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Employment (3)

Broad Institute: Cambridge, MA, US

2014-03 to present (Data Sciences Platform; Klarman Cell Observatory)
Employment
Source: Self-asserted source
Timothy Tickle

Harvard School of Public Health: MA, MA, US

2011-09 to 2014-03 | Postdoctoral Fellow (Biostatistics)
Employment
Source: Self-asserted source
Timothy Tickle

University of North Carolina at Charlotte: Charlotte, North Carolina, US

2005-08 to 2011-09 (Bioinformatics Department)
Employment
Source: Self-asserted source
Timothy Tickle

Education and qualifications (4)

Harvard School of Public Health: MA, MA, US

2011 to 2014 | Postdoctoral Fellow (Biostatistics)
Education
Source: Self-asserted source
Timothy Tickle

University of North Carolina at Charlotte: Charlotte, North Carolina, US

2005 to 2011 | Doctorate (Bioinformatics)
Education
Source: Self-asserted source
Timothy Tickle

University of North Carolina at Charlotte: Charlotte, North Carolina, US

2000 to 2004 | Bachelors of Science (Computer Science)
Education
Source: Self-asserted source
Timothy Tickle

Wake Forest University: Winston-Salem, North Carolina, US

1995 to 1999 | Bachelor of Arts (History)
Education
Source: Self-asserted source
Timothy Tickle

Works (43)

Toward a data infrastructure for the Plant Cell Atlas

Plant Physiology
2023-01-02 | Journal article
DOI: 10.1093/plphys/kiac468
Contributors: Noah Fahlgren; Muskan Kapoor; Galabina Yordanova; Irene Papatheodorou; Jamie Waese; Benjamin Cole; Peter Harrison; Doreen Ware; Timothy Tickle; Benedict Paten et al.
Source: check_circle
Crossref

Multivariable association discovery in population-scale meta-omics studies

PLOS Computational Biology
2021-11-16 | Journal article
DOI: 10.1371/journal.pcbi.1009442
Contributors: Himel Mallick; Luis Pedro Coelho; Ali Rahnavard; Lauren J. McIver; Siyuan Ma; Yancong Zhang; Long H. Nguyen; Timothy L. Tickle; George Weingart; Boyu Ren et al.
Source: check_circle
Crossref

A statistical model for describing and simulating microbial community profiles

PLOS Computational Biology
2021-09-13 | Journal article
DOI: 10.1371/journal.pcbi.1008913
Contributors: Siyuan Ma; Yana Bromberg; Boyu Ren; Himel Mallick; Yo Sup Moon; Emma Schwager; Sagun Maharjan; Timothy L. Tickle; Yiren Lu; Rachel N. Carmody et al.
Source: check_circle
Crossref

Multivariable Association Discovery in Population-scale Meta-omics Studies

2021-01-20 | Preprint
DOI: 10.1101/2021.01.20.427420
Contributors: Himel Mallick; Ali Rahnavard; Lauren J. McIver; Siyuan Ma; Yancong Zhang; Long H. Nguyen; Timothy L. Tickle; George Weingart; Boyu Ren; Emma H. Schwager et al.
Source: check_circle
Crossref

A single-cell and single-nucleus RNA-seq toolbox for fresh and frozen human tumors

Nature medicine
2020 | Journal article
Source: Self-asserted source
Timothy Tickle

Integrated scRNA-Seq Identifies Human Postnatal Thymus Seeding Progenitors and Regulatory Dynamics of Differentiating Immature Thymocytes

Immunity
2020 | Journal article
Source: Self-asserted source
Timothy Tickle

Single cell profiling of immature human postnatal thymocytes resolves the complexity of intra-thymic lineage differentiation and thymus seeding precursors.

bioRxiv
2020 | Journal article
Source: Self-asserted source
Timothy Tickle

Cumulus: a cloud-based data analysis framework for large-scale single-cell and single-nucleus RNA-seq

bioRxiv
2019 | Journal article
Source: Self-asserted source
Timothy Tickle

Decoding human fetal liver haematopoiesis

Nature
2019 | Journal article
Source: Self-asserted source
Timothy Tickle

The Pediatric Cell Atlas: defining the growth phase of human development at single-cell resolution

Developmental cell
2019 | Journal article
Source: Self-asserted source
Timothy Tickle

Single-cell RNA-seq identifies the neuropeptide NMU as a novel regulator of ILC2 function

2018 | Other
Source: Self-asserted source
Timothy Tickle

A tissue-mapped axolotl de novo transcriptome enables identification of limb regeneration factors

Cell reports
2017 | Journal article
Source: Self-asserted source
Timothy Tickle

Alterations in oral bacterial communities are associated with risk factors for oral and oropharyngeal cancer

Scientific reports
2017 | Journal article
Source: Self-asserted source
Timothy Tickle

Erratum: The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation.

Nature
2017 | Journal article
Source: Self-asserted source
Timothy Tickle

STAR-Fusion: fast and accurate fusion transcript detection from RNA-Seq

BioRxiv
2017 | Journal article
Source: Self-asserted source
Timothy Tickle

The neuropeptide NMU amplifies ILC2-driven allergic lung inflammation

Nature
2017 | Journal article
Source: Self-asserted source
Timothy Tickle

Erratum: MetaPhlAn2 for enhanced metagenomic taxonomic profiling

Nature Methods
2016 | Journal article
Source: Self-asserted source
Timothy Tickle

Fast and accurate fusion transcript detection using the Trinity Cancer Transcriptome Analysis Toolkit

2016 | Other
Source: Self-asserted source
Timothy Tickle

Sub-clinical detection of gut microbial biomarkers of obesity and type 2 diabetes

Genome medicine
2016 | Journal article
Source: Self-asserted source
Timothy Tickle

Associations between host gene expression, the mucosal microbiome, and clinical outcome in the pelvic pouch of patients with inflammatory bowel disease

Genome biology
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

Biogeography of the intestinal mucosal and lumenal microbiome in the rhesus macaque

Cell host & microbe
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

Compact graphical representation of phylogenetic data and metadata with GraPhlAn

PeerJ
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

Erratum: Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature (Journal of Clinical Investigation (2014) 124: 8 (3617-3633

Journal of Clinical Investigation
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

MetaPhlAn2 for enhanced metagenomic taxonomic profiling

Nature methods
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

The Journal of clinical investigation
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

The impact of high-performance computing best practice applied to next-generation sequencing workflows

BioRxiv
2015 | Journal article
Source: Self-asserted source
Timothy Tickle

78 Host Ileal APOA1 and DUOX2 Co-Expression Modules Are Associated With Microbial Shifts and Clinical Outcomes in Treatment Naive Pediatric Crohn Disease

Gastroenterology
2014 | Journal article
Source: Self-asserted source
Timothy Tickle

Gut microbiome composition and function in experimental colitis during active disease and treatment-induced remission

The ISME journal
2014 | Journal article
Source: Self-asserted source
Timothy Tickle

Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature

The Journal of clinical investigation
2014 | Journal article
Source: Self-asserted source
Timothy Tickle

Using HPC techniques to accelerate NGS workflows

F1000Research
2014 | Journal article
Source: Self-asserted source
Timothy Tickle

Computational meta'omics for microbial community studies

Molecular systems biology
2013 | Journal article
Source: Self-asserted source
Timothy Tickle

Two-stage microbial community experimental design

The ISME journal
2013 | Journal article
Source: Self-asserted source
Timothy Tickle

190 Functional Aspects of the Intestinal Microbiome in Inflammatory Bowel Disease

Gastroenterology
2012 | Journal article
Source: Self-asserted source
Timothy Tickle

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

Genome biology
2012 | Journal article
Source: Self-asserted source
Timothy Tickle

Data mining the serous ovarian tumor transcriptome

2011 | Dissertation or Thesis
Source: Self-asserted source
Timothy Tickle

Correlation analysis of Hox and Erbb family gene expression in ovarian cancer

2008 | Other
Source: Self-asserted source
Timothy Tickle

Correlation analysis of HOX, ErbB and IGFBP family gene expression in ovarian cancer

Cancer Investigation
2008 | Journal article
Source: Self-asserted source
Timothy Tickle

Genetic analysis of connective tissue in patients with congenital thoracic abnormalities

Interact Cardiovasc Thorac Surg
2008 | Journal article
Source: Self-asserted source
Timothy Tickle

Moving towards a systematic understanding of malignant ovarian cancer’s underlying genetic environment

2007 | Other
Source: Self-asserted source
Timothy Tickle

Towards the uniform distribution of null P values on Affymetrix microarrays

Genome biology
2007 | Journal article
Source: Self-asserted source
Timothy Tickle

Pax8, a human paired box gene, is over expressed in ovarian cancer

2006 | Other
Source: Self-asserted source
Timothy Tickle

Analysis of ovarian cancer microarray data using an application specific database system.

2005 | Other
Source: Self-asserted source
Timothy Tickle

High-Performance De Novo RNA-Transcript Assembly Leveraging Distributed Memory and Massive Parallelization

Journal article
Source: Self-asserted source
Timothy Tickle
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