD2 is required for DNA double-strand break repair and activation of the p53-mediated checkpoint.

2014-05 | Journal article
DOI: 10.7554/elife.02482
PMID: 24843002
PMC: PMC4038841
Contributors: Carvalho S; Vítor AC; Sridhara SC; Martins FB; Raposo AC; Desterro JM; Ferreira J; de Almeida SF
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

Developing a prototype of an Oncobiology serious game for medical education

2013 IEEE 2nd International Conference on Serious Games and Applications for Health (SeGAH)
2013-05 | Journal article
DOI: 10.1109/segah.2013.6665301
SOURCE-WORK-ID:

cv-prod-id-1826211

ISBN: 9781467361651
Contributors: Martins, Ana C.R.; Freitas, Frederico G.; Goncalves, Pedro R.; Prada, Rui; Desterro, Joana M.P.; Costa, L.; Crisostomo, M. Ines
Source: check_circle
CIÊNCIAVITAE

Splicing factors SF1 and U2AF associate in extraspliceosomal complexes

Molecular and Cellular Biology
2008 | Journal article
DOI:

10.1128/MCB.02015-07
Contributors: Rino, J.; Desterro, J.M.P.; Pacheco, T.R.; Gadella Jr., T.W.J.; Carmo-Fonseca, M.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

A stochastic view of spliceosome assembly and recycling in the nucleus

PLoS Computational Biology
2007 | Journal article
DOI:

10.1371/journal.pcbi.0030201
Contributors: Rino, J.; Carvalho, T.; Braga, J.; Desterro, J.M.P.; Lührmann, R.; Carmo-Fonseca, M.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

In vivo requirement of the small subunit of U2AF for recognition of a weak 3′ splice site

Molecular and Cellular Biology
2006 | Journal article
DOI:

10.1128/MCB.00350-06
Contributors: Pacheco, T.R.; Coelho, M.B.; Desterro, J.M.P.; Mollet, I.; Carmo-Fonseca, M.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

SUMO-1 modification alters ADAR1 editing activity

Molecular Biology of the Cell
2005 | Journal article
DOI:

10.1091/mbc.E05-06-0536
Contributors: Desterro, J.M.P.; Keegan, L.P.; Jaffray, E.; Hay, R.T.; O'Connell, M.A.; Carmo-Fonseca, M.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

SUMO-1 modification of human transcription factor (TF) IID complex subunits: Inhibition of TFIID promoter-binding activity through SUMO-1 modification of hsTAF5

Journal of Biological Chemistry
2005 | Journal article
DOI:

10.1074/jbc.M414149200
Contributors: Boyer-Guittaut, M.; Birsoy, K.; Potel, C.; Elliott, G.; Jaffray, E.; Desterro, J.M.; Hay, R.T.; Oelgeschläger, T.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Intracellular macromolecular mobility measured by fluorescence recovery after photobleaching with confocal laser scanning microscopes

Molecular Biology of the Cell
2004 | Journal article
DOI:

10.1091/mbc.E04-06-0496
Contributors: Braga, J.; Desterro, J.M.P.; Carmo-Fonseca, M.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Dynamic association of RNA-editing enzymes with the nucleolus

Journal of Cell Science
2003 | Journal article
DOI:

10.1242/jcs.00371
Contributors: Desterro, J.M.P.; Keegan, L.P.; Lafarga, M.; Berciano, M.T.; O'Connell, M.; Carmo-Fonseca, M.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

P14ARF promotes accumulation of SUMO-1 conjugated (H)Mdm2

FEBS Letters
2002 | Journal article
DOI:

10.1016/S0014-5793(02)03310-0
Contributors: Xirodimas, D.P.; Chisholm, J.; Desterro, J.M.S; Lane, D.P.; Hay, R.T.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Common properties of nuclear body protein SP100 and TIF1α chromatin factor: Role of SUMO modification

Molecular and Cellular Biology
2001 | Journal article
DOI:

10.1128/MCB.21.10.3314-3324.2001
Contributors: Seeler, J.-S.; Marchio, A.; Losson, R.; Desterro, J.M.P.; Hay, R.T.; Chambon, P.; Dejean, A.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Polymeric Chains of SUMO-2 and SUMO-3 are Conjugated to Protein Substrates by SAE1/SAE2 and Ubc9

Journal of Biological Chemistry
2001 | Journal article
DOI:

10.1074/jbc.M104214200
Contributors: Tatham, M.H.; Jaffray, E.; Vaughan, O.A.; Desterro, J.M.P.; Botting, C.H.; Naismith, J.H.; Hay, R.T.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation

Molecular and Cellular Biology
2000 | Journal article
DOI:

10.1128/MCB.20.22.8458-8467.2000
Contributors: Rodriguez, M.S.; Desterro, J.M.P.; Lain, S.; Lane, D.P.; Hay, R.T.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Regulation of transcription factors by protein degradation.

2000-08 | Journal article
DOI: 10.1007/pl00000760
PMID: 11028913
Contributors: Desterro JM; Rodriguez MS; Hay RT
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

An N-terminal p14ARF peptide blocks Mdm2-dependent ubiquitination in vitro and can activate p53 in vivo.

2000-05 | Journal article
DOI: 10.1038/sj.onc.1203593
PMID: 10822382
Contributors: Midgley CA; Desterro JM; Saville MK; Howard S; Sparks A; Hay RT; Lane DP
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

Control of NF-κB transcriptional activation by signal induced proteolysis of IκBα

Philosophical Transactions of the Royal Society B: Biological Sciences
1999 | Journal article
EID: 2-s2.0-0033615293
Contributors: Hay, R.T.; Vuillard, L.; Desterro, J.M.P.; Rodriguez, M.S.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1

Journal of Biological Chemistry
1999 | Journal article
DOI:

10.1074/jbc.274.15.10618
Contributors: Desterro, J.M.P.; Rodriguez, M.S.; Kemp, G.D.; Ronald T, H.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Role of SUMO modification in transcription activation

University of St Andrews
1999 | Dissertation or Thesis
SOURCE-WORK-ID:

cv-prod-id-1779797
Contributors: Desterro, Joana
Source: check_circle
CIÊNCIAVITAE

SUMO-1 modification activates the transcriptional response of p53

EMBO Journal
1999 | Journal article
DOI:

10.1093/emboj/18.22.6455
Contributors: Rodriguez, M.S.; Desterro, J.M.P.; Lain, S.; Midgley, C.A.; Lane, D.P.; Hay, R.T.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alpha.

1999-09 | Journal article
DOI: 10.1098/rstb.1999.0504
PMID: 10582246
PMC: PMC1692667
Contributors: Hay RT; Vuillard L; Desterro JM; Rodriguez MS
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

SUMO-1 modification of the acute promyelocytic leukaemia protein PML: implications for nuclear localisation.

1999-02 | Journal article
PMID: 9885291
Contributors: Duprez E; Saurin AJ; Desterro JM; Lallemand-Breitenbach V; Howe K; Boddy MN; Solomon E; de Thé H; Hay RT; Freemont PS
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

Structure of ubiquitin-conjugating enzyme 9 displays significant differences with other ubiquitin-conjugating enzymes which may reflect its specificity for sumo rather than ubiquitin

Acta Crystallographica Section D: Biological Crystallography
1998 | Journal article
DOI:

10.1107/S0907444998002480
Contributors: Giraud, M.-F.; Desterro, J.M.P.; Naismith, J.H.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activation.

1998-08 | Journal article
DOI: 10.1016/s1097-2765(00)80133-1
PMID: 9734360
Contributors: Desterro JM; Rodriguez MS; Hay RT
Source: Self-asserted source
Joana Desterro via Europe PubMed Central
grade
Preferred source (of 2)‎

Ubch9 conjugates SUMO but not ubiquitin

FEBS Letters
1997 | Journal article
DOI:

10.1016/S0014-5793(97)01305-7
Contributors: Desterro, J.M.P.; Thomson, J.; Hay, R.T.
Source: Self-asserted source
Joana Desterro via Scopus - Elsevier
grade
Preferred source (of 2)‎

The carboxy-terminus of I¿Ba determines susceptibility to degradation by the catalytic core of the proteasome

Oncogene
1997-10 | Journal article
DOI: 10.1038/sj.onc.1201560
SOURCE-WORK-ID:

cv-prod-id-1826563

ISSN: 0950-9232
ISSN: 1476-5594
Contributors: Kroll, Mathias; Conconi, Mariangela; Desterro, Maria Joana P; Marin, Antoine; Thomas, Dominique; Friguet, Bertrand; Hay, Ronald T; et al.
Source: check_circle
CIÊNCIAVITAE
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