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retinoblastoma, pediatric cancer, osteosarcoma, Rb, Uhrf1, Hells, epigenetics
United States

Activities

Employment (2)

University of California, Irvine: Irvine, CA, US

2022-07-01 to present | Associate Professor (Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Claudia Benavente

University of California Irvine: Irvine, CA, US

2014-10-01 to 2022-06-30 | Assistant Professor (Pharmaceutical Sciences)
Employment
Source: Self-asserted source
Claudia Benavente

Education and qualifications (4)

St. Jude Children's Research Hospital: Memphis, TN, US

2009-01-05 to 2014-09-12 | Postdoctoral Research Associate (Developmental Neurobiology)
Education
Source: Self-asserted source
Claudia Benavente

The University of Arizona: Tucson, AZ, US

2003-09 to 2007-12-15 | Ph.D. Cancer Biology (Interdisciplinary Department Programs)
Education
Source: Self-asserted source
Claudia Benavente

Universidad de Chile: Santiago de Chile, CL

2002-10-15 | Ingeniero en Biotecnologia Molecular (Facultad de Ciencias)
Education
Source: Self-asserted source
Claudia Benavente

Universidad de Chile: Santiago de Chile, CL

1997-03 to 2001-12-21 | Licenciado en Ingenieria en Biotecnologia Molecular (Facultad de Ciencias)
Education
Source: Self-asserted source
Claudia Benavente

Professional activities (2)

American Association for the Advancement of Science: D.C., D.C., US

2015 to present
Membership
Source: Self-asserted source
Claudia Benavente

American Association for Cancer Research: PA, PA, US

2008 to present
Membership
Source: Self-asserted source
Claudia Benavente

Funding (6)

Role of UHRF1 in osteosarcoma

2019-07-01 to 2024-06-30 | Grant
American Cancer Society (Atlanta, US)
GRANT_NUMBER:

RSG-19-031-01-DMC

Source: check_circle
American Cancer Society - ProposalCentral

Role of UHRF1 in osteosarcoma

2019-07 to 2023-06 | Grant
American Cancer Society (GA, GA, US)
Source: Self-asserted source
Claudia Benavente

Role of UHRF1 in osteosarcoma and its relationship to RB

2019-06-01 to 2024-05-31 | Grant
National Cancer Institute (Rockville, US)
GRANT_NUMBER: R01CA229696
Source: Self-asserted source
Claudia Benavente via DimensionsWizard

Role of UHRF1 in osteosarcoma

2018-07 to 2020-06 | Award
American Association for Cancer Research (PA, PA, US)
GRANT_NUMBER: 18-20-10-BENA
Source: Self-asserted source
Claudia Benavente
grade
Preferred source (of 2)‎

Genome instability and epigenetic deregulation in retinoblastoma and osteosarcoma

Source: Self-asserted source
Claudia Benavente via DimensionsWizard

Genome instability and epigenetic deregulation in retinoblastoma and osteosarcoma

Source: Self-asserted source
Claudia Benavente via DimensionsWizard

Works (24)

Oncogenic Roles of UHRF1 in Cancer

Epigenomes
2024-07-01 | Journal article
Contributors: Ahhyun Kim; Claudia A. Benavente
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Landscape and Treatment Options of Shapeshifting Small Cell Lung Cancer

Journal of Clinical Medicine
2024-05-26 | Journal article
Contributors: Yijun Gu; Claudia A. Benavente
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Exploring the Impact of Exosomal Cargos on Osteosarcoma Progression: Insights into Therapeutic Potential

International Journal of Molecular Sciences
2024-01-01 | Journal article
Contributors: Claire C. Chen; Claudia A. Benavente
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

UHRF1 overexpression promotes osteosarcoma metastasis through altered exosome production and AMPK/SEMA3E suppression.

Oncogenesis
2022-09-06 | Journal article
Contributors: Claudia Benavente
Source: Self-asserted source
Claudia Benavente

Retinoblastoma Tumor Suppressor Protein Roles in Epigenetic Regulation

Cancers
2020-09-29 | Journal article
Contributors: Frederick Guzman; Yasamin Fazeli; Meagan Khuu; Kelsey Salcido; Sarah Singh; Claudia A. Benavente
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

Single cell transcriptomics of human epidermis identifies basal stem cell transition states

Nature Communications
2020-08-25 | Journal article
Contributors: Shuxiong Wang; Michael L. Drummond; Christian F. Guerrero-Juarez; Eric Tarapore; Adam L. MacLean; Adam R. Stabell; Stephanie C. Wu; Guadalupe Gutierrez; Bao T. That; Claudia A. Benavente et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

UHRF1 upregulation mediates exosome release and tumor progression in osteosarcoma

2020-05-25 | Preprint
Contributors: Stephanie C. Wu; Ahhyun Kim; Loredana Zocchi; Claire Chen; Jocelyne Lopez; Kelsey Salcido; Jie Wu; Claudia A. Benavente
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Chromatin remodeling protein HELLS is critical for retinoblastoma tumor initiation and progression.

Oncogenesis
2020-02-18 | Journal article
Source: Self-asserted source
Claudia Benavente
grade
Preferred source (of 2)‎

Single cell transcriptomics of human epidermis reveals basal stem cell transition states

bioRxiv
2019 | Other
EID:

2-s2.0-85095538511

Part of ISSN: 26928205
Contributors: Wang, S.; Drummond, M.L.; Guerrero-Juarez, C.F.; Tarapore, E.; MacLean, A.L.; Stabell, A.R.; Wu, S.C.; Gutierrez, G.; That, B.T.; Benavente, C.A. et al.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Chromatin remodeling protein HELLS is upregulated by inactivation of the RB-E2F pathway and is nonessential for osteosarcoma tumorigenesis

Oncotarget
2018 | Journal article
EID:

2-s2.0-85052056757

Contributors: Wu, S.C.; Benavente, C.A.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

The cyclin-dependent kinase inhibitor flavopiridol (alvocidib) inhibits metastasis of human osteosarcoma cells

Oncotarget
2018 | Journal article
EID:

2-s2.0-85046738675

Contributors: Zocchi, L.; Wu, S.C.; Wu, J.; Hayama, K.L.; Benavente, C.A.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

DNA repair and epigenetic regulation in cancer

Molecular Medicines for Cancer: Concepts and Applications of Nanotechnology
2018-09-20 | Book chapter
Source: Self-asserted source
Claudia Benavente

Brg1 coordinates multiple processes during retinogenesis and is a tumor suppressor in retinoblastoma

Development (Cambridge)
2015 | Journal article
EID:

2-s2.0-84949433960

Contributors: Aldiri, I.; Ajioka, I.; Xu, B.; Zhang, J.; Chen, X.; Benavente, C.; Finkelstein, D.; Johnson, D.; Akiyama, J.; Pennacchio, L.A. et al.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Genetically engineered mouse and orthotopic human tumor xenograft models of retinoblastoma

Methods in molecular biology (Clifton, N.J.)
2015 | Journal article
EID:

2-s2.0-84954596792

Contributors: Benavente, C.A.; Dyer, M.A.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Genetics and epigenetics of human retinoblastoma

Annual Review of Pathology: Mechanisms of Disease
2015 | Book
EID:

2-s2.0-84921930606

Contributors: Benavente, C.A.; Dyer, M.A.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Chromatin remodelers HELLS and UHRF1 mediate the epigenetic deregulation of genes that drive retinoblastoma tumor progression

Oncotarget
2014 | Journal article
EID:

2-s2.0-84930462919

Contributors: Benavente, C.A.; Finkelstein, D.; Johnson, D.A.; Marine, J.-C.; Ashery-Padan, R.; Dyer, M.A.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Targeting the DNA repair pathway in Ewing sarcoma

Cell Reports
2014 | Journal article
EID:

2-s2.0-84919705139

Contributors: Stewart, E.; Goshorn, R.; Bradley, C.; Griffiths, L.M.; Benavente, C.; Twarog, N.R.; Miller, G.M.; Caufield, W.; Freeman, B.B.; Bahrami, A. et al.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Cross-species genomic and epigenomic landscape of retinoblastoma

Oncotarget
2013 | Journal article
EID:

2-s2.0-84880830430

Contributors: Benavente, A.C.; McEvoy, J.D.; Finkelstein, D.; Wei, L.; Kang, G.; Wang, Y.-D.; Neale, G.; Susan Ragsdale; Valentine, V.; Bahrami, A. et al.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

A novel retinoblastoma therapy from genomic and epigenetic analyses

Nature
2012 | Journal article
EID:

2-s2.0-84862777113

Contributors: Zhang, J.; Benavente, C.A.; McEvoy, J.; Flores-Otero, J.; Ding, L.; Chen, X.; Ulyanov, A.; Wu, G.; Wilson, M.; Wang, J. et al.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Effects of Niacin restriction on sirtuin and PARP responses to photodamage in human skin

PLoS ONE
2012 | Journal article
EID:

2-s2.0-84864452777

Contributors: Benavente, C.A.; Schnell, S.A.; Jacobson, E.L.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Nicotinic acid receptor abnormalities in human skin cancer: Implications for a role in epidermal differentiation

PLoS ONE
2011 | Journal article
EID:

2-s2.0-79957817724

Contributors: Bermudez, Y.; Benavente, C.A.; Meyer, R.G.; Coyle, W.R.; Jacobson, M.K.; Jacobson, E.L.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

NAD in skin: Therapeutic approaches for niacin

Current Pharmaceutical Design
2009 | Journal article
EID:

2-s2.0-62149099631

Contributors: Benavente, C.A.; Jacobson, M.K.; Jacobson, E.L.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Niacin restriction upregulates NADPH oxidase and reactive oxygen species (ROS) in human keratinocytes

Free Radical Biology and Medicine
2008 | Journal article
EID:

2-s2.0-38649118533

Contributors: Benavente, C.A.; Jacobson, E.L.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Subcellular distribution and mitogenic effect of basic fibroblast growth factor in mesenchymal uncommitted stem cells

Growth Factors
2003 | Journal article
EID:

2-s2.0-0242551560

Contributors: Benavente, C.A.; Sierralta, W.D.; Conget, P.A.; Minguell, J.J.
Source: Self-asserted source
Claudia Benavente via Scopus - Elsevier

Peer review (3 reviews for 3 publications/grants)

Review activity for Life science alliance. (1)
Review activity for Nature genetics. (1)
Review activity for Neurochemical research. (1)