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Microbiology, Escherichia coli, Inflammatory bowel disease, Infectious colitis, Host defense peptides, Two component signaling systems, Antibiotic resistance
Canada

Activities

Employment (4)

Toronto Metropolitan University: Toronto, CA

2015-01-01 to present | Associate Professor (Chemistry and Biology)
Employment
Source: Self-asserted source
Joseph McPhee

Toronto Metropolitan University: Toronto, ON, CA

2015-01-01 to present | Associate Professor (Chemistry and Biology (Faculty of Science))
Employment
Source: check_circle
Toronto Metropolitan University via ORCID Member Portal

McMaster University: Hamilton, ON, CA

2011-01-01 to 2014-12-01 | Postdoctoral Fellow (Institute for Infectious Disease Research)
Employment
Source: Self-asserted source
Joseph McPhee

Stony Brook University: Stony Brook, NY, US

2006-03-15 to 2010-11-15 | Postdoctoral fellow (Center for Infectious Disease)
Employment
Source: Self-asserted source
Joseph McPhee

Education and qualifications (2)

University of British Columbia: Vancouver, BC, CA

1999-09-01 to 2006-02-15 | PhD (Microbiology and Immunology)
Education
Source: Self-asserted source
Joseph McPhee

Saint Francis Xavier University: Antigonish, NS, CA

1995-09-01 to 1999-04-30 | BSc
Education
Source: Self-asserted source
Joseph McPhee

Professional activities (2)

Canadian Society of Microbiologists: Ottawa, Ontario, CA

2012-01-01 to present | Full
Membership
Source: Self-asserted source
Joseph McPhee

American Society for Microbiology: Washington, DC, US

2008-01-01 to present | Contributing Member
Membership
Source: Self-asserted source
Joseph McPhee

Works (33)

Omptin Proteases of Enterobacterales Show Conserved Regulation by the PhoPQ Two-Component System but Exhibit Divergent Protection from Antimicrobial Host Peptides and Complement

Infection and Immunity
2023-01-24 | Journal article
Contributors: Youn Hee Cho; Monir Riasad Fadle Aziz; Avery Malpass; Tanuja Sutradhar; Jasika Bashal; Veronica Cojocari; Joseph B. McPhee; Andreas J. Bäumler
Source: check_circle
Crossref

Salmonellaactively modulates TFEB in murine macrophages in a growth-phase and time-dependent manner

2022-12-04 | Preprint
Contributors: Subothan Inpanathan; Erika Ospina-Escobar; Vanessa Cruz Li; Zainab Adamji; Tracy Lackraj; Youn Hee Cho; Natasha Porco; Christopher H. Choy; Joseph B. McPhee; Roberto J. Botelho
Source: check_circle
Crossref

Inflammatory bowel disease-associated adherent-invasive Escherichia coli have elevated host-defense peptide resistance

FEMS Microbiology Letters
2022-10-26 | Journal article
Contributors: Youn Hee Cho; Michael J Renouf; Oluwafikemi Omotoso; Joseph B McPhee
Source: check_circle
Crossref

A mutation in the promoter of the pmrD gene of Shigella flexneri abrogates functional PhoPQ-PmrD-PmrAB signaling and polymyxin B resistance

2021-07-27 | Preprint
Contributors: Raymond Huynh; Joseph B. McPhee
Source: check_circle
Crossref

Molecular basis of bile-salt- and iron-induced enterohaemorrhagic E. coli resistance to cationic antimicrobial peptides

Microbiology
2020-12-01 | Journal article
Contributors: Chhatra B. Kunwar; Sarah Birstonas; Joseph B. McPhee; Debora Barnett Foster
Source: check_circle
Crossref

Conserved regulation of omptin proteases by the PhoPQ two-component regulatory system in Enterobacteriaceae

2020-02-28 | Preprint
Contributors: Youn Hee Cho; Monir Riasad Fadle Aziz; Tanuja Sutradhar; Jasika Bashal; Veronica Cojocari; Joseph B. McPhee
Source: check_circle
Crossref

Emergent Behavior of IBD-Associated Escherichia coli During Disease

Inflammatory Bowel Diseases
2018-10 | Journal article
Part of ISSN: 1078-0998
Contributors: Michael John Renouf; Youn Hee Cho; Joseph B McPhee
Source: Self-asserted source
Joseph McPhee via Crossref Metadata Search
grade
Preferred source (of 2)‎

A Single Amino Acid Change in the Response Regulator PhoP, Acquired during Yersinia pestis Evolution, Affects PhoP Target Gene Transcription and Polymyxin B Susceptibility.

Journal of bacteriology
2018-04 | Journal article
Contributors: Fukuto HS; Vadyvaloo V; McPhee JB; Poinar HN; Holmes EC; Bliska JB
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Correction: Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.

PLoS pathogens
2018-04 | Journal article
Contributors: Small CL; Xing L; McPhee JB; Law HT; Coombes BK
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

From Pigs to Patients: Transmissible, Single Gene-mediated Resistance to Colistin

Journal of Medical Microbiology & Diagnosis
2016 | Journal article
Part of ISSN: 2161-0703
Contributors: Joseph B McPhee; Shawn Lewenza
Source: Self-asserted source
Joseph McPhee via Crossref Metadata Search

Acute Infectious Gastroenteritis Potentiates a Crohn's Disease Pathobiont to Fuel Ongoing Inflammation in the Post-Infectious Period.

PLoS pathogens
2016-10 | Journal article
Contributors: Small CL; Xing L; McPhee JB; Law HT; Coombes BK
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central
grade
Preferred source (of 2)‎

Uncovering an Important Role for YopJ in the Inhibition of Caspase-1 in Activated Macrophages and Promoting Yersinia pseudotuberculosis Virulence.

Infection and immunity
2016-03 | Journal article
Contributors: Schoberle TJ; Chung LK; McPhee JB; Bogin B; Bliska JB
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Immunometabolism of obesity and diabetes: microbiota link compartmentalized immunity in the gut to metabolic tissue inflammation.

Clinical science (London, England : 1979)
2015-12 | Journal article
Contributors: McPhee JB; Schertzer JD
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Defective NOD2 peptidoglycan sensing promotes diet-induced inflammation, dysbiosis, and insulin resistance.

EMBO molecular medicine
2015-03 | Journal article
Contributors: Denou E; Lolmède K; Garidou L; Pomie C; Chabo C; Lau TC; Fullerton MD; Nigro G; Zakaroff-Girard A; Luche E et al.
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Multiple histidines in the periplasmic domain of the Salmonella enterica sensor kinase SsrA enhance signaling in response to extracellular acidification.

Molecular microbiology
2015-01 | Journal article
Contributors: Mulder DT; McPhee JB; Reid-Yu SA; Stogios PJ; Savchenko A; Coombes BK
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Host defense peptide resistance contributes to colonization and maximal intestinal pathology by Crohn's disease-associated adherent-invasive Escherichia coli.

Infection and immunity
2014-05 | Journal article
Contributors: McPhee JB; Small CL; Reid-Yu SA; Brannon JR; Le Moual H; Coombes BK
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Persistent infection with Crohn's disease-associated adherent-invasive Escherichia coli leads to chronic inflammation and intestinal fibrosis.

Nature communications
2013-01 | Journal article
Contributors: Small CL; Reid-Yu SA; McPhee JB; Coombes BK
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

L-asparaginase II produced by Salmonella typhimurium inhibits T cell responses and mediates virulence.

Cell host & microbe
2012-12 | Journal article
Contributors: Kullas AL; McClelland M; Yang HJ; Tam JW; Torres A; Porwollik S; Mena P; McPhee JB; Bogomolnaya L; Andrews-Polymenis H et al.
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Interleukin-10 induction is an important virulence function of the Yersinia pseudotuberculosis type III effector YopM.

Infection and immunity
2012-04 | Journal article
Contributors: McPhee JB; Mena P; Zhang Y; Bliska JB
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Letter to the Editor and response

Innate Immunity
2011 | Journal article
Part of ISSN: 1753-4259
Contributors: Joseph B McPhee; James B Bliska
Source: Self-asserted source
Joseph McPhee via Crossref Metadata Search

A draft genome of Yersinia pestis from victims of the Black Death.

Nature
2011-10 | Journal article
Contributors: Bos KI; Schuenemann VJ; Golding GB; Burbano HA; Waglechner N; Coombes BK; McPhee JB; DeWitte SN; Meyer M; Schmedes S et al.
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Adaptive resistance to the "last hope" antibiotics polymyxin B and colistin in Pseudomonas aeruginosa is mediated by the novel two-component regulatory system ParR-ParS.

Antimicrobial agents and chemotherapy
2010-06 | Journal article
Contributors: Fernández L; Gooderham WJ; Bains M; McPhee JB; Wiegand I; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Delineation of regions of the Yersinia YopM protein required for interaction with the RSK1 and PRK2 host kinases and their requirement for interleukin-10 production and virulence.

Infection and immunity
2010-06 | Journal article
Contributors: McPhee JB; Mena P; Bliska JB
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

The major outer membrane protein OprG of Pseudomonas aeruginosa contributes to cytotoxicity and forms an anaerobically regulated, cation-selective channel.

FEMS microbiology letters
2009-05 | Journal article
Contributors: McPhee JB; Tamber S; Bains M; Maier E; Gellatly S; Lo A; Benz R; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

The sensor kinase PhoQ mediates virulence in Pseudomonas aeruginosa.

Microbiology (Reading, England)
2009-03 | Journal article
Contributors: Gooderham WJ; Gellatly SL; Sanschagrin F; McPhee JB; Bains M; Cosseau C; Levesque RC; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Induction by cationic antimicrobial peptides and involvement in intrinsic polymyxin and antimicrobial peptide resistance, biofilm formation, and swarming motility of PsrA in Pseudomonas aeruginosa.

Journal of Bacteriology
2008-06 | Journal article
Contributors: Gooderham WJ; Bains M; McPhee JB; Wiegand I; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Secondary acylation of Klebsiella pneumoniae lipopolysaccharide contributes to sensitivity to antibacterial peptides.

The Journal of biological chemistry
2007-03 | Journal article
Contributors: Clements A; Tull D; Jenney AW; Farn JL; Kim SH; Bishop RE; McPhee JB; Hancock RE; Hartland EL; Pearse MJ et al.
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Contribution of the PhoP-PhoQ and PmrA-PmrB two-component regulatory systems to Mg2+-induced gene regulation in Pseudomonas aeruginosa.

Journal of bacteriology
2006-06 | Journal article
Contributors: McPhee JB; Bains M; Winsor G; Lewenza S; Kwasnicka A; Brazas MD; Brinkman FS; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Function and therapeutic potential of host defence peptides

Journal of Peptide Science
2005 | Journal article
Part of ISSN: 1075-2617
Contributors: Joseph B. Mcphee; Robert E. W. Hancock
Source: Self-asserted source
Joseph McPhee via Crossref Metadata Search

Salmonella’s Sensor for Host Defense Molecules

Cell
2005-08 | Journal article
Part of ISSN: 0092-8674
Contributors: Robert E.W. Hancock; Joseph B. McPhee
Source: Self-asserted source
Joseph McPhee via Crossref Metadata Search

Design of Host Defence Peptides for Antimicrobial and Immunity Enhancing Activities

Combinatorial Chemistry & High Throughput Screening
2005-05-01 | Journal article
Part of ISSN: 1386-2073
Contributors: Joseph McPhee; Monisha Scott; Robert Hancock
Source: Self-asserted source
Joseph McPhee via Crossref Metadata Search

Construction of a mini-Tn5-luxCDABE mutant library in Pseudomonas aeruginosa PAO1: a tool for identifying differentially regulated genes.

Genome research
2005-04 | Journal article
Contributors: Lewenza S; Falsafi RK; Winsor G; Gooderham WJ; McPhee JB; Brinkman FS; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Cationic antimicrobial peptides activate a two-component regulatory system, PmrA-PmrB, that regulates resistance to polymyxin B and cationic antimicrobial peptides in Pseudomonas aeruginosa.

Molecular microbiology
2003-10 | Journal article
Contributors: McPhee JB; Lewenza S; Hancock RE
Source: Self-asserted source
Joseph McPhee via Europe PubMed Central

Peer review (6 reviews for 6 publications/grants)

Review activity for ACS infectious diseases. (1)
Review activity for Communications biology. (1)
Review activity for JoVE. (1)
Review activity for Microbial pathogenesis. (1)
Review activity for Microbiology. (1)
Review activity for PLOS pathogens : (1)