Personal information

Activities

Employment (5)

University of Colorado - Anschutz Medical Campus: Aurora, CO, US

2021-07-21 to present | Research Instructor (Department of Biochemistry and Molecular Genetics)
Employment
Source: Self-asserted source
Thomas Germe

John Innes Centre: Norwich, Norfolk, GB

2014-07-15 to 2021-07-20 | Research scientist (Department of Biological Chemistry)
Employment
Source: Self-asserted source
Thomas Germe

University of Oxford: Oxford, Oxfordshire, GB

2012-08-01 to 2014-07-14 | Laboratory Manager (Department of Biochemistry)
Employment
Source: Self-asserted source
Thomas Germe

University of Oxford: Oxford, Oxfordshire, GB

2009-11-01 to 2012-07-01 | Postdoctoral scientist (Dunn School of pathology)
Employment
Source: Self-asserted source
Thomas Germe

Cancer Research UK: London, London, GB

2005-11-01 to 2009-10-31 | Post-doctoral scientist (Telomere Biology laboratory)
Employment
Source: Self-asserted source
Thomas Germe

Education and qualifications (4)

Sorbonne University: Paris, FR

2001-09-01 to 2005-10-21 | PhD Molecular Biology of the Cell
Education
Source: Self-asserted source
Thomas Germe

Université Paris-Sud: Orsay, Île-de-France, FR

2000-09-01 to 2001-07-01 | Master (DEA) Molecular Biology of the Cell
Education
Source: Self-asserted source
Thomas Germe

Ecole Normale Supérieure Département de Biologie: Paris, Île-de-France, FR

1998-09-01 to 2001-07-01 | Master (Magistère de L'Ecole Normale Supérieure) Biology/Biochemistry
Education
Source: Self-asserted source
Thomas Germe

Sorbonne Université Campus Pierre et Marie Curie: Paris, Île-de-France, FR

1996-09-01 to 1999-07-01 | Bachelor of Sciences Biology/Chemistry
Education
Source: Self-asserted source
Thomas Germe

Works (15)

Rapid, DNA-induced interface swapping by DNA gyrase

Dryad
2024-03-24 | Dataset
Contributors: Thomas Germe; Natassja G. Bush; Victoria Baskerville; Dominik Saman; Justin Benesch; Anthony Maxwell
Source: check_circle
DataCite

Rapid, DNA-induced interface swapping by DNA gyrase

2022-09 | Preprint
Contributors: Germe T; Bush NG; Baskerville V; Saman D; Benesch J; Maxwell A
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

<i>De novo</i> design of type II topoisomerase inhibitors as potential antimicrobial agents targeting a novel binding region.

RSC medicinal chemistry
2022-06 | Journal article
Contributors: Orritt KM; Feng L; Newell JF; Sutton JN; Grossman S; Germe T; Abbott LR; Jackson HL; Bury BKL; Maxwell A et al.
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

Potent DNA gyrase inhibitors bind asymmetrically to their target using symmetrical bifurcated halogen bonds

Nature Communications
2021-12 | Journal article
Part of ISSN: 2041-1723
Source: Self-asserted source
Thomas Germe

DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion.

Journal of molecular biology
2019-07 | Journal article
Contributors: Bax BD; Murshudov G; Maxwell A; Germe T
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.

Nucleic acids research
2018-03 | Journal article
Contributors: Germe T; Vörös J; Jeannot F; Taillier T; Stavenger RA; Bacqué E; Maxwell A; Bax BD
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance.

Nucleic acids research
2018-03 | Journal article
Contributors: Germe T; Vörös J; Jeannot F; Taillier T; Stavenger RA; Bacqué E; Maxwell A; Bax BD
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

Imidazopyrazinones (IPYs): non-quinolone bacterial topoisomerase inhibitors showing partial cross-resistance with quinolones.

Journal of medicinal chemistry
2018-03 | Journal article
Contributors: Jeannot F; Taillier T; Despeyroux P; Renard S; Rey A; Mourez M; Poeverlein C; Khichane I; Perrin MA; Versluys S et al.
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

Non-quinolone Topoisomerase Inhibitors

Antimicrobial Resistance in the 21st Century
2018-01-01 | Book chapter
Source: Self-asserted source
Thomas Germe

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

Proceedings of the National Academy of Sciences
2017-05 | Journal article
Contributors: Pan F. Chan; Thomas Germe; Benjamin D. Bax; Jianzhong Huang; Reema K. Thalji; Eric Bacqué; Anna Checchia; Dongzhao Chen; Haifeng Cui; Xiao Ding et al.
Source: Self-asserted source
Thomas Germe via Crossref Metadata Search

DNA topoisomerase IIα controls replication origin cluster licensing and firing time in Xenopus egg extracts.

2013-08 | Journal article
Contributors: Gaggioli V; Le Viet B; Germe T; Hyrien O
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

A non-canonical function of topoisomerase II in disentangling dysfunctional telomeres.

2009-09 | Journal article
Contributors: Germe T; Miller K; Cooper JP
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts.

2008-10 | Journal article
Contributors: Labit H; Perewoska I; Germe T; Hyrien O; Marheineke K
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

Topoisomerase II-DNA complexes trapped by ICRF-193 perturb chromatin structure.

2005-08 | Journal article
Contributors: Germe T; Hyrien O
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

Topoisomerase II can unlink replicating DNA by precatenane removal.

2001-11 | Journal article
Contributors: Lucas I; Germe T; Chevrier-Miller M; Hyrien O
Source: Self-asserted source
Thomas Germe via Europe PubMed Central

Peer review (1 review for 1 publication/grant)

Review activity for Cancer letters. (1)